SUNDAY |
4:00 pm - 9:00 pm | Arrival and Check-in (Office Closed 6:00 pm - 7:45 pm) |
6:00 pm | Dinner |
7:30 pm - 7:40 pm | Welcome / Introductory Comments by GRC Site Staff |
7:40 pm - 8:15 pm | Keynote Lecture |
7:40 pm - 8:10 pm | Joe Beavo (Univ. Washington) |
8:10 pm - 8:15 pm | Discussion |
8:15 pm - 9:30 pm | PDEs in lower organisms |
| Session Chair: Thomas Seebeck (Univ. Bern) |
8:15 pm - 8:30 pm | Thomas Seebeck (Univ. Bern) "PDEs in trypanosomes and related pathogens" |
8:30 pm - 8:35 pm | Discussion |
8:35 pm - 8:50 pm | Yasmin Shakur (Otsuka Maryland Medicinal Laboratories) "PDE inhibitors as anti-parasitics" |
9:05 pm - 9:10 pm | Discussion |
9:10 pm - 9:25 pm | Harry de Koning (Glasgow Uni)
"The mechanism of action of PDE inhibitors in Trypanosoma brucei: rapid elevation of cAMP levels leads to cell death through highly specific actions on cell division" |
9:25 pm - 9:30 pm | Discussion |
MONDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | PDEs in the Central Nervous System I |
| Session Chairs: Han-Ting Zhang (Univ. West Virginia) & Nick Brandon (Wyeth) |
9:00 am - 9:25 am | Chris Schmidt (Pfizer) "CNS activity of PDE9: A ubiquitous regulator of cGMP signaling" |
9:25 am - 9:30 am | Discussion |
9:30 am - 9:55 am | Nick Brandon (Wyeth) "Evaluation of the therapeutic potential of PDE10 inhibitors for schizophrenia" |
9:55 am - 10:00 am | Discussion |
10:00 am - 10:25 am | L. Ramirez (Leonard M. Miller School of Medicine)
"Spatially and temporally altered PDE 1A in descending locomotor systems and its therapeutic targeting following spinal cord injury" |
10:25 am - 10:30 am | Discussion |
10:30 am | Coffee Break / Group Photo |
11:00 am - 11:25 am | Tony West (Rosalyn Franklin Univ.) "Impact of Cyclic GMP-PDE Signaling Cascades on the Electrophysiological Properties of Striatal Neurons: Implications for Schizophrenia" |
11:25 am - 11:30 am | Discussion |
11:30 am - 11:55 am | Frank Boess (Lilly UK) "The potential of PDE2 as a therapeutic target for CNS disorders" |
11:55 am - 12:00 pm | Discussion |
12:00 pm - 12:25 pm | Jim O'Donnell (Univ. West Virginia) "Neuropsychopharmacological effects of inhibitors of phosphodiesterase-2" |
12:25 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 5:30 pm | Poster Session |
5:30 pm - 7:30 pm | Structural determinants of PDE activity and regulation |
| Session Chairs: J. Corbin (Vanderbilt Univ.) & J. Schultz (Univ. Tubingen) |
5:30 pm - 5:55 pm | Jay Pandit (Pfizer) "Crystal structure of full length PDE2" |
5:55 pm - 6:00 pm | Discussion |
6:00 pm - 6:15 pm | Hengming Ke (UNC) "Crystal structure of PDE8A and implication on the inhibitor selectivity" |
6:15 pm - 6:20 pm | Discussion |
6:20 pm - 6:35 pm | H. Wang (UNC)
"Structure-based discovery of inhibitors of parasite phosphodiesterases" |
6:35 pm - 6:40 pm | Discussion |
6:40 pm - 7:05 pm | Joachim Schultz (Univ. Tubingen) "Biochemical analysis of N-terminal tandem domains of phosphodiesterases" |
7:05 pm - 7:10 pm | Discussion |
7:10 pm - 7:25 pm | Sharron Francis (Vanderbilt Univ.) "Role of the Invariant Glutamine in PDE11 Catalytic Function and Potency of Inhibition by Tadalafil" |
