Sunday
4:00 pm - 8:00 pm
Arrival and Check-in
6:00 pm - 7:00 pm
Dinner
7:30 pm - 7:40 pm
Introductory Comments by GRC Site Staff / Welcome from the GRC Chair
7:40 pm - 9:30 pm
Genetics and Epigenetics of Cancer
Discussion Leader: Richard Wood (University of Texas MD Anderson Cancer Center, USA)
7:40 pm - 7:50 pm
Opening Remarks
7:50 pm - 8:10 pm
Ronny Drapkin (University of Pennsylvania Perelman School of Medicine, USA)
"Targeting Replicative Stress in Cyclin E-Amplified Tumors"
8:10 pm - 8:20 pm
Discussion
8:20 pm - 8:45 pm
Paul Northcott (St. Jude Children's Research Hospital, USA)
"Disentangling Genetic and Epigenetic Interplay in Medulloblastoma"
8:45 pm - 8:55 pm
Discussion
8:55 pm - 9:15 pm
Sharon Plon (Baylor College of Medicine, USA)
"Germline DNA Repair Mutations in Cancer Patients"
9:15 pm - 9:30 pm
Discussion
Monday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Cancer-Associated DNA Damage and Mutation
Discussion Leader: Karen Vasquez (The University of Texas at Austin, USA)
9:00 am - 9:20 am
Christoper Buck (National Cancer Institute, NIH, USA)
"APOBEC Mutagenesis, Viral Infection and Cancer"
9:20 am - 9:30 am
Discussion
9:30 am - 9:50 am
Dmitry Gordenin (Mechanisms of Genome Dynamics Group, National Institute of Environmental Health Sciences, NIH, USA)
"Mechanisms Underlying Mutation Load and Mutation Signatures"
9:50 am - 10:00 am
Discussion
10:00 am - 10:20 am
Laurence Ettwiller (New England Biolabs, USA)
"DNA Damage Is a Major Cause of Sequencing Errors, Confounding the Identification of Somatic Mutations in Tumor Samples"
10:20 am - 10:30 am
Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:20 am
Marcin Imielinski (Weill Cornell Medicine, USA)
"Signatures of Complex and Noncoding Variants in Cancer Whole Genome Sequences"
11:20 am - 11:30 am
Discussion
11:30 am - 11:50 am
Janet Rader (Medical College of Wisconsin, USA)
"Impact of Human Papillomavirus Integration and DNA Damage in Cervical Carcinogenesis"
11:50 am - 12:00 pm
Discussion
12:00 pm - 12:15 pm
Selected from Poster Abstracts: Anna Panchenko (National Center for Biotechnology Information, NIH, USA)
"Cancer Heterogeneity: From DNA Mutability to Protein Dysfunction"
12:15 pm - 12:20 pm
Discussion
12:20 pm - 12:30 pm
General Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
3:00 pm - 4:00 pm
Power Hour
The GRC Power Hour is an optional informal gathering open to all meeting participants. It is designed to help address the challenges women face in science and support the professional growth of women in our communities by providing an open forum for discussion and mentoring.
