Sunday
4:00 pm - 8:00 pm
Arrival and Check-in
6:00 pm - 7:00 pm
Dinner
7:30 pm - 7:40 pm
Introductory Comments by GRC Site Staff / Welcome from the GRC Chair
7:40 pm - 9:30 pm
Keynote Session: 25 Years of Rac and Rho
Session in honor of Alan Hall.
Discussion Leader: Tatiana Omelchenko (Memorial Sloan Kettering Cancer Center, USA)
7:40 pm - 7:50 pm
Opening Remarks
7:50 pm - 8:30 pm
Anne Ridley (King's College London, United Kingdom)
"Migration
Across the Endothelial Barrier"
8:30 pm - 8:40 pm
Discussion
8:40 pm - 9:20 pm
Sandrine Etienne-Mannevile (Institut Pasteur, France)
"Role
of Intermediate Filaments in Directed Collective Migration"
9:20 pm - 9:30 pm
Discussion
Monday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Group Photo
9:00 am - 12:30 pm
Directed Cell Migration in Development
Discussion Leader: Andrew Ewald (Johns Hopkins University School of Medicine, USA)
9:00 am - 9:25 am
Roberto Mayor (University College London, United Kingdom)
"Collective
Cell Migration During Development: The Case of the Neural Crest"
9:25 am - 9:35 am
Discussion
9:35 am - 10:00 am
Sally Horne-Badovinac (University of Chicago, USA)
"Fat2
and Lar Promote Epithelial Migration by Coordinating Leading Edge Trailing Edge Dynamics Between Neighboring Cells"
10:00 am - 10:10 am
Discussion
10:10 am - 10:20 am
Tatiana Omelchenko (Memorial Sloan Kettering Cancer Center, USA)
"The Small Rho GTPase GEF Beta-Pix Regulates Collective Mesoderm Migration In Vivo "
10:20 am - 10:25 am
Discussion
10:25 am - 10:35 am
Daria Siekhaus (Institute of Science and Technology Austria, Austria)
"Drosophila TNF, Eiger, Regulates Tissue Tension Through the Crumbs Complex to Facilitate Macrophage Invasive Migration During Embryogenesis"
10:35 am - 10:40 am
Discussion
10:40 am - 11:10 am
Coffee Break
11:10 am - 11:35 am
Brian Stramer (Kings College London, United Kingdom)
"Contact Inhibition Drives the Even Distribution of ECM During Drosophila Development"
11:35 am - 11:45 am
Discussion
11:45 am - 12:05 pm
Eduardo Moreno (Champalimaud Foundation, Portugal)
"Oncogene Induced Cell Intercalation and Tissue Destruction"
12:05 pm - 12:15 pm
Discussion
12:15 pm - 12:30 pm
Poster Previews
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Chemotaxis Signaling
Discussion Leader: Milka Sarris (University of Cambridge, United Kingdom)
7:30 pm - 7:55 pm
Carole Parent (National Cancer Institute, NIH, USA)
"Exosomes as Key Regulators of Signal Relay During Chemotaxis"
7:55 pm - 8:05 pm
Discussion
8:05 pm - 8:30 pm
Robert Insall (University of Glasgow, United Kingdom)
"Self-Generated Gradients - Chemotaxis Works Differently when Cells Make Their Own Directions"
8:30 pm - 8:40 pm
Discussion
8:40 pm - 9:05 pm
Peter Devreotes (Johns Hopkins University School of Medicine, USA)
"Excitable Networks in Directed Cell Migration"
9:05 pm - 9:15 pm
Discussion
9:15 pm - 9:25 pm
Peter Van Haastert (University of Groningen, The Netherlands)
"New Signaling Networks for Symmetry Breaking and Directed Cell Movement"
9:25 pm - 9:30 pm
Discussion
Tuesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Directed Cell Migration in Wound Repair
Discussion Leader: Ronald Germain (National Institute of Allergy and Infectious Diseases, NIH, USA)
9:00 am - 9:25 am
Anna Huttenlocher (University of Wisconsin-Madison, USA)
"Chemokine Signaling in Bidirectional Migration"
9:25 am - 9:35 am
Discussion
9:35 am - 9:45 am
William Holmes (Vanderbilt University, USA)
"Crosstalk Between Rac and Rho GTPases Promote Morphological Heterogeneity Among Motile Cells"
9:45 am - 9:50 am
Discussion
9:50 am - 10:15 am