7:25 pm - 7:30 pm | Discussion |
8:00 pm | Dinner |
TUESDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | PDEs in the Central Nervous System II |
| Session Chairs: C. Schmidt (Pfizer) & Eric Karran (Lilly UK) |
9:00 am - 9:25 am | Akira Sawa (Johns Hopkins Univ.) "Role for PDE4 in mental illnesses: schizophrenia and Huntington's disease" |
9:25 am - 9:30 am | Discussion |
9:30 am - 9:55 am | Mike DeVivo (Memory Pharmaceuticals) "PDE4 Inhibition: Potential Pro-Cognitive Effects through Multiple Mechanisms" |
9:55 am - 10:00 am | Discussion |
10:00 am - 10:25 am | Arjan Blockland (Univ. Masstricht) "Effects of sildenafil on cognition in humans" |
10:25 am - 10:30 am | Discussion |
10:30 am | Coffee Break |
11:00 am - 11:25 am | Bryan Devan (Towson University) "PDE5 inhibition, cognition and aging" |
11:25 am - 11:30 am | Discussion |
11:30 am - 11:55 am | Rick Cote (Univ. New Hampshire) "Allosteric regulation of PDE6" |
11:55 am - 12:00 pm | Discussion |
12:00 pm - 12:25 pm | Elena Nikulina (Hunter College)
"Inhibition of PDE4 by rolipram promotes axonal regeneration" |
12:25 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 5:30 pm | Poster Session |
5:30 pm - 7:30 pm | Hot topics |
| Session Chairs: Joe Beavo (Univ. of Washington) & Vince Manganiello (NIH) |
5:30 pm - 5:55 pm | M. Gibbs (Pfizer) "PDE10A inhibitors for the treatment of diabetes" |
5:55 pm - 6:00 pm | Discussion |
6:00 pm - 6:25 pm | Wito Richter (UCSF) "Regulation of b-adrenoceptor signaling by PDE4" |
6:25 pm - 6:30 pm | Discussion |
6:30 pm - 6:55 pm | Faiyaz A. Khan (NIH)
"Formation of different PDE3B macromolecular signaling complexes in response to insulin and CL316243(B3-agonist) in adipocyte membranes" |
6:55 pm - 7:00 pm | Discussion |
7:00 pm - 7:25 pm | A. Terrin (Glasgow Uni)
"FRET-based analysis of cAMP dynamics at the centrosome" |
7:25 pm - 7:30 pm | Discussion |
8:00 pm | Dinner |
WEDNESDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | Regulation of PDE activity |
| Session Chairs: M. Houslay (Univ. Glasgow) & R. Fischmeister (Univ. Paris) |
9:00 am - 9:25 am | Kjetil Tasken (Univ. Oslo) "cAMP-dependent modulation of T cell immune responses involves anchored signal complexes" |
9:25 am - 9:30 am | Discussion |
9:30 am - 9:55 am | Don Maurice (Queen's University) "Distinct cAMP-signaling Complexes Regulate Integrin-, and VE Cadherin-based, Adhesions in Vascular Endothelial Cells" |
9:55 am - 10:00 am | Discussion |
10:00 am - 10:25 am | Miles Houslay (Univ. Glasgow) "PDE4 and the compartmentalisation of cAMP signalling" |
10:25 am - 10:30 am | Discussion |
10:30 am | Coffee Break |
11:00 am - 11:25 am | Marco Conti (UCSF) "PDE4" |
11:25 am - 11:30 am | Discussion |
11:30 am - 11:45 am | Adam Lerner (Boston)
"PDE4 inhibitors and T/B cell lineage" |
11:45 am - 11:50 am | Discussion |
11:50 am - 12:05 pm | Eva Degerman (Lund Univ.) "Role and regulation of PDE3B" |
12:05 pm - 12:10 pm | Discussion |
12:10 pm - 12:25 pm | Vadim Arshavsky (Duke Univ.) "Role of PDE6/gamma and PDE-gamma like domain in RGS 9-2 in temporal regulation of G-protein signaling" |
