Saturday
1:00 pm - 5:00 pm
Arrival and Check-in
3:30 pm - 3:45 pm
Introductory Comments by GRC Site Staff / Welcome from the GRS Chair
3:45 pm - 4:30 pm
Keynote Session: Understanding the Molecular Basis of Cardiomyopathy
Discussion Leader: Frederick Baker (Augusta University, United States)
3:45 pm - 4:20 pm
James Spudich (Stanford University School of Medicine, United States)
"From Slime Mold to Human Cardiomyopathy: Lessons From Over Five Decades of Research"
4:20 pm - 4:30 pm
Discussion
4:30 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Motor Dysfunction and Disease
Discussion Leader: Marcus Begley (NCSU, United States)
7:30 pm - 7:45 pm
Giulia Manigrasso (MRC Laboratory of Molecular Biology, United Kingdom)
"An Intracellular Bacterium Hijacks BICD1/2-Dependent Dynein Motility to Evade Autophagy"
7:45 pm - 7:50 pm
Discussion
7:50 pm - 8:05 pm
Daniel Beaudet (Department of Bioengineering, McGill University, Canada)
"Tau Inhibits the Long-Range, Dynein-Mediated Motility of Early Phagosomes"
8:05 pm - 8:10 pm
Discussion
8:10 pm - 8:25 pm
Krishna Kishore Mahalingan (NINDS, NIH, United States)
"Mediation of Cisplatin Resistance Through Cis and Trans Effects on Microtubule Dynamics"
8:25 pm - 8:30 pm
Discussion
8:30 pm - 8:45 pm
Emma Turner (University of Sheffield, United Kingdom)
"Establishing an Experimental Pipeline to Determine Functional Effects of Neurodegenerative Mutations in Kinesin-1"
8:45 pm - 8:50 pm
Discussion
8:50 pm - 9:05 pm
Alexandra Hollo (National Institute of Health (NIH), United States)
"Molecular Regulatory Mechanisms of Human Myosin 7a"
9:05 pm - 9:10 pm
Discussion
9:10 pm - 9:25 pm
Neha Nandwani (Stanford University and Stanford Cardiovascular Institute, United States)
"Allosteric Destabilization of the Super-Relaxed State of Myosin by Hypertrophic Cardiomyopathy-Causing Mutations"
9:25 pm - 9:30 pm
Discussion
Sunday
7:30 am - 8:30 am
Breakfast
9:00 am - 11:00 am
Molecular Motors and Their Tracks
Discussion Leader: Agnieszka Kendrick (University of California, San Diego, United States)
9:00 am - 9:15 am
Abesh Bera (Iowa State University, United States)
"Differential Regulation of Astral Microtubules in a Shared Cytoplasm"
9:15 am - 9:20 am
Discussion
9:20 am - 9:35 am
Ezekiel Thomas (University of Colorado Anschutz, United States)
"The ß-tubulin Tail Differentially Regulates Budding Yeast Kinesin-5 Motors"
9:35 am - 9:40 am
Discussion
9:40 am - 9:55 am
Cristina Risi (Eastern Virginia Medical School, United States)
"Cryo Electron Microscopy Provides the Model of the Cardiac Myosin Binding Protein-C N-Terminus Interaction with the Thin Filament"
9:55 am - 10:00 am
Discussion
10:00 am - 10:15 am
Eva Karasmanis (University of California San Diego, United States)
"A Dynein-Lis1 Structure Captures an Intermediate State in Dynein’s Activation Pathway"
10:15 am - 10:20 am
Discussion
10:20 am - 10:35 am
Evelyn Smith (University of Sheffield, United Kingdom)
"Development and Optimisation of a New Single Molecule Assay to Study Kinesin-1 Activation"
10:35 am - 10:40 am
Discussion
10:40 am - 10:55 am
Adam Fenton (University of Pennsylvania, United States)
"TRAK2 Coordinates Opposing Microtubule Motors for Mitochondrial Transport"
10:55 am - 11:00 am
Discussion
11:00 am - 12:30 pm
Poster Session
Coffee will be served in the poster area from 11:00 am - 11:30 am
12:30 pm - 1:30 pm
Lunch
1:30 pm - 2:30 pm
Mentorship Component: Panel Discussion: Getting a Job (That Is Right for You) and Effective Professional Networking
Discussion Leader: Gillian Fitz (Vanderbilt University, United States)
1:30 pm - 2:30 pm
Panel Discussion
Getting a Job (That Is Right for You) and Effective Professional Networking
John Salogiannis (Larner College of Medicine at the University of Vermont, United States)
Alison Twelvetrees (The University of Sheffield, United Kingdom)
2:30 pm - 3:00 pm
Evaluation Period
Complete the GRS Evaluation Forms; Election of Future Chair(s)
3:00 pm
Seminar Concludes
