| SUNDAY |
| 2:00 pm - 9:00 pm | Arrival and Check-in |
| 6:00 pm | Dinner |
| 7:30 pm - 9:30 pm | Synthetic Methodologies - Part 1 |
| Discussion Leader: Greg Roth (Boehringer-Ingelheim-USA) |
| 7:30 pm - 8:10 pm | Peter Wipf (University of Pittsburgh)
"Peptide Mimetics- Pharma's Worst Nightmare?" |
| 8:10 pm - 8:50 pm | Mike Organ (York University-Ontario)
"Recent Advances in High Throughput Synthesis and Screening" |
| 8:50 pm - 9:30 pm | Kay Brummond (University of Pittsburgh)
"Allenes and Transistion Metals: A Diverging Strategy for Assembling Multiple Architecturally Unique Compounds" |
| MONDAY |
| 7:30 am - 8:30 am | Breakfast |
| 8:30 am | Group Photo |
| 9:00 am - 12:30 pm | Synthetic Methodologies - Part 2 |
| Discussion Leader: Phil Kumler (SUNY-Fredonia) |
| 9:00 am - 9:10 am | Chair's Welcome and Announcements |
| 9:10 am - 9:50 am | Shelli McAlpine (San Diego State University)
"Synthesis of Antibiotics: Synergimycin Derivatives and Holliday Junction binders" |
| 9:50 am - 10:30 am | Nina Kann (Chalmers University of Technology - Sweden)
"Solid Phase Synthesis Using Cobalt Carbonyl Complexes" |
| 10:30 am - 11:00 am | Coffee Break |
| 11:00 am - 11:45 am | Rodolfo Lavilla (University of Barcelona - Spain)
"New Tricks for an Old Co-factor: MCR's based on NADH Analogs" |
| 11:45 am - 12:30 pm | Bruce Hamper (Pharmacia - St. Louis)
"Parallel Synthesis of Targeted Heterocycles for Drug Discovery" |
| 12:30 pm | Lunch |
| 1:30 pm - 4:00 pm | Free Time |
| 4:00 pm - 6:00 pm | Poster Session #1 |
| 6:00 pm | Dinner |
| 7:30 pm - 9:30 pm | Natural Product-Like Libraries |
| Discussion Leader: Tom Sowin (Abbott Laboratories-USA) |
| 7:30 pm - 8:00 pm | Sheo Sing (Merck-Rahway)
"The Role of Natural Products in Drug Discovery" |
| 8:00 pm - 8:50 pm | Brian Warrington (GlaxoSmithKline-UK)
Part 1 - "Do Natural Products have a Role in Drug Discovery?"
Part 2 - "Why Microchemistry?" |
| 8:50 pm - 9:30 pm | John Porco (Boston University)
"Expanded Chemical Diversity Using Stereocontrolled Synthesis" |
| TUESDAY |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am - 12:30 pm | Computer Techniques In Combinatorial Chemistry |
| Discussion Leader: Daryl Sauer (Abbott Laboratories-USA) |
| 9:00 am - 9:45 am | Tudor Oprea (University of New Mexico)
"Understanding the Leadlike Space:
An Analysis of Leads, Drugs, and Leads that are Drugs" |
| 9:45 am - 10:30 am | David Nunn (Wyeth-USA)
"Compound Library Design Tools Using Multivariate Analysis" |
| 10:30 am | Coffee Break |
| 11:00 am - 11:45 am | Dick Cramer (Tripos-USA)
"Topomers: Discovering and Optimizing Leads Using 3D Shape for Library Design" |
| 11:45 am - 12:30 pm | Jun Xu (Discovery Partners -USA)
"Combinatorial Library Design Based upon Dynamic Classification and Multiple Propertities Optimization" |
| 12:30 pm | Lunch |
| 1:30 pm - 4:00 pm | Free Time |
| 4:00 pm - 6:00 pm | Poster Session #1 |
| 6:00 pm | Dinner |
| 7:30 pm - 9:30 pm | Lead Optimization Using Combinatorial Chemistry - Case Studies |
| Discussion Leader: Bruce Hamper (Pharmacia) |
| 7:30 pm - 8:10 pm | Andrew Baxter (AstraZeneca -UK)
