Saturday
1:00 pm - 5:00 pm
Arrival and Check-in
3:00 pm - 3:15 pm
Introductory Comments by GRC Site Staff / Welcome from the GRS Chair
3:15 pm - 4:00 pm
Keynote Session: Cyclic Nucleotide Phosphodiesterases: Potential Therapeutic Targets for Alcohol use Disorder
Discussion Leader: Ben Rombaut (University Hasselt, Belgium)
3:15 pm - 3:45 pm
Hanting Zhang (Qingdao University School of Pharmacy, China)
"PDE, a Valve for the Control of Alcohol Drinking"
3:45 pm - 4:00 pm
Discussion
4:00 pm - 5:30 pm
Poster Session
5:30 pm - 7:30 pm
Mapping the Pathway of Interactions to Investigate Functional Impact
Discussion Leaders: Romy Thomas (Max-Delbrück-Centrum for Molecular Medicine Berlin, Germany)
5:30 pm - 5:50 pm
Introduction by Discussion Leader
5:50 pm - 6:05 pm
Ben Rombaut (University Hasselt, Belgium)
"PDE4B as a Key Regulator of out of Control Microglia"
6:05 pm - 6:10 pm
Discussion
6:10 pm - 6:25 pm
Emma Parsons (University of Glasgow, United Kingdom)
"Analysis of Differentially Expressed Genes in PDE4D7 Silenced Prostate Cancer Cell Lines"
6:25 pm - 6:30 pm
Discussion
6:30 pm - 6:45 pm
Maria Ercu (Max-Delbrück-Centrum für Molekulare Medizin, Anchored Signalling department, Germany)
"Phosphodiesterase 3A Mutations Protect from Cardiac Damage"
6:45 pm - 6:50 pm
Discussion
6:50 pm - 7:05 pm
Nicolas Liem (Humboldt-University of Berlin, Germany)
"Novel Light-Activated Phosphodiesterases with High Affinity"
7:05 pm - 7:10 pm
Discussion
7:10 pm - 7:25 pm
Bernadin Ndongson Dongmo (University of Oslo, Norway)
"Effects of AAV9-Mediated Cardiac Phosphodiesterase 4B and 2A Overexpression in a Mouse Model of Heart Failure with Preserved Ejection Fraction"
7:25 pm - 7:30 pm
Discussion
8:00 pm - 9:00 pm
Dinner
Sunday
7:30 am - 8:30 am
Breakfast
9:00 am - 11:00 am
Recent Progress for Phosphodiesterases as Therapeutic Targets
Discussion Leader: Emma Parsons (University of Glasgow, United Kingdom)
9:00 am - 9:20 am
Introduction by Discussion Leader
9:20 am - 9:35 am
Elka Kyurkchieva (University of Glasgow, United Kingdom)
"Targeted Degradation of Short and Super-short PDE4 Isoforms Using Bifunctional Protein Degraders"
9:35 am - 9:40 am
Discussion
9:40 am - 9:55 am
Emily Willems (Maastricht University - School for Mental Health and Neuroscience, The Netherlands)
"Specific Inhibition of Phosphodiesterase 4D Long Isoforms Improves Neuronal Plasticity and Protects Against Aß Toxicity In Vitro"
9:55 am - 10:00 am
Discussion
10:00 am - 10:15 am
Chloe Gulliver (University of Glasgow, United Kingdom)
"PDE4D7 Expression Influences Prostate Cancer Development and Therapeutic Resistance."
10:15 am - 10:20 am
Discussion
10:20 am - 10:35 am
Ying Xu (Rutgers, The State University of New Jersey, United States)
"Phosphodiesterase Inhibitors and Alzheimer’s Disease: from Nature to Pharmacy"
10:35 am - 10:40 am
Discussion
10:40 am - 10:55 am
Walma Vasconcelos (Universite Paris Saclay, France)
"Regulation of Cardiac Pacemaker activity By PDE4B and PDE4D"
10:55 am - 11:00 am
Discussion
11:00 am - 12:30 pm
Poster Session
Coffee will be served in the poster area from 11:00 am - 11:30 am
12:30 pm - 1:30 pm
Lunch
1:30 pm - 2:30 pm
Mentorship Component: Building Academic Resilience
Discussion Leader: Emily Willems (Maastricht University - School for Mental Health and Neuroscience, The Netherlands)
1:30 pm - 1:50 pm
Leila Gobejishvili (University of Louisville, United States)
"Experiences from Our Own Careers"
1:50 pm - 2:00 pm
Discussion
2:00 pm - 2:20 pm
Tim Vanmierlo (Hasselt University / Maastricht University, Belgium)
"Experiences from Our Own Careers"
2:20 pm - 2:30 pm
Discussion
2:30 pm - 3:00 pm
Evaluation Period
Fill in GRS Evaluation Forms
3:00 pm
Seminar Concludes