SUNDAY |
2:00 pm - 9:00 pm | Arrival and Check-in |
6:00 pm | Dinner |
7:30 pm - 7:45 pm | Welcome / Introductory Comments by GRC Site Staff |
7:45 pm - 9:30 pm | GRS Presentations / Keynote Lecture |
| Discussion Leader: Joe Beavo (University of Washington) |
7:45 pm - 7:55 pm | TBA (Selected from GRS) |
7:55 pm - 8:00 pm | Discussion |
8:00 pm - 8:20 pm | TBA (Selected from GRS) |
8:20 pm - 8:30 pm | Discussion |
8:30 pm - 9:20 pm | Keynote: M. von Zastrow (University of California, San Francisco)
"A Novel Paradigm in cAMP Signal Transduction: GPCR Signaling from Endosomes" |
9:20 pm - 9:30 pm | Discussion |
MONDAY |
7:30 am - 8:30 am | Breakfast |
8:30 am | Group Photo |
9:00 am - 12:30 pm | CNS - Movement Disorders |
| Discussion Leader: James O'Donnell (University of Buffalo) |
9:00 am - 9:20 am | James Surmeier (Northwestern University)
"PDE10 Modulation of Intrastriatal Circuits"
|
9:20 am - 9:30 am | Discussion |
9:30 am - 9:50 am | Christopher Schmidt (Pfizer)
"Assessing the Therapeutic Potential of PDE 10, 9 and 2 Inhibitors for the Treatment of Huntington's Disease"
|
9:50 am - 10:00 am | Discussion |
10:00 am | Coffee Break |
10:30 am - 10:50 am | Anthony West (The Chicago Medical School at RFUMS)
"Targeting PDE's for the Treatment of Neurological Disorders"
|
10:50 am - 11:00 am | Discussion |
11:00 am - 11:20 am | Francesca Fusco (European Center for Brain Research, Rome)
"PDEs as Therapeutic Targets for Huntington's Disease"
|
11:20 am - 11:30 am | Discussion |
11:30 am - 11:40 am | Stefan Brocke (UCONN Health Center)
"Targeting PDE8 to Treat Inflammation In Vivo"
|
11:40 am - 11:45 am | Discussion |
11:45 am - 11:55 am | Pierre Vincent (CNRS UPMC)
"Inhibitors of Type 10 Phosphodiesterase with an Antipsychotic-Like Profile Reveal a Profound Difference Between D1 and D2 Striatal Neurons"
|
11:55 am - 12:00 pm | Discussion |
12:00 pm - 12:10 pm | Susana Neves (Mount Sinai School of Medicine)
"Phophodiesterase Control of AMPAR Trafficking"
|
12:10 pm - 12:15 pm | Discussion |
12:15 pm - 12:25 pm | Mark Gomelsky (University of Wyoming)
"Near-Infrared Window Light Activated Adenylate Cyclase as a New Optogenetic Tool"
|
12:25 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | CNS - Cognition |
| Discussion Leader: Arjan Blokland (Maastricht University) |
7:30 pm - 7:50 pm | Jos Prickaerts (Maastricht University)
"PDEs and Memory: Timing is Essential"
|
7:50 pm - 8:00 pm | Discussion |
8:00 pm - 8:20 pm | Robbert Havekes (University of Pennsylvania)
"Synaptic Plasticity and Memory Deficit by Sleep Loss Depend on Altered PDE4 Signaling"
|
8:20 pm - 8:30 pm | Discussion |
8:30 pm - 8:50 pm | Holger Rosenbrock (Boehringer Ingelheim Pharma GmbH & Co. KG)
"PDE Inhibition in Hippocampal LTP"
|
8:50 pm - 9:00 pm | Discussion |
9:00 pm - 9:20 pm | Arjan Blokland (Maastricht University)
"Translating Cognition Enhancing Properties from Animals to Man"
|
9:20 pm - 9:30 pm | Discussion |
TUESDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | Cyclic Nucleotide Signaling and Cardiac Disease |
| Discussion Leader: Don Maurice (Queen's University, Kingston, ON, Canada) |
9:00 am - 9:20 am | David Kass (The Johns Hopkins University, Baltimore, MD)
"Selective cGMP Targeting and Cardiac Stress Modulation by PDE9A"
|
9:20 am - 9:30 am | Discussion |
9:30 am - 9:50 am | Donald Bers (University of California, Davis, CA)
"Epac Isoform-Specific Localization and Signaling in Cardiac Myocytes"
|
9:50 am - 10:00 am | Discussion |
10:00 am | Coffee Break |
10:30 am - 10:50 am | John Scott (University of Washington, Seattle, WA)
"Guiding Signaling Through Anchored Enzyme Complexes: Surprisingly Local Control of Second Messenger Events"
|
10:50 am - 11:00 am | Discussion |
