Sunday
4:00 pm - 8:00 pm
Arrival and Check-in
6:00 pm - 7:00 pm
Dinner
7:30 pm - 7:40 pm
Introductory Comments by GRC Site Staff / Welcome from the GRC Chair
7:40 pm - 9:30 pm
Keynote Session: From Patients to Fossils
Discussion Leader: Abigail Tucker (King's College London, United Kingdom)
7:40 pm - 7:50 pm
Opening Remarks
7:50 pm - 8:25 pm
Mary Marazita (University of Pittsburgh, USA)
"Genomic and Phenomic Studies of Orofacial Cleft Families"
8:25 pm - 8:40 pm
Discussion
8:40 pm - 9:15 pm
Jukka Jernvall (University of Helsinki, Finland)
"What Is Important for the Developmental and Evolutionary Regulation of Tooth Form?"
9:15 pm - 9:30 pm
Discussion
Monday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Development of Orofacial Structures
Discussion Leader: Paul Sharpe (King's College London, United Kingdom)
9:00 am - 9:25 am
Rulang Jiang (Cincinnati Children's Hospital Medical Center, USA)
"Molecular Patterning of the Oral-Aboral Axis of the Mammalian Mandible"
9:25 am - 9:35 am
Discussion
9:35 am - 10:00 am
Igor Adameyko (Karolinska Institutet, Sweden)
"Single Cell Transcriptomics Helps to Understand Lineage Development During Mouse Incisor Self-Renewal"
10:00 am - 10:10 am
Discussion
10:10 am - 10:40 am
Coffee Break
10:40 am - 11:05 am
Joy Richman (University of British Columbia, Canada)
"The Effects of Selective Tooth Removal on the Continuously Renewing Adult Gecko Dentition"
11:05 am - 11:15 am
Discussion
11:15 am - 11:40 am
Michael Dixon (University of Manchester, United Kingdom)
"Hedgehog-Mediated Interactions During Development of the Secondary Palate"
11:40 am - 11:50 am
Discussion
11:50 am - 12:05 pm
Emily Bates (University of Colorado Anschutz Medical Campus, USA)
"An Unexpected Node in BMP Signaling: K+ Channels in Craniofacial Development"
12:05 pm - 12:10 pm
Discussion
12:10 pm - 12:25 pm
Katherine Fantauzzo (University of Colorado Anschutz Medical Campus, USA)
"Characterization of Alternative RNA Splicing Downstream of PDGFRalpha Signaling in the Palatal Mesenchyme"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:30 pm
Free Time
3:00 pm - 4:00 pm
Power Hour
The GRC Power Hour is an optional informal gathering open to all meeting participants. It is designed to help address the challenges women face in science and support the professional growth of women in our communities by providing an open forum for discussion and mentoring.
Organizer: Abigail Tucker (King's College London, United Kingdom)
4:30 pm - 6:00 pm
Poster Session
6:00 pm - 8:00 pm
Sensory Organs and Craniofacial Neural Crest
Discussion Leader: Andrea Streit (King's College London, United Kingdom)
6:00 pm - 6:30 pm
Linda Barlow (University of Colorado Denver, USA)
"Maintaining a Sense of Taste: Molecular Regulation of Taste Bud Cell Renewal"
6:30 pm - 6:40 pm
Discussion
6:40 pm - 6:55 pm
Jean-Pierre Saint-Jeannet (New York University College of Dentistry, USA)
"Dkk2 Is Required for Neural Crest Specification by Activating Wnt/β-Catenin Signaling in a GSK3B-Independent Manner"
6:55 pm - 7:00 pm
Discussion
7:00 pm - 7:30 pm
Tanya Whitfield (University of Sheffield, United Kingdom)
"Going Round in Circles: Development of the Zebrafish Semicircular Canal System"
7:30 pm - 7:40 pm
Discussion
7:40 pm - 7:55 pm
Lisa Taneyhill (University of Maryland, USA)
"Annexin A6 Controls Neuronal Membrane Dynamics Throughout Chick Cranial Sensory Gangliogenesis"
7:55 pm - 8:00 pm
Discussion
8:00 pm - 9:00 pm
Dinner
Tuesday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Group Photo
9:00 am - 12:30 pm
Gene Networks and Epigenetics in Craniofacial Development
Discussion Leader: Irma Thesleff (University of Helsinki, Finland)
9:00 am - 9:25 am
Filippo Rijli (Friedrich Miescher Institute for Biomedical Research, Switzerland)
