Sunday |
4:00 pm - 8:00 pm | Arrival and Check-in |
6:00 pm | Dinner |
7:30 pm - 7:40 pm | Welcome / Introductory Comments by GRC Site Staff |
7:40 pm - 9:30 pm | Keynote Session: Inherent Genomic Stability and
Instability |
| Discussion Leader: Sergei Mirkin (Tufts University, USA) |
7:40 pm - 7:50 pm | Opening Remarks |
7:50 pm - 8:30 pm | Philip Hanawalt (Stanford University, USA) "From Repair Replication to R-Loops in Half-a-Century" |
8:30 pm - 8:40 pm | Discussion |
8:40 pm - 9:20 pm | Stephen Kowalczykowski (University of California, Davis, USA) "Molecular Functions of BRCA1, BRCA2, and RAD51 Paralogs in Homologous Recombination" |
9:20 pm - 9:30 pm | Discussion |
Monday |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | Genome Weak Links |
| Discussion Leader: Richard Wood (University of Texas MD Anderson Cancer Center, USA) |
9:00 am - 9:10 am | Introduction by Discussion Leader |
9:10 am - 9:30 am | Richard Wood (University of Texas MD Anderson Cancer Center, USA) "Expanding
the Repertoire of Replicative DNA Polymerases" |
9:30 am - 9:35 am | Discussion |
9:35 am - 9:55 am | Catherine Freudenreich (Tufts University, USA) "Transcriptional Effects on CAG Repeat Instability and Fragility" |
9:55 am - 10:00 am | Discussion |
10:00 am - 10:20 am | Karen Vasquez (The University of Texas at Austin, USA) "Replication-Dependent
and Replication-Independent Models of DNA Structure-Induced Genetic Instability" |
10:20 am - 10:25 am | Discussion |
10:25 am - 10:55 am | Coffee Break |
10:55 am - 11:15 am | Susan Lovett (Brandeis University, USA) "Template-Switch Mutagenesis
and Genetic Rearrangements During DNA Repair" |
11:15 am - 11:20 am | Discussion |
11:20 am - 11:40 am | Thomas Petes (Duke University, USA) "DNA Structure-Based Determinants of Mutation Rates in Yeast" |
11:40 am - 11:45 am | Discussion |
11:45 am - 12:05 pm | Nancy Maizels (University of Washington, USA) "Repair at DNA Nicks" |
12:05 pm - 12:10 pm | Discussion |
12:10 pm - 12:20 pm | Selected from Poster Abstracts: Sheroy Minocherhomji (University of Copenhagen, Denmark) "Mitotic DNA Repair Synthesis Protects Against Chromosome Fragility" |
12:20 pm - 12:25 pm | Discussion |
12:25 pm - 12:30 pm | General Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
3:00 pm - 4:00 pm | Power Hour |
| The GRC Power Hour is an optional informal gathering open to all meeting participants. It is designed to help address the challenges women face in science and support the professional growth of women in our communities by providing an open forum for discussion and mentoring. |
| Organizer: Catherine Freudenreich (Tufts University, USA) |
4:00 pm - 6:00 pm | Poster Session |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | Environmental and Endogenous DNA Damage |
| Discussion Leader: Nicholas Geacintov (New York University, USA) |
7:30 pm - 7:35 pm | Introduction by Discussion Leader |
7:35 pm - 7:55 pm | Nicholas Geacintov (New York University, USA) "Removal of Environmental
DNA Damage by Competing BER and NER Pathways" |
7:55 pm - 8:00 pm | Discussion |
8:00 pm - 8:20 pm | Isao Kuraoka (Osaka University, Japan) "Function of Human Endonuclease V: From DNA to RNA" |
8:20 pm - 8:25 pm | Discussion |
8:25 pm - 8:35 pm | Selected from Poster Abstracts: Xiaohua Wu (The Scripps Research Institute, USA) "Repair of DNA Double-Strand Breaks Associated with Re-Replication" |
8:35 pm - 8:40 pm | Discussion |
8:40 pm - 9:00 pm | John Tainer (University of Texas MD Anderson Cancer Center, USA) "Nucleases Sculpt DNA to Control Outcomes at Replication Forks and Double-Strand Breaks" |
9:00 pm - 9:05 pm | Discussion |
9:05 pm - 9:25 pm | David Pellman (Dana-Farber Cancer Institute, USA) "Nuclear Organization and Genome Stability" |
9:25 pm - 9:30 pm | Discussion |
Tuesday |
7:30 am - 8:30 am | Breakfast |
8:30 am | Group Photo |
9:00 am - 12:30 pm | RNA-DNA Interplay in Genome Instability |
| Discussion Leader: Hannah Klein (New York University School of Medicine, USA) |
9:00 am - 9:10 am | Introduction by Discussion Leader |
9:10 am - 9:30 am | Hannah Klein (New York University School of Medicine, USA) "Ribonucleotide-Promoted Genome Instability" |
9:30 am - 9:35 am | Discussion |
