| Saturday |
| 1:30 pm - 4:30 pm | Arrival and Check-in |
| 3:00 pm - 3:15 pm | Introductory Comments by GRC Site Staff / Welcome by the GRS Conference Chair |
| 3:15 pm - 4:00 pm | New Layers of Complexity of PDE Signaling in the Cardiovascular System |
| Discussion Leader: Nachiket Pendse (West Virginia University School of Medicine, USA) |
| 3:15 pm - 3:25 pm | Delphine Mika (INSERM U1180, University of Paris-Sud, France)
"Regulation of Pacemaker Activity by PDE4 Isoforms" |
| 3:25 pm - 3:30 pm | Discussion |
| 3:30 pm - 3:40 pm | Jodi MacKeil (Queen's University, Canada)
"Leading the Charge in Sprouting Angiogenesis: The Roles of PDE4D and PDE3B in Regulating Tip Cell Invasion" |
| 3:40 pm - 3:45 pm | Discussion |
| 3:45 pm - 3:55 pm | Sarah Idres (INSERM U1180, University of Paris-Sud, France)
"Key Role of BK(Ca) Channels for PDE3 and PDE4 to Regulate Coronary Tone Is Lost in Heart Failure" |
| 3:55 pm - 4:00 pm | Discussion |
| 4:00 pm - 5:30 pm | Poster Session |
| 5:30 pm - 7:30 pm | Microdomains and Nanodomains of Cyclic Nucleotide Signaling |
| Discussion Leader: Cristina Molina (Institute of Pharmacology, West German Heart and Vascular Center, University Duisburg-Essen, Germany) |
| 5:30 pm - 5:45 pm | Axel Kraft (University Medical Center Hamburg-Eppendorf, Germany)
"Influence of Phosphodiesterases 4B and 4D on cAMP Signaling in Calcium Handling Microdomains of Adult Mouse Cardiomyocytes" |
| 5:45 pm - 5:50 pm | Discussion |
| 5:50 pm - 6:05 pm | Bracy Fertig (University of Glasgow, United Kingdom)
"Phosphodiesterase PDE4D9 Localises to the Myofilament to Regulate Troponin I Phosphorylation by Protien Kinase A" |
| 6:05 pm - 6:10 pm | Discussion |
| 6:10 pm - 6:25 pm | Ibrahim Bedioune (INSERM U1180, University of Paris-Sud, France)
"Differential Regulation of Cytoplasmic and Nuclear PKA Activities by β1- and β2-Adrenoceptors in Adult Cardiac Myocytes" |
| 6:25 pm - 6:30 pm | Discussion |
| 6:30 pm - 6:45 pm | Paulina Brzezinska (Queen's University, Canada)
"The Interplay of cAMP and Calcium Signaling in the Regulation of PDE1C in Human Vascular Smooth Muscle Cells" |
| 6:45 pm - 6:50 pm | Discussion |
| 6:50 pm - 7:05 pm | Will Capell (University of South Carolina School of Medicine, USA)
"Identification of Intramolecular Signals Controlling PDE11A4 Subcellular Compartmentalization" |
| 7:05 pm - 7:10 pm | Discussion |
| 7:10 pm - 7:25 pm | Zhenyu Wang (INSERM U1180, University of Paris-Sud, France)
"Mitochondrial Soluble Adenylyl Cyclase, Phosphodiesterases and Epac Regulate Cardiac Mitochondrial Function and Cell Death" |
| 7:25 pm - 7:30 pm | Discussion |
| 8:00 pm | Dinner |
| Sunday |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am - 11:00 am | Emerging Paradigms in Cyclic Nucleotide Phosphodiesterase Signaling / Keynote Session: The Multiple
Facets of cAMP Signaling |
| Discussion Leader: Delphine Mika (INSERM U1180, University of Paris-Sud, France) |
| 9:00 am - 9:15 am | Si Chen (University of Rochester, USA)
"The Role of PDE10A in Pathological Cardiac Remodeling and Dysfunction" |
| 9:15 am - 9:20 am | Discussion |
| 9:20 am - 9:35 am | Cristina Molina (Institute of Pharmacology, West German Heart and Vascular Center, University Duisburg-Essen, Germany)
"PDE8 Is a Novel Regulator of cAMP Signaling in Human Atrial Fibrillation" |
| 9:35 am - 9:40 am | Discussion |
| 9:40 am - 9:55 am | Nachiket Pendse (West Virginia University School of Medicine, USA)
"Lipid Modification of Phosphodiesterase 6 (PDE6) Is Crucial for Its Assembly and Color Vision" |
| 9:55 am - 10:00 am | Discussion |
| 10:00 am - 10:50 am | Manuela Zaccolo (University of Oxford, United Kingdom)
"cAMP: From Long-Range Messenger to Nano-Domain Signalling" |
| 10:50 am - 11:00 am | Discussion |
| 11:00 am - 12:30 pm | Poster Session |
| Coffee will be served in the poster area from 11:00 am - 11:30 am |
| 12:30 pm | Lunch |
| 1:30 pm - 2:30 pm | Mentorship Component: Building a
Successful Career in Scientific Research |
| Discussion Leaders: Alessandra Ghigo (University of Torino, Italy) and Sarah Rampersad (Queen's University, Canada) |
| 1:30 pm - 2:30 pm | Panel Discussion |
| "How to Succeed in Science: Tips and Advice for Young Scientists" |
|
- Viacheslav Nikolaev (University Medical Center Hamburg-Eppendorf, Germany)
- Jin Zhang (University of California, San Diego, USA)
|
| 2:30 pm - 3:00 pm | Evaluation Period |
| Fill in GRS Evaluation Forms |
| 3:00 pm | Seminar Concludes |