"Hit to Lead Case Studies" |
| 8:10 pm - 8:50 pm | Adam Gilbert (Wyeth -USA)
"Statistical Molecular Design and Multivariate Analysis of acyl Carrier Protein Synthase (AcpS) Inhibitors" |
| 8:50 pm - 9:30 pm | John Josey (Array BioPharma -USA)
"Target-based Libraries for Lead Identification and Optimization" |
| WEDNESDAY |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am - 12:30 pm | Large Libraries and High Throughput Methods |
| Discussion Leader: Shelli McAlpine (San Diego State University) |
| 9:00 am - 9:45 am | Daryl Sauer (Abbott Laboratories- USA)
"Design and Implementation of a High Throughput Organic Synthesis Service for Drug Discovery" |
| 9:45 am - 10:30 am | Chris Cooper (Bristol-Myers Squibb- USA)
"High Throughput Target Class Library Development and Production: Recent Applications of the IRORI NanoKanTM Combinatorial Chemistry System" |
| 10:30 am | Coffee Break |
| 11:00 am - 11:45 am | Nicolas Winssinger (University Louis Pasteur - France)
"From Split-Pool Libraries to Microarrays and Functional Profiling" |
| 11:45 am - 12:30 pm | Jacqueline Sharon (Boston University -School of Medicine)
"Polyclonal Antibody Libraries for Cancer and Infectious Diseases" |
| 12:30 pm | Lunch |
| 1:30 pm - 4:00 pm | Free Time |
| 4:00 pm - 6:00 pm | Poster Session #2 |
| 6:00 pm | Dinner |
| 7:30 pm - 9:30 pm | Purification and QC of Compound Libraries |
| Discussion Leader: Sam Gerritz (Bristol-Myers Squibb -USA) |
| 7:30 pm - 8:10 pm | Marc Towle (ArQule -USA)
"High Throughtput Purification Approaches to Support a Parallel Synthesis Platform" |
| 8:10 pm - 8:50 pm | Nathan Collins (ChemRx -USA)
"High Throughput Purification as a Commercial Process: The Accelerated Retention Window (ARW) Method as a Library Production Tool" |
| 8:50 pm - 9:30 pm | Larry Truesdale (Pfizer- San Diego)
"High Throughput Supercritical Fluid Chromatography for Combinatorial Libraries" |
| THURSDAY |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am - 12:30 pm | Target Directed Libraries |
| Discussion Leader: Kay Brummond (University of Pittsburgh) |
| 9:00 am - 9:45 am | Barry Bunin (Libraria -USA)
"The Identification of Novel Abl Kinase Inhibitors in Small Targeted Libraries Designed from Gene-Family Wide Public-Domain SAR and Predictive e-Screens" |
| 9:45 am - 10:30 am | Sam Gerritz (Bristol-Myers Squibb -USA)
"Target Class Libraries for the Discovery of New Leads" |
| 10:30 am | Coffee Break |
| 11:00 am - 11:45 am | Peter Brown (GlaxoSmithKline -USA)
"Design of Nuclear Receptors Targeted Arrays" |
| 11:45 am - 12:30 pm | Business Meeting:
"Election of 2004 Vice-chair / Conference Surveys" |
| 12:30 pm | Lunch |
| 1:30 pm - 4:00 pm | Free Time |
| 4:00 pm - 6:00 pm | Poster Session #2 |
| 6:00 pm | Dinner |
| 7:30 pm - 9:30 pm | Keynote Session: Chemistry and Chemical Genomics at Harvard's ICCB |
| Discussion Leader: A. Ganesan (University of Southampton-UK) |
| 7:30 pm - 9:30 pm | Stuart Schreiber, Eric Brauner, Paul Clemons, John Tallarico (Harvard University) |
| FRIDAY |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am | Depart |
