Sunday
4:00 pm - 8:00 pm
Arrival and Check-in
6:00 pm - 7:00 pm
Dinner
7:30 pm - 7:40 pm
Introductory Comments by GRC Site Staff / Welcome from the GRC Chair
7:40 pm - 9:30 pm
Keynote Session: Forces in Craniofacial Biology
Discussion Leader: Pamela Yelick (Tufts University, USA)
7:40 pm - 7:50 pm
Opening Remarks
7:50 pm - 8:25 pm
Emily Rayfield (University of Bristol, United Kingdom)
"Deducing the Influence of Mechanical Loads on Jaw Morphology"
8:25 pm - 8:40 pm
Discussion
8:40 pm - 9:15 pm
Michel Milinkovitch (Laboratory of Artificial and Natural Evolution (LANE), University Geneva, Switzerland)
"Patterning Epithelia Through Mechanical and Turing Instabilities"
9:15 pm - 9:30 pm
Discussion
Monday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Signalling in Craniofacial Development
Discussion Leader: Ophir Klein (University of California, San Francisco, USA)
9:00 am - 9:25 am
Yang Chai (University of Southern California, USA)
"Cranial Suture Regeneration and Restored Neurocognitive Function in Craniosynostosis"
9:25 am - 9:35 am
Discussion
9:35 am - 10:00 am
Marcia Gaete (Pontificia Universidad Católica de Chile, Chile)
"Psychology of Craniofacial Development"
10:00 am - 10:10 am
Discussion
10:10 am - 10:25 am
Hiroshi Kurosaka (Osaka University, Japan)
"Synergistic Role of GATA3 and Retinoic Acid Signaling in Primitive Choanae Development"
10:25 am - 10:30 am
Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:25 am
Michael Longaker (Stanford University, USA)
"Skeletal Stem Cells Powering Cranial Suture Fate: An Answer to Craniosynostosis?"
11:25 am - 11:35 am
Discussion
11:35 am - 12:00 pm
Amy Merrill (University of Southern California, USA)
"FGF Signaling in Development of the Cranial Vault"
12:00 pm - 12:10 pm
Discussion
12:10 pm - 12:25 pm
Heather Szabo-Rogers (University of Pittsburgh, USA)
"Endochondral Ossification Requires Protein-Protein Interactions Between Prickle1 and Dishevelled 2/3"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:30 pm
Free Time
3:00 pm - 4:00 pm
The GRC Power Hourâ„¢
The GRC Power Hourâ„¢ is designed to address challenges women face in science and issues of diversity and inclusion. The program supports the professional growth of all members of our communities by providing an open forum for discussion and mentoring.
Organizers: Pamela Yelick (Tufts University, USA) and Rena D'Souza (University of Utah, USA)
4:30 pm - 6:00 pm
Poster Session
6:00 pm - 8:00 pm
Tissue Interactions and Morphogenesis
Discussion Leader: Tathyane Teshima (Eastman Dental Institute, University College London, United Kingdom)
6:00 pm - 6:25 pm
Samantha Brugmann (Cincinnati Children's Hospital Medical Center, USA)
"Gli Synergizes with Hand2 to Drive a Motif-Dependent Transcriptional Program During Mandibular Development"
6:25 pm - 6:35 pm
Discussion
6:35 pm - 7:00 pm
Anthony Graham (King's College London, United Kingdom)
"Endodermal/Ectodermal Interfaces During Pharyngeal Segmentation"
7:00 pm - 7:10 pm
Discussion
7:10 pm - 7:20 pm
Charles Lovely (University of Louisville, USA)
"Genetic Screening for Ethanol-Sensitive Zebrafish Mutants Identifies a Requirement for Bmp Signaling in Endoderm and Jaw Development"
7:20 pm - 7:25 pm
Discussion
7:25 pm - 7:40 pm
Julian Petersen (Karolinska Institutet, Sweden)
"Casting Light on Early Craniofacial Development Using Single Cell Transcriptome Analysis"
7:40 pm - 7:45 pm
Discussion
7:45 pm - 7:55 pm
James Martin (Baylor College of Medicine, USA)
"Hippo-Signaling in Cranial Neural Crest Development"
7:55 pm - 8:00 pm
Discussion
8:00 pm - 9:00 pm
Dinner
Tuesday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Group Photo
9:00 am - 12:30 pm
Tissue Regeneration
Discussion Leader: Paul Sharpe (King's College London, United Kingdom)
9:00 am - 9:25 am
