Sunday
2:00 pm - 9:00 pm
Arrival and Check-in
6:00 pm - 7:00 pm
Dinner
7:30 pm - 7:40 pm
Introductory Comments by GRC Site Staff / Welcome from the GRC Chair
7:40 pm - 9:30 pm
Signals and the Extracellular Space
Discussion Leader: Anne Grapin-Botton (DanStem, University of Copenhagen, Denmark)
7:40 pm - 8:00 pm
Markus Affolter (University of Basel, Switzerland)
"Protein Binders as New Tools to Study Tissue Patterning and Growth"
8:00 pm - 8:10 pm
Discussion
8:10 pm - 8:20 pm
Selected from Poster Abstracts: Fred Etoc (Rockefeller University, USA)
"BMP/NOGGIN: Integration of a Turing Pair Within a Polarized Model Epiblast"
8:20 pm - 8:25 pm
Discussion
8:25 pm - 8:35 pm
Selected from Poster Abstracts: Benjamin Myers (Stanford University School of Medicine, USA)
"Ion Gradients Drive Patched Regulation of Hedgehog Signaling via the Smoothened Transmembrane Domain"
8:35 pm - 8:40 pm
Discussion
8:40 pm - 8:50 pm
Selected from Poster Abstracts: Dale Frank (Technion - Israel Institute of Technology, Israel)
"New Approaches to the Signaling Pathways Regulating Neural AP Patterning"
8:50 pm - 8:55 pm
Discussion
8:55 pm - 9:15 pm
Naama Barkai (Weizmann Institute of Science, Israel)
"Noise Buffering in Early Embryonic Development"
9:15 pm - 9:25 pm
Discussion
9:25 pm - 9:30 pm
General Discussion
Monday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Group Photo
9:00 am - 12:30 pm
Gene Regulatory Networks and Epigenetics
Discussion Leader: Alejandro Sanchez Alvarado (Stowers Institute for Medical Research / Howard Hughes Medical Institute, USA)
9:00 am - 9:25 am
James Briscoe (The Francis Crick Institute, United Kingdom)
"The Regulatory Logic of Vertebrate Neural Tube Development"
9:25 am - 9:35 am
Discussion
9:35 am - 9:45 am
Selected from Poster Abstracts: Shawn Little (University of Pennsylvania, USA)
"Common Patterns of Modulated Bursting Kinetics Generate Gene Expression Boundaries in Early Embryos"
9:45 am - 9:50 am
Discussion
9:50 am - 10:00 am
Selected from Poster Abstracts: Frank Conlon (University of North Carolina at Chapel Hill, USA)
"CHD4 Controls Cardiomyocyte Formation and Function Through the Direct Repression of Smooth and Skeletal Muscle Isoforms"
10:00 am - 10:05 am
Discussion
10:05 am - 10:35 am
Coffee Break
10:35 am - 10:45 am
Selected from Poster Abstracts: Robert Johnston (Johns Hopkins University, USA)
"High-Affinity Nodes Pair Homologous Chromosomes to Facilitate Interchromosomal Gene Regulation"
10:45 am - 10:50 am
Discussion
10:50 am - 11:00 am
Selected from Poster Abstracts: Sharmistha Kundu (Massachusetts General Hospital, USA)
"Polycomb Compacts Developmentally Regulated Genes into Cell-Type Specific Small Chromatin Domains"
11:00 am - 11:05 am
Discussion
11:05 am - 11:15 am
Selected from Poster Abstracts: Jamy Peng (St Jude Children's Research Hospital, USA)
"Chromatin Modifier UTX and 53BP1 Control Neurogenic Factors to Balance Human Neural Stem Cell Self-Renewal and Differentiation"
11:15 am - 11:20 am
Discussion
11:20 am - 11:50 am
Claude Desplan (New York University, USA)
"Generation of Neural Diversity"
11:50 am - 12:00 pm
Discussion
12:00 pm - 12:30 pm
Poster Previews
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
3:00 pm - 4:00 pm
Power Hour
The GRC Power Hour is an optional informal gathering open to all meeting participants. It is designed to help address the challenges women face in science and support the professional growth of women in our communities by providing an open forum for discussion and mentoring.
