SUNDAY |
4:00 pm - 9:00 pm | Arrival and Check-in |
6:00 pm | Dinner |
7:30 pm - 7:40 pm | Welcome / Introductory Comments |
7:40 pm - 9:30 pm | PERSPECTIVES ON NMR IN STRUCTURAL BIOLOGY |
| Discussion Leader: John Markley (University of Wisconsin) |
7:40 pm - 8:05 pm | James Prestegard (University of Georgia) "Defining Protein-Protein and Protein-Ligand Interactions with RDCs and Paramagnetic Effects" |
8:05 pm - 8:15 pm | Discussion |
8:15 pm - 8:40 pm | Guy Montelione (Rutgers University, New Jersey) "The Challenge of Assessing the Accuracy and Precision of Protein NMR Structures" |
8:40 pm - 8:50 pm | Discussion |
8:50 pm - 9:20 pm | Hartmut Oschkinat (FMP, Berlin) "Protein structure determination by MAS solid state NMR" |
9:20 pm - 9:30 pm | Discussion |
MONDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | EMERGING METHODS FOR STRUCTURE ELUCIDATION |
| Discussion Leader: Michael Nilges (Institut Pasteur, Paris) |
9:00 am - 9:25 am | Michele Vendruscolo (University of Cambridge, UK) "Protein structure determination using NMR chemical shifts" |
9:25 am - 9:35 am | Discussion |
9:35 am - 10:00 am | Marius Clore (NIH, Bethesda, Maryland) "Detection and visualization of transient intermediates and encounter complexes in macromolecular asociation using paramagnetic NMR" |
10:00 am - 10:10 am | Discussion |
10:10 am | Coffee Break / Group Photo |
10:40 am - 11:05 am | Miguel Llinas (Carnegie Mellon University, Pittsburgh) "Au-dessus des NUAGES/Beyond CLOUDS" |
11:05 am - 11:15 am | Discussion |
11:15 am - 11:30 am | Michael Habeck (MPl, Tübingen) "Recent Developments in Inferential Structure Determination" |
11:30 am - 11:35 am | Discussion |
11:35 am - 12:00 pm | Markus Zweckstetter (MPI, Göttingen) "Computational approaches for structure determination of soluble and solid-phase proteins" |
12:00 pm - 12:10 pm | Discussion |
12:10 pm - 12:25 pm | Guillaume Bouvignies (IBS, Grenoble) "High resolution determination of structure and dynamics using residual dipolar couplings" |
12:25 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session I |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | STRUCTURE AND DYNAMICS OF PROTEINS IN THE SOLID STATE |
| Discussion Leader: Anja Böckmann (IBCP, Lyon) |
7:30 pm - 7:55 pm | Rob Tycko (NIH, Bethesda, Maryland) "New concepts in dipolar recoupling for structural studies by solid state NMR" |
7:55 pm - 8:05 pm | Discussion |
8:05 pm - 8:30 pm | Ann McDermott (Columbia University, New York) "Studies of Protein Structure and Dynamics: Emphasis on Anisotropic Interactions" |
8:30 pm - 8:40 pm | Discussion |
8:40 pm - 9:05 pm | Lyndon Emsley (ENS, Lyon) "NMR Crystallography and Physical Chemistry of Proteins" |
9:05 pm - 9:10 pm | Discussion |
9:10 pm - 9:25 pm | Chad Rienstra (University of Illinois, Urbana, Champagne) "Solid-State NMR Protein Structure Refinement with Tensor Measurements" |
9:25 pm - 9:30 pm | Discussion |
TUESDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am - 11:00 am | NEW DIRECTIONS IN DATA ACQUISITION, PROCESSING AND ANALYSIS |
| Discussion Leader: Jeffrey Hoch (University of Connecticut) |
9:00 am - 9:25 am | Eriks Kupce (Varian Inc.) "Hyper-Dimensional NMR Spectroscopy" |
9:25 am - 9:35 am | Discussion |
9:35 am - 10:10 am | Dominique Marion (CNRS, IBS, Grenoble) "Non-linear acquisition and Fourier transform" |
