Sunday
2:00 pm - 9:00 pm
Arrival and Check-in
6:00 pm - 7:00 pm
Dinner
7:30 pm - 7:40 pm
Introductory Comments by GRC Staff / Welcome and Introduction from the Chairs
7:40 pm - 9:30 pm
Keynote Session: Organization of Motile Systems on the Organismic and Molecular Scale
Discussion Leader: Peter Friedl (Radboud University Nijmegen Medical Centre, The Netherlands)
7:40 pm - 7:50 pm
Introduction by Discussion Leader
7:50 pm - 8:30 pm
Michael Sheetz (University of Texas Medical Branch, United States)
"The Mechanobiology of Three Cell States: Normal, Transformed and Senescent"
8:30 pm - 8:40 pm
Discussion
8:40 pm - 9:20 pm
Denise Montell (University of California, United States)
"New Tricks for Rac and Rho Even After 30 years"
9:20 pm - 9:30 pm
Discussion
Monday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Group Photo
9:00 am - 12:30 pm
Cell Shape and Force Transmission
Discussion Leader: Peter Devreotes (Johns Hopkins University School of Medicine, United States)
9:00 am - 9:05 am
Introduction by Discussion Leader
9:05 am - 9:25 am
Dyche Mullins (UCSF, United States)
"How the Plasma Membrane Controls the Assembly and Physical Properties of Lamellipodial Actin Networks"
9:25 am - 9:30 am
Discussion
9:30 am - 9:50 am
Anna Akhmanova (Utrecht University, The Netherlands)
"Regulation of Cell Migration by Dynamic Microtubules"
9:50 am - 9:55 am
Discussion
9:55 am - 10:05 am
Wenhui Tang (MIT, United States)
"Collective Curvature Sensing and Fluidity in Three-Dimensional Multicellular Systems"
10:05 am - 10:10 am
Discussion
10:10 am - 10:20 am
Alexia Caillier (Loyola University Chicago, United States)
"T Cells Switch Migration Mode to Maneuver Complex Environments"
10:20 am - 10:25 am
Discussion
10:25 am - 10:55 am
Coffee Break
10:55 am - 11:05 am
Alexander Thiemicke (WCM, United States)
"Quantifying Cell Polarization Changes Over Time on Polarizing Micropatterns"
11:05 am - 11:10 am
Discussion
11:10 am - 11:30 am
Holger Knaut (New York University School of Medicine, United States)
"Pushing From Behind - The Mechanics of Tissue Migration"
11:30 am - 11:35 am
Discussion
11:35 am - 11:45 am
Ankita Jha (National Institutes of Health, United States)
"Front-Rear Polarity Establishment During Bleb-Based Migration Under Confinement"
11:45 am - 11:50 am
Discussion
11:50 am - 12:10 pm
Hideaki Matsubayashi (Tohoku University, Japan)
"Synthesizing Motility in Artificial Cells by Asymmetrically Reconstituted Actin Polymerization"
12:10 pm - 12:15 pm
Discussion
12:15 pm - 12:30 pm
General Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
3:00 pm - 4:00 pm
The GRC Power Hour™
The GRC Power Hour™ is designed to address diversity and inclusion in the scientific workplace by providing a safe environment for informal and meaningful conversations amongst colleagues of all career stages. The program supports the professional growth of all members of our communities, including ethnicity, race and/or gender identity by providing an open forum for discussion and mentoring.
