SUNDAY |
4:00 pm - 8:00 pm | Arrival and Check-in (Check-in Desk Closed 6:00 pm - 7:45 pm) |
6:00 pm | Dinner |
7:30 pm - 7:40 pm | Welcome / Introductory Comments by GRC Site Staff |
7:40 pm - 9:30 pm | PLACODES: Development and Function |
| Discussion Leader: Marianne Bronner-Fraser (California Institute of Technology, Pasadena, USA) |
7:40 pm - 8:05 pm | Gerhard Schlosser (National University of Ireland, Galway, Ireland) "Sense and sensibility -induction, specification and differentiation of cranial placodes" |
8:05 pm - 8:15 pm | Discussion |
8:15 pm - 8:40 pm | Andrea Streit (King’s College London, UK) "Cell fate decisions in the cranial sensory nervous system" |
8:40 pm - 8:50 pm | Discussion |
8:50 pm - 9:05 pm | Linda Barlow (University of Colorado, Denver, USA) "Regulation of taste bud progenitor cell development by Wnt/B-catenin signaling" |
9:05 pm - 9:10 pm | Discussion |
9:10 pm - 9:25 pm | Jean-Pierre Saint Jeannet (University of Pennsylvania, Philadelphia USA) "Attenuation of Sox9 function in the inner ear results in vestibular defects" |
9:25 pm - 9:30 pm | Discussion |
MONDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | NEURAL CREST CELLS: Development, Function and Disease |
| Discussion Leader: Paul Trainor (Stowers Institute for Medical Research, Kansas City, USA) |
9:00 am - 9:30 am | Marianne Bronner-Fraser (California Institute of Technology, Pasadena, USA) "Formation of the cranial neural crest" |
9:30 am - 9:40 am | Discussion |
9:40 am - 9:55 am | Mamoru Ishii (University of Southern California, Los Angeles, USA) "Sustainable stem cell potential of murine cranial neural crest" |
9:55 am - 10:00 am | Discussion |
10:00 am | Coffee Break / Group Photo |
10:30 am - 10:45 am | Tatjana Sauker-Spengler (California Institute of Technology, Pasadena, USA) "Polycomb Repressive Complex 1 fine-tunes the regulatory network during early steps of neural crest cell formation" |
10:45 am - 10:50 am | Discussion |
10:50 am - 11:15 am | Roberto Mayor (University College, London, UK) "Collective migration of neural crest cells" |
11:15 am - 11:25 am | Discussion |
11:25 am - 11:40 am | Gage Crump (University of Southern California, Los Angeles, USA) "Histone 3.3-dependent chromatine remodeling is essential for ectomesenchyme potential of the cranial neural crest" |
11:40 am - 11:45 am | Discussion |
11:45 am - 12:00 pm | Michela Ori (University of Pisa, Pisa, Italy) "5-HT2B receptor activity modulates morphogenenesis and patterning of the mandibular arch" |
12:00 pm - 12:05 pm | Discussion |
12:05 pm - 12:25 pm | Daisuke Sakai (Stowers Institute for Medical Research, Kansas City, USA) "Prevention of Treacher Collins syndrome craniofacial anomalies through inhibition of oxidative damage in neural crest cells" |
12:25 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 5:30 pm | Poster Session |
5:30 pm - 7:30 pm | DEVELOPMENTAL PATTERNING AND EVOLUTION |
| Discussion Leader: Chuck Kimmel (University of Oregon, Eugene, USA) |
5:30 pm - 5:45 pm | Melinda Modrell (University of Cambridge, Cambridge, UK) "A sixth sense: the development of vertebrate electroreceptors" |
5:45 pm - 5:50 pm | Discussion |
5:50 pm - 6:05 pm | Shannon Fisher (University of Pennsylvania, Philadelphia, USA) "Contribution of neural crest cells to the zebrafish skeleton" |
6:05 pm - 6:10 pm | Discussion |
6:10 pm - 6:35 pm | Michael Depew (King’s College London, UK) "Cephalic ectodermal competence factors establish upper jaw pattern and
morphology" |
6:35 pm - 6:40 pm | Discussion |
6:40 pm - 6:55 pm | Joy Richman (University of British Columbia, Vancouver, Canada) "Molecular control of tooth replacement in reptiles" |