10:00 am - 10:10 am | Discussion |
10:10 am | Coffee Break |
10:40 am - 10:55 am | Martin Billeter (Gothenberg University) "Multi-way Decomposition of NMR Spectra with Coupled Evolution Periods" |
10:55 am - 11:00 am | Discussion |
11:00 am - 11:15 am | Mehdi Mobli (University of Manchester) "Spectral Reconstruction Methods in Fast NMR: Reduced Dimensionality, Random Sampling, and Maximum Entropy" |
11:15 am - 11:20 am | Discussion |
11:20 am - 12:30 pm | PROTEIN DYNAMICS : COMPARING PREDICTION AND EXPERIMENT |
| Discussion Leader: Rafael Brüschweiler (Florida State University, NHFML) |
11:20 am - 11:45 am | David Case (Scripps Clinic) "Revisiting an old problem: the connections between MD simulations and NMR relaxation results" |
11:45 am - 11:55 am | Discussion |
11:55 am - 12:20 pm | Daniel Abergel (ENS, Paris) "Predicting protein dynamics from structures by a network of coupled rotators" |
12:20 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session I |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | KINETICS, INTERACTIONS AND DYNAMICS OF COMPLEX SYSTEMS |
| Discussion Leader: Arthur Palmer (University of Columbia, NY) |
7:30 pm - 7:55 pm | Carol Beth Post (Purdue University) "Structural insights on viral capsid proteins from NMR" |
7:55 pm - 8:05 pm | Discussion |
8:05 pm - 8:30 pm | Remco Sprangers (University of Toronto) "Quantitative NMR studies of the 20S proteasome reveals a dynamic macromolecular machine" |
8:30 pm - 8:40 pm | Discussion |
8:40 pm - 9:05 pm | Kathleen Hall (Washington University School of Medicine) "Networks of correlated residues in U1A RBD1" |
9:05 pm - 9:10 pm | Discussion |
9:10 pm - 9:25 pm | Luciano Mueller (Bristol-Myers Squibb) "High Through-Put NMR of Protein-Ligand Complexes" |
9:25 pm - 9:30 pm | Discussion |
WEDNESDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | PARTIALLY FOLDED, MISFOLDED AND UNFOLDED PROTEINS |
| Discussion Leader: Harald Schwalbe (University of Frankfurt, Germany) |
9:00 am - 9:25 am | Peter Wright (Scripps Clinic) "Characterization of the structure and dynamics of intrinsically disordered proteins" |
9:25 am - 9:35 am | Discussion |
9:35 am - 10:00 am | Tobin Sosnick (University of Chicago) "A statistical coil model of the unfolded state: Resolving the reconciliation problem" |
10:00 am - 10:10 am | Discussion |
10:10 am | Coffee Break |
10:40 am - 11:05 am | Harald Schwalbe (University of Frankfurt) "Conformation of the Polypeptide Chain in Model Peptides and in Non-native States of Proteins" |
11:05 am - 11:15 am | Discussion |
11:15 am - 11:30 am | Tomasz Religa (MRC, Cambridge) "Structural studies of a protein denatured state / folding intermediate" |
11:30 am - 11:35 am | Discussion |
11:35 am - 12:00 pm | Stephan Grzesiek (Biozentrum, Basel) "Conformational sampling from residual dipolar and hydrogen bond scalar couplings" |
12:00 am - 12:10 am | Discussion |
12:10 pm - 12:25 pm | Pau Bernado (Parc Cientific de Barcelona) "Structural Insights into natively unfolded proteins from NMR and small-angle x-ray scattering" |
12:25 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session II |
6:00 pm | Dinner |
7:00 pm - 7:30 pm | Business Meeting |
