Sunday
2:00 pm - 9:00 pm
Arrival and Check-in
6:00 pm - 7:00 pm
Dinner
7:30 pm - 7:40 pm
Introductory Comments by GRC Site Staff / Welcome from the GRC Chair
7:40 pm - 9:30 pm
Keynote Session: 50 Years of Positional Information
Discussion Leader: Alexander Schier (Harvard University, USA)
7:40 pm - 7:45 pm
Introduction by Discussion Leader: Positional Information in 2019
7:45 pm - 8:10 pm
James Sharpe (EMBL Barcelona, Spain)
"50(+1) Years of the French Flag Problem"
8:10 pm - 8:20 pm
Discussion
8:20 pm - 8:45 pm
Marja Timmermans (University of Tübingen, Germany)
"Boundary Formation by Mobile Small RNAs"
8:45 pm - 8:55 pm
Discussion
8:55 pm - 9:20 pm
Celeste Nelson (Princeton University, USA)
"Mechanical Forces and Epithelial Morphogenesis"
9:20 pm - 9:30 pm
Discussion
Monday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Group Photo
9:00 am - 12:30 pm
Developmental Time
Discussion Leader: Ehab Abouheif (McGill University, Canada)
9:00 am - 9:20 am
Swathi Arur (University of Texas MD Anderson Cancer Center, USA)
"Orchestration of Cellular Spatial Information and Differentiation: ERK Signaling in Germ Cell Development"
9:20 am - 9:30 am
Discussion
9:30 am - 9:50 am
Miki Ebisuya (EMBL Barcelona, Spain)
"Human Time vs Mouse Time in the Segmentation Clock"
9:50 am - 10:00 am
Discussion
10:00 am - 10:15 am
Selected from Poster Abstracts: Carla Mulas (Wellcome - MRC Cambridge Stem Cell Institute, United Kingdom)
"Out with the Old, in with the New: ERK Coordinates Cell Fate Rewiring in Early Development"
10:15 am - 10:20 am
Discussion
10:20 am - 10:50 am
Coffee Break
10:50 am - 11:10 am
Rick Livesey (University College London, United Kingdom)
"Studying Human Cerebral Cortex Development in Health and Disease with Stem Cell Systems"
11:10 am - 11:20 am
Discussion
11:20 am - 11:35 am
Selected from Poster Abstracts: Tian Hong (The University of Tennessee, Knoxville, USA)
"An Enriched Network Motif Family Regulates Multistep Cell Fate Transitions with Restricted Reversibility"
11:35 am - 11:40 am
Discussion
11:40 am - 11:55 am
Selected from Poster Abstracts: Alex Hughes (University of Pennsylvania, USA)
"Uncovering the Developmental Rules for Kidney Duct Morphogenesis by Programming Mesenchymal Remodeling in Space and Time"
11:55 am - 12:00 pm
Discussion
12:00 pm - 12:30 pm
Poster Previews
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
3:00 pm - 4:00 pm
The GRC Power Hourâ„¢
The GRC Power Hourâ„¢ is designed to address challenges women face in science and issues of diversity and inclusion. The program supports the professional growth of all members of our communities by providing an open forum for discussion and mentoring.
Organizers: Anne Ferguson-Smith (University of Cambridge, United Kingdom) and Mary Mullins (University of Pennsylvania, USA)
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Towards In Vitro Precision In Vivo
Discussion Leader: Swathi Arur (University of Texas MD Anderson Cancer Center, USA)
7:30 pm - 7:50 pm
Steven Zwick (Harvard University, USA)
"How Tissue Geometry and Mechanics Regulate Signaling During Gastrulation"
7:50 pm - 8:00 pm
Discussion
8:00 pm - 8:20 pm
Daniel Dickinson (University of Texas at Austin, USA)
"Dynamics of Cell Polarity Signaling in Early Development"
8:20 pm - 8:30 pm
Discussion
8:30 pm - 8:50 pm
Melissa Little (Murdoch Children's Research Institute, Australia)
"Recreating Human Kidney Tissue from Stem Cells: How Well Are We Mimicking What We Know of Normal Development?"