Organizers: Elena Kramer (Harvard University, USA) and James Briscoe (The Francis Crick Institute, United Kingdom)
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Tissue Mechanics
Discussion Leader: Eduardo Moreno (Champalimaud Foundation, Portugal)
7:30 pm - 7:50 pm
Yohanns Bellaiche (Institut Curie, France)
"Mitosis and Morphogenesis of Epithelial Tissues"
7:50 pm - 8:00 pm
Discussion
8:00 pm - 8:10 pm
Selected from Poster Abstracts: Natalie Heer (Massachusetts Institute of Technology, USA)
"Actomyosin-Based Tissue Folding Requires a Multicellular Myosin Gradient"
8:10 pm - 8:15 pm
Discussion
8:15 pm - 8:35 pm
Siobhan Braybrook (University of Cambridge , United Kingdom)
"Building Shapes with Gels: Where Development Meets Material Science"
8:35 pm - 8:45 pm
Discussion
8:45 pm - 8:55 pm
Selected from Poster Abstracts: Jose Pastor-Pareja (Tsinghua University, China)
"Basement Membrane Manipulation in Drosophila Wing Discs Affects Dpp Retention but Not Growth Mechanoregulation"
8:55 pm - 9:00 pm
Discussion
9:00 pm - 9:20 pm
Takashi Hiragi (European Molecular Biology Laboratory (EMBL), Germany)
"Symmetry Breaking and Self-Organisation in Mouse Development"
9:20 pm - 9:30 pm
Discussion
Tuesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Evolution and Development
Discussion Leader: Claude Desplan (New York University, USA)
9:00 am - 9:20 am
Lionel Christiaen (New York University, USA)
"Cell Fate Regulation in the Cardiopharyngeal Mesoderm of a Simple Chordate"
9:20 am - 9:30 am
Discussion
9:30 am - 9:40 am
Selected from Poster Abstracts: Ricardo Mallarino (Harvard University, USA)
"Developmental Mechanisms Underlying Stripe Patterns in Rodents"
9:40 am - 9:45 am
Discussion
9:45 am - 10:05 am
Kim Cooper (University of California, San Diego, USA)
"'What Big Feet You Have!' - How Is Skeletal Proportion Established in Development and Evolution?"
10:05 am - 10:15 am
Discussion
10:15 am - 10:45 am
Coffee Break
10:45 am - 10:55 am
Selected from Poster Abstracts: Patrick Tschopp (University of Basel, Switzerland)
"Transcriptional Convergence and Patterning During Vertebrate Skeletogenesis - From Embryonic Lineages to Single Cells"
10:55 am - 11:00 am
Discussion
11:00 am - 11:20 am
Elena Kramer (Harvard University, USA)
"Spurring Novelty in Columbines"
11:20 am - 11:30 am
Discussion
11:30 am - 11:50 am
Neelima Sinha (University of California, Davis, USA)
"How Tomato Defends Attacks from the Parasitic Plant Dodder"
11:50 am - 12:00 pm
Discussion
12:00 pm - 12:30 pm
Poster Previews
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Stem Cells and Their Niche
Discussion Leader: Dominique Bergmann (Stanford University, USA)
7:30 pm - 7:50 pm
Cedric Blanpain (Universite Libre de Bruxelles, Belgium)
"Stem Cell Dynamics During Epithelial Development, Homeostasis and Regeneration"
7:50 pm - 8:00 pm
Discussion
8:00 pm - 8:20 pm
Elliot Meyerowitz (California Institute of Technology, USA)
"Control of Morphogenesis by Feedbacks Between Mechanical and Chemical Signals in a Plant Stem Cell Niche"
8:20 pm - 8:30 pm
Discussion
8:30 pm - 8:50 pm
Kathy Niakan (The Francis Crick Institute, United Kingdom)
"Mechanisms of Lineage Specification in Human Embryos"
8:50 pm - 9:00 pm
Discussion
9:00 pm - 9:20 pm
Ruth Lehmann (Skirball Institute, NYU Langone Medical Center / Howard Hughes Medical Institute, USA)
"Germ Cell Formation in Drosophila : Protecting Totipotency"
9:20 pm - 9:30 pm
Discussion
Wednesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Regeneration and Stress Response
Discussion Leader: Neelima Sinha (University of California, Davis, USA)
9:00 am - 9:20 am
Iswar Hariharan (University of California, Berkeley, USA)
"Genetic Regulation of Growth and Regeneration"
9:20 am - 9:30 am
Discussion
9:30 am - 9:40 am
Selected from Poster Abstracts: Jingli Cao (Duke University, USA)
"Tension Creates an Endoreplication Wavefront that Leads Regeneration of Epicardial Tissue"
9:40 am - 9:45 am
Discussion
9:45 am - 9:55 am
Selected from Poster Abstracts: Lin-Chien Huang (The Scripps Research Institute, USA)
"Transcriptomic Analysis in Neuronal Activity-Induced Proliferating Neural Progenitor Cells and Newly-Differentiated Immature Neurons in Optic Tectum of Xenopus laevis "
9:55 am - 10:00 am
Discussion
10:00 am - 10:10 am
Selected from Poster Abstracts: Ashley Libby (Gladstone Institutes, University of California, San Francisco, USA)
"Mosaic Spatiotemporal Patterning of Pluripotent Stem Cells Using an Inducible CRISPR Interference Platform"
10:10 am - 10:15 am
Discussion
10:15 am - 10:45 am
Coffee Break
10:45 am - 11:05 am
Alejandro Sanchez Alvarado (Stowers Institute for Medical Research / Howard Hughes Medical Institute, USA)
"Regeneration, Plasticity and Cell Fate"
11:05 am - 11:15 am
Discussion
11:15 am - 11:25 am
Selected from Poster Abstracts: Hernan Lopez-Schier (Helmholtz Zentrum Munich, Germany)
"All Roads Lead to Rome: Non-Deterministic Structural Recovery During Organ Regeneration"
11:25 am - 11:30 am
Discussion
11:30 am - 11:40 am
Selected from Poster Abstracts: Jacqueline Dresch (Clark University, USA)
"Using Mathematical Modeling to Decipher the Regulatory Logic Behind CRM Architecture in the Drosophila Bithorax Complex"
11:40 am - 11:45 am
Discussion
11:45 am - 11:55 am
Selected from Poster Abstracts: Irina Matos (The Rockefeller University, USA)
"Identity and Architecture of Stem Cell Progenitors During Embryonic Skin Development!"
11:55 am - 12:00 pm
Discussion
12:00 pm - 12:20 pm
Ken Birnbaum (New York University, USA)
"Reorganization of the Stem Cell Niche During Plant Regeneration"
12:20 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:00 pm - 7:30 pm
Business Meeting
Nominations for the Next Vice Chair; Fill in Conference Evaluation Forms; Discuss Future Site and Scheduling Preferences; Election of the Next Vice Chair
7:30 pm - 9:30 pm
Growth, Apoptosis and Size Control
Discussion Leader: Iswar Hariharan (University of California, Berkeley, USA)
7:30 pm - 7:50 pm
Pierre Leopold (Institute of Biology Valrose (iBV), France)
"How to Make Growth Control Precise"
7:50 pm - 8:00 pm
Discussion
8:00 pm - 8:10 pm
Selected from Poster Abstracts: Hitoshi Matakatsu (University of Chicago, USA)
"Organ Size Control in Drosophila by a Fat Signaling Component, Approximated"
8:10 pm - 8:15 pm
Discussion
8:15 pm - 8:25 pm
Selected from Poster Abstracts: Sam Crossman (The Francis Crick Insitute, United Kingdom)
"Coordinating Cell Fate and Cell Survival in a Developing Epithelium"
8:25 pm - 8:30 pm
Discussion
8:30 pm - 8:50 pm
Miguel Torres (Spanish National Cardiovascular Research Centre (CNIC), Spain)
"Mechanisms and Physiological Roles of Cell Competition in the Mammalian Embryo"
8:50 pm - 9:00 pm
Discussion
9:00 pm - 9:20 pm
Eduardo Moreno (Champalimaud Foundation, Portugal)
"Three Types of Cell Competition and Their Importance in Development, Regeneration, Cancer and Ageing"
