This conference, previously entitled Mutagenesis and Carcinogenesis, was renamed to better reflect our concerns to deal with the large diversity of lesions in DNA, how they elicit cellular responses, induce mutations and Cancer. In each ession, we will try to cover current aspects ranging from chemistry and structural biology, to biochemistry, genetics and cellular biology. This year's sessions will include the following topics: spontaneous and chemical induced lesions, new insights into the replication of damaged DNA, post translational control of polymerase switching; error-free strategies to avoid Translesion synthesis and mutagenesis; DNA damage and how it is signalled; Mismatch Repair responses to DNA Damage; DNA damage in relation to Cancer. Young investigator are encouraged to apply as specific grants will be distributed; a few posters will be selected for oral presentation.