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Developmental Biology

Gordon Research Conference

Generation and Regeneration of Biological Tissues Through Cellular Diversification and Cooperation

June 25 - 30, 2017

Chair

Vice Chair

Mount Holyoke College

50 College Street

South Hadley, Massachusetts, United States

Venue and Travel Information

Conference Description

Developmental Biology taps from various areas of biology (including biochemistry, cell biology, genetics, genomics, molecular biology, and evolutionary biology), as well as from physics and mathematics, to explain how diverse cell types are generated and organized to generate functioning structures. Cellular diversification and self organization will be the two main themes of this conference. We will approach these themes in a variety of model organisms and cultured tissues. Thus we will explore how individual cell behaviors are controlled and how they contribute to tissue pattern and shape, under normal physiology, repair and regeneration. In light of the increased relevance of Developmental Biology to the generation of tissues and cells for therapeutic purposes, we have included a session on "Developmental Biology in Industry".

Related Meeting

This GRC will be held in conjunction with the "Developmental Biology" Gordon Research Seminar (GRS). Those interested in attending both meetings must submit an application for the GRS in addition to an application for the GRC. Refer to the associated GRS program page for more information.

Conference Program

Sunday
2:00 pm - 9:00 pm	Arrival and Check-in
6:00 pm - 7:00 pm	Dinner
7:30 pm - 7:40 pm	Introductory Comments by GRC Site Staff / Welcome from the GRC Chair
7:40 pm - 9:30 pm	Signals and the Extracellular Space Discussion Leader:
7:40 pm - 8:00 pm	"Protein Binders as New Tools to Study Tissue Patterning and Growth"
8:00 pm - 8:10 pm	Discussion
8:10 pm - 8:20 pm	Selected from Poster Abstracts: "BMP/NOGGIN: Integration of a Turing Pair Within a Polarized Model Epiblast"
8:20 pm - 8:25 pm	Discussion
8:25 pm - 8:35 pm	Selected from Poster Abstracts: "Ion Gradients Drive Patched Regulation of Hedgehog Signaling via the Smoothened Transmembrane Domain"
8:35 pm - 8:40 pm	Discussion
8:40 pm - 8:50 pm	Selected from Poster Abstracts: "New Approaches to the Signaling Pathways Regulating Neural AP Patterning"
8:50 pm - 8:55 pm	Discussion
8:55 pm - 9:15 pm	"Noise Buffering in Early Embryonic Development"
9:15 pm - 9:25 pm	Discussion
9:25 pm - 9:30 pm	General Discussion
Monday
7:30 am - 8:30 am	Breakfast
8:30 am - 9:00 am	Group Photo
9:00 am - 12:30 pm	Gene Regulatory Networks and Epigenetics Discussion Leader:
9:00 am - 9:25 am	"The Regulatory Logic of Vertebrate Neural Tube Development"
9:25 am - 9:35 am	Discussion
9:35 am - 9:45 am	Selected from Poster Abstracts: "Common Patterns of Modulated Bursting Kinetics Generate Gene Expression Boundaries in Early Embryos"
9:45 am - 9:50 am	Discussion
9:50 am - 10:00 am	Selected from Poster Abstracts: "CHD4 Controls Cardiomyocyte Formation and Function Through the Direct Repression of Smooth and Skeletal Muscle Isoforms"
10:00 am - 10:05 am	Discussion
10:05 am - 10:35 am	Coffee Break
10:35 am - 10:45 am	Selected from Poster Abstracts: "High-Affinity Nodes Pair Homologous Chromosomes to Facilitate Interchromosomal Gene Regulation"
10:45 am - 10:50 am	Discussion
10:50 am - 11:00 am	Selected from Poster Abstracts: "Polycomb Compacts Developmentally Regulated Genes into Cell-Type Specific Small Chromatin Domains"
11:00 am - 11:05 am	Discussion
11:05 am - 11:15 am	Selected from Poster Abstracts: "Chromatin Modifier UTX and 53BP1 Control Neurogenic Factors to Balance Human Neural Stem Cell Self-Renewal and Differentiation"
11:15 am - 11:20 am	Discussion
11:20 am - 11:50 am	"Generation of Neural Diversity"
11:50 am - 12:00 pm	Discussion
12:00 pm - 12:30 pm	Poster Previews
12:30 pm - 1:30 pm	Lunch
1:30 pm - 4:00 pm	Free Time
