| Sunday |
| 4:00 pm - 8:00 pm | Arrival and Check-in |
| 6:00 pm | Dinner |
| 7:30 pm - 7:40 pm | Welcome / Introductory Comments by GRC Site Staff |
| 7:40 pm - 9:30 pm | Keynote Session: At the Forefront of Cell Migration During Epithelial to Mesenchymal Transition |
| Discussion Leader: Carole Parent (Center for Cancer Research, NCI, NIH, USA) |
| 7:40 pm - 8:20 pm | Valerie Weaver (University of California, San Francisco, USA)
"Forcing Transformation and Metastasis" |
| 8:20 pm - 8:35 pm | Discussion |
| 8:35 pm - 9:15 pm | Anna Huttenlocher (University of Wisconsin, Madison, USA)
"Imaging Epithelial to Mesenchymal Transition" |
| 9:15 pm - 9:30 pm | Discussion |
| Monday |
| 7:30 am - 8:30 am | Breakfast |
| 8:30 am | Group Photo |
| 9:00 am - 12:30 pm | Gradient Sensing During Cell Migration |
| Discussion Leader: Orion Weiner (University of California, San Francisco School of Medicine, USA) |
| 9:00 am - 9:20 am | Peter Devreotes (Johns Hopkins University School of Medicine, USA)
"Insight for Metastasis: Common Mechanisms of Directed Cell Migration in Amoebae and Human Neutrophils" |
| 9:20 am - 9:30 am | Discussion |
| 9:30 am - 9:50 am | Richard Firtel (University of California, San Diego, USA)
"Spatiotemporal Control and the Biomechanics of Mammalian and Dictyostelium Cell Movement" |
| 9:50 am - 10:00 am | Discussion |
| 10:00 am - 10:30 am | Coffee Break |
| 10:30 am - 10:50 am | Len Stephens (The Babraham Institute, United Kingdom)
"PI3K Signaling During Health and Disease" |
| 10:50 am - 11:00 am | Discussion |
| 11:00 am - 11:20 am | Pablo Iglesias (Johns Hopkins University, USA)
"A Modular View of the Signaling System Regulating Chemotaxis" |
| 11:20 am - 11:30 am | Discussion |
| 11:30 am - 11:40 am | Selected from Poster Abstracts: Miho Iijima (Johns Hopkins University School of Medicine, USA)
"Controlling Cancer Metastasis by Engineering PTEN Membrane Recruitment" |
| 11:40 am - 11:45 am | Discussion |
| 11:45 am - 11:55 am | Selected from Poster Abstracts: Robert Insall (Beatson Institute for Cancer Research, United Kingdom)
"Melanoma Cell Chemotaxis: Self-Generated LPA Gradients Are a Key Driver of Metastasis" |
| 11:55 am - 12:00 pm | Discussion |
| 12:00 pm - 12:10 pm | Selected from Poster Abstracts: Robert Kay (MRC Laboratory of Molecular Biology, United Kingdom)
"A Master Protein Kinase Controlling Chemotaxis in Dictyostelium" |
| 12:10 pm - 12:15 pm | Discussion |
| 12:15 pm - 12:20 pm | Selected from Poster Abstracts: Pascale Charest (University of Arizona, USA)
"Protein Kinase A Promotes Adaptation of Chemoattractant Signal Transduction Pathways and Is Critical for Gradient Sensing in Dictyostelium" |
| 12:20 pm - 12:25 pm | Selected from Poster Abstracts: Daniel Cohen (Stanford University, USA)
"Directly Engineering Collective Cell Migration Through Herding Mechanisms" |
| 12:25 pm - 12:30 pm | Selected from Poster Abstracts: Hadir Marei (Cancer Research UK Manchester Institute, United Kingdom)
"Tiam1 and P-Rex1: Driving Differential Rac1 Protein Interactions" |
| 12:30 pm | Lunch |
