Sunday
2:00 pm - 9:00 pm
Arrival and Check-in
6:00 pm - 7:00 pm
Dinner
7:30 pm - 7:40 pm
Introductory Comments by GRC Site Staff / Welcome from the GRC Chair
7:40 pm - 9:30 pm
Cyclic Nucleotide Signaling Pathways: From Receptors to Targets
Discussion Leader: David Kass (Johns Hopkins University School of Medicine, United States)
7:40 pm - 8:00 pm
Carmen Dessauer (University of Texas Health Science Center at Houston, United States)
"Unique Scaffolding of Adenylyl Cyclase in Heart"
8:00 pm - 8:10 pm
Discussion
8:10 pm - 8:30 pm
Martin Lohse (Max Delbrück Center for Molecular Medicine, Germany)
"Nanometer-Sized Signaling Compartments of cAMP"
8:30 pm - 8:40 pm
Discussion
8:40 pm - 9:00 pm
Martina Schmidt (University of Groningen, The Netherlands)
"Non-Canonical Cyclic Nucleotide Signaling: Missing Link to Neuroinflammation in the Lung and Brain"
9:00 pm - 9:10 pm
Discussion
9:10 pm - 9:25 pm
Volodymyr Korkhov (Paul Scherrer Institute / ETH Zurich, Switzerland)
"Structure and Function of Membrane Adenylyl Cyclases"
9:25 pm - 9:30 pm
Discussion
Monday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Spatiotemporal Regulation of Cyclic Nucleotide Signaling
Discussion Leader: Viacheslav Nikolaev (University Medical Center Hamburg-Eppendorf, Germany)
9:00 am - 9:20 am
Manuela Zaccolo (University of Oxford, United Kingdom)
"Targeting cAMP Nanodomains for Precision Therapy"
9:20 am - 9:30 am
Discussion
9:30 am - 9:50 am
John Scott (University of Washington School of Medicine, United States)
"Exploring and Exploiting the Spatial Constraints of cAMP Signaling"
9:50 am - 10:00 am
Discussion
10:00 am - 10:20 am
Aldebaran Hofer (Harvard Medical School and VA Boston Healthcare System, United States)
"cAMP Signaling Microdomain of the Primary Cilium"
10:20 am - 10:30 am
Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:20 am
Mark Gomelsky (University of Wyoming, United States)
"Remote Control of cAMP Signaling in Mammals via Near-Infrared Light-Activated Enzymes"
11:20 am - 11:30 am
Discussion
11:30 am - 11:40 am
Andreas Bock (Rudolf-Boehm-Institute of Pharmacology, Medical Faculty, Leipzig University, Germany, Germany)
"PDEs Define a cAMP Signaling Nanoarchitecture in Intact Cells"
11:40 am - 11:45 am
Discussion
11:45 am - 11:55 am
Jason Zhang (University of Washington, United States)
"Phase Separation of a PKA Regulatory Subunit Controls cAMP Compartmentation and Oncogenic Signaling"
11:55 am - 12:00 pm
Discussion
12:00 pm - 12:10 pm
Paula Krieg (University Medical Center Hamburg-Eppendorf (UKE), Germany)
"PDE2A-Mediated cGMP/cAMP Cross-Talk Modulates Autoreactive T cell Activity"
12:10 pm - 12:15 pm
Discussion
12:15 pm - 12:25 pm
Kjetil Andressen (University of Oslo, Norway)
"Natriuretic Peptides Increase cGMP around Cardiomyocyte Mitochondria and Protect against Apoptosis"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Group Photo / Lunch
1:30 pm - 4:30 pm
Free Time
3:00 pm - 4:00 pm
The GRC Power Hour™
The GRC Power Hour™ is designed to address diversity and inclusion in the scientific workplace by providing a safe environment for informal and meaningful conversations amongst colleagues of all career stages. The program supports the professional growth of all members of our communities, including ethnicity, race and/or gender identity by providing an open forum for discussion and mentoring.
