Sunday
2:00 pm - 9:00 pm
Arrival and Check-in
6:00 pm - 7:00 pm
Dinner
7:30 pm - 7:40 pm
Introductory Comments by GRC Staff / Welcome and Introduction from the Chairs
7:40 pm - 9:30 pm
Keynote Session: The Genesis of Consciousness
Discussion Leader: George Mashour (University of Michigan, Ann Arbor, United States)
7:40 pm - 8:20 pm
Theofanis Panagiotaropoulos (NeuroSpin, France)
"The Role of Prefrontal Cortex in the Emergence of Consciousness"
8:20 pm - 8:35 pm
Discussion
8:35 pm - 9:15 pm
Biyu He (New York University Langone Medical Center, United States)
"Neural Mechanisms of Visual Perceptual Awareness"
9:15 pm - 9:30 pm
Discussion
Monday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Group Photo
9:00 am - 12:30 pm
Consciousness and Model Organisms
Discussion Leader: Margaret Sedensky (University of Washington, United States)
9:00 am - 9:45 am
Phil Morgan (University of Washington, United States)
"Exploiting Model Systems to Understand Anesthetic Mechanisms"
9:45 am - 10:00 am
Discussion
10:00 am - 10:30 am
Coffee Break
10:30 am - 11:15 am
Dinesh Pal (University of Michigan, United States)
"Cortical Control of Consciousness: Insights from Rodent Studies"
11:15 am - 11:30 am
Discussion
11:30 am - 12:15 pm
Boris Heifets (Stanford University School of Medicine, United States)
"Unraveling the Synergy between Psychedelic States and Setting using Brain-wide Imaging of Immediate Early Gene Expression in Mice"
12:15 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
3:00 pm - 4:00 pm
The GRC Power Hourâ„¢
The GRC Power Hourâ„¢ is designed to address diversity and inclusion in the scientific workplace by providing a safe environment for informal and meaningful conversations amongst colleagues of all career stages. The program supports the professional growth of all members of our communities, including ethnicity, race and/or gender identity by providing an open forum for discussion and mentoring.
Organizer: Christa Nehs (Van Dort) (Massachusetts General Hospital, United States)
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Phylogenetically Conserved Molecular Targets of Anesthesia
Discussion Leader: Michael Alkire (Long Beach VA and University of California, Irvine, United States)
7:30 pm - 8:15 pm
Bruno van Swinderen (Queensland Brain Institute, Australia)
"Worms are Unconscious, Flies are Conscious: Insights from Sleep and General Anesthesia"
8:15 pm - 8:30 pm
Discussion
8:30 pm - 9:15 pm
Slobodan Todorovic (University of Colorado Anschutz Medical Campus, United States)
"The Role of Voltage-gated Calcium Channels in Hypnotic Effects of General Anesthetics"
9:15 pm - 9:30 pm
Discussion
Tuesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Anesthetic Effects on Model Organisms
Discussion Leader: Mike Crowder (University of Washington School of Medicine, United States)
9:00 am - 9:45 am
Diany Paola Calderon (Weill Cornell Medical College, United States)
"Cortical Signatures Linked to Behavior Quantitatively Track Arousal Levels"
9:45 am - 10:00 am
Discussion
10:00 am - 10:30 am
Coffee Break
10:30 am - 11:15 am
Chris Connor (Brigham and Women's Hospital, Mass General Brigham, United States)
"C. Elegans and Anesthetic Pharmacology: Reverse Engineering in a known Neuronal Architecture"
11:15 am - 11:30 am
Discussion
11:30 am - 12:15 pm
Stu Forman (Massachusetts General Hospital, United States)
"Zebrafish Larvae as Translational Models for Anesthetic Pharmacology"
12:15 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Thalamo-Cortical and Cortico-Cortical Signaling in Anesthetic States
Discussion Leader: Robert Sanders (University of Sydney, Australia)
7:30 pm - 8:15 pm
Aeyal Raz (Rambam Health Care Campus, Israel)
"Anesthetic Modulation of Thalamo-Cortical Circuits"
8:15 pm - 8:30 pm
Discussion
8:30 pm - 9:15 pm
Matthew Banks (University of Wisconsin School of Medicine and Public Health, United States)
"Cortical Mechanisms of Loss of Consciousness During Anesthesia: Insights from Human Intracranial Electrophysiology"
9:15 pm - 9:30 pm
Discussion
Wednesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Subcortical Targets of Anesthetic Hypnosis and Sleep
Discussion Leader: Nick Franks (Imperial College, United Kingdom)
9:00 am - 9:45 am
Christa Nehs (Van Dort) (Massachusetts General Hospital, United States)
"Parabrachial Nucleus and Metabolic Contributions to Sleep and Anesthesia"
9:45 am - 10:00 am
Discussion
10:00 am - 10:30 am
Coffee Break
10:00 am - 10:45 am
Giancarlo Vanini (University of Michigan, United States)
"Preoptic Role in the Regulation of Spontaneous and Drug-Induced States of Arousal"
10:45 am - 11:00 am
Discussion
11:30 am - 12:15 pm
William Wisden (Imperial College London, United Kingdom)
"Dissecting how Anaesthetics and Sedatives Interact with Sleep-wake Circuitry"
12:15 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Perception and Its Ablation
Discussion Leader: Peter Goldstein (Weill Cornell Medical College, United States)
7:30 pm - 8:15 pm
Alexander Proekt (University of Pennsylvania, United States)
"Waves of Perception and Unconsciousness"
8:15 pm - 8:30 pm
Discussion
8:30 pm - 9:15 pm
Marcello Massimini (University of Milan, Italy)
"Bistability and Complexity: Cortical Mechanisms of Loss and Recovery of Consciousness"
9:15 pm - 9:30 pm
Discussion
Thursday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Business Meeting
Nominations for the Next Vice Chair(s); Complete the GRC Evaluation Forms; Discuss Future Dates and Venue; Election of the Next Vice Chair(s)
9:00 am - 12:30 pm
Dynamics of Anesthetics and Unconsciousness in Non-human Primates
Discussion Leader: Yuri Saalmann (University of Wisconsin-Madison, United States)
9:00 am - 9:45 am
Michelle Redinbaugh (Stanford University, United States)
"Central Thalamic Deep Brain Stimulation Affects Cortico-Striato-Thalamic Networks to Exert Bidirectional Influence over Consciousness"
9:45 am - 10:00 am
Discussion
10:00 am - 10:30 am
Coffee Break
10:00 am - 10:45 am
Yumiko Ishizawa (Massachusetts General Hospital, United States)
"Dynamics of Anesthetic-Induced Loss and Return of Consciousness Across Primate Neocortex"
10:45 am - 11:00 am
Discussion
11:30 am - 12:15 pm
Bechir Jarraya (NeuroSpin, France)
"Deep Brain Stimulation of the Thalamus Restores Signatures of Consciousness in Anesthetized Monkeys"
12:15 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
The Unconscious State in Humans
Discussion Leader: Seun Johnson-Akeju (MGH, United States)
7:30 pm - 8:15 pm
Harry Scheinin (University of Turku, Finland)
"Positron Emission Tomography Imaging to Identify Brain Structures Critical for Human Consciousness"
8:15 pm - 8:30 pm
Discussion
8:30 pm - 9:15 pm
Katie Warnaby (University of Oxford, United Kingdom)
"Slow Waves and Anesthetic Unconsciousness in Humans"
9:15 pm - 9:30 pm
Discussion
Friday
7:30 am - 8:30 am
Breakfast
9:00 am
Departure