Sunday
2:00 pm - 9:00 pm
Arrival and Check-in
6:00 pm - 7:00 pm
Dinner
7:30 pm - 7:40 pm
Introductory Comments by GRC Site Staff / Welcome from the GRC Chair
7:40 pm - 9:30 pm
Keynote Session: Innovations in Tissue Engineering Strategies for the Craniomaxillofacial Complex
Discussion Leader: Justine Lee (University of California, Los Angeles, United States)
7:40 pm - 7:50 pm
Opening Remarks
7:50 pm - 8:30 pm
Mark Wong (University of Texas Health Science Center at Houston, United States)
"Current and Future Approaches for Replacement of Craniomaxillofacial Hard Tissue"
8:30 pm - 8:40 pm
Discussion
8:40 pm - 9:20 pm
Luiz Bertassoni (Oregon Health and Science University, United States)
"Engineering Calcified Stem Cell and Vascular Niches with Nanoscale Precision In Vivo and On-a-Chip"
9:20 pm - 9:30 pm
Discussion
Monday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Gene Networks and Epigenetics in Craniofacial Development
Discussion Leader: Gage Crump (University of Southern California, United States)
9:00 am - 9:25 am
Brad Amendt (The University of Iowa, United States)
"New MicroRNA Technology Identifies Craniofacial/Tooth Developmental Mechanisms and Therapeutic Applications"
9:25 am - 9:35 am
Discussion
9:35 am - 9:45 am
Robert Cornell (University of Washington, United States)
"Paddling Upstream in The Periderm Gene Regulatory Network: A Massively Parallel Reporter Assay and Genome Engineering Indicate Two Variants Near IRF6 are Causal for Non-Syndromic Orofacial Cleft"
9:45 am - 9:50 am
Discussion
9:50 am - 10:05 am
Justin Cotney (UConn Health, United States)
"Gene Expression Dynamics in Early Human Craniofacial Development Reveal Normal and Disease Relevant Regulatory Networks"
10:05 am - 10:10 am
Discussion
10:10 am - 10:40 am
Coffee Break
10:40 am - 11:05 am
Axel Visel (Lawrence Berkeley National Laboratory, United States)
"Distant-Acting Enhancers in Craniofacial Development"
11:05 am - 11:15 am
Discussion
11:15 am - 11:40 am
James Nichols (University of Colorado Anschutz Medical Campus, United States)
"Buffering Craniofacial Variation"
11:40 am - 11:50 am
Discussion
11:50 am - 12:05 pm
Yuji Mishina (University of Michigan School of Dentistry, United States)
"Augmentation of BMP Signaling Causes Midfacial Defects in Mice via A Metabolites-Epigenomic Signaling Cascade."
12:05 pm - 12:15 pm
Discussion
12:15 pm - 12:25 pm
Greg Holmes (Icahn School of Medicine at Mount Sinai, United States)
"Single-Cell Analysis Identified Hhip as A Novel Regulator of Coronal Suture Development"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
3:00 pm - 4:00 pm
The GRC Power Hour™
The GRC Power Hour™ is designed to address diversity and inclusion in the scientific workplace by providing a safe environment for informal and meaningful conversations amongst colleagues of all career stages. The program supports the professional growth of all members of our communities, including ethnicity, race and/or gender identity by providing an open forum for discussion and mentoring.
Organizers: Mildred Embree (Columbia University Medical Center, United States) and Janina Kueper (University of Pittsburgh, United States)
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Clinical Genetics of Craniofacial Development and Disease
Discussion Leader: Andrew Wilkie (University of Oxford, United Kingdom)
7:30 pm - 7:55 pm
Janice Lee (National Institute of Dental and Craniofacial Research, United States)
"Multi-Modality Phenotyping for Human Craniofacial Morphology"
7:55 pm - 8:05 pm
Discussion
8:05 pm - 8:30 pm
Azeez Butali (University of Iowa, United States)
"Spectrum of Approaches to Unravel the Genetics and Genomics Etiology of Orofacial Clefts in an Ancestral Population"
8:30 pm - 8:40 pm
Discussion
8:40 pm - 8:55 pm
Anmon Sharir (Hebrew University of Jerusalem Israel, Israel)
"Hyperactive HRAS Signaling in Costello Syndrome Impairs Skull Base Synchondrosis Formation by Disruption of Chondrocyte Differentiation."
