Conference Description
The Cyclic Nucleotide Phosphodiesterases GRC is a premier, international scientific conference focused on advancing the frontiers of science through the presentation of cutting-edge and unpublished research, prioritizing time for discussion after each talk and fostering informal interactions among scientists of all career stages. The conference program includes a diverse range of speakers and discussion leaders from institutions and organizations worldwide, concentrating on the latest developments in the field. The conference is five days long and held in a remote location to increase the sense of camaraderie and create scientific communities, with lasting collaborations and friendships. In addition to premier talks, the conference has designated time for poster sessions from individuals of all career stages, and afternoon free time and communal meals allow for informal networking opportunities with leaders in the field.
The 3’,5’-cyclic adenosine monophosphate (cAMP) and 3’,5’-cyclic guanosine monophosphate (cGMP) pathways, which are regulated by cyclic nucleotide phosphodiesterases (PDEs), modulate a number of critical physiological processes. As such, targets within these signaling cascades have long been of high interest to drug discovery efforts.
The 2024 Gordon Conference on Cyclic Nucleotide Phosphodiesterases will present bleeding-edge research that is driving the field to reconceptualize the fundamental biology and therapeutic potential of targets within the cyclic nucleotide signaling cascades. State-of-the-art technological approaches that shed new light on the physiology of these cascades will be shared. Sophisticated molecular/biochemical mechanisms by which targets within these cascades may be manipulated for therapeutic gain will also be highlighted. Innovative research describing the therapeutic potential of various targets in the context of multiple diseases will also be explored. In this regard, a fresh systems-level approach will be taken, with a given session focusing on the same target in the context of different organs/diseases. By bringing together leaders and trainees in the fields of cancer, cardiology, immunology & inflammation, neurology/neuroscience/psychiatry, pulmonology, etc., the conference hopes to advance drug discovery efforts by stimulating deep discussion of the potential for efficacy versus side effects.
The conference will bring together an international community of seasoned investigators, emerging new leaders, and trainees from academia, pharma, and biotech to present talks and posters. Ample time will also be dedicated to social activities to facilitate networking and idea exchange. A Gordon Research Seminar (GRS) will be held in conjunction with this conference. Please join this wonderful community of engaged and supportive scientists to expand your collaborative networks, advance the field, and get inspired with your next great idea!
The topics, speakers, and discussion leaders for the conference sessions are displayed below. The conference chair is currently developing their detailed program, which will include the complete meeting schedule, as well as the talk titles for all speakers. The detailed program will be available by February 17, 2024. Please check back for updates.
Keynote Session: What We Thought We Knew Then and What (We Think) We Know Now
Discussion Leaders
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Martina Schmidt (University of Groningen, The Netherlands)
Speakers
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Joseph Beavo (University of Washington, United States)
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George Baillie (University of Glasgow, United Kingdom)
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Thomas Rich (University of South Alabama, United States)
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Emily Willems (Maastricht University - School for Mental Health and Neuroscience, The Netherlands)
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Elka Kyurkchieva (University of Glasgow, United Kingdom)
Shining a Light on Cyclic Nucleotide Signaling Pathways: Advancements in Biosensors and Structure
Discussion Leaders
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Rick Cote (University of New Hampshire, United States)
Speakers
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Manuela Zaccolo (University of Oxford, United Kingdom)
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Andreas Bock (Leipzig University, Medical Faculty, Germany)
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Jin Zhang (University of California, San Diego, United States)
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Christine Gee (Center for Molecular Neurobiology Hamburg, University Medical Center Hamburg-Eppendorf, Germany)
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Julia Gorelik (Imperial College London, United Kingdom)
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Roberta Kurelic (University Medical Center Hamburg-Eppendorf, Germany)
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Hengming Ke (University of North Carolina at Chapel Hill, United States)
The "Ins" and "Outs" of Cyclic Nucleotide Signaling: Intracellular Cyclases and Extracellular Cyclic Nucleotide Signaling
Discussion Leaders
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Finn Olav Levy (University of Oslo, Norway)
Speakers
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Laurinda Jaffe (University of Connecticut, United States)
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Michaela Kuhn (University of Würzburg, Germany)
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Andreas Guse (University Medical Center Hamburg-Eppendorf, Germany)
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Rosely Godinho (Escola Paulista de Medicina/ Universidade Federal de São Paulo, Brazil)
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Jordan VerPlank (Uniformed Services University of the Health Sciences, United States)
Do Unto Those Downstream as You Would Have Those Upstream Do Unto You: Cyclic Nucleotide Effectors
Discussion Leaders
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Thomas Brand (Imperial College London, United Kingdom)
Speakers
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John Scott (University of Washington School of Medicine, United States)
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Kimberly Dodge-Kafka (UConn Health, United States)
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Ying Xu (Rutgers, The State University of New Jersey, United States)
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Darren Browning (Medical College of Georgia, Augusta University, United States)
Buggin' Out with Cyclic Nucleotide Signaling: Pathogen and Other Non-Mammalian PDEs
Discussion Leaders
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Claire Lugnier (Université de Strasbourg/CNRS, France)
Speakers
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Masahiro Kasahara (Ritsumeikan University, Japan)
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Rob Leurs (Vrije Universiteit Amsterdam, The Netherlands)
1 Is Not the Lonliest Number: PDE1, PDE10, & PDE11
Discussion Leaders
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Leila Gobejishvili (University of Louisville, United States)
Speakers
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Charles Hoffman (Boston College, United States)
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Chen Yan (University of Rochester, United States)
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Pierre Vincent (CNRS, France)
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Gretchen Snyder (Intra-Cellular Therapies Inc, United States)
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Mikolaj Matloka (Celon Pharma SA, Poland)
Why Are We So Scared? Because PDE7, 8, 9!
Discussion Leaders
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Stefan Brocke (UConn Health, United States)
Speakers
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Hanting Zhang (Qingdao University School of Pharmacy, China)
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Cristina E. Molina (University Medical Center Hamburg - Eppendorf, Germany)
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Sumita Mishra (Johns Hopkins University School of Medicine, United States)
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George Gaitanaris (Omeros Corporation, United States)
The Most Explored: PDE4
Discussion Leaders
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Coleen Atkins (University of Miami, United States)
Speakers
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Nikoleta Pavlaki (Boston Children’s Hospital, Harvard Medical School, United States)
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Diego Montoya-Durango (University of Louisville, United States)
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Wito Richter (University of South Alabama, United States)
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Tatiana Lipina (University of Toronto, Canada)
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Yang Kevin Xiang (University of California, Davis, United States)
To Cross or Not To Cross the Streams, That Is the Question: PDE2 and PDE3 Crosstalk
Discussion Leaders
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Kjetil Tasken (Oslo University Hospital, Norway)
Speakers
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Donald Maurice (Queen's University, Canada)
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Delphine MIKA (INSERM U1180, France)
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Maike Frye (University Medical Center Hamburg-Eppendorf, Germany)
The GRC Power Hour™
Organizers
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Finn Olav Levy (University of Oslo, Norway)
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Leila Gobejishvili (University of Louisville, United States)