"Epigenetic Regulation of Face Formation"
9:25 am - 9:35 am
Discussion
9:35 am - 9:50 am
Justin Cotney (UConn Health, USA)
"High Resolution Epigenomic Atlas of Human Embryonic Craniofacial Development"
9:50 am - 9:55 am
Discussion
9:55 am - 10:20 am
Kristin Artinger (University of Colorado Denver, USA)
"The Balance of Positive and Negative Epigenetic Regulation in Craniofacial Development"
10:20 am - 10:30 am
Discussion
10:30 am - 10:55 am
Coffee Break
10:55 am - 11:10 am
Rena D'Souza (University of Utah, USA)
"Novel Therapies for Cleft Palate Correction In-Utero : Exploiting Pax9-Dependent Signaling in Posterior Palatogenesis"
11:10 am - 11:15 am
Discussion
11:15 am - 11:30 am
Sarah Knox (University of California, San Francisco, USA)
"How Aging Is Bad for Your Nerves but Not Necessarily Your Stem Cells"
11:30 am - 11:35 am
Discussion
11:35 am - 12:00 pm
Trevor Williams (University of Colorado Denver, USA)
"RNA Expression Dynamics Provides Mechanistic Insight into Mouse Facial Development"
12:00 pm - 12:10 pm
Discussion
12:10 pm - 12:25 pm
Robert Lipinski (University of Wisconsin-Madison, USA)
"Shh-Fox Drives Pericyte Differentiation and Function in Craniofacial Morphogenesis and Malformation"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:30 pm
Free Time
4:30 pm - 6:00 pm
Poster Session
6:00 pm - 8:00 pm
Modeling of Craniofacial Disorders
Discussion Leader: Yang Chai (University of Southern California, USA)
6:00 pm - 6:25 pm
Jason Pomerantz (University of California, San Francisco, USA)
"Skeletal Muscle Stem Cells of the Craniofacial Complex"
6:25 pm - 6:35 pm
Discussion
6:35 pm - 7:00 pm
Erica Davis (Duke University Medical Center, USA)
"Modeling Pediatric Genetic Disease: The Face and Its Associated Comorbidities"
7:00 pm - 7:10 pm
Discussion
7:10 pm - 7:35 pm
Lukas Sommer (University of Zurich, Switzerland)
"Control of Neural Crest-Specific Metabolism in Craniofacial Development and Beyond"
7:35 pm - 7:45 pm
Discussion
7:45 pm - 7:55 pm
Thomas Schilling (Ayala School of Biological Sciences, University of California, Irvine, USA)
"Mechanotransduction via TGFb Signaling Regulates Tendon Morphogenesis"
7:55 pm - 8:00 pm
Discussion
8:00 pm - 9:00 pm
Dinner
Wednesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Evolution of the Craniofacial Complex
Discussion Leader: Richard Schneider (University of California, San Francisco, USA)
9:00 am - 9:25 am
Robert Cerny (Charles University in Prague, Czech Republic)
"Ancient Pharyngeal Origins of Craniofacial Patterning"
9:25 am - 9:35 am
Discussion
9:35 am - 9:50 am
Jennifer Fish (University of Massachusetts Lowell, USA)
"Fgf8 Mediates Cananalization and Evolvability of the Jaw"
9:50 am - 9:55 am
Discussion
9:55 am - 10:20 am
Per Ahlberg (Uppsala University, Sweden)
"400 Million Years of Landmarks: Using Fossil Morphologies to Unravel the Origin of the Jawed Vertebrate Face"
10:20 am - 10:30 am
Discussion
10:30 am - 10:55 am
Coffee Break
10:55 am - 11:10 am
Matthew Harris (Harvard Medical School, USA)
"Exploring Cranial Evolution Through Phylogenomic Analyses of Fish Amongst the Ice"
11:10 am - 11:15 am
Discussion
11:15 am - 11:30 am
Lindsey Barske (Keck School of Medicine, University of Southern California, USA)
"Essential Role of Nr2f Nuclear Receptors in Patterning the Vertebrate Upper Jaw"
11:30 am - 11:35 am
Discussion
11:35 am - 12:00 pm
Marcelo Sanchez (University of Zurich, Switzerland)
"On Dog, Cat, Horse, Cow and Chicken Heads – Examining Morphological Diversity and Its Developmental Bases in Domesticated Animals"
12:00 pm - 12:10 pm
Discussion
12:10 pm - 12:25 pm
Mona Mozaffari (King's College London, United Kingdom)
"Building an Eardrum: The Novel Mammalian Pars Flaccida"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:30 pm
