Sunday
2:00 pm - 9:00 pm
Arrival and Check-in
6:00 pm - 7:00 pm
Dinner
7:30 pm - 7:40 pm
Introductory Comments by GRC Staff / Welcome and Introduction from the Chairs
7:40 pm - 9:30 pm
Keynote Session: Cell Diversity and Embryonic Patterning
Discussion Leader: Swathi Arur (University of Texas MD Anderson Cancer Center, United States)
7:40 pm - 7:50 pm
Introduction by Discussion Leader
7:50 pm - 8:10 pm
Claudio Stern (University College London, UK, United Kingdom)
"Some Mechanisms that Position the Embryonic Axis and Recent Progress with Understanding How Monozygotic Twins Arise."
8:10 pm - 8:20 pm
Discussion
8:20 pm - 8:40 pm
Anna Kicheva (Institute of Science and Technology Austria, Austria)
"Morphogens and the Organization of Spinal Cord Development"
8:40 pm - 8:50 pm
Discussion
8:50 pm - 9:05 pm
Dong-Yuan Chen (California Institute of Technology, United States)
"Basement Membrane Heterogeneity Cues Mammalian Body Axis Determination"
9:05 pm - 9:10 pm
Discussion
9:10 pm - 9:25 pm
Ruohan Zhong (Stowers Institute for Medical Research, United States)
"The Evolution of Centralization: Neural Architecture in the Sea Anemone Nematostella Vectensis"
9:25 pm - 9:30 pm
Discussion
Monday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Group Photo
9:00 am - 12:30 pm
Metabolic Fluxes in Development
Discussion Leader: Marianne Bronner (California Institute of Techno, United States)
9:00 am - 9:20 am
Aurelio Teleman (German Cancer Research Center (DKFZ), Germany)
"Nuclear Position Affects its Chromatin State"
9:20 am - 9:30 am
Discussion
9:30 am - 9:50 am
Jason Tennessen (Indiana University, United States)
"Exploring Metabolic Plasticity during Drosophila Melanogaster Larval Development"
9:50 am - 10:00 am
Discussion
10:00 am - 10:15 am
Kristina Stapornwongkul (EMBL Barcelona, Spain)
"Glucose - An Important Regulator of Germ Layer Induction"
10:15 am - 10:20 am
Discussion
10:20 am - 10:50 am
Coffee Break
10:50 am - 11:05 am
Isabella Burda (Cornell University, United States)
"Spatiotemporal Averaging of Cell Growth Direction during Arabidopsis Sepal Development is Robust to Cell Division Rate and may Rely on Microtubule"
11:05 am - 11:10 am
Discussion
11:10 am - 11:30 am
Tina Mukherjee (Institute for Stem Cell Science and Regenerative Medicine, India)
"Immune Metabolic States as Developmental Sensors of Animal Physiology"
11:30 am - 11:40 am
Discussion
11:40 am - 11:55 am
Martin Tran (Caltech, United States)
"Zombie-Memoir: A New System For Spatial, SingleCell Lineage Reconstruction During Development"
11:55 am - 12:00 pm
Discussion
12:00 pm - 12:30 pm
Poster Previews
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
3:00 pm - 4:00 pm
The GRC Power Hour™
The GRC Power Hour™ is designed to address diversity and inclusion in the scientific workplace by providing a safe environment for informal and meaningful conversations amongst colleagues of all career stages. The program supports the professional growth of all members of our communities, including ethnicity, race and/or gender identity by providing an open forum for discussion and mentoring.