11:00 am - 11:20 am | Julia Gorelik (Imperial College London, UK)
"Microdomains of cAMP Signaling in Normal and Failing Cardiomyocytes as Seen by the Nanoscale Functional Microscopy"
|
11:20 am - 11:30 am | Discussion |
11:30 am - 11:50 am | Kjetil Tasken (University of Oslo)
"Targeting Adrenergic Regulation of the SERCA2 Complex in the Heart"
|
11:50 am - 12:00 pm | Discussion |
12:00 pm - 12:10 pm | Frank Lezoulach (INSERM UMR-1048)
"Adaptive Autophagy Is Induced by the Activation of Epac1 During Cardiomyocyte Hypertrophy"
|
12:10 pm - 12:15 pm | Discussion |
12:15 pm - 12:25 pm | Ruwan Perera (Heart Research Center Goettingen)
"Microdomain Switch of PDE2 and 3 Modulates cGMP-Mediated Control on Beta-Adrenergic cAMP Signaling in Early Cardiac Disease"
|
12:25 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | Regulation of cAMP Signaling in the Cardiovascular System |
| Discussion Leader: Rodolphe Fischmeister (University Paris-Sud) |
7:30 pm - 7:50 pm | Boris Manoury (University Paris-Sud)
"Regulation of PDEs Function in Vascular Smooth Muscle Cells: Alterations in Heart Failure"
|
7:50 pm - 8:00 pm | Discussion |
8:00 pm - 8:20 pm | Tanya Mayadas (Brigham and Women's Hospital & Harvard Medical School)
"EPAC/PKA/AKAP9 in Endothelial Cell Function"
|
8:20 pm - 8:30 pm | Discussion |
8:30 pm - 8:50 pm | Delphine Mika (University of California San Francisco)
"PDE4 and the Specificity of β-Adrenergic Signaling in Cardiac Myocytes"
|
8:50 pm - 9:00 pm | Discussion |
9:00 pm - 9:10 pm | Konstantinos Lefkimmiatis (University of Oxford)
"The Outer Mitochondrial Membrane of Cardiac Myocytes Hosts a Privileged cAMP Signalling Cascade"
|
9:10 pm - 9:15 pm | Discussion |
9:15 pm - 9:25 pm | Euan Parnell (University of Glasgow)
"Novel Subcellular Targeting of Exchange Protein Activated by cAMP (EPAC)"
|
9:25 pm - 9:30 pm | Discussion |
WEDNESDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | PDE Inhibitors in On-Going Clinical Trials |
| Discussion Leader: Christopher Schmidt (Pfizer) |
9:00 am - 9:20 am | Garth Ringheim (Celgene Corporation)
"The Translational Medicine of Apremilast, a PDE4 Inhibitor in Development for Psoriasis, Psoriatic Arthritis, and Other Rheumatological and Dermatological Conditions"
|
9:20 am - 9:30 am | Discussion |
9:30 am - 9:50 am | Domenico Spina (King's College London)
"PDE Inhibitors in Asthma and COPD: Are They Safe and Clinically Effective?"
|
9:50 am - 10:00 am | Discussion |
10:00 am | Coffee Break |
10:30 am - 10:50 am | Larry Wennogle (Intracellular Therapies)
"Updating Progress on Phosphodiesterase 1 Inhibitors as Therapeutic Agents"
|
10:50 am - 11:00 am | Discussion |
11:00 am - 11:20 am | Kurt Jarnagin (Anacor)
"Topcial PDE4 Inhibitors for the Treatment of Atopic Dermatitis"
|
11:20 am - 11:30 am | Discussion |
11:30 am - 11:50 am | Christina Kruuse (Copenhagen University Hospital Herlev)
"Effect of Sildenafil on Skeletal and Cardiac Muscle Function in Becker Muscular Dystrophy: A Randomised, Double Blind, Placebo-Controlled Crossover Clinical Trial"
|
11:50 am - 12:00 pm | Discussion |
12:00 pm - 12:30 pm | Late Submission Abstracts |
12:00 pm - 12:10 pm | Sergei Rybalkin (University of Washington)
"Direct and Indirect Effects of PDE1 and PDE5 Inhibitors on Cardiac Cells"
|
12:10 pm - 12:15 pm | Discussion |
12:15 pm - 12:25 pm | Jonathan Klabnik (West Virginia University - Hea)
"Alleviation of Neuronal Oxidative Stress by Thioredoxin Through PDE2 Inhibition"
|
12:25 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session |
6:00 pm | Dinner |
7:00 pm - 7:30 pm | Business Meeting |
| Nominations for the Next Vice Chair; Fill in Conference Evaluation Forms; Discuss Future Site and Scheduling Preferences; Election of the Next Vice Chair |
7:30 pm - 9:30 pm | Phosphodiesterases and Gene Defects |
