The Computational Chemistry GRC has been held biennially since 1986, with chairs alternating between industry and academia. Computational chemistry has by now developed into a companion of experimental research in almost all branches of chemistry, and the scope and relevance of computational studies continues to grow at a rapid pace because of synergistic advances in methodology, algorithms, software, and hardware. The conference will cover the full spectrum of modern computational chemistry, with emphasis on the treatment of large complex systems. Topics will range from ab initio quantum chemistry and density functional theory through statistical mechanics and classical simulation to molecular modeling and cheminformatics. In all of these areas, the presentations will address both the development of new computational methods and cutting-edge applications of practical importance. The 2010 conference will adhere to the traditional GRC format: lectures and posters will focus on new unpublished work; extensive time will be set aside for discussion; and poster sessions will allow especially the younger participants to show and discuss their work. As in past conferences, it will bring together leading scientists from academia, industry, and government to share the latest advances in the field and to identify the challenges ahead.