SUNDAY |
4:00 pm - 8:00 pm | Arrival and Check-in (Office Closed 6:00 pm - 7:45 pm) |
6:00 pm | Dinner |
7:30 pm - 7:40 pm | Welcome / Introductory Comments by GRC Site Staff |
7:40 pm - 9:30 pm | Keynote Presentations: Roles of p53 in Cancer/Mechanisms of Translocations in Cancer |
| Chair of Session: Karen Vasquez (The University of Texas at Austin) |
7:40 pm - 8:25 pm | Carol Prives (Columbia University) "The p53 Network in Cancer" |
8:25 pm - 8:35 pm | Discussion |
8:35 pm - 9:20 pm | Fred Alt (Harvard Medical School) "Genome-wide Translocation Sequencing Reveals Mechanisms that Shape the Translocatome of Primary B Lymphocytes and Other Cell Types" |
9:15 pm - 9:30 pm | Discussion |
MONDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | Role of Telomeres in Genomic Instability and Cancer |
| Chair of Session: Patricia Opresko (University of Pittsburgh) |
| Discussion Leader: Jerry Shay (The University of Texas Southwestern Medical Center) |
9:00 am - 9:20 am | Patricia Opresko (University of Pittsburgh)
"Mechanisms for Suppressing Telomeric Instability" |
9:20 am - 9:30 am | Discussion |
9:30 am - 9:50 am | Jerry Shay (The University of Texas Southwestern Medical Center) "The Role of Telomere Dysfunction in Human Aging and Cancer" |
9:50 am - 10:00 am | Discussion |
10:00 am - 10:40 am | Group Photo / Coffee Break |
10:40 am - 11:00 am | Ronald Depinho (The University of Texas MD Anderson Cancer Center)
"Telomere Checkpoint Circuitry in Cancer and Aging" |
11:00 am - 11:10 am | Discussion |
11:10 am - 11:30 am | Virginia Zakian (Princeton University)
"Pif1 Family Helicases: Multifunctional Proteins that Affect Genome Integrity" |
11:30 am - 11:40 am | Discussion |
11:40 am - 11:55 am | Satoshi Tateishi (Kumamoto University)
"Loss of Rad18 Alleles Suppresses Tumorigenesis in p53-null Mice via Cellular Senescence"
|
11:55 am - 12:00 pm | Discussion |
12:00 pm - 12:15 pm | Vanessa Gottifredi (Fundación Instituto Leloir)
"A Kinase Independent Role of Chk1 in the Replication of Damaged DNA"
|
12:15 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | Choosing a DNA Polymerase for Translesion Synthesis; Mutagenic Outcomes |
| Chair of Session: Joann Sweasy (Yale University) |
| Discussion Leader: Richard Wood (The University of Texas M.D. Anderson Cancer Center) |
7:30 pm - 7:50 pm | Joann Sweasy (Yale University) "Base Excision Repair Variants and Genomic Instability" |
7:50 pm - 8:00 pm | Discussion |
8:00 pm - 8:20 pm | Richard Wood (The University of Texas M.D. Anderson Cancer Center) "DNA Polymerases, Chromosome Stability and Resistance to DNA Damaging Agents" |
8:20 pm - 8:30 pm | Discussion |
8:30 pm - 8:50 pm | Zachary Pursell (Vanderbilt University Medical Center) "Roles of Polε in DNA Replication, DNA Repair and Overall Genome Stability" |
8:50 pm - 9:00 pm | Discussion |
9:00 pm - 9:20 pm | Jean-Sebastien Hoffman (Institut de Pharmacologie et de Biologie Structurale, France) "Alternative DNA Polymerases Theta and Kappa Contribute to Genomic Replication Outside TLS" |
9:20 pm - 9:30 pm | Discussion |
TUESDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | Impact of DNA Structural Features on Genomic Instability |
| Chair of Session: Sergei Mirkin (Tufts University)
|
| Discussion Leader: Catherine Freudenreich (Tufts University) |
9:00 am - 9:20 am | Sergei Mirkin (Tufts University) "Expansions of DNA Repeats and Mutagenesis at a Distance: Two Sides of the Same Coin?" |
9:20 am - 9:30 am | Discussion |
9:30 am - 9:50 am | Catherine Freudenreich (Tufts University)
"Cellular Mechanisms to Maintain Stability of Repetitive DNA Sequences"
|
9:50 am - 10:00 am | Discussion |