8:50 pm - 9:00 pm
Discussion
9:00 pm - 9:15 pm
Selected from Poster Abstracts: Ashley Libby (Gladstone Institutes, University of California, San Francisco, USA)
"Engineering of Multicellular Organization and Morphogenesis of Human Pluripotent Stem Cells Using Automated Prediction"
9:15 pm - 9:20 pm
Discussion
9:20 pm - 9:30 pm
General Discussion
Tuesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Cell Identity and Robustness in the Era of Single-Cell 'Omics
Discussion Leader: Aleksandra Walczak (Laboratoire de Physique Théorique, École Normale Supérieure, CNRS, France)
9:00 am - 9:20 am
Antony Jose (University of Maryland, College Park, USA)
"Epigenetic Recovery from Transgenerational RNA Silencing in the C. elegans Germline"
9:20 am - 9:30 am
Discussion
9:30 am - 9:50 am
Alexander Schier (Harvard University, USA)
"Cellular Biographies: Reconstructing Developmental Trajectories and Lineages"
9:50 am - 10:00 am
Discussion
10:00 am - 10:15 am
Selected from Poster Abstracts: Yi-Jyun Luo (Harvard University, USA)
"Single-Cell Transcriptomics of the Acoel Hofstenia Reveals the Evolution of Bilaterian Cell Types and Stem Cell Regulation"
10:15 am - 10:20 am
Discussion
10:20 am - 10:50 am
Coffee Break
10:50 am - 11:10 am
Mary Teruel (Stanford University, USA)
"Stochastic Regulation of G1 Duration Controls Terminal Cell Differentiation and Cell Cycle Exit"
11:10 am - 11:20 am
Discussion
11:20 am - 11:35 am
Selected from Poster Abstracts: Andreas Sagner (Francis Crick Institute, United Kingdom)
"Single Cell Transcriptomics Reveals Spatial and Temporal Dynamics of Gene Expression in the Developing Mouse Spinal Cord"
11:35 am - 11:40 am
Discussion
11:40 am - 11:55 am
Selected from Poster Abstracts: Melanie Worley (University of California, Berkeley, USA)
"Single-Cell Analysis of Cell Fate Plasticity During Regeneration in Drosophila "
11:55 am - 12:00 pm
Discussion
12:00 pm - 12:30 pm
Poster Previews
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Chromatin and Epigenetic Influences on Cell Identity
Discussion Leader: James Briscoe (The Francis Crick Institute, United Kingdom)
7:30 pm - 7:50 pm
Anne Ferguson-Smith (University of Cambridge, United Kingdom)
"Evolution and Function of Vertebrate-Specific Atypical Notch Ligand"
7:50 pm - 8:00 pm
Discussion
8:00 pm - 8:20 pm
Esteban Mazzoni (New York University, USA)
"Hox Binding Logic During Spinal Cord Patterning"
8:20 pm - 8:30 pm
Discussion
8:30 pm - 8:50 pm
Doris Wagner (University of Pennsylvania, USA)
"Reprogramming of Cell Fate and Function in the Context of Chromatin"
8:50 pm - 9:00 pm
Discussion
9:00 pm - 9:15 pm
Selected from Poster Abstracts: Albert Tsai (EMBL Heidelberg, Germany)
"The Transcriptional Environment in the Nucleus Becomes Increasingly Heterogeneous as Embryonic Development Progresses"
9:15 pm - 9:20 pm
Discussion
9:20 pm - 9:30 pm
General Discussion
Wednesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Dynamic Imaging and Imaging Dynamics
Discussion Leader: James Sharpe (EMBL Barcelona, Spain)
9:00 am - 9:20 am
Niko Geldner (University of Lausanne, Switzerland)
"The Root Endodermis: An Independent Way of Building a Polarised Epithelium"
9:20 am - 9:30 am
Discussion
9:30 am - 9:45 am
Selected from Poster Abstracts: Jordi Guiu (Biotech Research and Innovation Centre (BRIC), University of Copenhagen, Denmark)
"Tracing the Origin of Adult Intestinal Stem Cells"
9:45 am - 9:50 am
Discussion
9:50 am - 10:05 am
Stephanie Ellis (The Rockefeller University, USA)
"Building the Best Barrier: How Cell Competition Shapes Epidermal Morphogenesis"
10:05 am - 10:10 am
Discussion
10:10 am - 10:45 am
Coffee Break
10:45 am - 11:05 am
Jan Huisken (Morgridge Institute for Research, USA)
"Real-Time Developmental Biology with a Shareable Microscopy Platform"
11:05 am - 11:15 am
Discussion
11:15 am - 11:30 am
Selected from Poster Abstracts: Cara Winter (Duke University, USA)
"Dynamics of the SHR-SCR Network Controlling Asymmetric Cell Division"
11:30 am - 11:35 am
Discussion
11:35 am - 11:50 am
