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Cytoskeletal Motors

Gordon Research Conference

Cytoskeletal Motors from Structure to Mechanism to Disease

July 8 - 13, 2018

Chair Samara L. Reck-Peterson

Vice Chair Steven S. Rosenfeld

Mount Snow

89 Grand Summit Way

West Dover, Vermont, United States

Venue and Travel Information

Conference Description

The 2018 GRC on Cytoskeletal Motors continues a tradition of more than 50 years of GRCs focused on how molecular motors work. This meeting has a strong history of uniting biophysicists, structural biologists, and cell biologists and is a premier venue for highlighting the newest and most exciting research in the field.

This meeting will bring together leaders in the field studying the mechanism of myosin, kinesin and dynein motors. A major focus will also be on how each of these motors interacts with its track (actin filaments or microtubules) and how track dynamics or modifications affect motor function.

Cytoskeletal motors also play an important role in normal human physiology and their dysfunction is involved in a wide range of diseases. This conference will have sessions on how defects in the cytoskeleton play a role in cardiovascular and muscle disease, cancer, and neurological disease.

Conference Program

Sunday
2:00 pm - 9:00 pm	Arrival and Check-in
6:00 pm - 7:00 pm	Dinner
7:30 pm - 7:40 pm	Introductory Comments by GRC Site Staff / Welcome from the GRC Chair
7:40 pm - 9:30 pm	Keynote Session: Motors, Tracks, and How Their Interactions Drive Their Functions Discussion Leader: Steven Rosenfeld (Mayo Clinic, USA)
7:40 pm - 7:45 pm	Introduction by Discussion Leader
7:45 pm - 8:20 pm	Eva Nogales (University of California, Berkeley, USA) "Visualizing Interactions that Regulate Microtubule Dynamics"
8:20 pm - 8:35 pm	Discussion
8:35 pm - 8:40 pm	Introduction by Discussion Leader
8:40 pm - 9:15 pm	Don Cleveland (Ludwig Institute for Cancer Research, USA) "Guarding the Genome: Chromosome Motors, Aneuploidy and Tumorigenesis"
9:15 pm - 9:30 pm	Discussion
Monday
7:30 am - 8:30 am	Breakfast
9:00 am - 12:30 pm	Motor Structure and Mechanism Discussion Leader: Marija Zanic (Vanderbilt University, USA)
9:00 am - 9:20 am	Andrew Carter (University of Cambridge, United Kingdom) "Cryo-EM Structures of Dynein/Dynactin Complexes"
9:20 am - 9:30 am	Discussion
9:30 am - 9:40 am	Morgan DeSantis (University of California, San Diego, USA) "Lis1 Has Two Opposing Modes of Regulating Cytoplasmic Dynein"
9:40 am - 9:45 am	Discussion
9:45 am - 9:55 am	Arne Gennerich (Albert Einstein College of Medicine, USA) "Single-Molecule Dissection of Cytoplasmic Dynein Tension Sensing"
9:55 am - 10:00 am	Discussion
10:00 am - 10:20 am	Kathleen Trybus (University of Vermont, USA) "Single Molecule Reconstitution of a Microtubule-Based mRNA Transport Complex"
10:20 am - 10:30 am	Discussion
10:30 am - 11:00 am	Coffee Break
11:00 am - 11:20 am	Carolyn Moores (ISMB, Birkbeck, University of London, United Kingdom) "Conservation and Specialization of Kinesin Motor Mechanisms"
11:20 am - 11:30 am	Discussion
11:30 am - 11:40 am	Matthieu Benoit (Albert Einstein College of Medicine, USA) "Mechanism of Microtubule Depolymerization by Kinesin-13s"
11:40 am - 11:45 am	Discussion
11:45 am - 11:55 am	Meredith Weck (Vanderbilt University, USA) "Tip-Enriched Adhesion Alters the Morphology and Dynamics of Actin-Based Protrusions"
11:55 am - 12:00 pm	Discussion
12:00 pm - 12:20 pm	Gregory Alushin (The Rockefeller University, USA) "Structural Plasticity at the Actin-Myosin Interface"