Free Time
4:30 pm - 6:00 pm
Poster Session
6:00 pm - 8:00 pm
Skull and Cranial Morphogenesis
Discussion Leader: Paul Trainor (Stowers Institute for Medical Research, USA)
6:00 pm - 6:25 pm
Radhika Atit (Case Western Reserve University, USA)
"The Good, the Bad, and the Ugly: Regulatory Mechanisms of Cranial Development"
6:25 pm - 6:35 pm
Discussion
6:35 pm - 7:00 pm
Shannon Fisher (Boston University School of Medicine, USA)
"Dynamics of Skull and Suture Formation in Zebrafish"
7:00 pm - 7:10 pm
Discussion
7:10 pm - 7:35 pm
Ethylin Wang Jabs (Icahn School of Medicine at Mount Sinai, USA)
"Integration of Systems and Developmental Biology in Skull Morphogenesis"
7:35 pm - 7:45 pm
Discussion
7:45 pm - 7:55 pm
Jacqui Tabler (Max Planck Institute for Molecular Cell Biology and Genetics, Germany)
"Mechanisms of Neurocranial Expansion"
7:55 pm - 8:00 pm
Discussion
8:00 pm - 9:00 pm
Dinner
Thursday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Business Meeting
Nominations for the Next Vice Chair; Fill in Conference Evaluation Forms; Discuss Future Site and Scheduling Preferences; Election of the Next Vice Chair
9:00 am - 12:30 pm
Clinical Genetics of Craniofacial Disorders
Discussion Leader: Samantha Brugmann (Cincinnati Children's Hospital Medical Center, USA)
9:00 am - 9:25 am
Paul Sharpe (King's College London, United Kingdom)
"Understanding and Manipulating Dental Pulp Stem Cell Environments"
9:25 am - 9:35 am
Discussion
9:35 am - 9:50 am
Timothy Cox (University of Washington, USA)
"Mutations in Components of the Epithelial Cadherin-p120-Catenin Complex Are a Significant Cause of Mendelian Non-Syndromic Cleft Lip and Palate"
9:50 am - 9:55 am
Discussion
9:55 am - 10:20 am
Jan Hu (University of Michigan, USA)
"Hereditary Dentin Defects"
10:20 am - 10:30 am
Discussion
10:30 am - 10:55 am
Coffee Break
10:55 am - 11:10 am
Andrew Timberlake (Yale University School of Medicine, USA)
"Exome Sequencing Reveals Novel Genetic Causes and Molecular Subtypes of Non-Syndromic Craniosynostosis"
11:10 am - 11:15 am
Discussion
11:15 am - 11:30 am
John Griffin (Yale University, USA / King's College London, United Kingdom)
"From Clinical Genetics to Biological Function; Rapgef5 Regulates the Nuclear Transport of Beta-Catenin"
11:30 am - 11:35 am
Discussion
11:35 am - 12:00 pm
Louise Bicknell (University of Otago, New Zealand)
"The Molecular Mechanisms Underlying Meier-Gorlin Syndrome"
12:00 pm - 12:10 pm
Discussion
12:10 pm - 12:25 pm
Marcela Buchtova (Institute of Animal Physiology and Genetics, Czech Academy of Sciences, Czech Republic)
"Disruption of Primary Cilia Function Initiates Region-Specific Defects in Odontogenesis"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:30 pm
Free Time
4:30 pm - 6:00 pm
Poster Session
6:00 pm - 8:00 pm
Tissue Regeneration and Craniofacial Stem Cells
Discussion Leader: Pamela Yelick (Tufts University, USA)
6:00 pm - 6:25 pm
Otger Campas (University of California, Santa Barbara, USA)
"Revealing the Mechanical Forces that Shape Embryonic Tissues and Organs in 3D"
6:25 pm - 6:35 pm
Discussion
6:35 pm - 7:00 pm
Eileen Gentleman (King's College London, United Kingdom)
"Designing Materials that Direct Stem Cell Fate to Regenerate Craniofacial Tissues"
7:00 pm - 7:10 pm
Discussion
7:10 pm - 7:35 pm
Ryan Chase Ransom (Stanford University, USA)
"Craniofacial Skeletal Stem Cell Dynamics in Mandibular Distraction Osteogenesis"
7:35 pm - 7:45 pm
Discussion
7:45 pm - 7:55 pm
Amnon Sharir (University of California, San Francisco, USA)
"Two Distinct Pools of Stem Cells Switch Behavior to Maintain and Repair the Mouse Incisor Epithelium"
7:55 pm - 8:00 pm
Discussion
8:00 pm - 9:00 pm
Dinner
Friday
7:30 am - 8:30 am
Breakfast
9:00 am
Departure