9:35 am - 9:55 am | Mark Bedford (University of Texas MD Anderson Cancer Center, USA) "The Link Between Arginine Methylation
and R-Loop Resolution" |
9:55 am - 10:00 am | Discussion |
10:00 am - 10:20 am | Francesca Storici (Georgia Institute of Technology, USA) "DNA Self-Repair by Transcript RNA" |
10:20 am - 10:25 am | Discussion |
10:25 am - 10:55 am | Coffee Break |
10:55 am - 11:15 am | Karlene Cimprich (Stanford University School of Medicine, USA) "RNA Meets DNA: Mechanisms for Transcription-Associated Genome Instability" |
11:15 am - 11:20 am | Discussion |
11:20 am - 11:40 am | Andres Aguilera (University of Seville, Spain) "Role of Chromatin and the DNA Damage Response in Transcription-Associated Genome Instability" |
11:40 am - 11:45 am | Discussion |
11:45 am - 12:05 pm | Evgeny Nudler (New York University School of Medicine, USA) "New Principles of Transcription-Coupled DNA Repair" |
12:05 pm - 12:10 pm | Discussion |
12:10 pm - 12:20 pm | Selected from Poster Abstracts: Giordano Liberi (L'Istituto di Genetica Molecolare (IGM), CNR, Italy) "Mechanisms that Rescue Replication Forks Arrested by Transcription" |
12:20 pm - 12:25 pm | Discussion |
12:25 pm - 12:30 pm | General Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | Oxidative DNA Damage and Base Excision Repair |
| Discussion Leader: Samuel Wilson (National Institute of Environmental Health Sciences, NIH, USA) |
7:30 pm - 7:35 pm | Introduction by Discussion Leader |
7:35 pm - 7:55 pm | Samuel Wilson (National Institute of Environmental Health Sciences, NIH, USA) "Mechanistic Studies of Base Excision Repair" |
7:55 pm - 8:00 pm | Discussion |
8:00 pm - 8:20 pm | Cynthia McMurray (Lawrence Berkeley National Laboratory, USA) "Death by DNA Repair" |
8:20 pm - 8:25 pm | Discussion |
8:25 pm - 8:45 pm | Yuan Liu (Florida International University, USA) "DNA Base Lesion Repair and Trinucleotide Repeat Instability" |
8:45 pm - 8:50 pm | Discussion |
8:50 pm - 9:10 pm | Guoliang Xu (Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, China) "Enzymatic DNA Oxidation in Epigenetic Regulation of Mammalian Development" |
9:10 pm - 9:15 pm | Discussion |
9:15 pm - 9:25 pm | Selected from Poster Abstracts: James Cleaver (University of California, San Francisco, USA) "Why Cockayne Patients Do Not Get Cancer Despite Their DNA Repair Deficiency" |
9:25 pm - 9:30 pm | Discussion |
Wednesday |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | Mutagenesis in Response to Arrested
Replication |
| Discussion Leader: Wei Yang (National Institutes of Health, USA) |
9:00 am - 9:10 am | Introduction by Discussion Leader |
9:10 am - 9:30 am | Wei Yang (National Institutes of Health, USA) "Tripartite DNA Lesion Recognition and Verification by XPC, TFIIH and XPA in Nucleotide Excision Repair" |
9:30 am - 9:35 am | Discussion |
9:35 am - 9:55 am | Simon Boulton (The Francis Crick Institute, United Kingdom) "Genome Stability and the Control of Homologous Recombination" |
9:55 am - 10:00 am | Discussion |
10:00 am - 10:20 am | Massimo Lopes (University of Zurich, Switzerland) "Replication Fork Remodelling upon DNA Replication Stress" |
10:20 am - 10:25 am | Discussion |
10:25 am - 10:55 am | Coffee Break |
10:55 am - 11:15 am | Naoko Shima (University of Minnesota, USA) "Functional Interactions Between Dormant Origins and BRCA2 in Genome Stability and Mouse Development" |
11:15 am - 11:20 am | Discussion |
11:20 am - 11:40 am | Frederick Alt (Harvard Medical School, USA) "Chromosomal Loop Domains, DNA Breaks and Translocations in Lymphoid and Neural Cells" |
11:40 am - 11:45 am | Discussion |
11:45 am - 12:05 pm | Kirill Lobachev (Georgia Institute of Technology, USA) "Mechanism of Endogenous and Damage-Induced Mutagenesis in Palindrome-Proximal Regions" |
12:05 pm - 12:10 pm | Discussion |
12:10 pm - 12:20 pm | Selected from Poster Abstracts: Duncan Smith (New York University, USA) "Pif1 Helicases Suppress Widespread Replisome Pausing at tRNA Genes in S. cerevisiae" |
12:20 pm - 12:25 pm | Discussion |
12:25 pm - 12:30 pm | General Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session |
6:00 pm | Dinner |
7:00 pm - 7:30 pm | Business Meeting |
| Nominations for the Next Vice Chair; Fill in Conference Evaluation Forms; Discuss Future Site and Scheduling Preferences; Election of the Next Vice Chair |
