Sunday
4:00 pm - 8:00 pm
Arrival and Check-in
6:00 pm - 7:00 pm
Dinner
7:30 pm - 7:40 pm
Introductory Comments by GRC Site Staff / Welcome from the GRC Chair
7:40 pm - 9:30 pm
Keynote Session: Protein Movies and Protein Design
Discussion Leader: Valerie Daggett (University of Washington, USA)
7:40 pm - 8:25 pm
Rohit Pappu (Washington University in St. Louis, USA)
"Contributions of Disorder to Protein Phase Transitions"
8:25 pm - 8:35 pm
Discussion
8:35 pm - 9:20 pm
Tanja Mittag (St. Jude Children's Research Hospital, USA)
"Linking Sequence-Ensemble Relationships and Phase Separation of a Low Complexity Domain"
9:20 pm - 9:30 pm
Discussion
Monday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
New Concepts to Measure and Describe Biomolecular Motion
Discussion Leader: Angela Gronenborn (University of Pittsburgh, USA)
9:00 am - 9:30 am
Benoit Roux (University of Chicago, USA)
"Insight by NMR and MD into Potassium Channel Gating"
9:30 am - 9:40 am
Discussion
9:40 am - 10:10 am
Nicola Salvi (Institut de Biologie Structurale, France)
"Capturing the Dynamics of Intrinsically Disordered Proteins Using NMR Relaxation and Molecular Dynamics Simulations"
10:10 am - 10:20 am
Discussion
10:20 am - 10:50 am
Coffee Break
10:50 am - 11:15 am
Selected from Poster Abstracts: Tatiana Agback (Swedish University of Agricultural Sciences, Sweden)
"Coupling of Dynamics and Allostery in the Apo MALT1 Paracaspase"
11:15 am - 11:25 am
Discussion
11:25 am - 11:50 am
Selected from Poster Abstracts: Baptiste Busi (École Polytechnique Fédérale de Lausanne, Switzerland)
"NMR Studies of Hierarchical Protein Dynamics"
11:50 am - 12:00 pm
Discussion
12:00 pm - 12:20 pm
Selected from Poster Abstracts: Albert Escobedo (IRB Barcelona, Spain)
"Side Chain to Main Chain Hydrogen Bonds in Polyglutamine Helices"
12:20 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Group Photo / Lunch
1:30 pm - 4:30 pm
Free Time
3:00 pm - 4:00 pm
The GRC Power Hourâ„¢
The GRC Power Hourâ„¢ is designed to address challenges women face in science and issues of diversity and inclusion. The program supports the professional growth of all members of our communities by providing an open forum for discussion and mentoring.
Organizers: Angela Gronenborn (University of Pittsburgh, USA) and Dorothee Kern (Howard Hughes Medical Institute / Brandeis University, USA)
4:30 pm - 6:00 pm
Poster Session
6:00 pm - 8:00 pm
Calculation of Mechanisms in Magnetic Resonance
Discussion Leader: Arthur Palmer (Columbia University, USA)
6:00 pm - 6:30 pm
Adriaan Bax (National Institutes of Health, USA)
"Stability of a Single Spring-Like Alpha-Helix Quantified by Modern NMR"
6:30 pm - 6:40 pm
Discussion
6:40 pm - 7:10 pm
Steffen Glaser (Technical University of Munich, Germany)
"Optimal Control of Spin Dynamics in NMR Experiments: Cooperative Pulses and Beyond"
7:10 pm - 7:20 pm
Discussion
7:20 pm - 7:50 pm
Selected from Poster Abstracts: Wim Vranken (Vrije Universiteit Brussel, Belgium)
"Auto-Encoding NMR Chemical Shifts from Their Native Vector Space to a Residue-Level Biophysical index"
7:50 pm - 8:00 pm
Discussion
8:00 pm - 9:00 pm
Dinner
Tuesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Processing Magnetic Resonance Data
Discussion Leader: Jeffrey Hoch (UConn Health, USA)
9:00 am - 9:30 am
Haribabu Arthanari (Dana-Farber Cancer Institute / Harvard Medical School, USA)