| 1:30 pm - 4:00 pm | Free Time |
| 4:00 pm - 6:00 pm | Poster Session |
| 6:00 pm | Dinner |
| 7:30 pm - 9:30 pm | Receptor and Calcium Signaling During Cell Migration |
| Discussion Leader: Jeffrey Segall (Albert Einstein College of Medicine, USA) |
| 7:30 pm - 7:50 pm | Tracy Handel (University of California, San Diego, USA)
"Structural Biology of the Metastasis Promoting
Chemokine Receptor, CXCR4" |
| 7:50 pm - 8:00 pm | Discussion |
| 8:00 pm - 8:20 pm | Narasimhan Gautam (Washington University at St. Louis School of Medicine, USA)
"Using Optical Control to Understand Immune and Cancer Cell Migration" |
| 8:20 pm - 8:30 pm | Discussion |
| 8:30 pm - 8:50 pm | Tobias Meyer (Stanford University, USA)
"Calcium Signaling During Chemotaxis" |
| 8:50 pm - 9:00 pm | Discussion |
| 9:00 pm - 9:10 pm | Selected from Poster Abstracts: Richard Gomer (Texas A&M University, USA)
"Human DPPIV Is a Neutrophil Chemorepellent and a Potential Therapeutic for ARDS" |
| 9:10 pm - 9:15 pm | Discussion |
| 9:15 pm - 9:25 pm | Selected from Poster Abstracts: Tian Jin (NIAID/NIH, USA)
"Experimental Measuring and Computational Simulating Spatiotemporal Dynamics of Ras Signaling During Chemoattractant Gradient Sensing" |
| 9:25 pm - 9:30 pm | Discussion |
| Tuesday |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am - 12:30 pm | Cytoskeletal Events During Cell Migration |
| Discussion Leader: Michael Sixt (Institute of Science and Technology Austria, Austria) |
| 9:00 am - 9:20 am | James Bear (University of North Carolina, Chapel Hill, USA)
"The Chemotaxis and Haptotaxis of
Mesenchymal Tumor Cells: Implications for Invasion and Metastasis" |
| 9:20 am - 9:30 am | Discussion |
| 9:30 am - 9:50 am | Orion Weiner (University of California, San Francisco School of Medicine, USA)
"Understanding and Outwitting Adaptation in
Eukaryotic Chemotaxis" |
| 9:50 am - 10:00 am | Discussion |
| 10:00 am - 10:30 am | Coffee Break |
| 10:30 am - 10:50 am | Gaudenz Danuser (University of Texas Southwestern, USA)
"Rules of Migration Plasticity in Primary
Melanoma" |
| 10:50 am - 11:00 am | Discussion |
| 11:00 am - 11:20 am | Julie Theriot (Stanford University Medical School, USA)
"Molecular
Biochemistry of Cytoskeletal Components During Cell Migration" |
| 11:20 am - 11:30 am | Discussion |
| 11:30 am - 11:40 am | Selected from Poster Abstracts: Dianne Cox (Albert Einstein College of Medicine, USA)
"A Novel Role for Wiskott-Aldrich Syndrome Protein (WASP) in the Regulation of Macrophage Nanotubes" |
| 11:40 am - 11:45 am | Discussion |
| 11:45 am - 11:55 am | Selected from Poster Abstracts: Vinay Swaminathan (National Heart Lung and Blood Institute, NIH, USA)
"Focal Adhesion Kinase Links Lamellipodial Actin and Nascent Adhesions to the ECM Through the Arp2/3 Complex to Regulate Leading Edge Dynamics and ECM Sensing" |
| 11:55 am - 12:00 pm | Discussion |
| 12:00 pm - 12:10 pm | Selected from Poster Abstracts: John Hammer (NHLBI/NIH, USA)
"Myosin 18A Coassembles with Nonmuscle Myosin II" |
| 12:10 pm - 12:15 pm | Discussion |
