| SUNDAY |
| 2:00 pm - 9:00 pm | Arrival and check-in |
| 6:00 pm | Dinner |
| 7:30 pm - 9:30 pm | DETERMINING CYCLIC NUCLEOTIDE PDEs FUNCTIONS
IN CELLS |
| Discussion Leader: Dr. D. Maurice (Queen's University, Canada) |
| 7:30 pm - 8:00 pm | Dr. M. Edbrooke (Glaxo Smith Kline, USA)
"Use of RNA Interference (RNAi) in Investigations of PDE-mediated cell functions" |
| 8:00 pm - 8:30 pm | Dr. C. Jin (Stanford University, USA)
"PDE4-null mice: The role of PDE4 in inflammatory cell responses" |
| 8:30 pm - 9:00 pm | Dr. V. Manganiello (NIH, USA)
"Comparison of the phenotype of PDE3A versus PDE3B KO mice" |
| 9:00 pm - 9:30 pm | Dr. E. Degerman (Lund University, Sweden)
"PDE3B transgenic mice: Phenotypic comparison to PDE3B-null mice" |
| MONDAY |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am - 12:30 pm | CYCLIC NUCLEOTIDES PDEs AS MODULAR ENZYMES
(Structure-Function-1) |
| Discussion Leader: Dr. M. Conti (Stanford University, USA) |
| 9:00 am - 9:30 am | Dr. K. Zhang (Plexxikon, USA)
"Structural basis of nucleotide specificity, hydrolysis and inhibitor binding by phosphodiesterases" |
| 9:30 am - 10:00 am | Dr. J. Pandet (Pfizer, UK)
"X-ray crystal structures of inhibitor complexes of PDE-10A and PDE-1b: two therapeutically important PDEs" |
| 10:00 am - 10:30 am | Dr. H. Ke (University of North Carolina, USA)
"Conformation variation of the catalytic sites of PDE4, 5, 9" |
| 10:30 am - 11:00 am | BREAK |
| 11:00 am - 11:30 am | Dr. M. Tota (Merck Research Laboratories, USA)
"Structural determinants of PDE3B inhibitor binding" |
| 11:30 am - 11:50 am | Dr. Z. Huang (Merck-Frosst Laboratories, Canada)
"Specificity and flux sensitivity of PDE4 isoform regulated cAMP signaling" |
| 11:50 am - 12:10 pm | Dr. J. Schultz (Universitat Tubingen, Germany)
"The tandem GAF domain ensemble: a surprising functional unit (not only for PDEs)" |
| 12:10 pm - 12:30 pm | Dr. S.S. Visweswariah (MRDG, India)
"Modeling and mutational analysis of the GAF domains of PDE5" |
| 12:30 pm | Lunch |
| 1:30 pm - 4:00 pm | Free Time |
| 4:00 pm - 5:30 pm | Poster Session 1 |
| 5:30 pm - 7:30 pm | CANCER: CURRENT ROLES FOR THERAPEUTICS AND
FUTURE POTENTIALS |
| Discussion Leader: Dr. A. Lerner (Boston Medical Center, USA) |
| 5:30 pm - 5:50 pm | Dr. A. Lerner (Boston Medical Center, USA)
"PDE4 inhibitor therapy for B cell chronic lymphocytic leukemia: The role of EPAC and PKA signaling in rolipram-induced apoptosis" |
| 5:50 pm - 6:10 pm | Dr. R. Aguiar (Harvard University, USA)
"Phosphodiesterase PDE4B in Lymphoma: Mechanisms of action and novel opportunities for clinical intervention" |
| 6:10 pm - 6:30 pm | Dr. C. Malbon (SUNY-Stony Brook, USA)
"The Wnt/Ca++/cyclic GMP Pathway in Development" |
| 6:30 pm - 6:50 pm | Dr. C. Lugnier (Universite Louis Pasteur de Strasbourg, France)
"Modulation of endothelial cell proliferation by PDE2 and PDE4: a potential therapeutical approach in angiogenesis" |
| 6:50 pm - 7:30 pm | Selected Poster Presentations |