10:00 am - 10:30 am | Coffee Break |
10:30 am - 10:40 am | Batsheva Kerem (The Hebrew University)
"Fork Stalling at AT-rich Sequences and Failure of Origin Activation Lead to Chromosomal Instability at Fragile Sites" |
10:40 am - 10:45 am | Discussion |
10:45 am - 10:55 am | Sarah Delaney (Brown University)
"Roles of Oxidative Damage and Repair in Expansion of Repetitive DNA" |
10:55 am - 11:00 am | Discussion |
11:00 am - 11:20 am | Karen Usdin (NIH) "DNA Damage Response Pathways in Triplet Repeat Diseases" |
11:20 am - 11:30 am | Discussion |
11:30 am - 11:45 am | Yuan Liu (Florida International University)
"Trinucleotide Repeat Deletion via a Unique Hairpin Bypass by DNA Polymerase Beta and FEN1 Cleavage" |
11:45 am - 11:50 am | Discussion |
11:50 am - 12:05 pm | Guliang Wang (The University of Texas at Austin) "DNA Structure-induced Genetic Instability and Cancer" |
12:05 pm - 12:10 pm | Discussion |
12:10 pm - 12:25 pm | Tasuku Honjo (Kyoto University, Japan) "Common Mechanisms for Immune Diversity and Genome Instability" |
12:25 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | Chromatin-mediated Genomic Instability |
| Chair of Session: Mary Ann Osley (The University of New Mexico) |
| Discussion Leader: Cecilia Mello (Stanford School of Medicine) |
7:30 pm - 7:50 pm | Mary Ann Osley (The University of New Mexico) "Repair of DNA Double-strand Breaks in Chromatin" |
7:50 pm - 8:00 pm | Discussion |
8:00 pm - 8:20 pm | Cecilia Mello (Stanford School of Medicine)
"DNA is not Naked: DNA Damage, Repair, and Chromatin" |
8:20 pm - 8:30 pm | Discussion |
8:30 pm - 8:40 pm | Alexander Strunnikov (Guangzhou Institutes of Biomedicine and Health)
"A Map of Anaphase Chromosomal Breaks Induced by Condensin Loss"
|
8:40 pm - 8:45 pm | Discussion |
8:45 pm - 8:55 pm | Peng Mao (Washington State University)
"Uncoupled H2B Ubiquitination and H3 Methylation Coordinate DNA Repair and DNA Damage Checkpoint Response"
|
8:55 pm - 9:00 pm | Discussion |
9:00 pm - 9:15 pm | Phyllis Strauss (Northeastern University)
"AP Endonuclease Regulates Histone H2B in Zebrafish Early Development"
|
9:15 pm - 9:30 pm | Discussion |
WEDNESDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | Repair of Carcinogenic/Chemotherapeutic DNA Damage |
| Chair of Session: Nicolas Geacintov (New York University) |
| Discussion Leader: John Essigmann (Massachusetts Institute of Technology) |
9:00 am - 9:20 am | Nicolas Geacintov (New York University) "Why Certain Bulky DNA Lesions are Resistant to NER" |
9:20 am - 9:30 am | Discussion |
9:30 am - 9:50 am | John Essigmann (Massachusetts Institute of Technology) "Programmable Anti-cancer Agents" |
9:50 am - 10:00 am | Discussion |
10:00 am - 10:30 am | Coffee Break |
10:30 am - 10:50 am | Sharon Cantor (U. Mass. Medical School) "Fanconi Anemia Proteins and Mismatch Repair Interactions" |
10:50 am - 11:00 am | Discussion |
11:00 am - 11:20 am | Steve West (Cancer Research UK, London Research Institute) "Regulatory Control of Recombination-mediated DNA Repair and Links to Cancer" |
11:20 am - 11:30 am | Discussion |
11:30 am - 11:45 am | John Rouse (University of Dundee, Scotland) "Fork and Molecular Knives in DNA Repair" |
11:45 am - 11:50 am | Discussion |
11:50 am - 12:05 pm | Samy Habib (The University of Texas Health Science Center)
"Novel Mechanism of Regulation of the DNA Damage and Repair in Carcinogenesis"
|
12:05 pm - 12:10 pm | Discussion |
12:10 pm - 12:25 pm | Marianna Yakubovskaya (Blokhin Cancer Research Center RAMS)
"Invasion of d(CA)10- and d(TG)10-oligonucleotides into (CA/TG)n-repetitive Region of Linearized and Supercoiled Plasmid" |