6:55 pm - 7:00 pm | Discussion |
7:00 pm - 7:25 pm | Stan Lyonnet (Université Paris Descartes, Paris, France) "Disruption of long-distance highly conserved non coding sequences at
the SOX9 locus, in craniofacial neurocristopathies" |
7:25 pm - 7:30 pm | Discussion |
8:00 pm | Dinner |
TUESDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | TISSUE INTERACTIONS AND MORPHOGENESIS |
| Discussion Leader: Andrea Streit (University College London, UK) |
9:00 am - 9:30 am | Irma Thesleff (University of Helsinki, Helsinki, Finland) "Placodes of teeth and other ectodemal appendages: regulation by signal pathways" |
9:30 am - 9:40 am | Discussion |
9:40 am - 9:55 am | Xuiping Wang (Harvard University, Boston, USA) "Molecular regulation of supernumerary tooth formation" |
9:55 am - 10:00 am | Discussion |
10:00 am | Coffee Break |
10:30 am - 11:00 am | Eldad Tzahor (Weizmann Institute of Science, Rehovot, Israel) "Neural crest - mesoderm interactions and the role of p53" |
11:00 am - 11:10 am | Discussion |
11:10 am - 11:40 am | Yang Chai (University of Southern California, Los Angeles, USA) "Cranial neural crest and myogenic progenitor interactions in tongue development" |
11:40 am - 11:50 am | Discussion |
11:50 am - 12:05 pm | Alon Kahana (University of Michigan, Ann Arbor, USA) "Retinoic acid regulates a balance between Pitx2 and Pitx3 expression to promote morphogenesis of extraocular muscles in zebrafish" |
12:05 pm - 12:10 pm | Discussion |
12:10 pm - 12:25 pm | Abigail Tucker (Kings College London, UK) "Mouse models of conductive hearing loss" |
12:25 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 5:30 pm | Poster Session |
5:30 pm - 7:30 pm | SIGNALING AND COMMUNICATION |
| Discussion Leader: Michael Depew (King’s College, London, UK) |
5:30 pm - 5:55 pm | Fred Relaix (UPMC-Paris VI, Paris, France) "Analysis of Pax3 and Pax7 functions and downstream genetic networks in craniofacial development" |
5:55 pm - 6:05 pm | Discussion |
6:15 pm - 6:30 pm | Yukiko Kurihara (University of Toyko, Japan) "Non-coding RNA regulation of endothelin signaling in branchial arch development" |
6:30 pm - 6:35 pm | Discussion |
6:35 pm - 7:00 pm | Filippo Rijli (Friedrich Miescher Institute, Basel, Switzerland) "Mapping the face in the somatosensory brain stem" |
7:00 pm - 7:10 pm | Discussion |
7:10 pm - 7:25 pm | Cathy Krull (University of Michigan, Ann Harbor, USA) "Development of the Brainstem Taste Relay Nucleus" |
7:25 pm - 7:30 pm | Discussion |
8:00 pm | Dinner |
WEDNESDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | CRANIOFACIAL SYNDROMES AND DISORDERS: MODELS AND GENETICS I |
| Discussion Leader: Andrew Wilkie (Weatherall Institute, Oxford, UK) |
9:00 am - 9:30 am | Danny Huylebroeck (University of Leuven, Belgium) "Conditional Zfhx1b mutant mice for studying Mowat-Wilson syndrome" |
9:30 am - 9:40 am | Discussion |
9:40 am - 9:55 am | Yuji Mishina (University of Michigan, Ann Arbor, USA) "Smad-dependent BMP signaling directs cranial neural crest cell fate towards chondrocytes to cause craniosynostois" |
9:55 am - 10:00 am | Discussion |
10:00 am | Coffee Break |
10:30 am - 11:00 am | Gary Landreth (Case Western University, Cleveland, USA) "Perturbation of the ERK-MAP Kinase pathway in Neuro-cardio-facial cutaneous syndromes" |
11:00 am - 11:10 am | Discussion |
11:10 am - 11:25 am | Heiko Peters (University of Newcastle, Newcastle upon Tyne, UK) "Inactivation of the cohesin-loading protein Nipbl in neural crest cells affects development of proximal skull elements" |
11:25 am - 11:30 am | Discussion |
