SUNDAY |
4:00 pm - 9:00 pm | Arrival and Check-in |
6:00 pm | Dinner |
7:30 pm - 7:40 pm | Welcome / Introductory Comments by GRC Site Staff |
7:40 pm - 9:30 pm | KEYNOTE ADDRESSES |
| Discussion Leader: John Hays (Oregon State University) |
7:40 pm - 8:25 pm | Larry Loeb (University of Washington) "How Mutations Cause Cancer" |
8:25 pm - 8:35 pm | Discussion |
8:35 pm - 9:20 pm | Max Wicha (University of Michigan) "Cancer Stem Cells" |
9:20 pm - 9:30 pm | Discussion |
MONDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | GENETIC LANDSCAPES OF CANCER |
| Discussion Leader: Christoph Klein (University of Regensburg) |
9:00 am - 9:25 am | Christoph Klein (Regensburg) "Mutation and selection during systemic cancer progression" |
9:25 am - 9:35 am | Discussion |
9:35 am - 10:00 am | Laura Wood (The Johns Hopkins University) "Genomic Analyses of Human Cancer" |
10:00 am - 10:10 am | Discussion |
10:10 am - 10:40 am | Coffee Break |
10:40 am - 11:05 am | Fred Alt (Harvard University) "IgH Class Switching, DNA End-Joining, Translocation, and Cancer" |
11:05 am - 11:15 am | Discussion |
11:15 am - 11:35 am | Group Photo |
11:35 am - 12:00 pm | Toshiyasu (Toshi) Taniguchi (University of Washington) "The Fanconi-Anemia-BRCA Pathway and chemosensitivity of human cancer" |
12:00 pm - 12:10 pm | Discussion |
12:10 pm - 12:25 pm | Christophe Cazaux (CNRS, Toulouse) "The Roles of Replication/Recombination/Repair TLS Polymerases in Replicative Stress and Cancer" |
12:25 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | POPULATION CANCER RISKS FROM DNA-REPAIR DEFICIENCIES AND ABERRANT DNA STRUCTURES |
| Discussion Leader: Harvey Mohrenweiser (Oregon Health and Sciences University) |
7:30 pm - 7:45 pm | Harvey Mohrenweiser (OHSU) "Contribution to Cancer Risk of the Extensive Population Variation in DNA Repair-Gene Sequences" |
7:45 pm - 7:50 pm | Discussion |
7:50 pm - 8:15 pm | Xifeng Wu (U.T. Texas M.D. Anderson Center, Houston) "Personalized Prediction of Cancer Risk and Outcome: Markers of Genetic Instability" |
8:15 pm - 8:25 pm | Discussion |
8:25 pm - 8:50 pm | David Wilson (National Institute of Aging, NIH, Baltimore) "Base Excision Repair Variation in the Human Population" |
8:50 pm - 9:00 pm | Discussion |
9:00 pm - 9:25 pm | Phyllis Strauss (Northeastern University) "How AP Endonuclease Controls Embryonic Survival in Zebrafish" |
9:25 pm - 9:30 pm | Discussion |
TUESDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | NOVEL MECHANISMS OF GENOMIC INSTABILITY |
| Discussion Leader: Joann Sweasy (Yale University) |
9:00 am - 9:20 am | Joann Sweasy (Yale) "Introduction" |
9:20 am - 9:45 am | Karen Vasquez (U. Texas M. D, Anderson, Smithville) "DNA-structure-induced Genetic Instability" |
9:45 am - 9:55 am | Discussion |
9:55 am - 10:10 am | Faye Rogers (Yale Medical School) "Altered Helical Structures in DNA Repair and Induction of Apoptosis" |
10:10 am - 10:15 am | Discussion |
10:15 am - 10:45 am | Coffee break |
10:45 am - 11:10 am | Peter Glazer (Yale University) "Down-regulation of DNA Repair in Hypoxia" |
11:10 am - 11:20 am | Discussion |
11:20 am - 11:45 am | Barbara Hohn (Friedrich-Miescher Institute, Basel) "Transgenerqtional Memory of Hyper-rec Phenotype in Plants" |
11:45 am - 11:55 am | Discussion |
11:55 am - 12:20 pm | Robert Wells (Texas A. and M. University) "Non-B DNA Conformations, Genomic Rearrangements, and Human Disease" |
12:20 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | CHEMOTHERAPY: DNA-REPAIR AND DAMAGE=SIGNALING IMPLICATIONS |
| Discussion Leader: Peter Karran (Cancer Research U.K., Clare Hall) |
7:30 pm - 7:50 pm | Peter Karran (Clare Hall) "Therapeutic DNA Damage: Implications for Cancer" |
7:50 pm - 7:55 pm | Discussion |
7:55 pm - 8:20 pm | Mark Kelley (Indiana University School of Medicine) "AP Endonuclease Ape1/Ref-1: A DNA-repair and Redox Signaling Target for Chemotherapy" |
8:20 pm - 8:30 pm | Discussion |
8:30 pm - 8:55 pm | Peter McHugh (Cancer Research UK, Oxford) "Mechanisms of Repair of DNA Inter-strand Cross-links" |
8:55 pm - 9:00 pm | Discussion |
9:00 pm - 9:25 pm | Anne Britt (U. Calif. Davis) "Identification of New Checkpoint Regulators in an Arabidopsis Model System" |
9:55 pm - 9:30 pm | Discussion |
WEDNESDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | EVENTS AT STALLED REPLICATION FORKS |