Organizer: Ana-Maria Lennon-Dumenil (Institut Curie, France)
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Collective Cell Migration
Discussion Leader: Denise Montell (University of California, United States)
7:30 pm - 7:35 pm
Introduction by Discussion Leader
7:35 pm - 7:55 pm
Nir Gov (Weizmann Institute of Science, Israel)
"A "Minimal Cell" Model: Cell Migration Driven by Curved Proteins that Recruit Actin Polymarization"
7:55 pm - 8:00 pm
Discussion
8:00 pm - 8:10 pm
Michael Riedl (Institute of Science and Technology Austria, Austria)
"Synchronization in Collectively Moving Inanimate and Living Active Matter"
8:10 pm - 8:15 pm
Discussion
8:15 pm - 8:35 pm
Daniel Cohen (Princeton University, United States)
"Cellular Herding: Understanding and Control of Collective Cell Dynamics"
8:35 pm - 8:40 pm
Discussion
8:40 pm - 8:50 pm
Subhash Arya (University of Michigan, United States)
"Secretion of DNA and Nuclear Envelope-Derived Exosomes from the Back of Actively Migrating Neutrophils"
8:50 pm - 8:55 pm
Discussion
8:55 pm - 9:15 pm
Benoit Ladoux ( CNRS Université Paris Cité, France)
"Nematic Activity in Collective Cell Migration"
9:15 pm - 9:20 pm
Discussion
9:20 pm - 9:30 pm
General Discussion
Tuesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Evolution of Cell Motility
Discussion Leader: Robert Insall (University of Glasgow, United Kingdom)
9:00 am - 9:05 am
Introduction by Discussion Leader
9:05 am - 9:25 am
Lillian Fritz-Laylin (University of Massachusetts Amherst, United States)
"Chytrid Fungi and the Evolution and Specification of Actin Networks"
9:25 am - 9:30 am
Discussion
9:30 am - 9:40 am
Tianqi Wang (Purdue University, United States)
"The Membrane Potential Gradient is Required for Neutrophil Directional Migration and the KCNJ13 is a Novel Regulator of Neutrophil Chemotaxis"
9:40 am - 9:45 am
Discussion
9:45 am - 10:05 am
Laurent Nguyen (University of Liege, Belgium)
"An Evo-Devo Perspective on Cortical Interneuron Migration in the Forebrain"
10:05 am - 10:10 am
Discussion
10:10 am - 10:20 am
Tanner Robertson (University of Wisconsin-Madison, United States)
"A Tessellated Lymphoid Network Provides Whole-Body T cell Surveillance in Zebrafish"
10:20 am - 10:25 am
Discussion
10:25 am - 10:55 am
Coffee Break
10:55 am - 11:05 am
Stephanie Woo (University of California Merced, United States)
"Contact Inhibition of Locomotion Functions as a Cell Spacing and Dispersal Mechanism in the Zebrafish Endoderm"
11:05 am - 11:10 am
Discussion
11:10 am - 11:30 am
Peter Devreotes (Johns Hopkins University School of Medicine, United States)
"Dynamic Self-Organizing Domains of the Plasma Membrane Control Cytoskeletal Activity in Cell Migration"
11:30 am - 11:35 am
Discussion
11:35 am - 11:45 am
Nathan Belliveau (University of Washington, United States)
"A Race to Identify the Genes that Support Neutrophil Cell Migration"
11:45 am - 11:50 am
Discussion
11:50 am - 12:10 pm
Elias Barriga (Instituto Gulbenkian de Ciencia, Portugal)
"Mechano-Electrical Control of Collective Cell Motion"
12:10 pm - 12:15 pm
Discussion
12:15 pm - 12:30 pm
General Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Pathfinding and Navigation
Discussion Leader: Milka Sarris (University of Cambridge, United Kingdom)
7:30 pm - 7:35 pm
Introduction by Discussion Leader
7:35 pm - 7:45 pm
Besaiz J. Sanchez Sanchez (King's College London, United Kingdom)
"Integration of Cortical and Lamellar Actin Networks is Required for the Migration of Drosophila Macrophages"
7:45 pm - 7:50 pm
Discussion
7:50 pm - 8:10 pm
Johanna Ivaska (University of Turku, Finland)
"Forces, Adhesion and Signaling in Migration Across Barriers"