11:30 am - 11:45 am | Pilar Cejudo-Martin (Burnham Institute, San Diego, USA) "Disruption of the podosome adaptor protein TKS4 (SH3PXD2B) causes the craniofacial abnormalities of Frank-Ter Haar syndrome" |
11:45 am - 11:50 am | Discussion |
11:50 am - 12:05 pm | M. Adela Mansilla (University of Iowa, Iowa City, USA) "The role of MAFB and ABCA4 in the etiology of cleft lip an palate" |
12:05 pm - 12:10 pm | Discussion |
12:10 pm - 12:25 pm | Victoria Leitch (Women and Children’s Health Research Institute, Adelaide, Australia) "The molecular mechanism of craniosynostosis: localized downregulation of RBP4 and its role in premature suture fusion" |
12:25 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 5:30 pm | Poster Session |
5:30 pm - 7:30 pm | CRANIOFACIAL SYNDROMES AND DISORDERS: MODELS AND GENETICS II |
| Discussion Leader: Rob Maxson (University of Southern California, Los Angeles, USA) |
5:30 pm - 6:00 pm | Max Muenke (National Institutes of Health, Bethesda, USA) "Holoprosencephaly: the genotype predicts the phenotype" |
6:00 pm - 6:10 pm | Discussion |
6:10 pm - 6:30 pm | Ralph Marcucio (University of California San Francisco, USA) "Mechanisms underlying covariation of the brain and face" |
6:30 pm - 6:35 pm | Discussion |
6:35 pm - 6:50 pm | Samantha Brugmann (Stanford University, Stanford, USA) "Primary cilia provide a common etiology for a spectrum of midfacial defects" |
6:50 pm - 6:55 pm | Discussion |
6:55 pm - 7:20 pm | Andy Copp (Institute Child Health, London, UK) "Mechanisms of cranial neural tube closure - normal and abnormal" |
7:20 pm - 7:30 pm | Discussion |
7:30 pm - 8:00 pm | Business Meeting |
| (Nominations for the next Vice Chair; Fill out Conference Evaluation Forms; Discuss future Site & Scheduling preferences; Election of the next Vice Chair) |
8:00 pm | Dinner |
THURSDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | STEMS CELLS, TISSUE ENGINEERING AND REGENERATION |
| Discussion Leader: Irma Thesleff (University of Helsinki, Finland) |
9:00 am - 9:15 am | Brigitte Arduini (Rockefeller University, New York, USA) "Neural crest differentiation from human ES and iPS cells" |
9:15 am - 9:20 am | Discussion |
9:20 am - 9:50 am | Jennifer Elisseeff (Johns Hopkins University, Baltimore, USA) "Tissue engineering and repair of craniofacial anomalies" |
9:50 am - 10:00 am | Discussion |
10:00 am | Coffee Break |
10:30 am - 10:55 am | Wayne Grayson (John Hopkins University, Baltimore, USA) "Engineering Patient-specific Craniofacial Grafts" |
10:55 am - 11:05 am | Discussion |
11:05 am - 11:30 am | Pam Yelick (Tufts Univeristy, Boston, USA) "Tooth and Dare" |
11:30 am - 11:40 am | Discussion |
11:40 am - 12:05 pm | Paul Sharp (King’s College London, UK) "Polycomb complex proteins regulate rodent incisor mesenchymal stem cells" |
12:05 pm - 12:10 pm | Discussion |
12:10 pm - 12:25 pm | Hidemitsu Harada (Iwate University, Iwate, Japan) "Live cell imaging of cervical loop epithelium in HERS formation process" |
12:25 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 5:30 pm | Poster Session |
5:30 pm - 7:30 pm | KEYNOTES: EVOLUTION, DEVELOPMENT AND DISEASE |
| Discussion Leader: Paul Trainor (Stowers Institute, Kansas City, USA) |
5:30 pm - 6:15 pm | Chuck Kimmel (University of Oregon, Eugene, USA) "Mechanisms of Craniofacial Variation and Evolution" |
6:15 pm - 6:30 pm | Discussion |
6:30 pm - 7:15 pm | Andrew Wilkie (Weatherall Institute, Oxford, UK) "Future directions for research into the craniosynostoses" |
7:15 pm - 7:30 pm | Discussion |
8:00 pm | Dinner |
FRIDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am | Depart |