8:55 pm - 9:00 pm
Discussion
9:00 pm - 9:10 pm
Eduardo Calpena (University of Oxford, United Kingdom)
"A New Locus for Craniosynostosis Caused by Copy Number Variants Flanking FOXD3"
9:10 pm - 9:15 pm
Discussion
9:15 pm - 9:25 pm
Sunil Singh (University of Washington, United States)
"Towards Finding the Missing Heritability for Orofacial Cleft, Progress in Dissecting the Transcriptional Regulatory Network Driving Zebrafish Periderm Differentiation"
9:25 pm - 9:30 pm
Discussion
Tuesday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Group Photo
9:00 am - 12:30 pm
Craniofacial Stem Cells
Discussion Leader: Shannon Fisher (Boston University School of Medicine, United States)
9:00 am - 9:25 am
Anh Le (University of Pennsylvania, United States)
"Gingiva Derived Mesenchymal Stem Cells: Application in Neuroregeneration."
9:25 am - 9:35 am
Discussion
9:35 am - 10:00 am
Jian-Fu Chen (University of Southern California (USC), United States)
"Human iPSC-Derived Suture Stem Cells for Tissue Regeneration and Treating Craniosynostosis"
10:00 am - 10:05 am
Discussion
10:05 am - 10:20 am
Daniel Doro (King's College London, United Kingdom)
"Suture Proximity and Embryonic Origins are Critical for the Outcome of Cranial Defects."
10:20 am - 10:25 am
Discussion
10:25 am - 10:55 am
Coffee Break
10:55 am - 11:15 am
Jacqueline Tabler (Max Planck Institute of Molecular Cell Biology and Genetics, Germany)
"Extracellular Structure Governs Nuclear Shape, Organization and Fate Choice in Embryonic Sutures"
11:15 am - 11:20 am
Discussion
11:20 am - 11:35 am
Hung-Jhen (Olivia) Chen (University of Southern California, United States)
"Nr5a2 Establishes Neural Crest Multipotency for Diverse Fates in the Jaw"
11:35 am - 11:40 am
Discussion
11:40 am - 11:55 am
Junichi Iwata (The University of Texas Health Science Center at Houston, School of Dentistry, United States)
"Loss of Sc5d Causes Cleft Palate Through Suppression of Hedgehog Signaling"
11:55 am - 12:00 pm
Discussion
12:00 pm - 12:30 pm
Poster Previews
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Craniofacial Tissue Interactions and Morphogenesis
Discussion Leader: Yang Chai (University of Southern California, United States)
7:30 pm - 7:55 pm
D'Juan Farmer (University of California, Los Angeles, United States)
"Tracing the Developmental Origins of Cranial Sutures"
7:55 pm - 8:05 pm
Discussion
8:05 pm - 8:30 pm
Juhee Jeong (New York University College of Dentistry, United States)
"Role of Lmx1b in Patterning of the Embryonic Head Mesenchyme"
8:30 pm - 8:40 pm
Discussion
8:40 pm - 9:05 pm
Joan Richtsmeier (The Pennsylvania State University, United States)
"Participation of Embryonic Cartilage and Dermal Bone in Skull Development"
9:05 pm - 9:15 pm
Discussion
9:15 pm - 9:25 pm
Sachiko Iseki (Tokyo Medical and Dental University, Japan)
"FGF18 Modulates M2-like Macrophage Polarization by Inducing CCL2-CCR2 Axis in Calvarial Bone Healing"
9:25 pm - 9:30 pm
Discussion
Wednesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Strategies for Craniofacial Tissue Regeneration
Discussion Leader: Mildred Embree (Columbia University Medical Center, United States)
9:00 am - 9:25 am
Maria Troulis (Mgh-Harvard, United States)
"Minimally Invasive Maxillofacial Surgery: Bench to Bedside, Bedside to Bench"
9:25 am - 9:35 am
Discussion
9:35 am - 10:00 am
Sang Jin Lee (Wake Forest University School of Medicine, United States)
"Recent Advances in 3D Bioprinting Technologies for Craniofacial Reconstruction"
10:00 am - 10:10 am
Discussion
10:10 am - 10:20 am
Daniela Roth (University of Alberta, Canada)
"Matrix Remodeling of Craniofacial Sutures in a Novel Experimental System of Suture Dysostosis"
10:20 am - 10:25 am
Discussion
10:25 am - 10:55 am
Coffee Break
10:55 am - 11:20 am
David Dean (The Ohio State University, United States)
"Point of Care Manufacturing of Regenerative Devices for Reconstructive Craniofacial Surgery"
11:20 am - 11:30 am
Discussion
11:30 am - 11:45 am
Brian Foster (The Ohio State University, United States)
"Bone Sialoprotein is Critical for Periodontal Mineralization and Alveolar Bone Healing"
11:45 am - 11:55 am
Discussion
11:55 am - 12:10 pm
Nik Kantaputra (Chiang Mai University, Thailand)
"GFPT1 Regulates Tooth Size: Lessons From The Biggest Teeth in The World"
12:10 pm - 12:15 pm
Discussion
12:15 pm - 12:25 pm
Jimmy Hu (UCLA, United States)
"Transcriptional Regionalization and Convergent Cell Movement Underlie Early Tooth Development."