Tobias Meyer (Stanford University, USA)
"Engulfed
Cadherin Fingers Guide Endothelial Cells During Collective Migration"
10:15 am - 10:25 am
Discussion
10:25 am - 10:35 am
Abhijit Deb Roy (University of Connecticut Health Center, USA)
"An Optogenetic Approach to Elucidate Contact Inhibition of Locomotion Between Osteoclasts and Osteoblasts"
10:35 am - 10:40 am
Discussion
10:40 am - 11:10 am
Coffee Break
11:10 am - 11:35 am
Will Wood (University of Bristol, United Kingdom)
"Detecting
Death and Damage: Macrophage Migration in Drosophila "
11:35 am - 11:45 am
Discussion
11:45 am - 11:55 am
Varuzhan Balasanyan (University of California, Santa Barbara, USA)
"Cells Recovering from the Brink of Apoptotic Cell Death Acquire Migration Capacity Through TGFβ Signaling and Snail"
11:55 am - 12:00 pm
Discussion
12:00 pm - 12:10 pm
Sylvain Gabriele (University of Mons, Belgium)
"The Mechanosensitivity of Motile Keratocytes Depends on α5β1 Integrin Engagement"
12:10 pm - 12:15 pm
Discussion
12:15 pm - 12:30 pm
Poster Previews
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Cell Migration in Cancer
Discussion Leader: Celeste Nelson (Princeton University, USA)
7:30 pm - 7:55 pm
Andrew Ewald (Johns Hopkins University School of Medicine, USA)
"Collective Cell Migrations Driving Mammary Morphogenesis and Breast Cancer Metastasis"
7:55 pm - 8:05 pm
Discussion
8:05 pm - 8:30 pm
Erik Sahai (The Francis Crick Institute, United Kingdom)
"Cancer
Cell Invasion in Complex Environments"
8:30 pm - 8:40 pm
Discussion
8:40 pm - 8:50 pm
Meghan Driscoll (University of Texas Southwestern Medical Center, USA)
"Identifying Stereotypical Cellular Morphological Structures from High-Resolution 3D Images of Living Cells"
8:50 pm - 8:55 pm
Discussion
8:55 pm - 9:20 pm
Cynthia Reinhart-King (Vanderbilt University, USA)
"Mechanical and Structural Matrix Cues Direct Metastatic Cell Migration"
9:20 pm - 9:30 pm
Discussion
Wednesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Immune Cell Migration
Discussion Leader: Anna Huttenlocher (University of Wisconsin-Madison, USA)
9:00 am - 9:25 am
Ronald Germain (National Institute of Allergy and Infectious Diseases, NIH, USA)
"Imaging the Immune
System – Insights into Control of Cell Directionality and Migration"
9:25 am - 9:35 am
Discussion
9:35 am - 10:00 am
Milka Sarris (University of Cambridge, United Kingdom)
"Gradient Sensing in Interstitial Leukocyte Migration"
10:00 am - 10:10 am
Discussion
10:10 am - 10:20 am
Judy Cannon (University of New Mexico School of Medicine, USA)
"Environmental Influences on T Cell Motion in Intact Tissues"
10:20 am - 10:25 am
Discussion
10:25 am - 10:35 am
Daniel Irimia (Harvard Medical School, USA)
"Multiple Chemoattractants and One Stop Signal Mediate Human Neutrophil Swarming"
10:35 am - 10:40 am
Discussion
10:40 am - 11:10 am
Coffee Break
11:10 am - 11:35 am
Orion Weiner (UCSF School of Medicine, USA)
"Signal Integration During Neutrophil Chemotaxis"
11:35 am - 11:45 am
Discussion
11:45 am - 11:55 am
Tian Jin (NIAID, NIH, USA)
"Phagocytes of Dictyostelium and Neutrophils Use Chemoattractant GPCRs to Mediate both Chemotaxis and Phagocytosis for Catching and Ingesting Bacteria"
11:55 am - 12:00 pm
Discussion
12:00 pm - 12:10 pm
Takanari Inoue (Johns Hopkins University, USA)
"Membrane Curvature Dictates Local PI3K Signaling"
12:10 pm - 12:15 pm
Discussion
12:15 pm - 12:30 pm
Poster Previews
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:00 pm - 7:30 pm
Business Meeting
Nominations for the Next Vice Chair; Fill in Conference Evaluation Forms; Discuss Future Site and Scheduling Preferences; Election of the Next Vice Chair
