SUNDAY |
2:00 pm - 9:00 pm | Arrival and Check-in (Office Closed 6:00 pm - 7:00 pm) |
6:00 pm | Dinner |
7:30 pm - 7:40 pm | Welcome / Introductory Comments by GRC Site Staff |
7:40 pm - 8:45 pm | KEYNOTE PRESENTATION |
| Discussion Leader: Joe Beavo (University of Washington) |
7:40 pm - 8:30 pm | Miles Houslay (University of Glasgow) "PDE4: Partnerships, fidelity and new therapeutic possibilities" |
8:30 pm - 8:45 pm | Discussion |
MONDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | PDE IN CELL FUNCTION AND REGULATION I |
| Discussion Leader: Vince Manganiello (NIH/NHLBI) |
9:00 am - 9:20 am | Graeme Bolger (University of Alabama at Birmingham) "AIP: A PDE4A-interacting protein and pituitary tumor suppressor" |
9:20 am - 9:30 am | Discussion |
9:30 am - 9:50 am | Brigitte Blackmann (University of California, San Francisco) "The function of PDE4B is confined to a membrane compartment in mouse embryonic
fibroblasts" |
9:50 am - 10:00 am | Discussion |
10:00 am | Group Photo / Coffee Break |
10:30 am - 10:50 am | Peter Backx (University of Toronto) "Functional overlap of PDE3A and PDE4D in mircodomains of cardiomyocytes" |
10:50 am - 11:00 am | Discussion |
11:00 am - 11:20 am | Youn Wook Chung (NIH/NHLBI) "Cardioprotection in PDE3B KO mice during ex vivo ischemia/reperfusion: Possible mechanisms" |
11:20 am - 11:30 am | Discussion |
11:30 am - 11:50 am | John Scott (University of Washington) "Cyclic AMP signaling in space and time" |
11:50 am - 12:00 pm | Discussion |
12:00 pm - 12:20 pm | Kjetil Tasken (University of Oslo) "Spatiotemporal control of cyclic AMP signaling processes in immune cells and adipocytes" |
12:20 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | PDE IN THE CENTRAL NERVOUS SYSTEM I |
| Discussion Leader: Tony West (Rosalind Franklin University) |
7:30 pm - 7:50 pm | Michelle Kelly (Pfizer) "PDE11A in brain is enriched in ventral hippocampus and deletion results in disease-related phenotypes" |
7:50 pm - 8:00 pm | Discussion |
8:00 pm - 8:20 pm | Guadalupe Mengod (Institut d'Investigacions Biomédiques de Barcelona) "Differential cAMP PDEs expression in experimental autoimmune encephalomyelitis in
mice" |
8:20 pm - 8:30 pm | Discussion |
8:30 pm - 8:50 pm | Jacob Nielsen (Lundbeck) "Behavioural profile of PDE10A inhibition at different levels of inhibition" |
8:50 pm - 9:00 pm | Discussion |
9:00 pm - 9:20 pm | Damien Pearse (University of Miami) "Cyclic AMP-PDEs and CNS injury" |
9:20 pm - 9:30 pm | Discussion |
TUESDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | STRUCTURAL DETERMINANTS OF PDE ACTIVITY & REGULATION |
| Discussion Leader: Sharron Francis (Vanderbilt University) |
9:00 am - 9:20 am | Jackie Corbin (Vanderbilt University) "Current insights into regulation of PDE5" |
9:20 am - 9:30 am | Discussion |
9:30 am - 9:50 am | Hengming Ke (University of North Carolina) "Structural implications on cGMP signaling and phosphorylation of phosphodiesterase-5" |
9:50 am - 10:00 am | Discussion |
10:00 am | Coffee Break |
10:30 am - 10:50 am | Chang-Guo Zhan (University of Kentucky) "Active site structures and catalytic mechanisms of phosphodiesterases" |
10:50 am - 11:00 am | Discussion |
11:00 am - 11:20 am | Doris Koesling (Ruhr University) "PDE5 activation in vitro and in vivo" |
11:20 am - 11:30 am | Discussion |
11:30 am - 11:50 am | David Adams (Heriot-Watt University) "Structural basis for rolipram-induced intracellular redistribution of PDE4A4" |
11:50 am - 12:00 pm | Discussion |
12:00 pm - 12:20 pm | Clint Miller (University of Rochester) "Novel role of PDE1 in regulating pathological cardiac remodeling" |
12:20 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | PDE IN LOWER ORGANISMS |
| Discussion Leader: Joachim Schultz (University of Tubingen) |
7:30 pm - 7:50 pm | Michael Pollastri (Northeastern University) "Discovery of trypanosomal PDE inhibitors via repurposing of human PDE medicinal
chemistry" |
7:50 pm - 8:00 pm | Discussion |
8:00 pm - 8:20 pm | GeertJan Sterk (Mercachem) "Cyclic nucleotide phophodiesterases of kinetoplastids: new targets for drug
development" |
8:20 pm - 8:30 pm | Discussion |
8:30 pm - 8:50 pm | Huanchen Wang (University of North Carolina) "Crystal structures of parasite tbrPDEB1, lmjPDEB1, tcrPDEC and their complexes and
implication on the inhibitor design" |
8:50 pm - 9:00 pm | Discussion |
9:00 pm - 9:20 pm | Harry De Koning (University of Glasgow) "Phosphodiesterase inhibitors reveal a critical role for cAMP in the cell division cycle of trypanosoma brucei" |