| Mr. Stuart Netherton (Queen's University at Kingston, Canada) |
| Dr. Massimo Zollo (Telethon Institute of Genetics and Medicine, Naples, Italy) |
| TBA |
| 8:00 pm | Dinner |
| TUESDAY |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am - 12:30 pm | CYCLIC NUCLEOTIDES PDEs AS MODULAR ENZYMES
(BINDING-THERAPEUTICS) |
| Discussion Leader: Dr. M. Houslay (University of Glasgow, UK) |
| 9:00 am - 9:30 am | Dr. M. Houslay (University of Glasgow, UK)
"Arrestin times for PDE4" |
| 9:30 am - 10:00 am | Dr. M. Conti (Stanford University, USA)
"Novel strategies to investigate the function of PDE4 in cyclic AMP signaling" |
| 10:00 am - 10:30 am | BREAK |
| 10:30 am - 11:00 am | Dr. S. Francis (Vanderbilt University, USA)
"PDE5: Relationship of structural features to regulatory and catalytic functions" |
| 11:00 am - 11:30 am | Dr. J. Corbin (Vanderbilt University, USA)
"Binding of Radiolabeled Sildenafil, Tadalafil and Vardenafil to PDE5" |
| 11:30 am - 12:00 pm | Dr. R. Coleman (Temple University, USA)
"New insights from the structure and function of the catalytic and regulatory regions of PDE3A" |
| 12:00 pm - 12:30 pm | Selected Poster Presentations |
| Dr. R. Cote (University of New Hampshire, USA) |
| Dr. H. Zhang (University of Tennessee Health Science Centre) |
| 12:30 pm | Lunch |
| 1:00 pm - 4:00 pm | Free Time |
| 4:00 pm - 5:30 pm | Poster Session 2 |
| 5:30 pm - 7:30 pm | THERAPEUTIC ACTIVITY OF CYCLIC NUCLEOTIDE PDE INHIBITORS IN CHRONIC LUNG DISEASES |
| Discussion Leader: Dr. M. Barnette (GSK, USA) |
| 5:30 pm - 6:00 pm | Dr. J. Hogg (University of British Columbia, Canada)
"Pathophysiology of COPD" |
| 6:00 pm - 6:30 pm | Dr. S. Archer (University of Alberta, Canada)
"PDE5 inhibitors: Novel Therapy for Pulmonary Hypertension" |
| 6:30 pm - 7:00 pm | Dr. R. Panettierri (University of Pennsylvania, USA)
"PDEs and their role in airway smooth muscle function and regulation" |
| 7:00 pm - 7:30 pm | Dr. S. Lim (GSK, UK)
"PDE inhibitors for the management of COPD" |
| 8:00 pm | Dinner |
| WEDNESDAY |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am - 12:30 pm | THERAPEUTIC POTENTIAL OF TARGETING CYCLIC
NUCLEOTIDE PDEs IN THE CENTRAL NERVOUS
SYSTEM |
| Discussion Leader: Dr. J. O'Donnell (University of Tennessee Health Sciences Center, USA) |
| 9:00 am - 9:25 am | Dr. J. O'Donnell (University of Tennessee Health Science Center, USA)
"Neuropsychopharmacological actions of PDE4 inhibitors" |
| 9:25 am - 9:50 am | Dr. G. Mengod (IIBB/CSIC (IDIBAPS), Spain)
"cAMP PDE/Alzheimer" |
| 9:50 am - 10:15 am | Dr. F. Minneti (Pfizer, USA)
"PDE10 Inhibitors: Potential as novel anti-psychotics?" |
| 10:15 am - 10:40 am | BREAK |
| 10:40 am - 11:05 am | Dr. A. Zhao (University of Pittsburgh, USA)
"Regulation of body weight and adipokine secretion by cAMP" |
| 11:05 am - 11:30 am | Dr. A. Parsons (GSK, UK)
"Role of PDE inhibitors as memory/cognition enhancers" |
| 11:30 am - 11:55 am | Dr. A. Hopper (Memory Pharmaceuticals, USA)