12:20 pm - 12:30 pm	Discussion
12:30 pm - 1:30 pm	Lunch
1:30 pm - 4:00 pm	Free Time
3:00 pm - 4:00 pm	Power Hour The GRC Power Hour is an optional informal gathering open to all meeting participants. It is designed to help address the challenges women face in science and support the professional growth of women in our communities by providing an open forum for discussion and mentoring. Organizers: Kassandra Ori-McKenney (University of California, Davis, USA) and Antonina Roll-Mecak (National Institutes of Health, USA)
4:00 pm - 6:00 pm	Poster Session
6:00 pm - 7:00 pm	Dinner
7:30 pm - 9:30 pm	Motors in Cardiovascular and Muscle Disease Discussion Leader: Gregory Alushin (The Rockefeller University, USA)
7:30 pm - 7:50 pm	Kathy Ruppel (Stanford University School of Medicine, USA) "Biochemistry and Biophysics of Purified Human Beta-Cardiac Myosin Carrying Hypertrophic Cardiomyopathy Mutations"
7:50 pm - 8:00 pm	Discussion
8:00 pm - 8:20 pm	Christine Seidman (Harvard Medical School, USA) "Discovering Sarcomere Function from Analyses of Human Mutations"
8:20 pm - 8:30 pm	Discussion
8:30 pm - 8:50 pm	Joseph Muretta (University of Minnesota, USA) "Mavacamten Stabilizes an Autoinhibited State of Two-Headed Cardiac Myosin"
8:50 pm - 9:00 pm	Discussion
9:00 pm - 9:20 pm	David Thomas (University of Minnesota, USA) "Spectroscopic Probes of Motors in Therapeutic Discovery"
9:20 pm - 9:30 pm	Discussion
Tuesday
7:30 am - 8:30 am	Breakfast
8:30 am - 9:00 am	Group Photo
9:00 am - 12:30 pm	Tracks: Structure, Dynamics and Interactions with Motors Discussion Leader: Radhika Subramanian (Massachusetts General Hospital / Harvard Medical School, USA)
9:00 am - 9:20 am	Antonina Roll-Mecak (National Institutes of Health, USA) "The Tubulin Code: How Cells Build Specificity into Microtubule Networks"
9:20 am - 9:30 am	Discussion
9:30 am - 9:40 am	Matthew King (Princeton University, USA) "Biomolecular Condensation of the Microtubule Nucleation Effector TPX2 Enhances Reaction Kinetics In Vivo"
9:40 am - 9:45 am	Discussion
9:45 am - 9:55 am	Jawdat Al-Bassam (University of California, Davis, USA) "A Tail-Motor Domain Interaction Regulates Kinesin-5 Antiparallel Microtubule Sliding Motility"
9:55 am - 10:00 am	Discussion
10:00 am - 10:20 am	Thomas Surrey (The Francis Crick Institute, United Kingdom) "Self-Organization of Mitotic Motors and Dynamic Microtubules In Vitro"
10:20 am - 10:30 am	Discussion
10:30 am - 11:00 am	Coffee Break
11:00 am - 11:10 am	Kassandra Ori-McKenney (University of California, Davis, USA) "Lattice Gating by Microtubule-Associated Proteins Controls Motor Activity"
11:10 am - 11:15 am	Discussion
11:15 am - 11:35 am	Elena Grintsevich (University of California, Los Angeles, USA) "Rapid Actin Filaments Remodeling via Oxidation by Mical Family Enzymes"
11:35 am - 11:45 am	Discussion
11:45 am - 11:55 am	Ronald Rock (University of Chicago, USA) "Rapid Rerouting of Myosin Traffic at the T Cell Immune Synapse"
11:55 am - 12:00 pm	Discussion
12:00 pm - 12:20 pm	Peter Bieling (Max Planck Institute of Molecular Physiology, Germany) "Load Adaptation of an Actin Network Motor"
12:20 pm - 12:30 pm	Discussion
12:30 pm - 1:30 pm	Lunch
1:30 pm - 4:00 pm	Free Time
4:00 pm - 6:00 pm	Poster Session
6:00 pm - 7:00 pm	Dinner
7:30 pm - 9:30 pm	Recent Breakthroughs in Cytoskeletal Research Discussion Leader: Jason Stumpff (University of Vermont, USA)