7:30 pm - 9:30 pm
Mechanics of Cell Migration
Discussion Leader: Tobias Meyer (Stanford University, USA)
7:30 pm - 7:55 pm
Nir Gov (Weizmann Institute of Science, Israel)
"Theoretical Models for Single and Collective Cell Motility"
7:55 pm - 8:05 pm
Discussion
8:05 pm - 8:30 pm
Clare Waterman (National Institutes of Health, USA)
"FMN2 Is a Melanoma Metastasis-Promoter that Mediates Formation of a Perinuclear Actin/Adhesion System to Protect Nuclei and DNA from Damage During Confined Cell Migration"
8:30 pm - 8:40 pm
Discussion
8:40 pm - 9:05 pm
Robert Kay (MRC Laboratory of Molecular Biology, United Kingdom)
"The Piezo Channel Transduces Mechanical Information to Control How Dictyostelium Cells Move"
9:05 pm - 9:15 pm
Discussion
9:15 pm - 9:25 pm
Christalyn Rhodes (Harvard T.H. Chan School of Public Health, USA)
"Rhinovirus Induces TGF-Beta Dependent Collective Cellular Migration in Airway Epithelial Cells in Normal and Asthmatic Donors"
9:25 pm - 9:30 pm
Discussion
Thursday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Migration and Metastasis
Discussion Leader: Erik Sahai (The Francis Crick Institute, United Kingdom)
9:00 am - 9:25 am
Peter Friedl (Radboud University Nijmegen Medical Centre, The Netherlands)
"Plasticity
of Cell Migration: Integrins and the Microenvironment"
9:25 am - 9:35 am
Discussion
9:35 am - 10:00 am
Raghu Kalluri (University of Texas MD Anderson Cancer Center, USA)
"The Biology and Function of EMT in Pancreatic Cancer"
10:00 am - 10:10 am
Discussion
10:10 am - 10:20 am
Minna Roh (Fred Hutchinson Cancer Research Center, USA)
"Macrophage-Dependent Cytoplasmic Transfer Drives Melanoma Metastasis In Vivo "
10:20 am - 10:25 am
Discussion
10:25 am - 10:55 am
Coffee Break
10:55 am - 11:20 am
Adam Marcus (Emory University School of Medicine, USA)
"Image-Guided Genomics Reveals Cellular Symbiosis During Cancer Invasion"
11:20 am - 11:30 am
Discussion
11:30 am - 11:40 am
Fanny Jaulin (Institut Gustave Roussy, France)
"Collective Epithelial-Based Metastases in Colorectal Carcinoma Patients"
11:40 am - 11:45 am
Discussion
11:45 am - 11:55 am
Jennifer Mitchel (Harvard T.H. Chan School of Public Health, USA)
"The Unjamming Transition Is Distinct from the Epithelial-to-Mesenchymal Transition"
11:55 am - 12:00 pm
Discussion
12:00 pm - 12:10 pm
Jamie Nosbisch (North Carolina State University, USA)
"A Reaction-Diffusion Model Explains Amplification of the Phospholipase C/Protein Kinase C Pathway in Fibroblast Chemotaxis"
12:10 pm - 12:15 pm
Discussion
12:15 pm - 12:30 pm
Poster Previews
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Cytoskeleton Dynamics in Migrating Cells
Discussion Leader: Sandrine Etienne-Mannevile (Institut Pasteur, France)
7:30 pm - 7:55 pm
James Bear (University of North Carolina School of Medicine, USA)
"GPCR vs. RTK Chemotaxis in Fibroblasts: Putting Old Players to Work in New Ways"
7:55 pm - 8:05 pm
Discussion
8:05 pm - 8:15 pm
Jordan Beach (Loyola University Stritch School of Medicine, USA)
"Actin Dynamics and Competition for Myosin Monomer Govern the Sequential Amplification of Myosin Filaments"
8:15 pm - 8:20 pm
Discussion
8:20 pm - 8:45 pm
Margaret Gardel (The University of Chicago, USA)
"Spatial Regulation of RhoA Reveals Zyxin-Mediated
Elasticity of Stress Fibers"
8:45 pm - 8:55 pm
Discussion
8:55 pm - 9:20 pm
Michael Sixt (Institute of Science and Technology Austria, Austria)
"Topography-Based Force Transduction"
9:20 pm - 9:30 pm
Discussion
Friday
7:30 am - 8:30 am
Breakfast
9:00 am
Departure