The following topics will be included at the second Gordon Research Conference on Craniofacial Morphogenesis and Tissue Regeneration: 1) Neural crest fate determination, ectoderm and endoderm interactions; 2) Craniofacial patterning, midline, frontonasal and the first branchial arch prominences development; 3) Placodes and their functional significance during craniofacial development; 4) Craniofacial organogenesis, such as tooth and palate morphogenesis; 5) Intramembranous bone formation and Suture biology; 6) Signaling interactions and gene regulation; 7) Human syndromes involving craniofacial defects; 8) Evolution biology; 9) Tissue engineering. The organizers of this GRC hope that the conference would provide a forum to spark new scientific collaborations, will foster the career development of young scientist, will advance our understanding of the molecular regulatory mechanism of craniofacial development and tissue regeneration and, ultimately, will contribute to the improvement of craniofacial health care.