Organizers: Michy Kelly (University of Maryland School of Medicine, United States) and Viacheslav Nikolaev (University Medical Center Hamburg-Eppendorf, Germany)
4:30 pm - 6:00 pm
Poster Session
6:00 pm - 8:00 pm
Structural, Molecular and Systems Dissection of PDE Signaling
Discussion Leader: Nikolai Artemyev (University of Iowa, United States)
6:00 pm - 6:10 pm
Introduction by Discussion Leader
6:10 pm - 6:30 pm
Robert Harvey (University of Nevada, Reno, United States)
"Spatiotemporal Aspects of cAMP Signaling in Cardiac Myocytes"
6:30 pm - 6:40 pm
Discussion
6:40 pm - 7:00 pm
Rick Cote (University of New Hampshire, United States)
"Molecular Architecture and Allosteric Regulation of PDE6 in its Nonactivated and Activated States: Therapeutic Implications for Retinal Degenerative Diseases"
7:00 pm - 7:10 pm
Discussion
7:10 pm - 7:20 pm
Jeremy Eberhard (Boston College, United States)
"Characterization of PDEs Inhibitors Using a Schizosaccharomyces Pombe Screening Platform"
7:20 pm - 7:25 pm
Discussion
7:25 pm - 7:35 pm
Ester Paolocci (University of Oxford, United Kingdom)
"The Role of Phosphodiesterases in the Primary Cilium and Ciliopathies"
7:35 pm - 7:40 pm
Discussion
7:40 pm - 8:00 pm
General Discussion
8:00 pm - 9:00 pm
Dinner
Tuesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Cyclic Nucleotide Signaling in Cardiovascular Systems
Discussion Leader: Rodolphe Fischmeister (Université Paris-Saclay, France)
9:00 am - 9:20 am
Yang Xiang (University of California, Davis, United States)
"Internal Beta1AR Signaling in Cardiac EC Coupling and Beyond"
9:20 am - 9:30 am
Discussion
9:30 am - 9:50 am
Grégoire Vandecasteele (INSERM / University Paris-Saclay, France)
"The RIa Subunit of cAMP-Dependent Protein Kinase is a Critical Negative Regulator of Cardiac Inotropy, Chronotropy and Arrhythmias"
9:50 am - 10:00 am
Discussion
10:00 am - 10:30 am
Coffee Break
10:30 am - 10:40 am
Grace Muller (Loyola University Chicago, United States)
"Phosphodiesterase 1 (PDE1) modulates cAMP signaling at the sarcolemmal membrane"
10:40 am - 10:45 am
Discussion
10:45 am - 11:05 am
David Kass (Johns Hopkins University School of Medicine, United States)
"Treating Cardiometabolic Syndrome with PDE9 Inhibition"
11:05 am - 11:15 am
Discussion
11:15 am - 11:25 am
Maria Ercu (Max-Delbrück-Centrum für Molekulare Medizin, Anchored Signalling department, Germany)
"Phosphodiesterase 3A Mutations Protect from Cardiac Damage"
11:25 am - 11:30 am
Discussion
11:30 am - 11:45 am
Aleksandra Judina (Imperial College London (Julia Gorelik research group), United Kingdom)
"Activation of Prostacyclin (PGI2) IP Receptor by Treprostinil in the Right Atrium is Associated with Stronger Fibroblast PKA Response"
11:45 am - 11:50 am
Discussion
11:50 am - 12:15 pm
Egor Skryabin (Institute of Experimental Cardiovascular Research, University Medical Center Hamburg-Eppendorf (UKE), Germany)
"Knockout of Specific PDE2A and PDE3A Isoforms in Primary Rat Cardiomyocytes Using CRISPR/Cas9"
12:15 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:30 pm
Free Time
4:30 pm - 6:00 pm
Poster Session
6:00 pm - 8:00 pm
Novel and Atypical Signaling
Discussion Leader: Manuela Zaccolo (University of Oxford, United Kingdom)
6:00 pm - 6:20 pm
Roland Seifert (Hannover Medical School, Germany)
"Signaling via cCMP and cUMP"
6:20 pm - 6:30 pm
Discussion
6:30 pm - 6:50 pm
Nikolai Artemyev (University of Iowa, United States)
