| SUNDAY |
| 2:00 pm - 9:00 pm | Arrival and Check-in |
| 6:00 pm | Dinner |
| 7:30 pm - 9:30 pm | Diversity-Oriented Synthesis |
| Discussion Leader: Jeffrey Aube (University of Kansas, Lawrence, USA) |
| 7:30 pm - 8:20 pm | Andrew Myers (Harvard University, Cambridge, USA)
Complex Natural Product Targets; Synthesis with a view towards Diversity |
| 8:20 pm - 8:55 pm | Prabhat Arya (National Research Council, Ottawa, Canada)
Natural Product-like Complex Polycyclics by Stereocontrolled Diversity Oriented Synthesis |
| 8:55 pm - 9:30 pm | Jared Shaw (ICCB, Harvard University, Cambridge, USA)
Concise, Stereoselective Approaches to Libraries of Structurally Diverse Small Molecules |
| MONDAY |
| 7:45 am - 8:30 am | Breakfast |
| 9:00 am - 12:30 pm | Newer Approaches to Drug Discovery |
| Discussion Leader: Adrian Hobson (Abbott Bioresearch Center, USA) |
| 9:00 am - 9:45 am | Michael Pirrung (Duke University, Durham, USA)
Stalking the Billion-dollar Molecule |
| 9:45 am - 10:30 am | Jeffrey Stafford (Syrrx, San Diego, USA)
Use of High-Throughput Nanovolume Crystallization in Structure-Based Drug Design |
| 10:30 am | Coffee Break |
| 11:00 am - 11:45 am | Daniel Erlanson (Sunesis, South San Francisco, USA)
Applications of Tethering to Drug Discovery |
| 11:45 am - 12:30 pm | Brent Stockwell (Columbia University, New York, USA)
Diagramming Disease Networks with Chemical and Biological Tools |
| 12:45 pm | Group Photo and Lunch |
| 1:30 pm - 4:00 pm | Free Time |
| 4:00 pm - 6:00 pm | Poster Session 1 |
| 6:00 pm | Dinner |
| 7:30 pm - 9:30 pm | Combinatorial Approaches to Catalysis |
| Discussion Leader: Fernando Albericio (University of Barcelona, Barcelona, Spain) |
| 7:30 pm - 8:10 pm | Albrecht Berkessel (University of Koln, Koln, Germany)
Combinatorial Methods in Biomimetic Catalysis |
| 8:10 pm - 8:50 pm | Helma Wennemers (University of Basel, Basel, Switzerland)
Peptide Receptors - From Molecular Recognition to Catalytic Activity |
| 8:50 pm - 9:30 pm | Johannes de Vries (DSM, Geleen, Netherlands)
Two Combinatorial Approaches to Asymmetric Hydrogenation: The Monophos-family and Transition Metal Catalysts Attached to Enzymes |
| TUESDAY |
| 7:45 am - 8:30 am | Breakfast |
| 9:00 am - 12:30 pm | Multicomponent Reactions |
| Discussion Leader: Christine Brotherton-Pleiss (Roche, Palo Alto, USA) |
| 9:00 am - 9:45 am | Jeffrey Aube (University of Kansas, Lawrence, USA)
Multicomponent Synthesis Inspired by Peptides and Alkaloids |
| 9:45 am - 10:30 am | Alexander Dömling (Morphochem, Munich, Germany)
High and Low Throughput MCR Chemistry |
| 10:30 am | Coffee Break |
| 11:00 am - 11:45 am | J. Yadav (Indian Institute of Chemical Technology, Hyderabad, India)
Entry to New Class of NCEs via Metal Catalyzed Reactions |
| 11:45 am - 12:30 pm | Christopher Hulme (Amgen, Thousand Oaks, USA)
New Diversity Oriented Synthetic Methods & a Multi-Component Reaction based Case Study of a Hit-lead Transition Targeting a G-protein Coupled Receptor |
| 12:30 pm | Lunch |
| 1:30 pm - 4:00 pm | Free Time |
| 4:00 pm - 6:00 pm | Poster Session 1 |
| 6:00 pm | Dinner |
| 7:30 pm - 9:30 pm | Lead Discovery and Optimization Case Studies - Part 1 |
| Discussion Leader: John Lambert (Biota, Melbourne, Australia) |
| 7:30 pm - 8:10 pm | Konrad Bleicher (Roche, Basel, Switzerland)
Integrated Library Design and Parallel Synthesis Techniques for the Generation of Targeted Compound Libraries towards G-protein Coupled Receptors |