| 12:15 pm - 12:20 pm | Selected from Poster Abstracts: Bojana Gligorijevic (Temple University, USA)
"Tumor Microenvironment Predicts Tumor Cell Fate" |
| 12:20 pm - 12:25 pm | Selected from Poster Abstracts: Joanna MacKay (University of Pennsylvania, USA)
"Stiff Substrates Enhance Leukocyte Recruitment from Fluid Flow" |
| 12:25 pm - 12:30 pm | Selected from Poster Abstracts: Ritankar Majumdar (National Cancer Institute, NIH, USA)
"Exosomes Mediate LTB4 Signal Relay During Neutrophil Chemotaxis" |
| 12:30 pm | Lunch |
| 1:30 pm - 4:00 pm | Free Time |
| 4:00 pm - 6:00 pm | Poster Session |
| 6:00 pm | Dinner |
| 7:30 pm - 9:30 pm | Cell Migration and Function |
| Discussion Leader: Daniel Fletcher (University of California, Berkeley, USA) |
| 7:30 pm - 7:50 pm | Jingsong Xu (University of Illinois, USA)
"Oxidant Sensing by TRPM2 Inhibits Neutrophil
Migration and Mitigates Inflammation" |
| 7:50 pm - 8:00 pm | Discussion |
| 8:00 pm - 8:20 pm | Daria Siekhaus (Institute of Science and Technology Austria, Austria)
"Studying the Invasive Migration of
Drosophila Immune Cells" |
| 8:20 pm - 8:30 pm | Discussion |
| 8:30 pm - 8:50 pm | Konstantinos Konstantopoulos (Johns Hopkins University, USA)
"Water Permeation Regulates Tumor
Cell Migration in Confined Microenvironments" |
| 8:50 pm - 9:00 pm | Discussion |
| 9:00 pm - 9:10 pm | Selected from Poster Abstracts: Justin Chung (Johns Hopkins University School of Public Health, USA)
"Keratin-Dependent Regulation of Gene Expression During Tumor Cell Growth and Invasion" |
| 9:10 pm - 9:15 pm | Discussion |
| 9:15 pm - 9:25 pm | Selected from Poster Abstracts: Fanny Jaulin (Gustave Roussy Institute - CNRS, France)
"Collective Behavior in Colorectal Carcinoma Dissemination to the Peritoneal Cavity" |
| 9:25 pm - 9:30 pm | Discussion |
| Wednesday |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am - 12:30 pm | Cell Migration in In Vivo Settings |
| Discussion Leader: Andrew Ewald (Johns Hopkins University School of Medicine, USA) |
| 9:00 am - 9:20 am | John Condeelis (Albert Einstein College of Medicine, USA)
"Mechanisms of Chemotaxis-Regulated Tumor Cell
Dissemination In Vivo" |
| 9:20 am - 9:30 am | Discussion |
| 9:30 am - 9:50 am | Peter Friedl (Radbound University Nijmegen, The Netherlands)
"Tissue Guidance of Cancer Cell Invasion In Vivo" |
| 9:50 am - 10:00 am | Discussion |
| 10:00 am - 10:30 am | Coffee Break |
| 10:30 am - 10:50 am | Michael Sixt (Institute of Science and Technology Austria, Austria)
"How Do Cells Make Directional
Decisions?" |
| 10:50 am - 11:00 am | Discussion |
| 11:00 am - 11:20 am | Erik Sahai (Cancer Research UK London Research Institute, United Kingdom)
"Cancer Cell Invasion in Complex Environments" |
| 11:20 am - 11:30 am | Discussion |
| 11:30 am - 11:40 am | Selected from Poster Abstracts: Frank Gertler (Massachusetts Institute of Technology, USA)
"Regulation of Bi-Directional Signaling Between the Matrisome and Tumor Cells" |
| 11:40 am - 11:45 am | Discussion |
| 11:45 am - 11:55 am | Selected from Poster Abstracts: Andrew Ewald (Johns Hopkins University School of Medicine, USA)
