SUNDAY |
4:00 pm - 8:00 pm | Arrival and Check-in (Check-in Desk Closed 6:00 pm - 7:45 pm) |
5:00 pm | Welcome Mixer |
6:00 pm | Dinner |
7:30 pm - 7:50 pm | Welcome / Introductory Comments by GRC Site Staff and Chair |
7:50 pm - 9:30 pm | Perspectives for NMR and Computation in Structural Biology |
| Discussion Leader: Stephan Grzesiek (University of Basel) |
7:50 pm - 8:30 pm | Lyndon Emsley (Ecole Normale Superieure de Lyon)
"Protein NMR Crystallography" |
8:30 pm - 8:40 pm | Discussion |
8:40 pm - 9:20 pm | Michele Parrinello (ETH Zurich)
"The well-tempered ensemble" |
9:20 pm - 9:30 pm | Discussion |
MONDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | New Efficient Avenues for Structure Determination |
| Discussion Leader: Lewis Kay (University of Toronto) |
9:00 am - 9:25 am | Ad Bax (National Institutes of Health)
"Chemical shifts, SAXS, and dipolar couplings: how can they help?" |
9:25 am - 9:35 am | Discussion |
9:35 am - 10:00 am | Michele Vendruscolo (University of Cambridge)
"Determination of the Dynamics of Proteins Using Residual Dipolar Couplings" |
10:00 am - 10:10 am | Discussion |
10:10 am - 10:40 am | Coffee Break / Group Photo |
10:40 am - 11:05 am | Alexandre Bonvin (Utrecht University)
"Structural biology on the GRID: the tale of the WeNMR virtual research community" |
11:05 am - 11:15 am | Discussion |
11:15 am - 11:40 am | David Wishart (University of Alberta)
"Advances in Predicting Chemical Shifts from Structure and Structure from Chemical Shifts" |
11:40 am - 11:50 am | Discussion |
11:50 am - 12:15 pm | Jens Meiler (Vanderbilt University)
"De novo membrane protein folding from sparse NMR data" |
12:15 pm - 12:25 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 5:30 pm | Poster Session I |
5:30 pm - 7:30 pm | Advances in Speed and Sensitivity of Data Acquisition |
| Discussion Leader: Jeff Hoch (University of Connecticut) |
5:30 pm - 5:55 pm | Thomas Prisner (Goethe University Frankfurt)
"Dynamic Nuclear Polarization at High Magnetic Fields in the Liquid State" |
5:55 pm - 6:05 pm | Discussion |
6:05 pm - 6:30 pm | Guy Montelione (Rutgers University)
"Assessment of Protein NMR Structures Determined by Automated and Manual Analysis Methods" |
6:30 pm - 6:40 pm | Discussion |
6:40 pm - 6:50 pm | Eriks Kupce (Agilent Techmologies)
"Compressive Sensing with Multiple Receivers in NMR Spectroscopy" |
6:50 pm - 6:55 pm | Discussion |
6:55 pm - 7:20 pm | Lucio Frydman (Weizmann Institute of Science)
"Novel RF Strategies For a Faster and More Efficient Acquisition of Multidimensional NMR Spectra" |
7:20 pm - 7:30 pm | Discussion |
8:00 pm | Dinner |
TUESDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | Computer Simulations of Biomolecular Structure and Dynamics |
| Discussion Leader: Art Palmer (Columbia University) |
9:00 am - 9:25 am | Valerie Daggett (University of Washington)
"Dynameomics: Motion, entropy, and NMR order parameters" |
9:25 am - 9:35 am | Discussion |
9:35 am - 10:00 am | Kresten Lindorff-Larsen (D.E. Shaw Research)
"Testing and improving force fields for long-timescale MD simulations" |
10:00 am - 10:10 am | Discussion |
10:10 am - 10:30 am | Coffee Break |
10:30 am - 10:55 am | Rafael Brueschweiler (Florida State University)
"From NMR Parameters to Boltzmann Ensembles" |
10:55 am - 11:05 am | Discussion |
11:05 am - 11:30 am | David Case (Rutgers University)
"New Analyses of Chemical Shifts and Anisotropies in Proteins and Nucleic Acids" |
11:30 am - 11:40 am | Discussion |
11:40 am - 12:05 pm | Martin Blackledge (CEA/CNRS/UJF Grenoble)
"Developing a Quantitative Understanding of Functional Disorder in Proteins" |
12:05 pm - 12:15 pm | Discussion |
12:15 pm - 12:25 pm | Tanja Kortemme (UCSF)
"Robotics-inspired approaches to modeling protein conformations and designing functional interactions" |
12:25 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 5:30 pm | Poster Session II |
5:30 pm - 7:30 pm | Structure and Dynamics in the Solid State |
| Discussion Leader: Lyndon Emsley (Ecole Normale Superieure de Lyon) |
5:30 pm - 5:55 pm | Mei Hong (Iowa State University)
"Structure and dynamics of the influenza M2 proton channel by solid-state NMR" |
5:55 pm - 6:05 pm | Discussion |
6:05 pm - 6:30 pm | Beat Meier (ETH Zurich)
"Amyloids and Prions as seen by Solid-State NMR" |
6:30 pm - 6:40 pm | Discussion |
6:40 pm - 7:05 pm | Bernd Reif (Technische Universität München)
"Quantification of dynamics in rotating solids using perdeuterated proteins" |
7:05 pm - 7:15 pm | Discussion |
7:15 pm - 7:25 pm | Robert Tycko (National Institutes of Health)
"Incorporating Novel Torsion Angle Constraints into Solid State NMR Structures" |
7:25 pm - 7:30 pm | Discussion |
8:00 pm | Dinner |
WEDNESDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | New Approaches to Detect Biomolecular Dynamics |
| Discussion Leader: Peter Wright (The Scripps Research Institute) |
9:00 am - 9:25 am | Lewis Kay (University of Toronto)
"Seeing the invisible by solution NMR spectroscopy" |
9:25 am - 9:35 am | Discussion |
9:35 am - 10:00 am | Art Palmer (Columbia University)
"Protein dynamics from experiment and simulation" |
10:00 am - 10:10 am | Discussion |
10:10 am - 10:30 am | Coffee Break |
10:30 am - 10:55 am | Marius Clore (National Institutes of Health)
"Hybrid structure determination methods, paramagnetic relaxation and differential relaxation" |
10:55 am - 11:05 am | Discussion |
11:05 am - 11:30 am | Gabriele Varani (University of Washington)
"Intermediate motions in RNA from solid state and solution NMR" |
11:30 am - 11:40 am | Discussion |
11:40 am - 12:05 pm | Hashim Al-Hashimi (University of Michigan)
"Transient Hoogsteen Base-Pairs in Canonical Duplex DNA" |
12:05 pm - 12:15 pm | Discussion |
12:15 pm - 12:25 pm | Nicolai Skrynnikov (Purdue University)
"Toward a comprehensive model of protein disorder: long MD simulations validated through experimental data" |
12:25 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 5:30 pm | Free Time / Optional Activities: Excursion to Lucca; Mountain hiking |
4:00 pm - 5:30 pm | Poster Session III (Optional) |
5:30 pm - 7:30 pm | Quantifying Structure and Dynamics of Disordered Protein States |
| Discussion Leader: Martin Blackledge (CEA/CNRS/UJF Lyon) |
5:30 pm - 5:50 pm | Peter Wright (The Scripps Research Institute)
"Folding and binding of intrinsically disordered proteins" |
5:50 pm - 6:00 pm | Discussion |
6:00 pm - 6:20 pm | Julie Forman-Kay (University of Toronto)
"ENSEMBLE characterization of intrinsically disordered proteins and their dynamic complexes" |
6:20 pm - 6:30 pm | Discussion |
6:30 pm - 6:50 pm | Markus Zweckstetter (Max-Planck-Institut für biophysikalische Chemie)
"Folding and Misfolding of Tau" |
6:50 pm - 7:00 pm | Discussion |
7:00 pm - 7:20 pm | Jane Dyson (The Scripps Research Institute)
"Examining unstructured and partly structured proteins by NMR" |
7:20 pm - 7:30 pm | Discussion |
7:30 pm - 8:00 pm | Business Meeting |
| Nominations for the next Vice Chair; Fill out Conference Evaluation Forms; Discuss future Site & Scheduling preferences; Election of the next Vice Chair |
8:00 pm | Dinner |
THURSDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | Combining NMR with Complementary Techniques |
| Discussion Leader: Jim Prestegard (University of Georgia) |
9:00 am - 9:25 am | Jill Trewhella (University of Sydney)
"Combining SAXS and NMR data for improved structure determination: requirements for accurate and reliable scattering data" |
9:25 am - 9:35 am | Discussion |
9:35 am - 10:00 am | Justin Benesch (University of Oxford)
"Integrating NMR with Ion-Mobility Mass Spectrometry: Monitoring Structural Dynamics on the Secondary to Quaternary Levels" |
10:00 am - 10:10 am | Discussion |
10:10 am - 10:30 am | Coffee Break |
10:30 am - 10:55 am | Ben Schuler (University of Zurich)
"Single molecule spectroscopy of protein folding dynamics" |
10:55 am - 11:05 am | Discussion |
11:05 am - 11:30 am | Claudio Luchinat (University of Florence)
"Computational aspects of paramagnetism-based NMR" |
11:30 am - 11:40 am | Discussion |
11:40 am - 12:05 pm | Marcellus Ubbink (Leiden University)
"Structure and dynamics of protein complexes from paramagnetic NMR and modeling" |
12:05 pm - 12:15 pm | Discussion |
12:15 pm - 12:25 pm | Frans Mulder (University of Groningen)
"Protein 'random coil' chemical shifts derived from intrinsically disordered proteins" |
12:25 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 5:30 pm | Poster Session III |
5:30 pm - 7:30 pm | NMR Detection of Biomolecular Function in Complex Systems |
| Discussion Leader: Jane Dyson (The Scripps Research Institute) |
5:30 pm - 5:55 pm | Masahiro Shirakawa (Kyoto University)
"Mechanics of cells and intracellular macromolecules measured by magnetic resonance" |
5:55 pm - 6:05 pm | Discussion |
6:05 pm - 6:30 pm | Phil Selenko (FMP Berlin)
"Looking at proteins inside live cells with NMR spectroscopy" |
6:30 pm - 6:40 pm | Discussion |
6:40 pm - 7:05 pm | Jerome Boisbouvier (CEA/CNRS/UJF Grenoble)
"Towards Real-Time NMR Studies of Biological Machineries" |
7:05 pm - 7:15 pm | Discussion |
7:15 pm - 7:25 pm | Remco Sprangers (Max-Planck-Institut for Developmental Biology)
"Insights into the mechanism of the 250 kDa exosome complex" |
7:25 pm - 7:30 pm | Discussion |
8:00 pm | Dinner |
10:00 pm | Disco Night |
FRIDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am | Departure |