"Cognitive Enhancing Effects of PDE4 Inhibition" |
| 11:55 am - 12:30 pm | Selected Poster Presentations |
| Dr. J deVente |
| TBA |
| 12:30 pm | Lunch |
| 1:00 pm - 4:00 pm | Free Time |
| 4:00 pm - 5:30 pm | Poster Session 3 |
| 5:30 pm - 7:30 pm | THERAPEUTIC UTILITY OF CYCLIC NUCLEOTIDE PDE
INHIBITION IN CARDIOVASCULAR AND IMMUNOLOGIC DISEASES-2 |
| Discussion leader: Dr. J. Beavo (University of Washington, USA) |
| 5:30 pm - 6:00 pm | Dr. J. Beavo (University of Washington, USA)
"PDE splice form specific regulation: Roles in macrophage development and function" |
| 6:00 pm - 6:30 pm | Dr. J. Madrenas (Robarts Research Institute, Canada)
"Regulation of T cell activation by PDE4B2: a dynamic interplay" |
| 6:30 pm - 7:00 pm | Dr. R. Schermuly (Klinische Forschergruppe- Respiratorische Insuffizienz, Germany)
"Prostanoids and PDE inhibitors in experimental pulmonary hypertension" |
| 7:00 pm - 7:30 pm | Selected Poster Presentations |
| Dr. M-J Leroy |
| Dr. S. Rybalkin |
| 8:00 pm | Dinner |
| THURSDAY |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am - 12:30 pm | THERAPEUTIC UTILITY OF CYCLIC NUCLEOTIDE PDE
INHIBITION IN CARDIOVASCULAR AND IMMUNOLOGIC DISEASES-1 |
| Discussion Leader: Dr. N. Pyne (Strathclyde University, UK) |
| 9:00 am - 9:30 am | Dr. N. Pyne (Strathclyde University, UK)
"Hypoxic-dependent changes in PDE3/5 expression: mechanisms and functional consequences" |
| 9:30 am - 10:00 am | Dr. S. Grtarsdttir (deCODE Genetics, Iceland)
"The PDE4D gene and its association with ischemic stroke" |
| 10:00 am - 10:30 am | Dr. G. Vandecasteele (Universite Paris-Sud, France)
"Regulation of cAMP signals by cyclic nucleotide PDEs in intact cardiac myocytes" |
| 10:30 am - 11:00 am | Break |
| 11:00 am - 11:30 am | Dr. M. Movsesian (University of Utah, USA)
"cAMP-mediated signaling in heart failure" |
| 11:30 am - 12:00 pm | Dr. C. Yan (University of Rochester, USA)
"Role of phosphodiesterase 3 in cardiovascular diseases" |
| 12:00 pm - 12:30 pm | Dr. C. Smith (New York Medical College, USA)
"Regulation of Cardiovascular PDE5A in Pathophysiology" |
| 12:30 pm | Lunch |
| 1:30 pm - 4:00 pm | Free Time |
| 4:00 pm - 5:30 pm | Poster Session 4 |
| 5:30 pm - 7:30 pm | INHIBITORS OF NOVEL CYCLIC NUCLEOTIDE PDES:
POTENTIAL THERAPEUTIC TARGETS |
| Discussion Leader: Dr. M. Giembycz (University of Calgary, Canada) |
| 5:30 pm - 6:00 pm | Dr. M. Giembycz (University of Calgary, Canada)
"Phosphodiesterase 7A: A new Therapeutic Target for Alleviating Chronic Inflammation?" |
| 6:00 pm - 6:30 pm | Dr. K. Omori (Tanabe Seiyaku Co. Ltd, Japan)
"A Novel Phosphodiesterase from the Human Malaria Parasite" |
| 6:30 pm - 7:30 pm | Selected Poster Presentations |
| Tasmina Goraya (Cambridge University, UK) |
| Andrea Johner (Zellbiologisches Institut, Switzerland) |
| Sunil Laxman (University of Washington, USA) |
| TBA |
| 8:00 pm | Dinner |
| FRIDAY |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am | Departure |