9:20 pm - 9:30 pm | Discussion |
WEDNESDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | PDE IN THE CENTRAL NERVOUS SYSTEM II |
| Discussion Leader: Frank Menniti (cyclicM) |
9:00 am - 9:20 am | Larry Wennogle (Intra-Cellular Therapies) "Phosphodiesterase 1 as a target for pharmaceutical development for disease indications
of the central nervous system" |
9:20 am - 9:30 am | Discussion |
9:30 am - 9:50 am | Han-Ting Zhang (West Virginia University) "Targeting PDE4 isoforms for memory enhancement" |
9:50 am - 10:00 am | Discussion |
10:00 am | Coffee Break |
10:30 am - 10:50 am | Nick Brandon (Pfizer) "Understanding PDE10A regulation by phosphorylation and palmitoylation plus an update on PDE10A drug discover" |
10:50 am - 11:00 am | Discussion |
11:00 am - 11:20 am | Akira Sawa (Johns Hopkins University) "Disturbance of PDE signaling in neurodegenerative disorders" |
11:20 am - 11:30 am | Discussion |
11:30 am - 11:50 am | Rick Cote (University of New Hampshire) "Novel mechanisms of allosteric regulation of PDE6" |
11:50 am - 12:00 pm | Discussion |
12:00 pm - 12:20 pm | Vishy Ramamurthy (West Virginia University) "Lack of PDE4 alters the light response of retinal photoreceptor cells" |
12:20 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | PDE IN CELL FUNCTION AND REGULATION II |
| Discussion Leader: Don Maurice (Queens University) |
7:30 pm - 7:50 pm | George Baillie (University of Glasgow) "Selective SUMO modification of cAMP-specific phosphodiesterase-4D5 regulates the
functional consequences of phosphorylation by PKA and ERK" |
7:50 pm - 8:00 pm | Discussion |
8:00 pm - 8:20 pm | Thomas Rich (University of South Alabama) "Phosphodiesterase-mediated regulation of pulmonary endothelial barrier integrity" |
8:20 pm - 8:30 pm | Discussion |
8:30 pm - 8:50 pm | Claire Lugnier (University of Strasbourg) "NCS 613, a specific PDE4 inhibitor, delays systemic lupus erythematosus (SLE) progression in MRL/lpr lupus-prone mice model" |
8:50 pm - 9:00 pm | Discussion |
9:00 pm - 9:20 pm | Manuela Zaccolo (University of Glasgow) "Cyclic GMP modulates compartmentalized cAMP signals via PDEs activity" |
9:20 pm - 9:30 pm | Discussion |
THURSDAY |
7:30 am - 8:30 am | Breakfast |
8:30 am - 9:00 am | Business Meeting |
| (Nominations for the next Vice Chair; Fill out Conference Evaluation Forms; Discuss future Site & Scheduling preferences; Election of the next Vice Chair) |
9:00 am - 12:30 pm | DRUG DISCOVERY AND PDE/PDE AND CARDIOVASCULAR SYSTEM |
| Discussion Leader: Miles Houslay (University of Glasgow) |
9:00 am - 9:20 am | Alex Burgin (Emerald Biostructures) "Phosphodiesterase-4 enzyme activity is regulated by controlling access to the active
site" |
9:20 am - 9:40 am | Mark Gurney (Emerald Biostructures) "Design of PDE4 allosteric modulators with improved tolerability" |
9:40 am - 10:00 am | Discussion |
10:00 am | Coffee Break |
10:30 am - 10:50 am | Charles Hoffman (Boston College) "Use of fission yeast-base HTS to detect PDE inhibitors" |
10:50 am - 11:00 am | Discussion |
11:00 am - 11:20 am | Herrmann Tenor (Nycomed) "Roflumilast in COPD - from PDE4 inhibition to clinical benefit" |
11:20 am - 11:30 am | Discussion |
11:30 am - 11:50 am | Candace Adamo (University of Washington) "The effect of PDE5 Inhibitors on cardiac function in dystrophin-null(mdx) mice" |
11:50 am - 12:00 pm | Discussion |
12:00 pm - 12:20 pm | Matthew Movsesian (University of Utah) "PDE3-binding proteins and the compartmentation of cAMP-mediated signaling in human myocardium" |
12:20 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | PDE AND CANCER |
| Discussion Leader: Marco Conti (University of California, San Francisco) |
7:30 pm - 7:50 pm | Gary Piazza (University of Alabama at Birmingham) "PDE5, a novel anticancer target" |
7:50 pm - 8:00 pm | Discussion |
8:00 pm - 8:20 pm | Adam Lerner (Boston University) "PDE4 inhibitors and apoptosis in lymphocytic leukemia" |
8:20 pm - 8:30 pm | Discussion |
8:30 pm - 8:50 pm | Rakesh Kukreja (Virginia Commonwealth University) "PDE-5 inhibition in potentiation of anti-tumor activity of doxorubicin" |
8:50 pm - 9:00 pm | Discussion |
9:00 pm - 9:20 pm | Jun Yang (St. Jude’s Children’s Research Hospital) "PDE4B pharmacogenetics in childhood acute lymphoblastic leukemia" |
9:20 pm - 9:30 pm | Discussion |
FRIDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am | Depart |