"Maturation of Phosphodiesterase 6 by the Complex of HSP90 with AIPL1"
6:50 pm - 7:00 pm
Discussion
7:00 pm - 7:20 pm
Thomas Brand (Imperial College London, United Kingdom)
"Heteromeric Interaction of POPDC Proteins Is Essential for Membrane Trafficking"
7:20 pm - 7:30 pm
Discussion
7:30 pm - 7:40 pm
Frank Lezoualc'h (Institute of Metabolic and Cardiovascular Diseases, INSERM UMR-1297, University of Toulouse, France)
"Palmitoylation-Dependent Activation of Soluble Adenylyl Cyclase Promotes Cardiomyocyte Death"
7:40 pm - 7:45 pm
Discussion
7:45 pm - 7:55 pm
Elka Kyurkchieva (University of Glasgow, United Kingdom)
"Targeted Degradation of Short and Super-short PDE4 Isoforms Using Bifunctional Protein Degraders"
7:55 pm - 8:00 pm
Discussion
8:00 pm - 9:00 pm
Dinner
Wednesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Selective PDE Targeting of Central Nervous System Functions
Discussion Leader: Michy Kelly (University of Maryland School of Medicine, United States)
9:00 am - 9:20 am
Achim Schmidtko (Goethe University Frankfurt, Germany)
"Functions of Phosphodiesterases in Pain Processing"
9:20 am - 9:30 am
Discussion
9:30 am - 9:50 am
Pierre Vincent (CNRS, France)
"Functional Contribution of Phosphodiesterase Activities in Striatal Neurons"
9:50 am - 10:00 am
Discussion
10:00 am - 10:20 am
Jacob Nielsen (Lundbeck, Denmark)
"Molecular Mechanism of PDE1 Activation"
10:20 am - 10:30 am
Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:20 am
Hanting Zhang (Qingdao University School of Pharmacy, China)
"PDE7: A Novel Target for CNS Diseases"
11:20 am - 11:30 am
Discussion
11:30 am - 11:40 am
Holger Rosenbrock (Boehringer Ingelheim Pharma GmbH & Co. KG, Germany)
"Effects of the Novel Phosphodiesterase-2 Inhibitor BI 474121 on Mouse Auditory Event-Related Potentials Biomarkers and Rodent Cognition Tasks Related to Schizophrenia"
11:40 am - 11:45 am
Discussion
11:45 am - 11:55 am
Fernando Padovan Neto (University of São Paulo, Brazil)
"Phosphodiesterase 10A (PDE10A) in L-DOPA-Induced Dyskinesias"
11:55 am - 12:00 pm
Discussion
12:00 pm - 12:10 pm
Ying Xu (Rutgers, The State University of New Jersey, United States)
"Targeting Mitochondria-Localized Phosphodiesterase 2A for Treatment of Alzheimer’s Disease and Mild Cognitive Impairment"
12:10 pm - 12:15 pm
Discussion
12:15 pm - 12:25 pm
Emily Willems (Maastricht University - School for Mental Health and Neuroscience, The Netherlands)
"Specific Inhibition of Phosphodiesterase 4D Long Isoforms Improves Neuronal Plasticity and Protects Against Aß Toxicity In Vitro"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:30 pm
Free Time
4:30 pm - 6:00 pm
Poster Session
6:00 pm - 8:00 pm
PDEs in Vascular and Metabolic Processes
Discussion Leader: Paul Epstein (UConn Health, United States)
6:00 pm - 6:10 pm
Introduction by Discussion Leader
6:10 pm - 6:30 pm
Andrea Isidori (Sapienza University of Rome, Italy)
"Vascular Inflammation and Metabolic Effects of Selective PDE-5 inhibition: Experimental and Clinical Studies"
6:30 pm - 6:40 pm
Discussion
6:40 pm - 7:00 pm
Leila Gobejishvili (University of Louisville, United States)
"Pleiotropic Roles of Phosphodiesterase 4 in Hepatic Inflammatory and Fibrotic Processes in Humans and Mice"
7:00 pm - 7:10 pm
Discussion
7:10 pm - 7:30 pm
Bernadin Ndongson Dongmo (University of Oslo, Norway)