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Mechanical and Bioelectrical Forces in CMF Tissue Development and Regeneration
Discussion Leader: Mehran Moazen (University College London, United Kingdom)
7:30 pm - 7:55 pm
Susan Herring (University of Washington, United States)
"Mechanical Enhancement of Craniofacial Growth—When Does it Work?"
7:55 pm - 8:05 pm
Discussion
8:05 pm - 8:30 pm
Vaibhav Pai (Tufts University, United States)
"Endogenous Bioelectric Networks as Targets for Regenerative Medicine: Electroceuticals."
8:30 pm - 8:40 pm
Discussion
8:40 pm - 8:55 pm
Elias Barriga (Instituto Gulbenkian de Ciencia, Portugal)
"Cell to Substrate Stiffness Ratios at The Onset of Collective Cell Motion."
8:55 pm - 9:00 pm
Discussion
9:00 pm - 9:10 pm
Neha Shroff (UCSF, United States)
"Mechanical Forces Induce Signaling Center Formation During Tooth Development."
9:10 pm - 9:15 pm
Discussion
9:15 pm - 9:25 pm
Shaun Abrams (National Institutes of Health, United States)
"Tissue-Specific Requirements for Centrioles in Craniofacial Morphogenesis"
9:25 pm - 9:30 pm
Discussion
Thursday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Business Meeting
Nominations for the Next Vice Chair(s); Complete the GRC Evaluation Forms; Discuss Future Dates and Venue; Election of the Next Vice Chair(s)
9:00 am - 12:30 pm
Evolution and Comparative Biology of the Craniofacial Complex
Discussion Leaders: Abigail Tucker (King's College London, United Kingdom)
9:00 am - 9:25 am
Liran Carmel (The Hebrew University of Jerusalem, Israel)
"Using DNA Methylation Maps of Ancient Humans to Study Evolutionary Adaptations"
9:25 am - 9:35 am
Discussion
9:35 am - 10:00 am
Christopher Martin (University of California, Berkeley, United States)
"Developing a Novel System for Craniofacial Genetics: The Evolution of Scale-Biting in Caribbean Pupfishes"
10:00 am - 10:10 am
Discussion
10:10 am - 10:30 am
Thomas Schilling (University of California, Irvine, United States)
"Genetic Control of Early Establishment of Skeletal Growth Zones"
10:30 am - 10:35 am
Discussion
10:35 am - 11:05 am
Coffee Break
11:05 am - 11:30 am
Daniel Medeiros (University of Colorado, Boulder, United States)
"Head Development in Modern Jawless Chordates Points to Early Events in Vertebrate Craniofacial Evolution"
11:30 am - 11:40 am
Discussion
11:40 am - 12:05 pm
Kory Evans (Rice University, United States)
"Evolutionary Mosaics and The Interplay Between Innovation and Integration in the Vertebrate Skull"
12:05 pm - 12:15 pm
Discussion
12:15 pm - 12:25 pm
Katherine Woronowicz (Boston Children's Hospital / Harvard Medical School, United States)
"Dissecting an Ultraconserved Hub of Craniofacial Development"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Sense Organs and Cranial Neural Crest
Discussion Leader: Samantha Brugmann (Cincinnati Children's Hospital Medical Center, United States)
7:30 pm - 7:55 pm
Joanna Wysocka (Stanford University School of Medicine, United States)
"Making Faces: Transcriptional Enhancers and Emergence of Form and Function During Human Development and Evolution"
7:55 pm - 8:05 pm
Discussion
8:05 pm - 8:30 pm
Karen Liu (King's College London, United Kingdom)
"Dissecting Epithelia and Mesenchymal Functions of p120-catenin in Neural Crest Anomalies."
8:30 pm - 8:40 pm
Discussion
8:40 pm - 8:55 pm
Rebekah Charney (UC Riverside, United States)
"The Mowat-Wilson Syndrome Factor ZEB2 Controls the Early Formation of Human Cranial Neural Crest Through BMP Signaling Modulation"
8:55 pm - 9:00 pm
Discussion
9:00 pm - 9:10 pm
Shuyi Nie (Georgia Institute of Technology, United States)
"Coordinated Activity of Cdc42ep1 and Septin Filaments in Actin Regulation and Neural Crest Cell Migration."
9:10 pm - 9:15 pm
Discussion
9:15 pm - 9:25 pm
Paul Iyyanar (Cincinnati Children's Hospital Medical Center, United States)
"Alx1 is Required in Both Cranial Neural Crest and Cranial Mesoderm for Extraocular Muscle Development"
9:25 pm - 9:30 pm
Discussion
Friday
7:30 am - 8:30 am
Breakfast
9:00 am
Departure