SUNDAY |
4:00 pm - 9:00 pm | Arrival and Check-in |
6:00 pm | Dinner |
7:15 pm | Conference Overview (R. Kip Guy and Site Coordinator) |
7:30 pm - 9:30 pm | THE STATE OF COMBICHEM |
| Discussion Leader: R. Kip Guy (St Jude Children’s Research Hospital) |
7:30 pm - 8:00 pm | Charles Craik (UCSF)
"Defining the role of proteolytic enzymes using combinatorial substrate libraries" |
8:00 pm - 8:10 pm | Discussion |
8:10 pm - 8:40 pm | Adrian Hobson (Abbott)
"Applications of Parallel Synthesis in Hit To Lead" |
8:40 pm - 8:50 pm | Discussion |
8:50 pm - 9:20 pm | Anthony Czarnik (UN-Reno)
"Combinatorial Chemistry's Unsolved Grand Challenges" |
9:20 pm - 9:30 pm | Discussion |
MONDAY |
7:45 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | HOW DO WE DESIGN A LIBRARY? |
| Discussion Leader: Tudor Oprea (U-NM) |
9:00 am - 9:30 am | Herbert Waldman (MPI)
"Biology Oriented Synthesis (BIOS)" |
9:30 am - 9:40 am | Discussion |
9:40 am - 10:10 am | Niklas Blomberg (Astrazeneca)
"Structure driven design of lead generation libraries" |
10:10 am - 10:20 am | Discussion |
10:20 am - 10:50 am | Coffee Break |
10:50 am - 11:20 am | Michal Vieth (Eli Lilly)
"Lessons from compound libraries through fragments, privileged structures and chemogenomics" |
11:20 am - 11:30 am | Discussion |
11:30 am - 12:00 pm | John Irwin (UCSF)
"ZINC: A public access library for HTS and virtual screening" |
12:00 pm - 12:10 pm | Discussion |
12:10 pm - 12:30 pm | Poster Talks (Various) |
12:45 pm | Group Photo follwed by Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | JUST WHAT IS A VALIDATED HIT? |
| Discussion Leader: Stephen Frye (GlaxoSmithKline)
|
7:30 pm - 8:00 pm | Ansgar Schuffenauer (Novartis)
"Sampling the chemistry space with an HTS library" |
8:00 pm - 8:10 pm | Discussion |
8:10 pm - 8:40 pm | Ferenc Darvas (ComInnex) "Integrating a serendipity-enhancing knowledge management tool, chemical genomics, and mesofluidic reactor batteries for hit generation and synthesis" |
8:40 pm - 8:50 pm | Discussion |
8:50 pm - 9:30 pm | Round Table Discussion
Ansgar Schuffenauer, Susan Catalano, Jim Inglese, Mike Lawrence |
TUESDAY |
7:45 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | CASE STUDIES: EUROPEAN ACADEMIC COMBICHEM |
| Discussion Leader: Morten Grøtli (Göteborg University) |
9:00 am - 9:30 am | Morten Meldal (Carlsberg Laboratory)
"Optically encoded beads for rapid automated decoding of split mix libraries" |
9:30 am - 9:40 am | Discussion |
9:40 am - 10:10 am | Stefan Bräse (U Karlsruhe)
"Multifunctional linkers as tools in diversity-orriented solid phase syntheses" |
10:10 am - 10:20 am | Discussion |
10:20 am - 10:50 am | Coffee Break |
10:50 am - 11:20 am | Nina Kann (Chalmers U)
"Synthesis and Applications of P-Chirogenic Phosphine Libraries" |
11:20 am - 11:30 am | Discussion |
11:30 am - 12:00 pm | Richard Lee (UT-Memphis)
"Design and synthesis of optimization libraries for tuberculosis therapeutics" |
12:00 pm - 12:10 pm | Discussion |
12:10 pm - 12:30 pm | Poster Talks (Various) |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | AN OVERVIEW OF THE NIH ROADMAP PROGRAM |
| Discussion Leader: John Schwab (NIH/NIGMS)
|
7:30 pm - 7:40 pm | Roadmap Overview by John Schwab |
7:40 pm - 8:00 pm | Theresa Philippi (NIH/NHGRI)
"The NIH Molecular Libraries Initiative: Chemical Tools for the Genome Era" |
8:00 pm - 8:20 pm | Jim Inglese (NIH/NHGRI)