12:25 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session |
6:00 pm | Dinner |
7:00 pm - 7:30 pm | Business Meeting |
| Nominations for the next Vice Chair; Fill out Conference Evaluation Forms; Discuss future Site & Scheduling preferences; Election of the next Vice Chair |
7:30 pm - 9:30 pm | DNA Repair Deficiency Syndromes and Cancer |
| Chair of Session: William Hahn (Harvard Medical School) |
| Discussion Leader: Richard Kolodner (Ludwig Institute for Cancer Research, UCSD) |
7:30 pm - 7:50 pm | William Hahn (Harvard Medical School) "Functional Genomics to Identify Cancer Dependencies" |
7:50 pm - 8:00 pm | Discussion |
8:00 pm - 8:20 pm | Richard Kolodner (Ludwig Institute for Cancer Research, UCSD) "Coupling of Mismatch Repair to DNA Replication" |
8:20 pm - 8:30 pm | Discussion |
8:30 pm - 8:50 pm | Judy Garber (Harvard Medical School) "Cancer Risk and Prevention" |
8:50 pm - 9:00 pm | Discussion |
9:00 pm - 9:10 pm | Ashok Bhagwat (Wayne State University)
"Uracils in Genomic DNA: A New Marker for Lymphomagenesis" |
9:10 pm - 9:15 pm | Discussion |
9:15 pm - 9:25 pm | Or Shahar (The Hebrew University of Jerusalem)
"Live Imaging of Induced and Controlled DNA Double-strand Break Formation Reveals New Aspects of Homologous Recombination Repair in Human Cells"
|
9:25 pm - 9:30 pm | Discussion |
THURSDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | Targeting DNA Repair Pathways in Cancer Therapy |
| Chair of Session: Robert Hromas (The University of Florida) |
| Discussion Leader: Steve Jackson (University of Cambridge, U.K.) |
9:00 am - 9:20 am | Robert Hromas (The University of Florida) "Mechanisms of Chk1 Downstream Activities" |
9:20 am - 9:30 am | Discussion |
9:30 am - 9:50 am | Steve Jackson (University of Cambridge, U.K.) "Sensing and Responding to DNA Double-strand Breaks in the Context of Chromatin" |
9:50 am - 10:00 am | Discussion |
10:00 am - 10:30 am | Coffee Break |
10:30 am - 10:50 am | Michael Stratton (Wellcome Trust Sanger Institute) "Patterns of Mutation in Human Cancer Genomes" |
10:50 am - 11:00 am | Discussion |
11:00 am - 11:20 am | Alan Tomkinson (The University of New Mexico)
"DNA Ligase Inhibitors as Probes of Altered DNA Repair in Cancer Cells" |
11:20 am - 11:30 am | Discussion |
11:30 am - 11:45 am | Kevin Mills (The Jackson Laboratory)
"Homologous Recombination in the Repair of AID-Induced Genomic Breaks: Developmental and Therapeutic Implications" |
11:45 am - 11:50 am | Discussion |
11:50 am - 12:00 pm | Christopher Bakkenist (University of Pittsburgh)
"ATM Physically and Functionally Interacts with PCNA to Regulate DNA Synthesis"
|
12:00 pm - 12:05 pm | Discussion |
12:05 pm - 12:15 pm | Long Shan Li (UT Southwestern Medical Center at Dallas)
"NQO1-mediated 'Kiss of death' Targeted Therapy for Panceratic Cancer"
|
12:15 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | Role of PARP in Genomic Stability and Cancer Chemotherapy |
| Chair of Session: Rob Sobol (University of Pittsburgh) |
| Discussion Leader: Samuel Wilson (NIEHS) |
7:30 pm - 7:50 pm | Rob Sobol (University of Pittsburgh) "Role of PARP1 in Repair and Responses to DNA Damage" |
7:50 pm - 8:00 pm | Discussion |
8:00 pm - 8:20 pm | Samuel Wilson (NIEHS) "PARP-1 Recognition of Early BER Intermediates" |
8:20 pm - 8:30 pm | Discussion |
8:30 pm - 8:50 pm | James Ford (Stanford University) "PARP Inhibitors and Breast Cancer Therapy" |
8:50 pm - 9:00 pm | Discussion |
9:00 pm - 9:20 pm | Thomas Helleday (University of Oxford, U.K.) "Dissecting the PARP1-BRCA2 Synthetic Lethal Mechanism" |
9:20 pm - 9:30 pm | Discussion |
FRIDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am | Departure |