7:30 pm - 7:50 pm	Michael Greenberg (Washington University in St. Louis, USA) "Understanding Familial Cardiomyopathies from the Ground Up"
7:50 pm - 8:00 pm	Discussion
8:00 pm - 8:10 pm	Ashley Arthur (University of Minnesota, USA) "MyTH4-FERM Myosin and VASP Cooperation During Filopodia Initiation"
8:10 pm - 8:15 pm	Discussion
8:15 pm - 8:25 pm	Roberto Steiner (King's College London, United Kingdom) "Structural Basis for Isoform-Specific Kinesin-1 Recognition of Y-Acidic Cargo Adaptors"
8:25 pm - 8:30 pm	Discussion
8:30 pm - 8:40 pm	Gary Brouhard (McGill University, Canada) "The Structure of C. elegans Microtubules In Vivo and In Vitro and Its Implication for Motor Proteins"
8:40 pm - 8:45 pm	Discussion
8:45 pm - 8:55 pm	Marija Zanic (Vanderbilt University, USA) "Dynamic Instability of Microtubule Minus Ends"
8:55 pm - 9:00 pm	Discussion
9:00 pm - 9:20 pm	Radhika Subramanian (Massachusetts General Hospital / Harvard Medical School, USA) "A Primary Cilium Architect: How Kif7 Fine-Tunes Microtubule Length"
9:20 pm - 9:30 pm	Discussion
Wednesday
7:30 am - 8:30 am	Breakfast
9:00 am - 12:30 pm	Motor Engineering and Reconstituted Systems Discussion Leader: Weihong Qiu (Oregon State University, USA)
9:00 am - 9:20 am	Zev Bryant (Stanford University, USA) "Design, Performance and Applications of Controllable Cytoskeletal Motors"
9:20 am - 9:30 am	Discussion
9:30 am - 9:50 am	Sivaraj Sivaramakrishnan (University of Minnesota, Twin Cities, USA) "Biophysical Regulation of Myosin VI Motility by Cargo Adaptor Proteins"
9:50 am - 10:00 am	Discussion
10:00 am - 10:10 am	Abrar Bhat (National Centre for Biological Sciences, India) "Differential Actin-Binding Affinity Leads to Sorting and Specific Clustering in a Reconstituted, Active Acto-Myosin-Membrane Composite Layer"
10:10 am - 10:15 am	Discussion
10:15 am - 10:25 am	Abdullah Chaudhary (McGill University, Canada) "MAP7 Regulates the Motility of Bidirectional Cargoes via Motor Persistence"
10:25 am - 10:30 am	Discussion
10:30 am - 11:00 am	Coffee Break
11:00 am - 11:20 am	Kristen Verhey (University of Michigan Medical School, USA) "Engineering Inhibitable Kinesin-2 Motors to Study Ciliary Trafficking"
11:20 am - 11:30 am	Discussion
11:30 am - 11:40 am	Scott Forth (Rensselaer Polytechnic Institute, USA) "Probing the Mechanics of Micron-Scale Microtubule Networks"
11:40 am - 11:45 am	Discussion
11:45 am - 11:55 am	Jamie Rickman (The Francis Crick Institute, United Kingdom) "A Computational Model of Motor-Microtubule Self-Organization: Two Critical Parameters Drive Polar Versus Nematic Network Formation"
11:55 am - 12:00 pm	Discussion
12:00 pm - 12:20 pm	Manuel Thery (Hopital Saint Louis, CEA, France) "Microtubule Mechanics and Turnover"
12:20 pm - 12:30 pm	Discussion
12:30 pm - 1:30 pm	Lunch
1:30 pm - 4:00 pm	Free Time
4:00 pm - 6:00 pm	Poster Session
6:00 pm - 7:00 pm	Dinner
7:00 pm - 7:30 pm	Business Meeting Nominations for the Next Vice Chair; Fill in Conference Evaluation Forms; Discuss Future Site and Scheduling Preferences; Election of the Next Vice Chair
7:30 pm - 9:30 pm	Motors in Cancer Discussion Leader: Silvia Jansen (Washington University in St. Louis, USA)
7:30 pm - 7:50 pm	David Pellman (Dana-Farber Cancer Insitute / Harvard Medical School, USA) "Genome Damage from Cytoskeletal Contractile Forces"
7:50 pm - 8:00 pm	Discussion
8:00 pm - 8:10 pm	Heidi Malaby (University of Vermont, USA) "Where the K-Fiber Ends: The Importance of Kif18A Neck Linker Length for Mitotic Localization"
8:10 pm - 8:15 pm	Discussion