8:10 pm - 8:15 pm
Discussion
8:15 pm - 8:35 pm
Andrew Ewald (Johns Hopkins University, United States)
"Diverse Migratory Strategies and Molecular Mechanisms of Metastasis Can Co-exist in the Same Breast Tumor"
8:35 pm - 8:40 pm
Discussion
8:40 pm - 8:50 pm
Satomi Matsuoka (Osaka University, Japan)
"Sphingomyelin Metabolism is Essential for Ras Activation, Clustering and Excitability in Cell Migration"
8:50 pm - 8:55 pm
Discussion
8:55 pm - 9:05 pm
Matthias Krause (King's College London, United Kingdom)
"Control of Lamellipodial Arp2/3 Activity Supporting Cell Migration"
9:05 pm - 9:10 pm
Discussion
9:10 pm - 9:20 pm
Stefan Lundgren (University of California, Davis, United States)
"Signaling Dynamics Distinguish High and Low Priority Neutrophil Attractant Receptors"
9:20 pm - 9:25 pm
Discussion
9:25 pm - 9:30 pm
General Discussion
Wednesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Inflammation and Regeneration
Discussion Leader: Orion Weiner (UCSF School of Medicine, United States)
9:00 am - 9:05 am
Introduction by Discussion Leader
9:05 am - 9:25 am
Ana-Maria Lennon-Dumenil (Institut Curie, France)
"Dendritic Cell Migration at Various Scales"
9:25 am - 9:30 am
Discussion
9:30 am - 9:40 am
John Hammer (National Heart, Lung, and Blood Institute, NIH, United States)
"Myosin 10 at the Tips of Filopodia-Derived Retraction Fibers Supports Adhesion During Mitosis When Conventional Focal Adhesions Disassemble"
9:40 am - 9:45 am
Discussion
9:45 am - 10:05 am
Milka Sarris (University of Cambridge, United Kingdom)
"Neutrophil Migration and Signaling Dynamics at Sites of Tissue Damage"
10:05 am - 10:10 am
Discussion
10:10 am - 10:20 am
Laura Faure (Institute for Bioengineering of Catalonia, Spain)
"A New System Revels That Single Epithelial Cells Can Exert Pushing Forces on Their Environment"
10:20 am - 10:25 am
Discussion
10:25 am - 10:55 am
Coffee Break
10:55 am - 11:05 am
Yelena Bernadskaya (New York University, United States)
"Better Together: Polarization and Directionality of Collective Cell Migration"
11:05 am - 11:10 am
Discussion
11:10 am - 11:30 am
Andres Hidalgo (Yale University, United States)
"Data Noise and Immune Behaviors"
11:30 am - 11:35 am
Discussion
11:35 am - 11:45 am
Benjamin Lin (NYU School of Medicine, United States)
"An AMPK Phosphoregulated RhoGEF Feedback Loop Drives Shape Invariant Amoeboid Migration In Vivo"
11:45 am - 11:50 am
Discussion
11:50 am - 12:10 pm
Balázs Enyedi (Semmelweis University, Hungary)
""Inflamapping" with GEM-LTB4: Live Visualization of LTB4 Gradients With a Novel Fluorescent Biosensor"
12:10 pm - 12:15 pm
Discussion
12:15 pm - 12:30 pm
General Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Pathophysiology and Mailignancy
Discussion Leader: David Sherwood (Duke University, United States)
7:30 pm - 7:35 pm
Introduction by Discussion Leader
7:35 pm - 7:55 pm
Peter Friedl (Radboud University Nijmegen Medical Centre, The Netherlands)
"Exploring the Crossroads of Collective Invasion, Metastasis and Therapy Resistance"
7:55 pm - 8:00 pm
Discussion
8:00 pm - 8:10 pm
Motoyuki Ogawa (University of Tokyo, Japan)
"NOS3-Mediated S-Nitrosylation Induces FGF21 as a "Kick-Me-Out" Signal to Cause a Tumor-Suppressive Cell Competition"
8:10 pm - 8:15 pm
Discussion
8:15 pm - 8:35 pm
Danijela Matic Vignjevic (Institut Curie, France)
"Cell-Cell and Cell-Matrix Adhesions in Migrating Gut Epithelial Cells in Homeostasis"
8:35 pm - 8:40 pm
Discussion
8:40 pm - 8:50 pm
Samantha Stam (University of Utah, United States)
"A Molecular Link Between Mitochondria and Cell Polarity Tethers Mitochondria and is Tuned by Relative Expression Level"