Mildred Embree (Columbia University Medical Center, USA)
"Drug Based Modulation of Endogenous Fibrocartilage Stem Cells for TMJ Regeneration"
9:25 am - 9:35 am
Discussion
9:35 am - 10:00 am
Sarah Heilshorn (Stanford University, USA)
"The Use of Protein-Engineering to Create Biomaterials for 3D Printing and Stem Cell Expansion"
10:00 am - 10:10 am
Discussion
10:10 am - 10:25 am
Joanna Smeeton (Columbia University, USA)
"Robust Regeneration of Ligaments Supporting the Adult Zebrafish Jaw Joint"
10:25 am - 10:30 am
Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:15 am
Val Yianni (King's College London, United Kingdom)
"Dissecting MSC Dynamics in a Regenerative Model Using Single Cell RNAseq"
11:15 am - 11:20 am
Discussion
11:20 am - 11:35 am
Justine Lee (UCLA Division of Plastic and Reconstructive Surgery, USA)
"Modulating an Extracellular Matrix-Inspired Skull Regenerative Material with Osteoprotegerin"
11:35 am - 11:40 am
Discussion
11:40 am - 11:55 am
Giuseppe Intini (University of Pittsburgh, USA)
"Distraction of the Calvarial Suture Niche Sustains Full Regeneration of a Remote Calvarial Critical Size Bone Defect"
11:55 am - 12:00 pm
Discussion
12:00 pm - 12:30 pm
Poster Previews
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:30 pm
Free Time
4:30 pm - 6:00 pm
Poster Session
6:00 pm - 8:00 pm
Evolution and Comparative Biology of the Craniofacial Complex
Discussion Leader: Melanie Debiais-Thibaud (ISEM, Université de Montpellier, France)
6:00 pm - 6:25 pm
Craig Albertson (University of Massachusetts Amherst, USA)
"Craniofacial Evo-Devo: Insights from Bony Fishes"
6:25 pm - 6:35 pm
Discussion
6:35 pm - 6:50 pm
Vladimir Soukup (Charles University in Prague, Czech Republic)
"Salamander External Gill as a Craniofacial Model to Test the Paradigm of Patterned Body Appendages"
6:50 pm - 6:55 pm
Discussion
6:55 pm - 7:10 pm
Ashley Seifert (University of Kentucky, USA)
"Do Cellular Stress Resistance Mechanisms Underlie Mammalian Regenerative Ability?"
7:10 pm - 7:15 pm
Discussion
7:15 pm - 7:30 pm
Andrew Gillis (University of Cambridge, United Kingdom)
"Dual Embryonic Origin of the Jawed Vertebrate Gill Arch Skeleton and the Evolutionary Origin of Paired Fins"
7:30 pm - 7:40 pm
Discussion
7:40 pm - 7:55 pm
Elena Boer (University of Utah, USA)
"Genetic and Developmental Mechanisms of Craniofacial Variation in Domestic Pigeons"
7:55 pm - 8:00 pm
Discussion
8:00 pm - 9:00 pm
Dinner
Wednesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Sense Organs and Cranial Neural Crest
Discussion Leader: Jennifer Fish (University of Massachusetts Lowell, USA)
9:00 am - 9:25 am
Gage Crump (University of Southern California, USA)
"Diversification of Neural Crest Derivatives in the Zebrafish Head"
9:25 am - 9:35 am
Discussion
9:35 am - 10:00 am
Aaron Tward (University of California, San Francisco, USA)
"Cellular Dynamics in the Ear"
10:00 am - 10:10 am
Discussion
10:10 am - 10:25 am
Kathryn Cheah (The University of Hong Kong, Hong Kong SAR China)
"Distinct and Cooperative Roles of SOX9 and SOX10 in Different Compartments of the Inner Ear Are Essential for Fluid Homeostasis and Hearing"
10:25 am - 10:30 am
Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:25 am
Laura Kerosuo (National Institute of Dental and Craniofacial Research, NIH, USA)
"Dissecting the Formation and Maintenance of the Neural Crest Stem Cell Niche"
11:25 am - 11:35 am
Discussion
11:35 am - 11:50 am
Mary McKinney (Stowers Institute for Medical Research, USA)
"Visualizing the Dynamic Interplay Between the Mesoderm and Neural Crest During Chick Head Morphogenesis"
11:50 am - 11:55 am
Discussion
11:55 am - 12:10 pm
Andre Tavares (The George Washington University, USA)
"Identification of Novel Candidate Genes Associated with SIX1 and Branchio-Oto-Renal Syndrome"