8:15 pm - 8:35 pm	Ryoma Ohi (University of Michigan, USA) "Total Inhibition of Mitotic Spindle Assembly in Animal Cells"
8:35 pm - 8:45 pm	Discussion
8:45 pm - 8:55 pm	John Fadul (Huntsman Cancer Institute, University of Utah, USA) "Basal Extrusion of KRas-Transformed Cells Drives Invasion and Loss of Epithelial Identity"
8:55 pm - 9:00 pm	Discussion
9:00 pm - 9:20 pm	Douglas Robinson (Johns Hopkins School of Medicine, USA) "Harnessing the Adaptive Potential of Mechanoresponsive Proteins to Overwhelm Pancreatic Cancer Dissemination and Invasion"
9:20 pm - 9:30 pm	Discussion
Thursday
7:30 am - 8:30 am	Breakfast
9:00 am - 12:30 pm	Motors in Neurological Function and Disease Discussion Leader: Jessica Henty-Ridilla (SUNY Upstate Medical University, USA)
9:00 am - 9:20 am	Erika Holzbaur (University of Pennsylvania, USA) "Motors in Neurons: Express Shipping and Localized Delivery"
9:20 am - 9:30 am	Discussion
9:30 am - 9:50 am	Lukas Kapitein (Utrecht University, The Netherlands) "Sorting out Polarized Transport in Neurons"
9:50 am - 10:00 am	Discussion
10:00 am - 10:20 am	Jill Wildonger (University of Wisconsin-Madison, USA) "Putting the Brakes on Motor Activity During Polarized Transport in Neurons"
10:20 am - 10:30 am	Discussion
10:30 am - 11:00 am	Coffee Break
11:00 am - 11:20 am	John Hammer (Cell Biology and Physiology Center, National Heart, Lung, and Blood Institute, NIH, USA) "Myosin 18A Targets a Rac GEF to Regulate Dendritic Spine Morphology"
11:20 am - 11:30 am	Discussion
11:30 am - 11:40 am	Catherine Drerup (National Institute of Child Health and Human Development, NIH, USA) "Regulation and Function of Retrograde Mitochondrial Transport"
11:40 am - 11:45 am	Discussion
11:45 am - 12:05 pm	Elizabeth Engle (Boston Children's Hospital, USA) "TUBB3 in Health and Disease"
12:05 pm - 12:15 pm	Discussion
12:15 pm - 12:25 pm	Sandra Encalada (The Scripps Research Institute, USA) "Biogenesis of Prion Protein Aggregates in Axons Involve Molecular Motor-Dependent Secretory and Endocytic Pathways"
12:25 pm - 12:30 pm	Discussion
12:30 pm - 1:30 pm	Lunch
1:30 pm - 4:00 pm	Free Time
4:00 pm - 6:00 pm	Poster Session
6:00 pm - 7:00 pm	Dinner
7:30 pm - 9:30 pm	Late-Breaking Topics in in Cytoskeletal Research Discussion Leader: Peter Bieling (Max Planck Institute of Molecular Physiology, Germany)
7:30 pm - 7:50 pm	Gaia Pigino (Max Planck Institute of Molecular Cell Biology and Genetics, Germany) "Ciliary Assembly and Intraflagellar Transport"
7:50 pm - 8:00 pm	Discussion
8:00 pm - 8:10 pm	Richard McKenney (University of California, Davis, USA) "Focal Accumulations of Tau Protein Differentially Regulate Dynein-Driven Motility"
8:10 pm - 8:15 pm	Discussion
8:15 pm - 8:25 pm	Larisa Gheber (Ben-Gurion University of the Negev, Israel) "Synthetic-Evolution Approach to Study the Plasticity of Phospho-Regulation of the Mitotic Kinesin-5 Cin8"
8:25 pm - 8:30 pm	Discussion
8:30 pm - 8:40 pm	Melissa Gardner (University of Minnesota, USA) "Microtubule Structural State Recognition by the End-Binding Protein EB1"
8:40 pm - 8:45 pm	Discussion
8:45 pm - 8:55 pm	Karl Petersen (Institut Curie, France) "Mechanisms of Myosin VI Functional Diversity at Membrane-Bound Organelles"
8:55 pm - 9:00 pm	Discussion
9:00 pm - 9:20 pm	Lee Sweeney (University of Florida, USA) "Myo10 Drives Filopodia of Mammalian Myoblasts to Promote Cell Fusion and Muscle Regeneration Following Injury"
9:20 pm - 9:30 pm	Discussion
Friday
7:30 am - 8:30 am	Breakfast
9:00 am	Departure

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