3:00 pm - 4:00 pm	Power Hour The GRC Power Hour is an optional informal gathering open to all meeting participants. It is designed to help address the challenges women face in science and support the professional growth of women in our communities by providing an open forum for discussion and mentoring. Organizers: and
4:00 pm - 6:00 pm	Poster Session
6:00 pm - 7:00 pm	Dinner
7:30 pm - 9:30 pm	Tissue Mechanics Discussion Leader:
7:30 pm - 7:50 pm	"Mitosis and Morphogenesis of Epithelial Tissues"
7:50 pm - 8:00 pm	Discussion
8:00 pm - 8:10 pm	Selected from Poster Abstracts: "Actomyosin-Based Tissue Folding Requires a Multicellular Myosin Gradient"
8:10 pm - 8:15 pm	Discussion
8:15 pm - 8:35 pm	"Building Shapes with Gels: Where Development Meets Material Science"
8:35 pm - 8:45 pm	Discussion
8:45 pm - 8:55 pm	Selected from Poster Abstracts: "Basement Membrane Manipulation in Drosophila Wing Discs Affects Dpp Retention but Not Growth Mechanoregulation"
8:55 pm - 9:00 pm	Discussion
9:00 pm - 9:20 pm	"Symmetry Breaking and Self-Organisation in Mouse Development"
9:20 pm - 9:30 pm	Discussion
Tuesday
7:30 am - 8:30 am	Breakfast
9:00 am - 12:30 pm	Evolution and Development Discussion Leader:
9:00 am - 9:20 am	"Cell Fate Regulation in the Cardiopharyngeal Mesoderm of a Simple Chordate"
9:20 am - 9:30 am	Discussion
9:30 am - 9:40 am	Selected from Poster Abstracts: "Developmental Mechanisms Underlying Stripe Patterns in Rodents"
9:40 am - 9:45 am	Discussion
9:45 am - 10:05 am	"'What Big Feet You Have!' - How Is Skeletal Proportion Established in Development and Evolution?"
10:05 am - 10:15 am	Discussion
10:15 am - 10:45 am	Coffee Break
10:45 am - 10:55 am	Selected from Poster Abstracts: "Transcriptional Convergence and Patterning During Vertebrate Skeletogenesis - From Embryonic Lineages to Single Cells"
10:55 am - 11:00 am	Discussion
11:00 am - 11:20 am	"Spurring Novelty in Columbines"
11:20 am - 11:30 am	Discussion
11:30 am - 11:50 am	"How Tomato Defends Attacks from the Parasitic Plant Dodder"
11:50 am - 12:00 pm	Discussion
12:00 pm - 12:30 pm	Poster Previews
12:30 pm - 1:30 pm	Lunch
1:30 pm - 4:00 pm	Free Time
4:00 pm - 6:00 pm	Poster Session
6:00 pm - 7:00 pm	Dinner
7:30 pm - 9:30 pm	Stem Cells and Their Niche Discussion Leader:
7:30 pm - 7:50 pm	"Stem Cell Dynamics During Epithelial Development, Homeostasis and Regeneration"
7:50 pm - 8:00 pm	Discussion
8:00 pm - 8:20 pm	"Control of Morphogenesis by Feedbacks Between Mechanical and Chemical Signals in a Plant Stem Cell Niche"
8:20 pm - 8:30 pm	Discussion
8:30 pm - 8:50 pm	"Mechanisms of Lineage Specification in Human Embryos"
8:50 pm - 9:00 pm	Discussion
9:00 pm - 9:20 pm	"Germ Cell Formation in Drosophila: Protecting Totipotency"
9:20 pm - 9:30 pm	Discussion
Wednesday
7:30 am - 8:30 am	Breakfast
9:00 am - 12:30 pm	Regeneration and Stress Response Discussion Leader:
9:00 am - 9:20 am	"Genetic Regulation of Growth and Regeneration"
9:20 am - 9:30 am	Discussion
9:30 am - 9:40 am	Selected from Poster Abstracts: "Tension Creates an Endoreplication Wavefront that Leads Regeneration of Epicardial Tissue"
9:40 am - 9:45 am	Discussion
9:45 am - 9:55 am	Selected from Poster Abstracts: "Transcriptomic Analysis in Neuronal Activity-Induced Proliferating Neural Progenitor Cells and Newly-Differentiated Immature Neurons in Optic Tectum of Xenopus laevis"
9:55 am - 10:00 am	Discussion
10:00 am - 10:10 am	Selected from Poster Abstracts: "Mosaic Spatiotemporal Patterning of Pluripotent Stem Cells Using an Inducible CRISPR Interference Platform"
10:10 am - 10:15 am	Discussion
10:15 am - 10:45 am	Coffee Break
10:45 am - 11:05 am	"Regeneration, Plasticity and Cell Fate"
11:05 am - 11:15 am	Discussion
11:15 am - 11:25 am	Selected from Poster Abstracts: "All Roads Lead to Rome: Non-Deterministic Structural Recovery During Organ Regeneration"
11:25 am - 11:30 am	Discussion
11:30 am - 11:40 am	Selected from Poster Abstracts: "Using Mathematical Modeling to Decipher the Regulatory Logic Behind CRM Architecture in the Drosophila Bithorax Complex"