| Discussion Leader: Marco Conti (University of California San Francisco) |
7:30 pm - 7:50 pm | Caroline Silve (INSERM, France)
"PRKAR1A and PDE4D Mutations Cause Similar Skeletal Dysplasia but with or Without Resistance to Hormones Signaling Through cAMP"
|
7:50 pm - 8:00 pm | Discussion |
8:00 pm - 8:20 pm | Eamonn Sheridan (St James's Hospital Leeds)
"A Germline Mutation in PDE10a Results in a Congenital Movement Disorder Characterised by Non-Progressive Chorea and Mild Learning Difficulties"
|
8:20 pm - 8:30 pm | Discussion |
8:30 pm - 8:50 pm | Anna Lindstrand (Karolinska Institutet)
"Different Mutations in PDE4D Associated with Developmental Disorders with Mirror Phenotypes" |
8:50 pm - 9:00 pm | Discussion |
9:00 pm - 9:20 pm | Mark Gurney (Tetra Discovery Partners)
"Molecular Regulation and Neuropharmacoology of Subtype-Selective PDE4 Inhibitors"
|
9:20 pm - 9:30 pm | Discussion |
THURSDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | Phosphodiesterases and Cancer |
| Discussion Leader: Adam Lerner (Boston University School of Medicine) |
9:00 am - 9:20 am | Rajkumar Savai (Max Planck Institute, Bad Nauheim, Germany)
"Role of Phosphodiesterase-4 (PDE4) in Lung Cancer"
|
9:20 am - 9:30 am | Discussion |
9:30 am - 9:50 am | Gary Piazza (University of South Alabama Mitchell Cancer Institute)
"Phosphodiesterase 10A: A Novel Cancer Target"
|
9:50 am - 10:00 am | Discussion |
10:00 am | Coffee Break |
10:30 am - 10:50 am | Nicolas Dumaz (INSERM U976, Paris, France)
"The Role of PDE4 in Melanoma Development"
|
10:50 am - 11:00 am | Discussion |
11:00 am - 11:20 am | George Baillie (University of Glasgow)
"Marking Prostate Cancer Progression by Changing Phosphodiesterase (PDE4D7) Expression"
|
11:20 am - 11:30 am | Discussion |
11:30 am - 11:40 am | Tony Parker (University of Liverpool)
"Initiation and Termination of cAMP Responses in Pancreatic Ductal Adenocarcinoma Cells" |
11:40 am - 11:45 am | Discussion |
11:45 am - 12:30 pm | Late Submission Abstracts |
11:45 am - 11:55 am | Shao-En Ong (University of Washington)
"Unbiased Quantitative Phosphoproteomics to Dissect PDE4- and PDE8-Dependent Signaling Pathways"
|
11:55 am - 12:00 pm | Discussion |
12:00 pm - 12:10 pm | Michy Kelly (University of South Carolina)
"Control of PDE11A4 Subcellular Compartmentalization via N-Terminal Phosphorylation and Homodimerization"
|
12:10 pm - 12:15 pm | Discussion |
12:15 pm - 12:25 pm | Rob Leurs (VU University Amsterdam)
"Discovery of Potent and Selective Inhibitors of Trypanosomal Phosphodiesterase B1"
|
12:25 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | PDE: New Avenues to Drug Design |
| Discussion Leader: Frank Menniti (Mnemosyne Pharmaceuticals, Inc) |
7:30 pm - 7:50 pm | Rick Cote (University of New Hampshire, Durham NH)
"Evolutionary and Structural Approaches to Identifying Novel Phosphodiesterase Inhibitors"
|
7:50 pm - 8:00 pm | Discussion |
8:00 pm - 8:20 pm | Patsy Babbitt (University of California, San Francisco)
"Global Analysis of Protein Superfamilies' for Functional Inference"
|
8:20 pm - 8:30 pm | Discussion |
8:30 pm - 8:50 pm | Peder Cedervall (Pfizer)
"Structural Insights into the Regulation of PDE4 Activity"
|
8:50 pm - 9:00 pm | Discussion |
9:00 pm - 9:10 pm | Giuseppe Melacini (McMaster University)
"Tapping the Translation Potential of cAMP-Signaling: Molecular Basis for Selectivity in Eukaryotic cAMP-Binding Domains"
|
9:10 pm - 9:15 pm | Discussion |
9:15 pm - 9:25 pm | Luc de Waal (Dana-Farber Cancer Institute)
"An Integrated Genomic Characterization of PDE3A as the Target of a Small Molecule Identifies a Novel Cancer Dependency"
|
9:25 pm - 9:30 pm | Discussion |
FRIDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am | Departure |