| Discussion Leader: Alan Lehmann (University of Sussex, UK) |
9:00 am - 9:25 am | Alan Lehmann (Sussex) "Ubiquitination of PCNA and Polymerases in Response to DNA Damage" |
9:25 am - 9:35 am | Discussion |
9:35 am - 10:00 am | Peter Burgers (Washington University, St. Louis) "An Essential Role for Rev1 Binding to Ubiquitinated PCNA during Mutagenesis" |
10:00 am - 10:10 am | Discussion |
10:10 am - 10:40 am | Coffee Break |
10:40 am - 11:05 am | Lajos Haracska (Hungarian Academy of Sciences, Szeged) "Role of Yeast Rad5 and its Human Ortholog SHPRH in Postreplication Repair" |
11:05 am - 11:15 am | Discussion |
11:15 am - 11:40 am | Agnes Cordonnier (INSERM, CNRS, Illkirch, France) "Regulation and Role of PCNA Monoubiquitination in Eukaryotic Cell Extracts" |
11:40 am - 11:45 am | Discussion |
11:45 am - 12:05 pm | Kyungjae Myung (NHGRI, NIH) "Suppression of DNA-damage-induced Chromosomal Rearrangements by Damage Avoidance and Other Pathways" |
12:05 pm - 12:10 pm | Discussion |
12:10 pm - 12:25 pm | Martin Cohn (Harvard Medical School) "Regulation of the Fanconi Anemia Pathway by a DAF1-contaning Multi-subunit Protein Complex" |
12:25 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session |
6:00 pm | Dinner |
7:00 pm - 7:30 pm | Business Meeting |
| (Nominations for the next Vice Chair; Fill out Conference Evaluation Forms; Discuss future Site & Scheduling preferences; Election of the next Vice Chair) |
7:30 pm - 9:30 pm | PATHWAYS THAT PROCESS DAMAGED DNA |
| Discussion Leader: Ed Loechler (Boston University) |
7:30 pm - 7:55 pm | Ed Loechler (BU) "Evidence for Two Active Sites in Y-Family Polymerases: Biological Implications?" |
7:55 pm - 8:00 pm | Discussion |
8:00 pm - 8:25 pm | Nick Geacintov (New York University) "Structure-Function Relationships in the Recognition and Excision of Bulky Lesions" |
8:25 pm - 8:35 pm | Discussion |
8:35 pm - 9:00 pm | Robert Fuchs (CNRS, Marseilles) "Mechanisms of Mutagenesis without Semi-conservative DNA Replication" |
9:00 pm - 9:10 pm | Discussion |
9:10 pm - 9:25 pm | Zvi Livneh (Weizmann Institute) "The Role of DNA Polymerase Zeta in Mammalian TLS: Evidence for a Two Polymerase Mechanism" |
9:25 pm - 9:30 pm | Discussion |
THURSDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | RECOGNITION OF DNA DAMAGE |
| Discussion Leader: Wei Yang (NIDDK, NIH) |
9:00 am - 9:25 am | Wei Yang (NIH) "Finding Needles in a Haystack" |
9:25 am - 9:35 am | Discussion |
9:35 am - 10:00 am | James Stivers (The Johns Hopkins University) "Linking Dynamics of Damaged Base Pairs to Recognition by Enzymes" |
10:00 am - 10:10 am | Discussion |
10:10 am - 10:35 am | Coffee Break |
10:35 am - 11:00 am | Lorena Beese (Duke University) "DNA-lesion-recognition Complexes" |
11:00 am - 11:10 am | Discussion |
11:10 am - 11:35 am | Jennifer Brodbelt (University of Texas at Austin) "Novel Mass Spectrometric Strategies for Analysis of DNA Adducts" |
11:35 am - 11:45 am | Discussion |
11:45 am - 12:00 pm | Stephen Chaney (University of North Carolina) "Selective Recognition of Cisplatin and Oxaliplatin-GG Adducts by Cellular Proteins: Importance of Differential Conformational Dynamics" |
12:00 pm - 12:05 pm | Discussion |
12:05 am - 12:25 pm | Veronica Maher (Michigan State University) "DNA-damage-induced Mutagenesis, Then and Now" |
12:25 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | REPAIR AND TOLERATION OF DNA DAMAGE IN DEVELOPMENT AND AGING |
| Discussion Leader: Laura Niedernhofer (University of Pittsburgh) |
7:30 pm - 7:55 pm | Laura Niedernhofer (Pittsburgh) "Aging-associated Degenerative Diseases Driven by Endogenous DNA Damage" |
7:55 pm - 8:00 pm | Discussion |
8:00 pm - 8:15 pm | Marc Curtis (Oregon State University) "Roles of Pol Eta and Pol Zeta in Orderly Development of UVB-irradiated Plant Tissues" |
8:15 pm - 8:20 pm | Discussion |
8:20 pm - 8:45 pm | Larry Marnett (Vanderbilt University) "In Vivo Metabolism of Deoxynucleoside Adducts and the Development of Non-Invasive Biomarkers of Endogenous DNA Damage" |
8:45 pm - 8:55 pm | Discussion |
8:55 pm - 9:20 pm | Judy Campisi (Lawrence Berkeley Lab) "Linkage of the DNA-Damage Response to Cancer and Aging" |
9:20 pm - 9:30 pm | Discussion |
FRIDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am | Departure |