"Resolution Beyond the Nyquist Grid: Encoding Information in Peak Shapes"
9:30 am - 9:40 am
Discussion
9:40 am - 10:10 am
Krzysztof Kazimierczuk (University of Warsaw, Poland)
"Acquiring and Processing Non-Stationary NMR Signals"
10:10 am - 10:20 am
Discussion
10:20 am - 10:50 am
Coffee Break
10:50 am - 11:15 am
Selected from Poster Abstracts: Kwaku Dayie (University of Maryland, USA)
"Structure and Dynamics of Large RNA NMR Facilitated by Chemo-Enzymatic Isotopic (19F, 13C, 2H, 15N) Labeling"
11:15 am - 11:25 am
Discussion
11:25 am - 11:50 am
Selected from Poster Abstracts: Jeffrey Purslow (Iowa State University, USA)
"Active Site Breathing of the Human RNA Demethylase Alkbh5 Revealed by Solution NMR and Accelerated Molecular Dynamics Simulations"
11:50 am - 12:00 pm
Discussion
12:00 pm - 12:20 pm
Selected from Poster Abstracts: Angus Robertson (National Institutes of Health, USA)
"Amyloid Beta Under Pressure"
12:20 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:30 pm
Free Time
4:30 pm - 6:00 pm
Poster Session
6:00 pm - 8:00 pm
Advances in Pulse Sequence Design
Discussion Leader: Haribabu Arthanari (Dana-Farber Cancer Institute / Harvard Medical School, USA)
6:00 pm - 6:30 pm
Ann McDermott (Columbia University, USA)
"Design of Novel Solid State NMR Pulse Sequences for Membrane Proteins"
6:30 pm - 6:40 pm
Discussion
6:40 pm - 7:00 pm
Selected from Poster Abstracts: Mihajlo Novakovic (Weizmann Institute of Science, Israel)
"Looped, PROjective SpectroscopY (L-PROSY): Improved Schemes for Executing Multidimensional NOESY/TOCSY/CP Polarization Transfers with Multi-Fold Sensitivity Enhancements"
7:00 pm - 7:10 pm
Discussion
7:10 pm - 7:30 pm
Selected from Poster Abstracts: Robbin Schnieders (Goethe Universität Frankfurt, Germany)
"Development of Heteronuclear-Detected NMR Experiments for Characterization of NH- and NH2-Groups in RNA"
7:30 pm - 7:40 pm
Discussion
7:40 pm - 7:55 pm
Selected from Poster Abstracts: Fa-An Chao (National Cancer Institute at Frederick, NIH, USA)
"Application of Geometric Approximation and Adiabatic Pulses to Simultaneously Reveal a Wide Range of Conformational Dynamics"
7:55 pm - 8:00 pm
Discussion
8:00 pm - 9:00 pm
Dinner
Wednesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Molecular Movies: IDPs, Droplets, Oligonucleotides and Complexes
Discussion Leader: Dorothee Kern (Howard Hughes Medical Institute / Brandeis University, USA)
9:00 am - 9:30 am
Frank Noe (Freie Universität Berlin, Germany)
"Optimal Combination of Simulation and Experimental Data via Augmented Markov Models"
9:30 am - 9:40 am
Discussion
9:40 am - 10:10 am
Katja Petzold (Karolinska Institute, Sweden)
"Dynamics in Regulatory RNAs: Methods and Examples"
10:10 am - 10:20 am
Discussion
10:20 am - 10:50 am
Coffee Break
10:50 am - 11:20 am
Donghan Lee (University of Louisville, USA)
"Functional Dynamics Through High-Power Relaxation Dispersion"
11:20 am - 11:30 am
Discussion
11:30 am - 11:50 am
Selected from Poster Abstracts: Kiran Sankar Chatterjee (National Centre for Biological Sciences, India)
"Importance of Co-Conservation of Interacting Aromatic Pairs Inside a Protein Core"
11:50 am - 12:00 pm
Discussion
12:00 pm - 12:20 pm
Selected from Poster Abstracts: Kaitlyn Ledwitch (Vanderbilt University, USA)
