Discussion Leader: William Bennett, City of Hope National Medical Center and Beckman Res. Inst.

• Philip Leder, Harvard Medical School, Boston, MA
  "Genome instability syndromes in mice"
• Charis Eng, Dana-Farber Cancer Institute, Boston, MA
  "PTEN mutations in two inherited hamartoma-cancer syndromes and sporadic tumors"
• Stanley Hamilton, Johns Hopkins Univ. School of Medicine, Baltimore, MD
  "Hereditary colon cancer"

Discussion Leader: Melanie Ehrlich, Tulane Med. Sch., New Orleans, LA

• Peter Laird, Univ. S. Calif., Sch. of Medicine, Los Angeles, CA
  "DNA methylation as a key player in genetic and epigenetic mechanisms of cancer"
• Jill James, National Center for Toxicol. Research, Jefferson, AR
  "DNA damage, repair and methylation dysregulation during multistage hepatocarcinogenesis"
• Jean-Pierre Issa, Johns Hopkins Sch. of Medicine, Baltimore MD
  "Mismatch repair deficiency and promoter methylation in colon cancer: Chicken or egg?"
• David Rodenhiser, Univ. W. Ontario, Ontario, Canada
  "CpG methylation at transcription factor binding sites within 5' regulatory and coding regions of tumor suppressing genes"
• Melanie Ehrlich, Tulane Med. Sch., New Orleans, LA
  "Hypomethylation in pericentromeric DNA vs. global methylation levels in ovarian tumors and in ICF, a pericentromeric chromosomal rearrangement-prone disease"

Discussion Leader: Wolf Reik, Brabraham Inst., Cambridge, UK

• Wolf Reik, Brabraham Inst., Cambridge, UK
  "New imprinting mutations in the distal chromosome 7 imprinting cluster in the mouse"
• Ben Tycko, Columbia Univ. College of Physicians and Surgeons, New York, NY
  "Genomic imprinting and imprinted genes in Wilms' tumors"
• Jeremy Squire, Ontario Cancer Institute, Ontario, Canada
  "FISH analysis of imprinted genes associated with neoplasia"
• Joanne Thorvaldsen, Univ. of Pennsylvania, Philadelphia, PA
  "The H19 differentially methylated region is required for imprinted expression of H19 and Igf2"
• Itamar Simon, Hebrew U. Med. School
  "Time of replication imprint formation during gametogenesis"

Discussion Leader: Bruce Demple, Harvard School of Public Health, Boston, MA

• Priscilla Cooper, Lawrence Berkeley National Laboratory, Univ. of California, Berkeley, CA
  "Defects in transcription-coupled repair of oxidative DNA damage in xeroderma pigmentosum and Cockayne syndrome: mechanisms and consequences"
• Sandy Markowitz, Univ. of Ohio, Cleveland OH
  "DNA repair defects and TGF-ß receptor mutations define a novel pathway of colon carcinogenesis"
• A.T. Natarajan, Leiden University, The Netherlands
  "DNA repair and heterochromatin"
• James P. Carney, Lawrence Berkeley Nat. Lab., Univ. of Calif., San Francisco, CA
  "The hMre11/hRad50 protein complex and Nijmegen breakage syndrome"
• Tomas Prolla, Univ. of Wisconsin, Madison, WI
  "Tumor susceptibility and spontaneous mutation in mice deficient for M1h1, Pms1 and Pms2 DNA mismatch repair"

• Swati P. Deb, Univ. Texas Health Sciences Center, San Antonio, TX
  "Function and dysfunction of the human oncoprotein MDM2"
• Arnaud Coquelle, Institut Pasteur, Paris, France
  "Role of fragile sites in mammalian gene amplification"
• Chiayeng Wang, Center for Mol. Biol. of Oral Disease, Chicago, IL
  "An alternative mechanism of PAX3-FKHR induced oncogenesis"
• Tej K. Pandita, College of Physicians and Surgeons, Columbia Univ., New York, NY
  "Telomeres and ATM function: in cancer cells and in meiosis"
• Carol L. Rosenberg, Cancer Res. Center, Boston Univ. Med. Center, Boston, MA
  "Genetically abnormal clones in histologically normal breast tissue"

Discussion Leader: Bernard Dutrillaux, Institut Curie, Paris, France

• Sverre Heim, Institute for Cancer Research, Oslo, Norway
  "Clonal chromosome abnormalities in neoplastic cells: evidence of genetic instability"
• Catherine Reznikoff, Univ. Wisc. Comprehensive Cancer Center, Madison, WI
  "TP53 mutation, karyotypic instability, and bladder cancer pathogenesis"
• Yvonne Dragan, McArdle Lab. for Cancer Research, Madison, WI
  "Genetic changes associated with progression of rat hepatocarcinogenesis"
• Xifeng Wu, Univ. Texas M.D. Anderson Cancer Ctr., Houston, TX
  "Mutagen Sensitivity and Tobacco Carcinogenesis"

Discussion Leader: Edison T. Liu, National Cancer Institute, NIH, Bethesda, MD

• Ralph Scully, Dana-Farber Cancer Institute, Boston, MA
  "Molecular biology of BRCA1 and BRCA2"
• Daniel Haber, Mass. General Hosp., Boston, MA
  "Differential contributions of BRCA1 and BRCA2 to early-onset breast cancer"
• Giske Ursin, USC/Norris Comprehensive Cancer Center, Los Angeles, CA
  "Hormones, breast cancer, and BRCA mutations"

Discussion Leader: William Bennett, City of Hope Nat. Med. Center & Beckman Res. Inst.

• Steve Tannenbaum, Mass. Inst. Tech., Cambridge, MA
  "Nitric oxide in carcinogenesis"
• Raymond N. DuBois, Vanderbilt Univ., Nashville, TN
  "Role of cyclooxygenase in colorectal carcinogenesis"
• Wade V. Welshons, Univ. Missouri, Columbia, MO
  "Fetal exposure to endocrine disruptors and risk factors for hormone-dependent cancers"
• Eleanor Rogan, Univ. of Nebraska Med. Center, Omaha, NE
  "The role of endogenous catechol estrogens in tumor initiation"

Discussion Leader: R.N. Kolesnick, Memorial-Sloan Kettering, New York, NY

• Scott Lowe, Cold Spring Harbor Lab., Cold Spring Harbor, NY
  "Apoptosis and cancer therapy"
• Anthony E. Pegg, Pennsylvania State Univ., Hershey, PA
  "Inactivation of 0⁶-alkylguanine DNA alkyltransferase to enhance chemotherapy"
• Michael S. O'Reilly, Children's Hospital, Boston, MA
  "Tumor dormancy by angiogenesis suppression"