12:25 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 5:30 pm | Poster Session |
5:30 pm - 7:30 pm | PDE compartmentalization in temporal and spatial control of cyclic nucleotide signaling |
| Session Chairs: M. Conti (UCSF) & M. Zaccolo (Univ of Glasgow) |
5:30 pm - 5:55 pm | John Scott (Vollum Institute) "PDEs and AKAPs" |
5:55 pm - 6:00 pm | Discussion |
6:00 pm - 6:25 pm | Thomas Rich (Univ. South Alabama) "The roles of PDE4 activity in shaping cAMP signals" |
6:25 pm - 6:30 pm | Discussion |
6:30 pm - 6:55 pm | Manuela Zaccolo (Univ. Glasgow) "Mechanisms underlying cAMP/PKA compartmentalized signalling" |
6:55 pm - 7:00 pm | Discussion |
7:00 pm - 7:25 pm | George Baillie (Univ. Glasgow) "Regulation and targeting of PDE4D5" |
7:25 pm - 7:30 pm | Discussion |
7:30 pm - 8:00 pm | Business Meeting |
| (Nominations for the next Vice Chair; Fill out Conference Evaluation Forms; Discuss future Site & Scheduling preferences; Election of the next Vice Chair) |
8:00 pm | Dinner |
THURSDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | PDE5: beyond MED |
| Session Chairs: G. Butrous (Pfizer) & Claire Lugnier (Strasbourg) |
9:00 am - 9:25 am | Hunter Champion (John Hopkins) "PDE5 and pulmonary hypertension" |
9:25 am - 9:30 am | Discussion |
9:30 am - 9:55 am | Robin Steinhorn (Northwestern) "PDE5 and pulmonary hypertension" |
9:55 am - 10:00 am | Discussion |
10:00 am - 10:25 am | David Kass (Johns Hopkins Univ.) "PDE5 and myocyte hypertrophy" |
10:25 am - 10:30 am | Discussion |
10:30 am | Coffee Break |
11:00 am - 11:25 am | Rakesh Kukreja (Virginia Commonwealth U.) "Cardioprotective Siganling following PDE-5 Inhibition" |
11:25 am - 11:30 am | Discussion |
11:30 am - 11:45 am | John Burnett (Mayo Clinic) "PDE5 Renal function" |
11:45 am - 11:50 am | Discussion |
11:50 am - 12:05 pm | Peter Sandner (Bayer Health Care AG) "PDE5 and symptomatic Benign Prostatic Hyperplasia (BPH)" |
12:05 pm - 12:10 pm | Discussion |
12:10 pm - 12:25 pm | Christina Kruuse (Glostrup Hospital) "PDE5 and the cerebrovasculature" |
12:25 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 5:30 pm | Poster Session |
5:30 pm - 7:30 pm | PDEs and the regulation of the cardiovascular system |
| Session Chairs: D. Kass (John Hopkins) & Don Maurice (Queens Univ.) |
5:30 pm - 5:45 pm | Peter Backx (Univ. Ontario)
"Functional consequences of cAMP compartmentation in heart" |
5:45 pm - 5:50 pm | Discussion |
5:50 pm - 6:05 pm | Matthew Movsesian (Univ. Utah) "PDE1C1 in human myocardium" |
6:05 pm - 6:10 pm | Discussion |
6:10 pm - 6:25 pm | Lindsay Wilson (Queen's Univ.) "Coupling between cyclic nucleotides and phosphatidyl-inositol signalling: Roles for PDE3 and PDE5" |
6:25 pm - 6:30 pm | Discussion |
6:30 pm - 6:55 pm | Grégoire Vandecasteele (INSERM U769, Univ. Paris Sud) "Modulation of β-adrenergic responses by PDE3 and PDE4 in cardiac myocytes" |
6:55 pm - 7:00 pm | Discussion |
7:00 pm - 7:25 pm | E. Patrucco (Univ. Washington) "PDE8 in the heart" |
7:25 pm - 7:30 pm | Discussion |
8:00 pm | Dinner |
FRIDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am | Depart |