Saturday
1:00 pm - 5:00 pm
Arrival and Check-in
3:30 pm - 3:45 pm
Introductory Comments by GRC Staff / Welcome and Introduction from the Chairs
3:45 pm - 4:30 pm
Keynote Session: Nucleus in Cell Migration: Cargo or Driver?
Discussion Leader: Benjamin Lin (NYU School of Medicine, United States)
3:45 pm - 3:50 pm
Introduction by Discussion Leader
3:50 pm - 4:20 pm
Carole Parent (University of Michigan, United States)
"The Neutrophil Nucleus: A Signaling Hub During Chemotaxis and NET Release."
4:20 pm - 4:30 pm
Discussion
4:30 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Biophysical Forces in Migrating Cells
Discussion Leaders: Sally Horne-Badovinac (University of Chicago, United States) and Tamas Nagy (University of California, San Francisco, United States)
7:30 pm - 7:40 pm
Shailaja Seetharaman (University of Chicago, United States)
"Mechanical Cues Tune the Differential Localization of LIM Domain Proteins"
7:40 pm - 7:45 pm
Discussion
7:45 pm - 7:55 pm
Isabela Corina Fortunato (Institute for Bioengineering of Catalonia (IBEC), Spain)
"Cell Guidance in Non-Monotonic Patterns of Fibronectin Density"
7:55 pm - 8:00 pm
Discussion
8:00 pm - 8:10 pm
Franklin Staback Rodríguez (University of Pennsylvania, United States)
"Cytoskeletal Regulation of Differential T Cell Chemotactic Responses"
8:10 pm - 8:15 pm
Discussion
8:15 pm - 8:25 pm
Ye Lim Lee (Washington University in St. Louis, United States)
"Matrix Obstructions Cause Multiscale Disruption in Collective Epithelial Migration by Suppressing the Physical Function of Leader Cells"
8:25 pm - 8:30 pm
Discussion
8:30 pm - 8:40 pm
Mugdha Sathe (University of Washington, United States)
"Migration of Zebrafish Epidermal T-Cells in Response to Electrical Signals After Wounding"
8:40 pm - 8:45 pm
Discussion
8:45 pm - 8:55 pm
Bo Gong (Weill Cornell Medicine, United States)
"Cell Movement Directed by Polarized ER-PM Contacts"
8:55 pm - 9:00 pm
Discussion
9:00 pm - 9:10 pm
Patricia Reis-Rodrigues (Institute of Science and Technology - IST Austria, Austria)
"A DOCK8 Dependent Central Actin Pool Acts as a Capacitor for F-Actin and Maintains Cellular Coherence"
9:10 pm - 9:15 pm
Discussion
9:15 pm - 9:25 pm
Benjamin Winer (Memorial Sloan Kettering Cancer Center and University of California San Francisco, United States)
"Pushing the Envelope: Plasma Membrane Abundance as an Integrator of Neutrophil Phagocytosis and Movement"
9:25 pm - 9:30 pm
Discussion
Sunday
7:30 am - 8:30 am
Breakfast
9:00 am - 11:00 am
The Many Modes of Cell Migration
Discussion Leaders: Michael Sixt (Institute of Science and Technology Austria, Austria) and Tatsat Banerjee (Johns Hopkins University School of Medicine, United States)
9:00 am - 9:10 am
Janina Kroll (Ludwig-Maximilians-University Munich, Germany)
"Nucleokinesis During Amoeboid Migration"
9:10 am - 9:15 am
Discussion
9:15 am - 9:25 am
Dhiman Pal (Johns Hopkins University School of Medicine, United States)
"Optical Activation of the Ras-Akt Network Tunes Polarity and Organizes Protrusions in Neutrophil Migration"
9:25 am - 9:30 am
Discussion
9:30 am - 9:40 am
Sierra Schwabach (University of Chicago, United States)
"Local Cell-Cell Interactions Mediate Global Symmetry Breaking in Collectively Migrating Follicle Cells"
9:40 am - 9:45 am
Discussion
9:45 am - 9:55 am
Wenhui Tang (MIT, United States)
"Collective Curvature Sensing and Fluidity in Three-Dimensional Multicellular Systems"
9:55 am - 10:00 am
Discussion
10:00 am - 10:10 am
Abhishek Mukherjee (National Institutes of Health, United States)
"Forces Due to Apical Constrictions and Cell Migration Oppose Each Other to Modulate Organ Morphogenesis from a Migrating Tissue"
10:10 am - 10:15 am
Discussion
10:15 am - 10:25 am
Madeleine Schmitt (Ludwig-Maximilians-University Munich, Germany)
"Mechanical Centrosome Fracturing During Cell Navigation"
10:25 am - 10:30 am
Discussion
10:30 am - 10:40 am
Jon Schrope (University of Wisconsin - Madison, United States)
"Open-Fluid Interfaces Enable the Study of Neutrophil Response to Physical Confinement and Biochemical Cues"
10:40 am - 10:45 am
Discussion
10:45 am - 11:00 am
General Discussion
11:00 am - 12:30 pm
Poster Session
Coffee will be served in the poster area from 11:00 am - 11:30 am
12:30 pm - 1:30 pm
Lunch
1:30 pm - 2:30 pm
Extracellular Cues Directing Migration
Discussion Leader: Ankita Jha (National Institutes of Health, United States)
1:30 pm - 1:35 pm
Introduction by Discussion Leader
1:35 pm - 2:05 pm
Johanna Ivaska (University of Turku, Finland)
"Holding On and Letting Go – Integrin Activity and Traffic in Cell Migration"
2:05 pm - 2:15 pm
Discussion
2:15 pm - 2:30 pm
General Discussion
2:30 pm - 3:00 pm
Evaluation Period
Complete the GRS Evaluation Forms; Election of Future Chair(s)
3:00 pm
Seminar Concludes