"Effects of AAV9-Mediated Cardiac Phosphodiesterase 4B and 2A Overexpression in a Mouse Model of Heart Failure with Preserved Ejection Fraction"
7:30 pm - 7:40 pm
Discussion
7:40 pm - 8:00 pm
General Discussion
8:00 pm - 9:00 pm
Dinner
Thursday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Business Meeting
Nominations for the Next Vice Chair; Fill in Conference Evaluation Forms; Discuss Future Site and Scheduling Preferences; Election of the Next Vice Chair
9:00 am - 12:30 pm
PDE Mediated Signaling in Immunological and Inflammatory Processes
Discussion Leader: Joseph Beavo (University of Washington, United States)
9:00 am - 9:20 am
Gretchen Snyder (Intra-Cellular Therapies Inc, United States)
"PDE1 Inhibitors in the Treatment of Neuroinflammation and Cancer: Targeting Tumor-Associated Macrophages as a Strategy to Enhance the Response to Immune Checkpoint Inhibitors"
9:20 am - 9:30 am
Discussion
9:30 am - 9:50 am
Tim Vanmierlo (Hasselt University / Maastricht University, Belgium)
"Phosphodiesterase 4D Inhibition boosts Remyelination"
9:50 am - 10:00 am
Discussion
10:00 am - 10:20 am
Stefan Brocke (UConn Health, United States)
"Cyclic Nucleotide Phosphodiesterase 8 as a Target to Treat Autoimmune Inflammation"
10:20 am - 10:30 am
Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:20 am
Kjetil Tasken (Oslo University Hospital, Norway)
"Cyclic AMP Regulation of Gap Junction Conductivity and Invasiveness of Glioblastoma"
11:20 am - 11:30 am
Discussion
11:30 am - 11:50 am
Ralf Hoffmann (Philips Research / University of Glasgow, The Netherlands)
"The Role of PDE4D7 in Aggressive Prostate Cancer and its Potential Link to the Innate and Adaptive Immune Response"
11:50 am - 12:00 pm
Discussion
12:00 pm - 12:10 pm
Roberta Kurelic (University Medical Center Hamburg-Eppendorf, Germany)
"Regulation of Cyclic-Nucleotide Cross-Talk in CD4+ T Cells"
12:10 pm - 12:15 pm
Discussion
12:15 pm - 12:25 pm
Christian Hesslinger (Boehringer Ingelheim Pharma GmbH & Co KG, Germany)
"PDE4B Inhibitor (BI 1015550) for Fibrotic Lung Diseases"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:30 pm
Free Time
4:30 pm - 6:00 pm
Poster Session
6:00 pm - 8:00 pm
Therapeutic Considerations and Path to the Clinic
Discussion Leader: Gretchen Snyder (Intra-Cellular Therapies Inc, United States)
6:00 pm - 6:20 pm
Coleen Atkins (University of Miami, United States)
"Treating Synaptic Loss in Traumatic Brain Injury with a PDE4B Allosteric Inhibitor"
6:20 pm - 6:30 pm
Discussion
6:30 pm - 6:50 pm
George Baillie (University of Glasgow, United Kingdom)
"Selective Silencing of Phosphodiesterase type 4D Short-Forms using "First-in-Class" PDE4 PROTACS"
6:50 pm - 7:00 pm
Discussion
7:00 pm - 7:10 pm
Peter Sandner (Bayer AG, Pharmaceuticals, Germany)
"Enhancing cGMP Signaling Beyond PDE Inhibition: Discovery, Development and Therapeutic Use of sGC Stimulators and sGC Activators"
7:10 pm - 7:15 pm
Discussion
7:15 pm - 7:25 pm
Walma Vasconcelos (Universite Paris Saclay, France)
"Regulation of cardiac pacemaker activity by PDE4B and PDE4D"
7:25 pm - 7:30 pm
Discussion
7:30 pm - 7:40 pm
Melissa Schepers (Hasselt University - Maastricht University, Belgium)
"Inhibition of Phosphodiesterase 4D but not 4B Improves Functional and Histopathological Outcome After Hemisection Spinal Cord Injury"
7:40 pm - 7:45 pm
Discussion
7:45 pm - 8:00 pm
Closing Remarks
8:00 pm - 9:00 pm
Dinner
Friday
7:30 am - 8:30 am
Breakfast
9:00 am
Departure