"Distant Metastasis Occurs Through Collective Epithelial Dissemination" |
| 11:55 am - 12:00 pm | Discussion |
| 12:00 pm - 12:10 pm | Selected from Poster Abstracts: Ronen Alon (The Weizmann Institute of Science, Israel)
"Chemoattracted Leukocytes Squeeze Through Inflamed Endothelial Barriers via Myosin-Independent Displacement of Endothelial Actin Guided by Leukocyte Nuclear Lobes" |
| 12:10 pm - 12:15 pm | Discussion |
| 12:15 pm - 12:20 pm | Selected from Poster Abstracts: Gema Malet-Engra (IFOM, Italy)
"Collective Cell Motility Promotes Chemotactic Prowess and Resistance to Chemorepulsion" |
| 12:20 pm - 12:25 pm | Selected from Poster Abstracts: Shirin Pocha (University of California, Santa Barbara, USA)
"The Role of Basolatteral Complexes in Collective Cell Migration" |
| 12:25 pm - 12:30 pm | Selected from Poster Abstracts: Elena Scarpa (University College London, United Kingdom)
"A Contact Dependent Polarity Leads to Adhesion Disassembly in Contact Inhibition of Locomotion" |
| 12:30 pm | Lunch |
| 1:30 pm - 4:00 pm | Free Time |
| 4:00 pm - 6:00 pm | Poster Session |
| 6:00 pm | Dinner |
| 7:00 pm - 7:30 pm | Business Meeting |
| Nominations for the Next Vice Chair; Fill in Conference Evaluation Forms; Discuss Future Site and Scheduling Preferences; Election of the Next Vice Chair |
| 7:30 pm - 9:30 pm | Mechanotransduction During Cell Migration |
| Discussion Leader: Xavier Trepat (Institut de Bioenginyeria de Catalunya, Spain) |
| 7:30 pm - 7:50 pm | Daniel Fletcher (University of California, Berkeley, USA)
"The
Multiple Modes of Mechanotransduction" |
| 7:50 pm - 8:00 pm | Discussion |
| 8:00 pm - 8:20 pm | Wolfgang Losert (University of Maryland, USA)
"Dynamic Contact Guidance of Cell Migration via Actin Waves" |
| 8:20 pm - 8:30 pm | Discussion |
| 8:30 pm - 8:40 pm | Selected from Poster Abstracts: Daniel Irimia (Massachusetts General Hospital, Harvard Medical School, USA)
"Novel Tools for Old Questions in Neutrophil Migration" |
| 8:40 pm - 8:45 pm | Discussion |
| 8:45 pm - 8:55 pm | Selected from Poster Abstracts: Kandice Tanner (NCI/NIH, USA)
"Is There a Morphogenetic Program That Governs Tissue Tropism?" |
| 8:55 pm - 9:00 pm | Discussion |
| 9:00 pm - 9:10 pm | Selected from Poster Abstracts: Xavier Trepat (Institut de Bioenginyeria de Catalunya, Spain)
"Control of Cell-Cell Forces and Collective Cell Migration by the Intercellular Adhesome" |
| 9:10 pm - 9:15 pm | Discussion |
| 9:15 pm - 9:25 pm | Selected from Poster Abstracts: Mingming Wu (Cornell University, USA)
"Microfluidics for Cancer Cell Invasion" |
| 9:25 pm - 9:30 pm | Discussion |
| Thursday |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am - 12:30 pm | Collective Cell Migration |
| Discussion Leader: Anna Huttenlocher (University of Wisconsin, Madison, USA) |
| 9:00 am - 9:20 am | Denise Montell (University of California, Santa Barbara, USA)
"E-Cadherin Orchestrates Collective Chemotaxis of
Border Cells" |
| 9:20 am - 9:30 am | Discussion |
| 9:30 am - 9:50 am | Eric Theveneau (CNRS/Universite Paul Sabatier, France)