8:50 pm - 8:55 pm
Discussion
8:55 pm - 9:15 pm
Kandice Tanner (NIH, United States)
"Microenvironment Regulation of Metastasis"
9:15 pm - 9:20 pm
Discussion
9:20 pm - 9:30 pm
General Discussion
Thursday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Business Meeting
Nominations for the Next Vice Chair(s); Complete the GRC Evaluation Forms; Discuss Future Dates and Venue; Election of the Next Vice Chair(s)
9:00 am - 12:30 pm
Polarity and Directional Guidance
Discussion Leader: Dyche Mullins (UCSF, United States)
9:00 am - 9:05 am
Introduction by Discussion Leader
9:05 am - 9:25 am
Orion Weiner (UCSF School of Medicine, United States)
"Breaking the Diffusion Limit: Rapid Signal Propagation within and Between Migrating Cells"
9:25 am - 9:30 am
Discussion
9:30 am - 9:40 am
Meghan Driscoll (University of Minnesota, United States)
"Migration Through Dense Environments via Protease-Free Digging"
9:40 am - 9:45 am
Discussion
9:45 am - 10:05 am
Marino Arroyo (Universitat Politècnica de Catalunya, Spain)
"Physical Principles of Cellular Dynamics During Homeostasis in Intestinal Organoids"
10:05 am - 10:10 am
Discussion
10:10 am - 10:20 am
Abhijit Deb Roy (Johns Hopkins Medical Institute, United States)
"Dynamic Microtubule Acetylation Drives Actomyosin Contractility in Directional Cell Migration"
10:20 am - 10:25 am
Discussion
10:25 am - 10:55 am
Coffee Break
10:55 am - 11:05 am
Jose Martínez Magdaleno (University of Fribourg, Switzerland)
"Exocrine Gland-Resident Memory CD8+ T Cells Use Mechanosensing for Tissue Surveillance"
11:05 am - 11:10 am
Discussion
11:10 am - 11:30 am
Robert Insall (University of Glasgow, United Kingdom)
"Self-Generated Gradients, Interacting Attractants, and Negative Chemotaxis"
11:30 am - 11:35 am
Discussion
11:35 am - 11:45 am
Maria Akhmanova (IST Austria, Austria)
"Macrophage Infiltration into Cell-Packed Tissues: Effects of Tissue Divisions"
11:45 am - 11:50 am
Discussion
11:50 am - 12:10 pm
Janis Burkhardt (University of Pennsylvania and Children's Hospital of Philadelphia Research Institute, United States)
"Chemoattractant-Specific T cell Motile Mechanisms"
12:10 pm - 12:15 pm
Discussion
12:15 pm - 12:30 pm
General Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Cell-Tissue Crosstalk
Discussion Leader: Johanna Ivaska (University of Turku, Finland)
7:30 pm - 7:35 pm
Introduction by Discussion Leader
7:35 pm - 7:45 pm
Jörg Renkawitz (Ludwig Maximilian University of Munich, Germany)
"Centrosome Fracturing by Cellular Motility Forces"
7:45 pm - 7:50 pm
Discussion
7:50 pm - 8:10 pm
Jordan Jacobelli (Univ. of Colorado School of Medicine / Barbara Davis Center, United States)
"Ena/VASP Proteins Regulate T Cell-Antigen Presenting Cell Interactions and T Cell Activation In Vivo"
8:10 pm - 8:15 pm
Discussion
8:15 pm - 8:25 pm
Arnold Hayer (McGill University, Canada)
"Pulsatile Rho Dynamics Drive Membrane Retractions in Motile Endothelial Cells"
8:25 pm - 8:30 pm
Discussion
8:30 pm - 8:40 pm
Tatsat Banerjee (Johns Hopkins University School of Medicine, United States)
"Dynamics of Inner Membrane Surface Charge Defines the Polarity During Amoeboid Migration"
8:40 pm - 8:45 pm
Discussion
8:45 pm - 8:55 pm
Jack Strickland (University of California - San Francisco, United States)
"Probing Cell-Cell Communication During Neutrophil Swarming"
8:55 pm - 9:00 pm
Discussion
9:00 pm - 9:20 pm
David Sherwood (Duke University, United States)
"Specialized High Capacity Mitochondria Fuel Cell Invasion Through Basement Membrane"
9:20 pm - 9:25 pm
Discussion
9:25 pm - 9:30 pm
General Discussion
Friday
7:30 am - 8:30 am
Breakfast
9:00 am
Departure