11:40 am - 11:45 am	Discussion
11:45 am - 11:55 am	Selected from Poster Abstracts: "Identity and Architecture of Stem Cell Progenitors During Embryonic Skin Development!"
11:55 am - 12:00 pm	Discussion
12:00 pm - 12:20 pm	"Reorganization of the Stem Cell Niche During Plant Regeneration"
12:20 pm - 12:30 pm	Discussion
12:30 pm - 1:30 pm	Lunch
1:30 pm - 4:00 pm	Free Time
4:00 pm - 6:00 pm	Poster Session
6:00 pm - 7:00 pm	Dinner
7:00 pm - 7:30 pm	Business Meeting Nominations for the Next Vice Chair; Fill in Conference Evaluation Forms; Discuss Future Site and Scheduling Preferences; Election of the Next Vice Chair
7:30 pm - 9:30 pm	Growth, Apoptosis and Size Control Discussion Leader:
7:30 pm - 7:50 pm	"How to Make Growth Control Precise"
7:50 pm - 8:00 pm	Discussion
8:00 pm - 8:10 pm	Selected from Poster Abstracts: "Organ Size Control in Drosophila by a Fat Signaling Component, Approximated"
8:10 pm - 8:15 pm	Discussion
8:15 pm - 8:25 pm	Selected from Poster Abstracts: "Coordinating Cell Fate and Cell Survival in a Developing Epithelium"
8:25 pm - 8:30 pm	Discussion
8:30 pm - 8:50 pm	"Mechanisms and Physiological Roles of Cell Competition in the Mammalian Embryo"
8:50 pm - 9:00 pm	Discussion
9:00 pm - 9:20 pm	"Three Types of Cell Competition and Their Importance in Development, Regeneration, Cancer and Ageing"
9:20 pm - 9:30 pm	Discussion
Thursday
7:30 am - 8:30 am	Breakfast
9:00 am - 12:30 pm	Tissues and Organs in a Dish Discussion Leader:
9:00 am - 9:20 am	"Cerebral Organoids: Studying Human Brain Development in 3D In Vitro Culture"
9:20 am - 9:30 am	Discussion
9:30 am - 9:40 am	Selected from Poster Abstracts: "Assembly of 3D Forebrain Spheroids to Model Human Interneuron Migration"
9:40 am - 9:45 am	Discussion
9:45 am - 9:55 am	Selected from Poster Abstracts: "Cerebral Organoids and Neurospheres as Models to Study Microcephaly Mechanisms"
9:55 am - 10:00 am	Discussion
10:00 am - 10:10 am	Selected from Poster Abstracts: "Modulation of Phase Shift Between Wnt- and Notch-Signaling Oscillations Controls Mesoderm Segmentation"
10:10 am - 10:15 am	Discussion
10:15 am - 10:45 am	Coffee Break
10:45 am - 11:05 am	"Organoids as a Model to Elucidate the Mechanisms of Pancreas Development"
11:05 am - 11:15 am	Discussion
11:15 am - 11:25 am	Selected from Poster Abstracts: "Morphogenesis of Epithelial Cells"
11:25 am - 11:30 am	Discussion
11:30 am - 11:40 am	Selected from Poster Abstracts: "The CUP-SHAPED COTYLEDON 2 Transcription Factor Acts as a Quantitative Trigger During Arabidopsis thaliana Leaf Morphogenesis"
11:40 am - 11:45 am	Discussion
11:45 am - 11:55 am	Selected from Poster Abstracts: "Global Morphogenetic Flow Is Accurately Predicted by the Spatial Distribution of Myosin Motors"
11:55 am - 12:00 pm	Discussion
12:00 pm - 12:20 pm	"Liver Organoids for the Study of Liver Biology and Disease"
12:20 pm - 12:30 pm	Discussion
12:30 pm - 1:30 pm	Lunch
1:30 pm - 4:00 pm	Free Time
4:00 pm - 6:00 pm	Poster Session
6:00 pm - 7:00 pm	Dinner
7:30 pm - 9:30 pm	Developmental Biology and Cancer Discussion Leader:
7:30 pm - 7:50 pm	"Metabolic Regulation of Neuronal Dedifferentiation"
7:50 pm - 8:00 pm	Discussion
8:00 pm - 8:10 pm	Selected from Poster Abstracts: "Signal Induced Regulation of the Small RNA Biogenesis Pathway During Germ Cell Development"
8:10 pm - 8:15 pm	Discussion
8:15 pm - 8:25 pm	Selected from Poster Abstracts: "Deconstructing Eutely: Mechanisms of Phenotypic Robustness in the Epidermis of C. elegans"
8:25 pm - 8:30 pm	Discussion
8:30 pm - 8:40 pm	Selected from Poster Abstracts: "Illuminating Erk's Role in Programming Cell Fates During Early Embryogenesis Using Optogenetics"
8:40 pm - 8:45 pm	Discussion
8:45 pm - 9:05 pm	"Targeting the Hippo Signaling Pathway in Cancers"
9:05 pm - 9:15 pm	Discussion
9:15 pm - 9:30 pm	General Discussion: Developmental Biology in Industry
Friday
7:30 am - 8:30 am	Breakfast
9:00 am	Departure

Contributors

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