Organizers: Marianne Bronner (California Institute of Techno, United States) and Ken Poss (Duke University, United States)
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Gene Regulation
Discussion Leader: Anna Kicheva (Institute of Science and Technology Austria, Austria)
7:30 pm - 7:50 pm
Martha Bulyk (Brigham & Women's Hospital and Harvard Medical School, United States)
"Transcriptional Silencers in Drosophila Embryonic Mesoderm"
7:50 pm - 8:00 pm
Discussion
8:00 pm - 8:15 pm
Ana Hernandez (University of Cambridge, United Kingdom)
"Tissue Fitness and Influence of Stem Cell Fates"
8:15 pm - 8:20 pm
Discussion
8:20 pm - 8:30 pm
William Jones (University of Pennsylvania, United States)
"A New Mechanism of Dorsal Axial Organizer Repression by Integrator Complex Subunit 6"
8:30 pm - 8:35 pm
Discussion
8:35 pm - 8:45 pm
Valerie Tornini (Yale University, United States)
"Big Roles for Tiny Peptides in Vertebrate Neurodevelopment"
8:45 pm - 8:50 pm
Discussion
8:50 pm - 9:10 pm
Wei Xie (Tsinghua University, China)
"Decoding the Transcription Circuitry in Early Mammalian Development"
9:10 pm - 9:20 pm
Discussion
9:20 pm - 9:30 pm
General Discussion
Tuesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Regeneration
Discussion Leader: Sally Dunwoodie (Victor Chang Cardiac Research Institute, Sydney, Australia, Australia)
9:00 am - 9:20 am
Mansi Srivastava (Harvard University, United States)
"Hofstenia Miamia, as a New Model Acoel Species for Studies of Regeneration"
9:20 am - 9:30 am
Discussion
9:30 am - 9:50 am
Ken Poss (Duke University, United States)
"Signal Control During Tissue Regeneration"
9:50 am - 10:00 am
Discussion
10:00 am - 10:15 am
Charisios Tsiairis (Friedrich Miescher Institute for Biomedical Research, Switzerland)
"Organiser Emergence in Regenerating Hydra via Mechanochemical Signalling"
10:15 am - 10:20 am
Discussion
10:20 am - 10:50 am
Coffee Break
10:50 am - 11:10 am
Dasaradhi Palakodeti (Institute for Stem Cell Science and Regenerative Medicine, India)
"Sneak Peek into Mechanisms that Regulate Cellular Plasticity and Regeneration"
11:10 am - 11:20 am
Discussion
11:20 am - 11:35 am
Heather Le Bleu (University of Oregon, United States)
"Voltage-gated Calcium Channels Control Zebrafish Fin Size and Shape"
11:35 am - 11:40 am
Discussion
11:40 am - 11:55 am
Alex Hughes (University of Pennsylvania, United States)
"Interpreting Geometric Rules of Early Kidney Formation for Synthetic Morphogenesis"
11:55 am - 12:00 pm
Discussion
12:00 pm - 12:30 pm
Poster Previews
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Dynamic Signaling at Tissue Scale
Discussion Leader: Claudio Stern (University College London, UK, United Kingdom)
7:30 pm - 7:50 pm
Daniel Ríos Barrera (Universidad Nacional Autónoma de México, Mexico)
"Morphogenesis across Scales: How Trafficking and Adhesion Contribute to Drosophila Tracheal Development."
7:50 pm - 8:00 pm
Discussion
8:00 pm - 8:30 pm
Susanna Brantley (Duke University, United States)
"Input-Output Dynamics of BMP Signaling in the Early Drosophila Embryo"
8:30 pm - 8:35 pm
Discussion
8:35 pm - 9:05 pm
Muhammed Simsek (Cincinnati Children's, United States)
"Time Mechanisms of Sequential Segmentation in Vertebrate Embryos"
9:05 pm - 9:10 pm
Discussion
9:10 pm - 9:25 pm
Lydia Djenoune (Massachusetts General Hospital / Harvard Medical School, United States)
"Cilia Function as Calcium-Mediated Mechanosensors that Instruct Left-Right Asymmetry"
9:25 pm - 9:30 pm
Discussion
Wednesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Lineage Tracing Revisited in the Age of Single Cell Genomics
Discussion Leader: James Briscoe (The Francis Crick Institute, United Kingdom)
9:00 am - 9:20 am
Marianne Bronner (California Institute of Techno, United States)
"Signaling and Transcriptional Interactions that Lead to Neural Crest Formation Both at the Tissue and the Molecular Level"
9:20 am - 9:30 am
Discussion
9:30 am - 9:45 am
Alexandru Bacanu (Harvard University, United States)
"Contact Mediated Spatial Patterning of an Early Human-Specific Astrocytic Lineage"
9:45 am - 9:50 am
Discussion
9:50 am - 10:10 am
Celina Juliano (UCD, United States)
"Mechanisms of Development and Regeneration in Hydra"
10:10 am - 10:20 am
Discussion
10:20 am - 10:50 am
Coffee Break
10:50 am - 11:10 am
Allon Klein (Harvard Medical School, United States)