12:10 pm - 12:15 pm
Discussion
12:15 pm - 12:25 pm
Elizabeth Schock (Northwestern University, USA)
"Retention of Stem Cell Potential in the Neural Crest Is Mediated Through a Shared SoxB1 and SoxE Pluripotency GRN"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:30 pm
Free Time
4:30 pm - 6:00 pm
Poster Session
6:00 pm - 8:00 pm
Clinical Genetics
Discussion Leader: Justine Lee (UCLA Division of Plastic and Reconstructive Surgery, USA)
6:00 pm - 6:25 pm
Jacqueline Hecht (The University of Texas Health Science Center at Houston, USA)
"New Approaches to Identifying NSCLP Genetic Variation"
6:25 pm - 6:35 pm
Discussion
6:35 pm - 7:00 pm
Eric Liao (Harvard Medical School, USA)
"Functional Analysis of IRF6 Target Genes in Craniofacial Development"
7:00 pm - 7:10 pm
Discussion
7:10 pm - 7:35 pm
Andrew Wilkie (University of Oxford, United Kingdom)
"Clinical Genetics"
7:35 pm - 7:45 pm
Discussion
7:45 pm - 7:55 pm
Elizabeth Leslie (Emory University, USA)
"Uncovering the Genome-Wide Contribution of De Novo Mutations in Orofacial Clefts"
7:55 pm - 8:00 pm
Discussion
8:00 pm - 9:00 pm
Dinner
Thursday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Business Meeting
Nominations for the Next Vice Chair; Fill in Conference Evaluation Forms; Discuss Future Site and Scheduling Preferences; Election of the Next Vice Chair
9:00 am - 12:30 pm
Craniofacial Disorders
Discussion Leader: Karen Liu (King's College London, United Kingdom)
9:00 am - 9:25 am
Ela Knapik (Vanderbilt University Medical Center, USA)
"ECM Trafficking Block Causes Craniofacial CATIFA Syndrome"
9:25 am - 9:35 am
Discussion
9:35 am - 10:00 am
Robert Maxson (Keck School of Medicine, University of Southern California, USA)
"Cellular Mechanisms of Craniosynostosis in Saethre-Chotzen Syndrome"
10:00 am - 10:10 am
Discussion
10:10 am - 10:25 am
Scott Parnell (University of North Carolina at Chapel Hill, USA)
"Elucidating Candidate Genes that Modify Susceptibility to Alcohol-Induced Craniofacial Dysmorphology"
10:25 am - 10:30 am
Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:25 am
Carroll Ann Trotman (Tufts University School of Dental Medicine, USA)
"The Power of the Face: Restoring Function Following Paralysis and Clefting"
11:25 am - 11:35 am
Discussion
11:35 am - 12:00 pm
Sebastian Dworkin (La Trobe University, Australia)
"Grainyhead-Like (Grhl)-Dependent Pathways in Palatal Clefting"
12:00 pm - 12:10 pm
Discussion
12:10 pm - 12:25 pm
Steve Twigg (University of Oxford, United Kingdom)
"Towards a Single Cell Transcriptomic Atlas of the Coronal Suture"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:30 pm
Free Time
4:30 pm - 6:00 pm
Poster Session
6:00 pm - 8:00 pm
Cell and Tissue Mechanics
Discussion Leader: Robert Maxson (Keck School of Medicine, University of Southern California, USA)
6:00 pm - 6:15 pm
Sachiko Iseki (Tokyo Medical and Dental University, Japan)
"Mechanical Cues of Polyrotaxanes Control Osteogenic Differentiation for Adjunct Treatment of Craniosynostosis"
6:15 pm - 6:20 pm
Discussion
6:20 pm - 6:30 pm
Jan Krivanek (Masaryk University, Czech Republic)
"Dentin Structure Is Determined by Presence or Absence of Enamel"
6:30 pm - 6:35 pm
Discussion
6:35 pm - 7:00 pm
Elias Barriga (Instituto Gulbenkian de Ciencia, Portugal)
"Collective Cell Motion in Embryogenesis and Regeneration"
7:00 pm - 7:10 pm
Discussion
7:10 pm - 7:20 pm
William Barrell (King's College London, United Kingdom)
"Investigating GSK3 in Mouse Cranial Neural Crest Cell Delamination and Early Migration using Live In Vivo Imaging"
7:20 pm - 7:25 pm
Discussion
7:25 pm - 7:50 pm
Mehran Moazen (University College London, United Kingdom)
"Biomechanics of Calvarial Development"
7:50 pm - 8:00 pm
Discussion
8:00 pm - 9:00 pm
Dinner
Friday
7:30 am - 8:30 am
Breakfast
9:00 am
Departure