"Quantitative High Throughput Screening for Chemical Genomics" |
8:20 pm - 8:40 pm | Nicholas Cosford (U Penn/U Pitt)
"Chemistry at the MLSCN's: From Assays to Probes" |
8:40 pm - 9:00 pm | Steve Bryant (NIH/NLM)
"PubChem: An Information Resource Linking Chemistry and Biology" |
9:00 pm - 9:30 pm | Combined Discussion |
WEDNESDAY |
7:45 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | CASE STUDIES 1 |
| Discussion Leader: Tony Czarnik (UN-Reno) |
9:00 am - 9:30 am | Steve Djuric (Abbot Laboratories)
"The use of Multicomponent Coupling Reactions to produce Novel and Diverse "Pharmacologically Relevant" Molecules for Incorporation into Screening Collections" |
9:30 am - 9:40 am | Discussion |
9:40 am - 10:10 am | Graham F. Smith (Pfizer) "An Integrated Approach to Drug Discovery using Parallel Synthesis" |
10:10 am - 10:20 am | Discussion |
10:20 am - 10:50 am | Coffee Break |
10:50 am - 11:20 am | Mike Lawrence (Bristol-Meyers Squibb)
"From HTS to Leads to Clinic: Application of Array Synthesis" |
11:20 am - 11:30 am | Discussion |
11:30 am - 12:00 pm | Kay Severin (EPF-Lausanne)
"Dynamic Combinatorial Chemistry with Metal Complexes" |
12:00 pm - 12:10 pm | Discussion |
12:10 pm - 12:30 pm | Poster Talks (Various) |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | NEW TECHNOLOGIES |
| Discussion Leader: Daryl Sauer (Abbott)
|
7:30 pm - 8:00 pm | Peter Seeberger (ETH)
"Microreactors as tools for reaction screening and multi-step synthesis" |
8:00 pm - 8:10 pm | Discussion |
8:10 pm - 8:40 pm | Alex Godfrey (Eli Lilly)
"Re-examining Key Workflows in High Throughput Medicinal Chemistry" |
8:40 pm - 8:50 pm | Discussion |
8:50 pm - 9:20 pm | Uli Schubert (Dutch Polymer Institute)
"Inkjet printing: The key technology for discrete thin film and single dot libraries" |
9:20 pm - 9:30 pm | Discussion |
THURSDAY |
7:45 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | CASE STUDIES 2 |
| Discussion Leader: Christine Brotherton-Pleiss (Roche Biosciences) |
9:00 am - 9:30 am | Stephen Frye (GlaxoSmithKline)
"Target-Class Focused High Throughput Chemistry" |
9:30 am - 9:40 am | Discussion |
9:40 am - 10:10 am | Richard Jones (Thales Nano) "Chemical validation of novel hydrogenation, ozonolysis, and high pressure microfluidic reactors as new tools for organic synthesis" |
10:10 am - 10:20 am | Discussion |
10:20 am - 10:50 am | Coffee Break |
10:50 am - 11:20 am | Siegfried Reich (SGX Pharmaceuticals)
"Crystallography-Driven Fragment-Based Lead Generation for Oncology Targets" |
11:20 am - 11:30 am | Discussion |
11:30 am - 12:00 pm | TBA |
12:00 pm - 12:10 pm | Discussion |
12:10 pm - 12:30 pm | Business Meeting |
| (Nominations for the next Vice Chair; Fill out Conference Evaluation Forms; Discuss future Site & Scheduling preferences; Election of the next Vice Chair) |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | CHEMICAL GENETICS |
| Discussion Leader: Nina Kann (Chalmers U)
|
7:30 pm - 8:00 pm | Tudor Oprea (UNM)
"Mining chemical space: Understanding chemical probes, leads and drugs" |
8:00 pm - 8:10 pm | Discussion |
8:10 pm - 8:40 pm | Morten Grøtli (Göteborg University)
"Development of kinase inhibitors-tools for dissecting the HOG1 pathway" |
8:40 pm - 8:50 pm | Discussion |
8:50 pm - 9:20 pm | Andrea Cochran (Genentech)
"Understanding beta-sheet stability using phage display" |
9:20 pm - 9:30 pm | Discussion |
FRIDAY |
7:45 am - 8:30 am | Breakfast |