"Integrative Membrane Protein Structure Modeling from Sparse Paramagnetic NMR Data and Small-Angle Scattering Data"
12:20 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:30 pm
Free Time
4:30 pm - 6:00 pm
Poster Session
6:00 pm - 8:00 pm
Hybrid Methods
Discussion Leader: Alexandre Bonvin (Utrecht University, The Netherlands)
6:00 pm - 6:30 pm
Michael Habeck (University of Göttingen, Germany)
"Inferential Structure Determination with Hybrid Data"
6:30 pm - 6:40 pm
Discussion
6:40 pm - 7:10 pm
Juli Feigon (University of California, Los Angeles, USA)
"Integrative Structural Biology of Telomerase"
7:10 pm - 7:20 pm
Discussion
7:20 pm - 7:50 pm
Selected from Poster Abstracts: Alexander Grishaev (National Institute of Standards and Technology, USA)
"Simultaneous Determination of Structure, Conformational Dynamics and Hydration of RNA and DNA from NMR, Wide-Angle X-Ray and Neutron Scattering, and Molecular Simulation"
7:50 pm - 8:00 pm
Discussion
8:00 pm - 9:00 pm
Dinner
Thursday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Business Meeting
Nominations for the Next Vice Chair; Fill in Conference Evaluation Forms; Discuss Future Site and Scheduling Preferences; Election of the Next Vice Chair
9:00 am - 12:30 pm
Conformation and Configuration of Small Biomolecules
Discussion Leader: Christina Thiele (Technische Universität Darmstadt, Germany)
9:00 am - 9:30 am
Armando Navarro-Vázquez (Universidade Federal de Pernambuco, Brazil)
"Multiparameter Configurational and Conformational Analysis: Speeding up CASE-3D"
9:30 am - 9:40 am
Discussion
9:40 am - 10:10 am
Julien Orts (ETH Zürich, Switzerland)
"Identification of Small-Molecule Inhibitors of Functionally Relevant Macromolecular Interactions"
10:10 am - 10:20 am
Discussion
10:20 am - 10:50 am
Coffee Break
10:50 am - 11:15 am
Selected from Poster Abstracts: Ashley De Lio (University of Illinois at Urbana-Champaign, USA)
"Functional Plasma Membrane Activation: Ions Take Charge"
11:15 am - 11:25 am
Discussion
11:25 am - 11:50 am
Selected from Poster Abstracts: Stefan Immel (Technical University of Darmstadt, Germany)
"RDCs, RQCs and RCSA Driven Floating-Chirality Distance Geometry Calculations: Unbiased and Highly Efficient Stereochemical Analysis Based on Anisotropic NMR Parameters"
11:50 am - 12:00 pm
Discussion
12:00 pm - 12:20 pm
Selected from Poster Abstracts: Leonard Mueller (University of California, Riverside, USA)
"NMR Crystallography in Tryptophan Synthase: Proton Positions, Stable Intermediates, and Transition States"
12:20 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:30 pm
Free Time
4:30 pm - 6:00 pm
Poster Session
6:00 pm - 8:00 pm
Metabolomics by NMR
Discussion Leader: Rafael Bruschweiler (The Ohio State University, USA)
6:00 pm - 6:30 pm
Daniella Goldfarb (Weizmann Institute of Science, Israel)
"Tracking Proteins' Conformations in Cells with EPR Distance Measurements"
6:30 pm - 6:40 pm
Discussion
6:40 pm - 7:10 pm
Elaine Holmes (Imperial College London, United Kingdom)
"Computational Development of Metabolic Profiling Technologies to Systems Biology and Translational Medicine Problems"
7:10 pm - 7:20 pm
Discussion
7:20 pm - 7:50 pm
Selected from Poster Abstracts: Julien Wist (Universidad del Valle, Colombia)
"Metaboscope: About Sharing Data"
7:50 pm - 8:00 pm
Discussion
8:00 pm - 9:00 pm
Dinner
Friday
7:30 am - 8:30 am
Breakfast
9:00 am
Departure