| (Nominations for the next Vice Chair; Fill out Conference Evaluation Forms; Discuss future Site & Scheduling preferences; Election of the next Vice Chair) |
7:30 pm - 9:30 pm | DOMAIN DYNAMICS IN BIOMOLECULES |
| Discussion Leader: Rafael Brüschweiler (Florida State University, NHFML) |
7:30 pm - 7:55 pm | David Fushman (University of Maryland) "Structure and domain dynamics in multidomain proteins by NMR. Di-ubiquitin as a study case" |
7:55 pm - 8:05 pm | Discussion |
8:05 pm - 8:30 pm | Claudio Luchinat (CERM, University of Florence) "Extracting information from dynamically averaged NMR parameters" |
8:30 pm - 8:40 pm | Discussion |
8:40 pm - 9:05 pm | Nico Tjandra (NIH, Bethesda, Maryland) "Characterization of slow domain motion in protein" |
9:05 pm - 9:15 pm | Discussion |
9:10 pm - 9:25 pm | Klaartje Houben (IBS Grenoble) "Insights into the dynamics of the partly unfolded protein domain PX important for RNA synthesis in Sendai Virus" |
9:25 pm - 9:30 pm | Discussion |
THURSDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | FROM PROTEIN DYNAMICS TO FUNCTION |
| Discussion Leader: Stephan Grzesiek (Biozentrum, Basel) |
9:00 am - 9:25 am | Arthur Palmer (University of Columbia, New York) "New methods and applications of spin relaxation in proteins" |
9:25 am - 9:35 am | Discussion |
9:35 am - 10:00 am | Dorothee Kern (Brandeis University, Massachussetts) "Linkage between stability, dynamics and structure for enzyme catalysis" |
10:00 am - 10:10 am | Discussion |
10:10 am | Coffee Break |
10:35 am - 11:00 am | Christian Griesinger (MPI, Göttingen) "Protein internal and domain motion studied by rdcs" |
11:00 am - 11:10 am | Discussion |
11:10 am - 11:25 am | Tony Mittermaier (McGill University, Montreal) "Side-Chain Interactions in the Folding Pathway of a Fyn SH3 Domain Mutant Studied by Relaxation Dispersion NMR Spectroscopy" |
11:25 am - 11:30 am | Discussion |
11:30 am - 11:45 am | Josh Wand (University of Pennsylvania) "An unprecedented role for residual protein entropy in protein-protein molecular recognition revealed by NMR relaxation" |
11:45 am - 11:50 am | Discussion |
11:50 am - 12:05 pm | Frans Mulder (University of Gröningen) "In search of the protein glass transition for calbindin D9k" |
12:05 pm - 12:10 pm | Discussion |
12:10 pm - 12:25 pm | Carine van Heijenoort (CNRS, Gif-sur Yvette, Paris) "NMR multidomain proteins stability and folding analysis : conformational exchange, temperature and pH stability variation in human annexin 1 first domain" |
12:25 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session II |
6:00 pm | Conference Dinner |
7:30 pm - 8:50 pm | MACROMOLECULAR COMPLEXES USING NMR AND COMPLEMENTARY TECHNIQUES |
| Discussion Leader: Martin Blackledge (CEA, IBS, Grenoble) |
7:30 pm - 8:00 pm | Maxim Pethoukov (EMBL Hamburg) "Small-angle X-ray and neutron scattering as complementary methods to NMR" |
8:00 pm - 8:10 pm | Discussion |
8:10 pm - 8:40 pm | Alexander Bonvin (Utrecht University) "Beyond "simple" protein-protein modelling using HADDOCK..." |
8:40 pm - 8:50 pm | Discussion |
7:30 pm - 8:50 pm | PERSPECTIVES IN BIOMOLECULAR NMR |
8:50 pm - 9:20 pm | Ad Bax (NIH, Bethesda, Maryland) "Weak alignment provides new NMR opportunities" |
9:20 pm - 9:30 pm | Discussion |
FRIDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am | Departure |