SUNDAY |
4:00 pm - 9:00 pm | Arrival and Check-in (Office Closed 6:00 pm - 7:45 pm) |
6:00 pm | Dinner |
7:30 pm - 7:50 pm | Welcome / Introductory Comments by GRC Site Staff and Chair |
7:50 pm - 9:30 pm | Perspectives on NMR in Structural and Systems Biology |
| Discussion Leader: Rafael Brüschweiler |
7:50 pm - 8:30 pm | Lewis Kay (University of Toronto)
"Seeing the invisible with NMR spectroscopy" |
8:30 pm - 8:40 pm | Discussion |
8:40 pm - 9:20 pm | Jeremy Nicholson (Imperial College, London)
"Structure and pathway information recovery from biological NMR spectroscopic data" |
9:20 pm - 9:30 pm | Discussion |
MONDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | New Approaches in Rapid Multi-Dimensional NMR: Acquisition, Processing, Automation |
| Discussion Leader: Christina Redfield |
9:00 am - 9:25 am | Thomas Szyperski (SUNY Buffalo)
"Advances in GFT projection NMR spectroscopy" |
9:25 am - 9:35 am | Discussion |
9:35 am - 10:00 am | Jeffrey Hoch (University of Connecticut)
"Optimal strategies for sparse sampling" |
10:00 am - 10:10 am | Discussion |
10:10 am - 10:35 am | Martin Billeter (Goteborg University)
"Multi-way decomposition for complete assignment and structure of proteins" |
10:35 am - 10:45 am | Discussion |
10:45 am - 11:15 am | Coffee Break / Group Photo |
11:15 am - 11:40 am | Bernhard Brutscher (IBS Grenoble)
"Tools for fast data acquisition and analysis in protein NMR spectroscopy" |
11:40 am - 11:50 am | Discussion |
11:50 am - 12:05 pm | Victor Jaravine (Goteborg University)
"Hyper-dimensional real-time NMR spectroscopy in structural genomics" |
12:05 pm - 12:10 pm | Discussion |
12:10 pm - 12:25 pm | Krzysztof Kazimierczuk (University of Warsaw)
"What can multidimensional Fourier transform do?" |
12:25 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time / Excursion |
4:00 pm - 5:30 pm | Poster Session [PDF] |
5:30 pm - 7:30 pm | NMR of Partially Folded, Unfolded and Misfolded proteins |
| Discussion Leader: Stephan Grzesiek |
5:30 pm - 5:55 pm | Julie Forman-Kay (Hospital for Sick Children, Toronto)
"Characterization of the intrinsically disordered protein ensembles and their interactions in biological regulation" |
5:55 pm - 6:05 pm | Discussion |
6:05 pm - 6:30 pm | Martin Blackledge (IBS Grenoble)
"NMR characterization of conformational disorder in unfolded and partially folded proteins" |
6:30 pm - 6:40 pm | Discussion |
6:40 pm - 7:05 pm | Peter Wright (The Scripps Research Institute, La Jolla)
"Mapping protein folding landscapes by NMR: new insights into folding intermediates" |
7:05 pm - 7:15 pm | Discussion |
7:15 pm - 7:25 pm | Jeff Peng (U. of Notre Dame)
"A site-to-site communication mechanism within modular proteins?" |
7:25 pm - 7:30 pm | Discussion |
8:00 pm | Dinner |
TUESDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | NMR Opportunities in Metabolomics/Metabonomics |
| Discussion Leader: Jeremy Nicholson |
9:00 am - 9:25 am | David Wishart (University of Alberta)
"Automated metabolite identification and quantification by NMR" |
9:25 am - 9:35 am | Discussion |
9:35 am - 10:00 am | Art Edison (University of Florida)
"The life of a worm: sex, food, and starvation - the role of small molecules in the ecology of C. elegans" |
10:00 am - 10:10 am | Discussion |
10:10 am - 10:35 am | Jules Griffin (University of Cambridge, UK)
"Application of NMR spectroscopy based metabolomics to understanding the regulation of systemic metabolism" |
10:35 am - 10:45 am | Discussion |
10:45 am - 11:15 am | Coffee Break |
11:15 am - 11:40 am | Gerhard Wagner (Harvard University)
"Metabolic changes due to expression of oncogenes" |
11:40 am - 11:50 am | Discussion |
11:50 am - 12:05 pm | John Markley (U. of Wisconsin, Madison)
"BMRB database for metabolites and other small molecules of biological importance" |
12:05 pm - 12:10 pm | Discussion |
12:10 pm - 12:25 pm | Leo Cheng (Harvard Medical School)
"Metabolomic imaging in medicine" |
12:25 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time / Excursion |
4:00 pm - 5:30 pm | Poster Session [PDF] |
5:30 pm - 7:30 pm | Exploring the Potential of Ultra-Fast/Ultra-High Sensitivity NMR |
| Discussion Leader: Thomas Szyperski |
5:30 pm - 5:55 pm | Lucio Frydman (Weizmann Institute)
"Some unusual experiments at the interface of NMR, EPR and MRI" |
5:55 pm - 6:05 pm | Discussion |
6:05 pm - 6:30 pm | Ulrich Guenther (NMR Center Birmingham, UK)
"New methods for DNP-NMR in biological applications" |
6:30 pm - 6:40 pm | Discussion |
6:40 pm - 6:55 pm | Christian Griesinger (MPI Goettingen)
"Towards a shuttle DNP spectrometer" |
6:55 pm - 7:00 pm | Discussion |
7:00 pm - 7:15 pm | Silvia Cavagnero (U. of Wisconsin, Madison)
"Photo-CIDNP-based enhancement of 1H and 15N polarization in heteronuclear NMR" |
7:15 pm - 7:20 pm | Discussion |
8:00 pm | Dinner |
WEDNESDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | Quantitative Computational Approaches to the Prediction of Protein Structure and Dynamics |
| Discussion Leader: Martin Billeter |
9:00 am - 9:25 am | Carlos Simmerling (SUNY, Stony Brook)
"Challenges and successes in the comparison of atomic-level simulations to experimental data" |
9:25 am - 9:35 am | Discussion |
9:35 am - 10:00 am | Art Palmer (Columbia U.)