9:20 pm - 9:30 pm
Discussion
Thursday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Tissues and Organs in a Dish
Discussion Leader: Cedric Blanpain (Universite Libre de Bruxelles, Belgium)
9:00 am - 9:20 am
Juergen Knoblich (Institute of Molecular Biotechnology (IMBA), Austria)
"Cerebral Organoids: Studying Human Brain Development in 3D In Vitro Culture"
9:20 am - 9:30 am
Discussion
9:30 am - 9:40 am
Selected from Poster Abstracts: Jimena Andersen (Stanford University, USA)
"Assembly of 3D Forebrain Spheroids to Model Human Interneuron Migration"
9:40 am - 9:45 am
Discussion
9:45 am - 9:55 am
Selected from Poster Abstracts: Patricia Garcez (Federal University of Rio de Janeiro, Brazil)
"Cerebral Organoids and Neurospheres as Models to Study Microcephaly Mechanisms"
9:55 am - 10:00 am
Discussion
10:00 am - 10:10 am
Selected from Poster Abstracts: Katharina Sonnen (European Molecular Biology Laboratory, Germany)
"Modulation of Phase Shift Between Wnt- and Notch-Signaling Oscillations Controls Mesoderm Segmentation"
10:10 am - 10:15 am
Discussion
10:15 am - 10:45 am
Coffee Break
10:45 am - 11:05 am
Anne Grapin-Botton (DanStem, University of Copenhagen, Denmark)
"Organoids as a Model to Elucidate the Mechanisms of Pancreas Development"
11:05 am - 11:15 am
Discussion
11:15 am - 11:25 am
Selected from Poster Abstracts: Zhechun Zhang (Harvard University, USA)
"Morphogenesis of Epithelial Cells"
11:25 am - 11:30 am
Discussion
11:30 am - 11:40 am
Selected from Poster Abstracts: Aude Maugarny-Cales (Institut Jean-Pierre Bourgin, INRA, France)
"The CUP-SHAPED COTYLEDON 2 Transcription Factor Acts as a Quantitative Trigger During Arabidopsis thaliana Leaf Morphogenesis"
11:40 am - 11:45 am
Discussion
11:45 am - 11:55 am
Selected from Poster Abstracts: Sebastian Streichan (Kavli Institute for Theoretical Physics, University of California, Santa Barbara, USA)
"Global Morphogenetic Flow Is Accurately Predicted by the Spatial Distribution of Myosin Motors"
11:55 am - 12:00 pm
Discussion
12:00 pm - 12:20 pm
Meritxell Huch (University of Cambridge , United Kingdom)
"Liver Organoids for the Study of Liver Biology and Disease"
12:20 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Developmental Biology and Cancer
Discussion Leader: Jean-Paul Vincent (Francis Crick Institute, United Kingdom)
7:30 pm - 7:50 pm
Louise Cheng (Peter MacCallum Cancer Centre, Australia)
"Metabolic Regulation of Neuronal Dedifferentiation"
7:50 pm - 8:00 pm
Discussion
8:00 pm - 8:10 pm
Selected from Poster Abstracts: Swathi Arur (University of Texas MD Anderson Cancer Center, USA)
"Signal Induced Regulation of the Small RNA Biogenesis Pathway During Germ Cell Development"
8:10 pm - 8:15 pm
Discussion
8:15 pm - 8:25 pm
Selected from Poster Abstracts: Michalis Barkoulas (Imperial College London, United Kingdom)
"Deconstructing Eutely: Mechanisms of Phenotypic Robustness in the Epidermis of C. elegans "
8:25 pm - 8:30 pm
Discussion
8:30 pm - 8:40 pm
Selected from Poster Abstracts: Heath Johnson (Princeton University, USA)
"Illuminating Erk's Role in Programming Cell Fates During Early Embryogenesis Using Optogenetics"
8:40 pm - 8:45 pm
Discussion
8:45 pm - 9:05 pm
Anwesha Dey (Genentech Inc, USA)
"Targeting the Hippo Signaling Pathway in Cancers"
9:05 pm - 9:15 pm
Discussion
9:15 pm - 9:30 pm
General Discussion: Developmental Biology in Industry
Friday
7:30 am - 8:30 am
Breakfast
9:00 am
Departure