"On the Requirement for Cell Cycle Progression during Cellular Differentiation: A Problem Revisited with Single Cell Genomics"
11:10 am - 11:20 am
Discussion
11:20 am - 11:35 am
Bianca Dumitrascu (Columbia University, United States)
"Statistical Machine Learning for Learning Representations of Embryonic Leve"
11:35 am - 11:40 am
Discussion
11:40 am - 11:55 am
Kathryn Cheah (The University of Hong Kong, Hong Kong SAR China)
"Progenitor-Like Cells Contributing to Cellular Diversity in Fetal Development and Postnatal Maturation of the Nucleus Pulposus in the Intervertebral Disc"
11:55 am - 12:00 pm
Discussion
12:00 pm - 12:30 pm
Poster Previews
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Tissue Mechanics and Morphogenesis
Discussion Leader: Daniel Ríos Barrera (Universidad Nacional Autónoma de México, Mexico)
7:30 pm - 7:50 pm
Charlotte Kirchhelle (ENS de Lyon, France)
"A Concept for Edge-Based Growth Control in Plants"
7:50 pm - 8:00 pm
Discussion
8:00 pm - 8:15 pm
Fridtjof Brauns (Kavli Institute for Theoretical Physics, University of California Santa Barbara, United States)
"Patterning of Morphogenetic Anisotropy Fields"
8:15 pm - 8:20 pm
Discussion
8:20 pm - 8:35 pm
Nikolas Claussen (University of California, Santa Barbara, United States)
"Cell Geometry and the Mechanism of Epithelial Tissue Dynamics during Convergent Extension"
8:35 pm - 8:40 pm
Discussion
8:40 pm - 9:00 pm
Miltos Tsiantis (Max Planck Institute for Plant Breeding Research, Germany)
"Leaf Development and Diversity: From Understanding to Reconstructing"
9:00 pm - 9:10 pm
Discussion
9:10 pm - 9:25 pm
Carl Modes (Max Planck Institute of Molecular Cell Biology and Genetics (MPI-CBG), Germany)
"Topology and Geometry Together in Development"
9:25 pm - 9:30 pm
Discussion
Thursday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Business Meeting
Nominations for the Next Vice Chair(s); Complete the GRC Evaluation Forms; Discuss Future Dates and Venue; Election of the Next Vice Chair(s)
9:00 am - 12:30 pm
Developmental Origin of Disease
Discussion Leader: Ashley Libby (The Francis Crick Institute, United Kingdom)
9:00 am - 9:25 am
Sally Dunwoodie (Victor Chang Cardiac Research Institute, Sydney, Australia, Australia)
"Identifying Genetic and Environmental Causes of Congenital Malformation"
9:25 am - 9:35 am
Discussion
9:35 am - 10:00 am
Anwesha Dey (Genentech, United States)
"Targeting the Hippo Pathway in Cancers."
10:00 am - 10:10 am
Discussion
10:10 am - 10:30 am
Sahin Naqvi (Stanford University, United States)
"Tuning Transcription Factor Dosage to Reconcile Dosage Sensitivity and Robustness in Development"
10:30 am - 10:35 am
Discussion
10:35 am - 11:05 am
Coffee Break
11:05 am - 11:30 am
Richard Gilbertson (University of Cambridge, United Kingdom)
"Deep Learning Mapping of Aging, Inflammation and Cancer in Multiorgan Species"
11:30 am - 11:40 am
Discussion
11:40 am - 12:00 pm
Rohan Bhattacharya (Duke University, United States)
"SMAD2 Variants in Human iPS Cells Dysregulate Development of the Glomerular Capillary Wall"
12:00 pm - 12:05 pm
Discussion
12:05 pm - 12:25 pm
Scott Wilcockson (Francis Crick Institute, United Kingdom)
"Mitotic Erasure Shapes Fgf/Erk Signaling Dynamics and Patterning of the Presumptive Mesendoderm"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Transgenerational Inheritance
Discussion Leader: Kalki Kukreja (Harvard University, United States)
7:30 pm - 7:55 pm
Shosei Yoshida (National Institute for Basic Biology, Japan)
"Wave and Cycle Patterning of Mammalian Spermatogenesis"
7:55 pm - 8:05 pm
Discussion
8:05 pm - 8:30 pm
Yaniv Elkouby (The Hebrew University of Jerusalem, Faculty of Medicine, Israel)
"Multi-Step Cellular Control over Balbiani Body Molecular Condensation by Microtubules in Zebrafish Oocyte Polarity"
8:30 pm - 8:40 pm
Discussion
8:40 pm - 9:00 pm
Madeleine Linneberg-Agerholm (Novo Nordisk Foundation Center for Stem Cell Medicine (reNEW), Denmark)
"Oct4 Supports Enhancer Priming in the Mouse Primitive Endoderm to Enable Plasticity in Regulative Development"
9:00 pm - 9:05 pm
Discussion
9:05 pm - 9:25 pm
Honghao Song (Harvard university, United States)
"Uncovering the Genes and Mechanisms behind Cell Competition in Female Drosophila Melanogaster"
9:25 pm - 9:30 pm
Discussion
Friday
7:30 am - 8:30 am
Breakfast
9:00 am
Departure