"Protein dynamics: experiment and theory on fast and slow timescales" |
10:00 am - 10:10 am | Discussion |
10:10 am - 10:35 am | Valerie Daggett (University of Washington)
"Dynameomics" |
10:35 am - 10:45 am | Discussion |
10:45 am - 11:15 am | Coffee Break |
11:15 am - 11:30 am | Scott Showalter (Florida State University and NHMFL)
"Dynamic control of ligand binding modes of the p53-binding cleft in MDM2" |
11:30 am - 11:35 am | Discussion |
11:35 am - 11:50 am | Matthias Buck (Case Western Reserve U., Cleveland)
"Using an ensemble approach in the refinement of an NMR derived structure. Comparison with the x-ray structure and molecular dynamics calculations" |
11:50 am - 11:55 am | Discussion |
11:55 am - 12:10 pm | Kresten Lindorff-Larsen (D.E. Shaw Research)
"Evaluating molecular mechanics force fields by comparison with NMR experiments" |
12:10 pm - 12:15 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 5:30 pm | Free Time / Excursion |
5:30 pm - 7:30 pm | Protein Structure and Dynamics by Solid State NMR |
| Discussion Leader: Joshua Wand |
5:30 pm - 5:55 pm | Chad Rienstra (University of Illinois, Urbana-Champaign)
"Can magic-angle spinning NMR protein structures exceed the quality of crystallography and solution NMR?" |
5:55 pm - 6:05 pm | Discussion |
6:05 pm - 6:30 pm | Bernd Reif (FMP, Berlin)
"Characterization of dynamics in rotating solids using perdeuterated proteins" |
6:30 pm - 6:40 pm | Discussion |
6:40 pm - 7:00 pm | Gianluigi Veglia (U. of Minnesota)
"Hybrid solution and solid-state NMR approach to determine the high-resolution structure and topology of membrane proteins" |
7:00 pm - 7:10 pm | Discussion |
7:15 pm - 8:00 pm | Business Meeting |
| (Nominations for the next Vice Chair; Fill out Conference Evaluation Forms; Discuss future Site & Scheduling preferences; Election of the next Vice Chair) |
8:00 pm | Dinner |
THURSDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | Unique NMR Insights on Biomolecular Dynamics in Solution |
| Discussion Leader: James Prestegard |
9:00 am - 9:25 am | Ad Bax (NIH)
"Chemical shifts, dipolar couplings, and what to do with it all" |
9:25 am - 9:35 am | Discussion |
9:35 am - 10:00 am | Bertil Halle (Lund University)
"Nanosecond to microsecond protein dynamics probed by magnetic relaxation dispersion of buried water molecules" |
10:00 am - 10:10 am | Discussion |
10:10 am - 10:35 am | Joshua Wand (University of Pennsylvania)
"Towards a quantitative dynamical proxy for protein conformational entropy" |
10:35 am - 10:45 am | Discussion |
10:45 am - 11:15 am | Coffee Break |
11:15 am - 11:40 am | Dorothee Kern (Brandeis University)
"Pathways of conformational transitions elucidated by pressure NMR and MD" |
11:40 am - 11:50 am | Discussion |
11:50 am - 12:15 pm | Hashim Al-Hashimi (University of Michigan)
"Visualizing motions in RNA by NMR" |
12:15 pm - 12:25 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 5:30 pm | Poster Session [PDF] |
5:30 pm - 7:30 pm | Biomolecular Complexes and Interactions |
| Discussion Leader: Peter Wright |
5:30 pm - 5:55 pm | Christina Redfield (University of Oxford)
"NMR studies of the bacterial disulfide oxidoreductase, DsbD" |
5:55 pm - 6:05 pm | Discussion |
6:05 pm - 6:30 pm | Claudio Luchinat (University of Florence)
"Inter-domain and inter-molecular structural relationships probed by paramagnetic metal ions in solution and in the solid state" |
6:30 pm - 6:40 pm | Discussion |
6:40 pm - 6:55 pm | Smita Mohanty (Auburn University)
"Structural basis for the function of yeast oligosaccharyltransferase subunits: Ost4p and Stt3p" |
6:55 pm - 7:00 pm | Discussion |
7:00 pm - 7:25 pm | James Prestegard (University of Georgia)
"Structures of proteins and protein-carbohydrate complexes from sparse labeling and paramagnetic constrains" |
7:25 pm - 7:30 pm | Discussion |
8:00 pm | Dinner |
FRIDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am | Depart |