1. Saturday Evening, June 12 - Keynote Lecture

• Johannes Bos, Univ. of Utrecht New Insights and Questions Regarding Interconnectivity of cAMP and Ras-like GTPases

2.Sunday Morning, June 13 - Regulation of Intracellular Signaling and Phosphorylation Cascades

Discussion Leader: Miles Houslay, Glasgow University

• Charles Rubin, Albert Einstein Med.SchoolIntracellular Targeting of Signals Carried by cAMP
• lain Fraser, Vollurn InstituteFunctional Implications of PKA- Anchoring
• Marc Montminy, Joslin ClinicHow cAMP-responsive Activators Regulate Gene Expression
• Ann Graybiel, MITA New Paradigm for cAMP-signaling via PKA-independent Pathways: cAMP-GEFs

3.Sunday Evening, June 13 - Mechanisms Involved in Intracellular Localization of PDEs and Compartmentalization of Cyclic Nucleotide Signals

Discussion Leader: Joe Beavo, U. Washington

• Marco Conti, StanfordSubcellular Localization of PDE4D Variants: Interactions with Scaffold/Adapter Proteins
• Stephen Yarwood/lan Macphee, Glasgow UniversityIdentification of a Signaling Scaffold Protein ) Which Selectively Interacts with PDE4D5
• Graerne Bolger, Utah Health Sciences Ctr.Regulation of PDE4 Activity by Scaffold Proteins and Interactions among Various Functional Domains

Short Presentations

• Kjetil Tasken, U. Oslo, Norway
• Sergei Rybalkin, U. Washington

4.Monday Morning, June 14 - Regulation and Function of PDE6 in Visual Transduction

Discussion Leader: Nicolai Artemyev, U. Iowa

• Wolfgang Baehr, Utah Health Sciences CtrPDE6 Genes and Disease
• Ted Wensel, BaylorRegulation of Photoreceptor PDE6 by Transducin, RSG9 and Zinc
• Rick Cote, U. New HampshireBinding Properties and Regulatory Significance of the Non-catalytic cGMP-binding Sites on PDE6
• Nicolai Artemyev, University of Iowahe interface Between PDE6 and Transducin

Short Presentations

• Hongmei Mou, U. New Hampshire
• Marion Turkol Vanderbilt University
• Nigel Pyne, U. Strathclyde, Scotland

5.Monday Evening, June 14 - Physiological Roles and Regulation of Specific PDEs

Discussion Leader: Claire Lugnier, University of Strasbourg

• Catherine Jin, StanfordRole of PDE4 in Hormone and Neuroft-ansmitter Signaling: New Insights from PDE4 Null Mice
• Donald Maurice, Queens University, CanadaRole of PDE4D3 Targeting in Vascular Smooth Muscle Cell Functions
• Mark Giembycz, NHLI, LondonRegulation of Pro-inflammatory Genes Relevant to Pulmonary Disease by PDE4 Inhibitors

Short Presentations

• Peng Wang, Schering-Plough Research Institute
• Peter Peachell, University of Sheffield, UK
• Tarnari Michaeli, Albert Einstein College of Medicine

6.Tuesday Morning, June 15 - Bench to Bedside: PDE Inhibitors as Therapeutic Agents in Human Subjects and Animal Models

Discussion Leader: Christian Schudt, Byk Gulden

• Ted Torphy, SmithKline BeechamPDE4 Inhibitors in Treatment of Pulmonary Disease: from Concept to Clinic
• Junichi Kambayashi, Jasmin Shakur and Yonnge Liu,Clinical Applications of the Oral PDE3 Inhibitor Cilostazol
• Otsuka America(PLETAL) as an Antiplatelet and Claudication Drug
• David Stirling, CelgeneSeICID's:Novel and Selective PDE4 Inhibitors

Short Presentations

• Adam Lerner, Boston Medical Center
• Claire Lugnier, University of Strasbourg, France
• Carolyn Smith, New York Medical College
• Celine Mehats, Inserm Unit -361, France

7. Tuesday Evening, June 15 - PDE Structure/Function

Discussion Leader: Sharron Francis, Vanderbilt

• Zheng Huang, Merck Frosst CanadaMolecular Mechanisms for Differential Binding of Specific Inhibitors to PDE4
• Mike Luther, Glaxo WellcomeInsights into Mechanism and Specificity of PDEs as Revealed through the Three Dimensional Structure of PDE4
• Jackie Corbin/Sharron Francis, VanderbiltPDE5 Structure and Function

Short Presentations

• Wei Zhang, Temple University
• Deitrich Dettmer, University of Leipzig, Germany

8.Wednesday Morning, June 16 - Signaling Pathways that Regulate PDE Activity and Function

Discussion Leader: Eva Degerman, Lund University

• Miles Houslay, Glasgow UniversityRegulation of PDE4 by ERK2 and PKA
• Faiyaz Ahmad, NHLBI, NIHCytokine Regulation of PDE3 and PDE4 by PKB and MAPkinase Signals in FDCP2 Myeloid cells

Short Presentations

• James Polson, University of South Florida
• Peter Sandner, University of Regensburg, Germany
• Lucienne Sanchez, Massachusetts General Hospital
• James O'Donnell, Louisiana State Medical Center
• Carrol D'Sa, Yale University

9.Wednesday Evening, June 16 - Novel PDE Genes/PDEs in "Lower Organisms"

Discussion Leader: Marco Conti, Stanford

• Kenji Omori, Tanabe SeiyakuCloning of cDNA and Characterization of PDE I OA, a Novel cAMP- and cGMP-PDE
• Scott Soderling, U. WashingtonCharacterization of New PDE Gene Families
• Peter Thomason, Cambridge, EnglandIntersection of Signal Pathways in Dictyosteliurn Development

Short Presentations

• Paul Epstein, University of Connecticut Health Center
• Matthew Movsesian, University of Utah Health Science Center
• Gudrun Pahlke, University of Kaiserlauten, Germany