Selected from Poster Abstracts: Eszter Posfai (Princeton University, USA)
"Expanding the Fluorescent Reporter Toolkit in Mouse Using a Novel CRISPR-Mediated Genome Editing Method"
11:50 am - 11:55 am
Discussion
11:55 am - 12:00 pm
General Discussion
12:00 pm - 12:30 pm
Poster Previews
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:00 pm - 7:30 pm
Business Meeting
Nominations for the Next Vice Chair; Fill in Conference Evaluation Forms; Discuss Future Site and Scheduling Preferences; Election of the Next Vice Chair
7:30 pm - 9:30 pm
New Concepts of Pattern
Discussion Leader: Miki Ebisuya (EMBL Barcelona, Spain)
7:30 pm - 7:55 pm
Mary Mullins (University of Pennsylvania, USA)
"BMP Morphogen Gradient Formation and Interpretation (Positional Information Session Redux)"
7:55 pm - 8:05 pm
Discussion
8:05 pm - 8:25 pm
Ehab Abouheif (McGill University, Canada)
"Obligate Endosymbiosis in Ants Reveals Developmental Steps to Major Evolutionary Transitions"
8:25 pm - 8:35 pm
Discussion
8:35 pm - 8:55 pm
Danelle Devenport (Princeton University, USA)
"Patterning Morphogenesis via the Planar Cell Polarity Pathway"
8:55 pm - 9:05 pm
Discussion
9:05 pm - 9:20 pm
Selected from Poster Abstracts: Hanh Vu (Max Planck Institute of Molecular Cell Biology and Genetics, Germany)
"Multi-Scale Coordination of Planar Cell Polarity in Planarians"
9:20 pm - 9:25 pm
Discussion
9:25 pm - 9:30 pm
General Discussion
Thursday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Metabolism and Growth Control
Discussion Leader: Anne Grapin-Botton (MPI-CBG Dresden, Germany / DanStem, University of Copenhagen, Denmark)
9:00 am - 9:20 am
Ditte Andersen (University of Copenhagen, Denmark)
"The Role of the Dilp8/Lgr3 Pathway in Adjusting Final Organ Size and Minimizing Developmental Noise"
9:20 am - 9:30 am
Discussion
9:30 am - 9:50 am
Tristan Rodriguez (Imperial College London, United Kingdom)
"Cell Competition and the Regulation of Growth in the Early Mouse Embryo"
9:50 am - 10:00 am
Discussion
10:00 am - 10:15 am
Selected from Poster Abstracts: Yunxiao Zhang (Stanford University, USA)
"Structural Basis for Cholesterol Transport-Like Activity of the Hedgehog Receptor Patched"
10:15 am - 10:20 am
Discussion
10:20 am - 10:50 am
Coffee Break
10:50 am - 11:10 am
Nicolas Rohner (Stowers Institute for Medical Research, USA)
"Metabolic Adaptation in Cavefish"
11:10 am - 11:20 am
Discussion
11:20 am - 11:35 am
Selected from Poster Abstracts: Christen Mirth (School of Biological Sciences, Monash University, Australia)
"Coordinating Organ Growth and Patterning in the Developing Larvae "
11:35 am - 11:40 am
Discussion
11:40 am - 12:00 pm
Jonathan Rodenfels (Yale University, USA)
"The Energetic Costs of Early Development"
12:00 pm - 12:05 pm
Discussion
12:05 pm - 12:25 pm
Blair Benham-Pyle (Stowers Institute for Medical Research, USA)
"A Single-Cell Reconstruction of Planarian Regeneration"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Developmental Robustness in Noisy Systems
Discussion Leader: Dominique Bergmann (Stanford University, USA)
7:30 pm - 7:50 pm
Adrienne Roeder (Cornell University, USA)
"How Fluctuations in a Transcription Factor Initiate Cell Patterning in Arabidopsis Sepals"
7:50 pm - 8:00 pm
Discussion
8:00 pm - 8:20 pm
Aleksandra Walczak (Laboratoire de Physique Théorique, École Normale Supérieure, CNRS, France)
"Precision in a Rush: Cell Fate Decisions from Time Dependent Data"
8:20 pm - 8:30 pm
Discussion
8:30 pm - 8:50 pm
Christoph Zechner (Max Planck Institute of Molecular Cell Biology and Genetics / Center for Systems Biology Dresden, Germany)
"Inferring Context-Dependent Transcriptional Regulation from Cell-Lineage Data"
8:50 pm - 9:00 pm
Discussion
9:00 pm - 9:15 pm
Selected from Poster Abstracts: Sophie Herszterg (Francis Crick Institute, United Kingdom)
"Contributions of Fate Plasticity and Mechanics to Vein Patterning in the Drosophila Wing"
9:15 pm - 9:20 pm
Discussion
9:20 pm - 9:30 pm
General Discussion
Friday
7:30 am - 8:30 am
Breakfast
9:00 am
Departure