"Cell-Microenvrionment Interactions During Collective Cell Migration" |
| 9:50 am - 10:00 am | Discussion |
| 10:00 am - 10:30 am | Coffee Break |
| 10:30 am - 10:50 am | Darren Gilmour (European Molecular Biology Laboratory, Germany)
"Directional Tissue Migration
Through a Self-Generated Chemokine Gradient" |
| 10:50 am - 11:00 am | Discussion |
| 11:00 am - 11:20 am | Pascal Silberzan (Institut Curie, France)
"Emergence of Collective Cell Behaviors in
Complex Microenvironments" |
| 11:20 am - 11:30 am | Discussion |
| 11:30 am - 11:40 am | Selected from Poster Abstracts: Ajay Chitnis (NICHD/NIH, USA)
"Using Agent Based Models to Understand Morphogenesis of the Zebrafish Posterior Lateral Line Primordium" |
| 11:40 am - 11:45 am | Discussion |
| 11:45 am - 11:55 am | Selected from Poster Abstracts: Eli Arama (Weizmann Institute of Science, Israel)
"Irradiation-Induced Cell Migration and Invasion of Apoptosis-Resistant Epithelial Cells in Drosophila" |
| 11:55 am - 12:00 pm | Discussion |
| 12:00 pm - 12:10 pm | Selected from Poster Abstracts: Mihoko Kato (California Institute of Technology, USA)
"LINKIN, a Cell Adhesion Molecule Required During Collective Migration" |
| 12:10 pm - 12:15 pm | Discussion |
| 12:15 pm - 12:20 pm | Selected from Poster Abstracts: Kirk Schroeder (Essen BioScience, USA)
"A New Technology for In Vitro Chemotaxis Assays" |
| 12:20 pm - 12:25 pm | Selected from Poster Abstracts: Monica Skoge (University of California, San Diego, USA)
"Molecular Mechanisms of Memory in Chemotaxis" |
| 12:25 pm - 12:30 pm | Selected from Poster Abstracts: Safia Thaminy (ETH Zurich, Switzerland)
"Understanding the Mechanism of Cancer Progression Under Hypoxia" |
| 12:30 pm | Lunch |
| 1:30 pm - 4:00 pm | Free Time |
| 4:00 pm - 6:00 pm | Poster Session |
| 6:00 pm | Dinner |
| 7:30 pm - 9:30 pm | Cell Polarity and Adhesion During Cell Migration |
| Discussion Leader: James Bear (University of North Carolina, Chapel Hill, USA) |
| 7:30 pm - 7:50 pm | Johanna Ivaska (University of Turku, Finland)
"Integrin-Mediated Regulation of Breast Cancer Metastasis" |
| 7:50 pm - 8:00 pm | Discussion |
| 8:00 pm - 8:20 pm | Gregg Gundersen (Columbia University, USA)
"Integrin Recycling Is Coupled to Adhesion Formation by FAK and Src to Promote Cell Migration" |
| 8:20 pm - 8:30 pm | Discussion |
| 8:30 pm - 8:50 pm | Alpha Yap (The University of Queensland, Australia)
"Active Mechanical Tissues, Cell Junctions and Cancer Cell Extrusion" |
| 8:50 pm - 9:00 pm | Discussion |
| 9:00 pm - 9:10 pm | Selected from Poster Abstracts: Jason Haugh (North Carolina State University, USA)
"F-Actin Bundles Direct the Initiation and Orientation of Lamellipodia Through Adhesion-Based Signaling" |
| 9:10 pm - 9:15 pm | Discussion |
| 9:15 pm - 9:25 pm | Selected from Poster Abstracts: Takanari Inoue (Johns Hopkins University, USA)
"Interplay Between Chemotaxis and Contact Inhibition of Locomotion Determines Exploratory Cell Migration" |
| 9:25 pm - 9:30 pm | Discussion |
| Friday |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am | Departure |