| 8:10 pm - 8:50 pm | Shahzad Rahman (GlaxoSmithKline, Harlow, United Kingdom)
High Throughput Medicinal Chemistry: from Lead Generation to Optimisation |
| 8:50 pm - 9:30 pm | Masaki Yamada (Tanabe, Osaka, Japan)
Case studies: Design and Synthesis of Target-Based Libraries |
| WEDNESDAY |
| 7:45 am - 8:30 am | Breakfast |
| 9:00 am - 12:30 pm | Solid-phase Synthesis and Supported Reagents |
| Discussion Leader: Helma Wennemers (University of Basel, Basel, Switzerland) |
| 9:00 am - 9:45 am | Fernando Albericio (University of Barcelona, Barcelona, Spain)
Solid-Phase Synthesis of Natural Products: Gaining Diversity by Different Steps in the Procedure |
| 9:45 am - 10:30 am | Dennis Hall (University of Alberta, Edmonton, Canada)
Solid-phase Parallel Synthesis of Receptors and Sensors for Carbohydrates in Neutral Aqueous Environment |
| 10:30 am | Coffee Break |
| 11:00 am - 11:45 am | Steve Smith (Syngenta, Bracknell, United Kingdom)
Microencapsulated Palladium Catalysts: Application in Parallel Synthesis |
| 11:45 am - 12:30 pm | Jan Scicinski (Nuada, Durham, USA)
An Analytical Platform for Screening Reactivity |
| 12:30 pm | Lunch |
| 1:30 pm - 4:00 pm | Free Time |
| 4:00 pm - 6:00 pm | Poster Session 2 |
| 6:00 pm | Dinner |
| 7:30 pm - 9:30 pm | Chemical Biology |
| Discussion Leader: A. Ganesan (University of Southampton, Southampton, United Kingdom) |
| 7:30 pm - 8:10 pm | Maurizio Pellecchia (Burnham Institute, San Diego, USA)
Targeting Apoptosis by Chemical Biology: a Structure Based Approach |
| 8:10 pm - 8:50 pm | Andrew MacMillan (University of Alberta, Edmonton, Canada)
Biochemical Machinery of Combinatorial Protein Expression |
| 8:50 pm - 9:30 pm | Gregory Weiss (University of California, Irvine, USA)
Combinatorial Libraries for Proteomics |
| 9:30 pm - 10:00 pm | Business Meeting |
| THURSDAY |
| 7:45 am - 8:30 am | Breakfast |
| 9:00 am - 12:30 pm | Instrumentation and Enabling Technologies |
| Discussion Leader: John Josey (Array Biopharma, Boulder, USA) |
| 9:00 am - 9:45 am | Oliver Kappe (University of Graz, Graz, Austria)
Microwaves in Combinatorial and High-Throughput Synthesis. New Trends and Applications |
| 9:45 - 10:30 am | David Oare (Gilead, Foster City, USA)
Challenges and Choices for Supporting Array Synthesis on a Small Scale |
| 10:30 am | Coffee Break |
| 11:00 am - 11:45 am | Paul Hanson (University of Kansas, Lawrence, USA)
Ring-Opening Metathesis Polymerization: An Enabling Technology for
Combinatorial Chemistry |
| 11:45 am - 12:30 pm | John Nuss (Exelixis, South San Francisco, USA)
Enhancing Lead Generation and Optimization via High-Throughput Synthesis Methods |
| 12:30 pm | Lunch |
| 1:30 pm - 4:00 pm | Free Time |
| 4:00 pm - 6:00 pm | Poster Session 2 |
| 6:00 pm | Dinner |
| 7:30 pm - 9:30 pm | Lead Discovery and Optimization Case Studies - Part 2 |
| Discussion Leader: Samuel Gerritz (Bristol-Myers-Squibb) |
| 7:30 pm - 8:10 pm | Neerja Bhatnagar (Aventis, Romainville, France)
From Active to Lead in Medicinal Chemistry: Contribution of Combinatorial Chemistry |
| 8:10 pm - 8:50 pm | John Lambert (Biota, Melbourne, Australia)
Design and Synthesis of Small Molecule Libraries to Address Respiratory Viral Disease |
| 8:50 pm - 9:30 pm | Marc-Andre Poupart (Boehringer Ingelheim, Laval, Canada)
Inhibitors of the Hepatitis C Virus NS5B Polymerase: Optimization of Benzimidazole-5-Carboxylic Acid Derivatives Using Parallel Synthesis |
| FRIDAY |
| 7:45 am - 8:30 am | Breakfast |
| 9:00 am | Depart |
