Arrival and Registration
Dinner
Opening Remarks

Keynote Lecture by Paolo Sassone-Corsi

• Paolo Sassone-Corsi
  Coupling cAMP signaling to gene expression

Get-Together Social

Breakfast

Morning Session Topic: Cyclic Nucleotide Signaling: New Developments
Discussion Leader: Miles Houslay

• Ravi Iyengar
  Structure and function of adenylyl cyclase isoenzymes
• Charles Rubin
  Intracellular targeting of PKAI and PKAII isoforms
• Suzanne Lohmann
  Profiles of cGMP-dependent protein kinases and their substrates
• Break
• Dario Alessi
  Role of PDK1 in activating AGC kinases
• Walter Kolch
  Signal integration by Raf kinases

Lunch
Free of All Formal Activity
Poster Session
Dinner

Evening Session Topic: Expression and Regulation of Known and Newly Discovered PDEs
Discussion Leader: Jackie Corbin

• Miles Houslay
  Regulation of PDE4 enzymes by extracellular-signal regulated kinase (ERK)
• Tamar Michaeli
  Properties and role of PDE7 in signaling
• Kenji Omoric
  DNA cloning and characterization of novel phosphodiesterase PDE11A
• Nigel Pyne
  Identification and regulatory properties of PDE5 inhibitory proteins

Breakfast

Morning Session Topic: PDE Structure/Function and Drug Interaction
Discussion Leader: Vincent Manganiello

• John Colicelli
  Identifying isozyme-specificity determinants in phosphodiesterases
• S. Francis/J. Corbin
  Multiple effects of PDE5 phosphorylation by PKG/PKA
• James Hurley
  Insights into cyclic GMP regulation of phosphodiesterases from the structure of a GAF domain
• Break
• Robert Xu
  Insights into phosphodiesterase mechanism and specificity revealed by the atomic structure of PDE4
• 3 - 4 Short talks

Lunch
Free of All Formal Activity
Poster Session
Dinner

Evening Session Topic: Mechanisms of Subcellular Targeting and Regulation of PDEs
Discussion Leader: Marco Conti

• Vincent Manganiello
  PDE3 subcellular localization and activation
• Eva Degerman
  Mechanism of PDE3B regulation
• Robert Colman
  Structure function analysis of the catalytic region of PDE3A
• 2 Short talks

Breakfast

Morning Session Topic: The Physiology and Pharmacology of PDEs in the CNS and Cardiovascular System
Discussion Leader: Joseph Beavo

• Ronald Duman
  Characterization of PDE4 isozymes involved in the action of antidepressant treatment
• James O'Donnell
  Functional implications of PDE4 involvement in NMDA receptor-mediated signaling
• Carolyn Smith
  Cardiovascular PDE3A and PDE5A regulation in heart failure and the chronic of endothelial cell nitric oxide synthase: tissue-specific PDE adaptation
• Break
• Donald Maurice
  Angiotensin-mediated regulation of PDE4D expression in blood vessel smooth muscle cells: roles of PKA and MAPK on mRNA stability
• 3 - 4 Short talks

Lunch
Free of All Formal Activity
Poster Session
Dinner

Evening Session Topic: Therapeutic Applications of PDE Inhibitors: Bench to Bedside
Discussion Leader: Claire Lugnier

• Catherine Jin
  Insights into the role of PDE4 in airway hyperreactivity and inflammation from PDE4B and PDE4D knockout mice
• Mary Barnette
  The identification and characterization of Ariflo, a novel second generation PDE4 inhibitor for the treatment of COPD
• Annette Robichaud
  Mechanisms of emesis induced by PDE4 inhibitors: new insights
• Steve Newsome
  Toxicology of PDE4 inhibitors

Breakfast

Morning Session Topic: PDEs and the Regulation of Pulmonary Function and Inflammation
Discussion Leader: Clive Page

• Joseph Beavo
  PDE structure and function
• David Essayen
  PDE isozymes, PDE inhibitors, and T cell function
• Clive Page
  PDE inhibitors in asthma and COPD
• Break
• 4-5 Short talks and discussion

Lunch
Free of All Formal Activity
Poster Session
Banquet

Evening Session Topic: PDEs and Sensory Transmission
Discussion Leader: Theodore Wensel

• Theodore Wensel
  Structural basis for regulation of PDE6 by RGS9-1 and of GAP activity by PDE6 gamma
• Terry Cook
  The delta subunit of type 6 PDE
• Rick Cote
  Complex regulation of PDE6 during phototransduction by noncatalytic cGMP binding sites and by the inhibitory gamma subunit
• Robert Margolskee
  Heterotrimeric gustducin activates PDE and PLC to mediate taste transduction

Breakfast
Departure