7:30 pm - 9:30 pm | Checkpoints and Strand-Break Repair |
| Discussion Leader: Karlene Cimprich (Stanford University School of Medicine, USA) |
7:30 pm - 7:35 pm | Introduction by Discussion Leader |
7:35 pm - 7:55 pm | Lee Zou (Massachusetts General Hospital Cancer Center, Harvard University, USA) "New Insights into the Functions
of ATR in DNA Repair" |
7:55 pm - 8:00 pm | Discussion |
8:00 pm - 8:20 pm | Dale Ramsden (University of North Carolina, Lineberger Comprehensive Cancer Center, USA) "The Contribution of DNA Polymerases to Double Strand Break Repair" |
8:20 pm - 8:25 pm | Discussion |
8:25 pm - 8:45 pm | Sylvie Doublie (University of Vermont, USA) "When the 3'-End Justifies the Means, or How a Family A Polymerase Solves a Major Challenge" |
8:45 pm - 8:50 pm | Discussion |
8:50 pm - 9:10 pm | Mitch McVey (Tufts University, USA) "Meaningful Mistakes: Using Translesion Polymerases During Double-Strand Break Repair" |
9:10 pm - 9:15 pm | Discussion |
9:15 pm - 9:25 pm | Selected from Poster Abstracts: Richard Pomerantz (Temple University Lewis Katz School of Medicine, USA) "New Mechanisms of Polymerase Theta-Mediated End-Joining" |
9:25 pm - 9:30 pm | Discussion |
Thursday |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | FoSTeS, Kataegis and Chromothripsis |
| Discussion Leader: Anna Malkova (University of Iowa, USA) |
9:00 am - 9:10 am | Introduction by Discussion Leader |
9:10 am - 9:30 am | Anna Malkova (University of Iowa, USA) "Genetic Instability Resulting from DNA Synthesis Associated with Double-Strand Break Repair" |
9:30 am - 9:35 am | Discussion |
9:35 am - 9:55 am | James Lupski (Baylor College of Medicine, USA) "Mechanisms for Disease Associated Genomic Rearrangements" |
9:55 am - 10:00 am | Discussion |
10:00 am - 10:20 am | Thanos Halazonetis (University of Geneva, Switzerland) "Mechanisms of Oncogene-Induced DNA Replication Stress" |
10:20 am - 10:25 am | Discussion |
10:25 am - 10:35 am | Selected from Poster Abstracts: Jane Kim (Tufts University, USA) "Break-Induced Replication Drives Large-Scale CAG Repeat Expansion in Budding Yeast" |
10:35 am - 10:40 am | Discussion |
10:40 am - 11:10 am | Coffee Break |
11:10 am - 11:30 am | Youri Pavlov (UNMC Eppley Cancer Center, University of Nebraska, USA) "En Route to APOBEC-Induced Mutation Clusters" |
11:30 am - 11:35 am | Discussion |
11:35 am - 11:55 am | Lawrence Loeb (University of Washington, USA) "Extensive Subclonal Mutations Characterize Many Human Cancers; Origin and Consequences" |
11:55 am - 12:00 pm | Discussion |
12:00 pm - 12:10 pm | Selected from Poster Abstracts: Ashok Bhagwat (Wayne State University, USA) "DNA Damage at the Replication Fork: The Role of APOBEC Enzymes" |
12:10 pm - 12:15 pm | Discussion |
12:15 pm - 12:25 pm | Selected from Poster Abstracts: Robert P. Fuchs (CNRS UMR7258, France) "Gymnastics Between Sister Chromatids and Timing of Events at the Replication Fork Upon Encounter of a Replication-Blocking Lesion in E. coli" |
12:25 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | Emerging Therapies Based on Cancer Genomics |
| Discussion Leader: Thomas Helleday (Karolinska Institutet, Sweden) |
7:30 pm - 7:35 pm | Introduction by Discussion Leader |
7:35 pm - 7:55 pm | Thomas Helleday (Karolinska Institutet, Sweden) "Targeting DNA Repair to Poison Cells with Damaged Nucleosides" |
7:55 pm - 8:00 pm | Discussion |
8:00 pm - 8:20 pm | Zvi Livneh (Weizmann Institute of Science, Israel) "Harnessing DNA Repair for Cancer Prevention and Early Detection" |
8:20 pm - 8:25 pm | Discussion |
8:25 pm - 8:45 pm | Tarun Kapoor (The Rockefeller University, USA) "Chemical Proteomics: Shining Light on Phosphorylation-Dependent Protein-Protein Interactions Required for Genome Stability" |
8:45 pm - 8:50 pm | Discussion |
8:50 pm - 9:10 pm | James Ford (Stanford University School of Medicine, USA) "Chemoprevention Targeting
BRCA1-Mutation Associated DNA Repair Defects" |
9:10 pm - 9:15 pm | Discussion |
9:15 pm - 9:25 pm | Selected from Poster Abstracts: Menachem Rubinstein (Weizmann Institute of Science, Israel) "Programmed DNA Damage: Potential Clinical Implications" |
9:25 pm - 9:30 pm | Discussion |
Friday |
7:30 am - 8:30 am | Breakfast |
9:00 am | Departure |