Organizer: Hannah Klein (New York University School of Medicine, USA)
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Foundations of DNA Damage, Mutation and Cancer
Discussion Leader: Wim Vermeulen (Erasmus Medical Center, The Netherlands)
7:30 pm - 8:05 pm
Susan Wallace (University of Vermont, USA)
"Fifty Years of DNA Repair: From Finding Nth to Finding How Nth Finds Damage"
8:05 pm - 8:15 pm
Discussion
8:15 pm - 8:35 pm
Nicola Waddell (QIMR Berghofer Medical Research Institute, Australia)
"Genome Sequencing to Understand Tumorigenesis"
8:35 pm - 8:45 pm
Discussion
8:45 pm - 8:55 pm
Selected from Poster Abstracts: Gaorav Gupta (The University of North Carolina at Chapel Hill, USA)
"A p53-Independent DNA Damage Response Suppresses Oncogene-Induced Proliferation and Genomic Instability"
8:55 pm - 9:00 pm
Discussion
9:00 pm - 9:20 pm
Cristian Tomasetti (Johns Hopkins University, USA)
"The Etiology of Mutations in Cancer"
9:20 pm - 9:30 pm
Discussion
Tuesday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Group Photo
9:00 am - 12:30 pm
Cancer and DNA Repair Pathways
Discussion Leader: Ronny Drapkin (University of Pennsylvania Perelman School of Medicine, USA)
9:00 am - 9:20 am
Jo Morris (University of Birmingham, United Kingdom)
"Dissecting the Functions of BRCA1"
9:20 am - 9:30 am
Discussion
9:30 am - 9:50 am
Natalia Tretyakova (University of Minnesota, USA)
"Cellular Repair of DNA-Protein Cross-Links Induced by Antitumor Drugs"
9:50 am - 10:00 am
Discussion
10:00 am - 10:20 am
Joann Sweasy (Yale University, USA)
"Functional Consequences of DNA Repair Gene Mutations in Cancer"
10:20 am - 10:30 am
Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:20 am
Anna Lindstrand (Karolinska Institutet, Sweden)
"Whole Genome Characterization of Germline Chromosomal Rearrangements Reveals Underlying Disease Mechanisms"
11:20 am - 11:30 am
Discussion
11:30 am - 11:50 am
Helen Piwnica-Worms (The University of Texas MD Anderson Cancer Center, USA)
"shRNA Screen Targeting the DDRome Identifies Synthetic Lethal Interactions with Chk1 Inhibitor"
11:50 am - 12:00 pm
Discussion
12:00 pm - 12:15 pm
Selected from Poster Abstracts: Olivier Cinquin (University of California, Irvine, USA)
"A Genome-Wide Assay of DNA Repair Capacity"
12:15 pm - 12:20 pm
Discussion
12:20 pm - 12:30 pm
General Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Cancer Treatments Based on DNA Repair
Discussion Leader: Helen Piwnica-Worms (The University of Texas MD Anderson Cancer Center, USA)
7:30 pm - 7:50 pm
Neil Johnson (Fox Chase Cancer Center, USA)
"BRCA1 Mutations and Mechanisms of PARP Inhibitor Resistance"
7:50 pm - 8:00 pm
Discussion
8:00 pm - 8:20 pm
Jing Wang (TESARO, USA)
"Preclinical Antitumor Activity of Niraparib and Its Combination with Anti-Pd-1 Therapy"
8:20 pm - 8:30 pm
Discussion
8:30 pm - 8:50 pm
Lauren Byers (The University of Texas MD Anderson Cancer Center, USA)
"Targeting DNA Damage Responses for the Treatment of Lung Cancer"
8:50 pm - 9:00 pm
Discussion
9:00 pm - 9:15 pm
Selected from Poster Abstracts: Viktoriya Sidorenko (Stony Brook University, USA)
"Liver-Kidney Organs-on-a-Chip Reveal Distant Site for Bioactivation of Aristolochic Acid"
9:15 pm - 9:20 pm
Discussion
9:20 pm - 9:30 pm
General Discussion
Wednesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
New Targets
Discussion Leader: Jo Morris (University of Birmingham, United Kingdom)
9:00 am - 9:20 am
Tony Huang (New York University School of Medicine, USA)
"Roles of DNA Polymerase Kappa in Subverting Replication Stress in Cancer Cells"
9:20 am - 9:30 am
Discussion
9:30 am - 9:50 am
Wim Vermeulen (Erasmus Medical Center, The Netherlands)
"Resistance to Platinum-Based Drugs Requires Multiple DNA Repair Pathways"
9:50 am - 10:00 am
Discussion
10:00 am - 10:20 am
Andrew Holland (Johns Hopkins University School of Medicine, USA)
"Centrosome Amplification Is Sufficient to Promote Spontaneous Tumorigenesis in Mammals"
10:20 am - 10:30 am
Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:20 am
Sylvie Doublie (University of Vermont, USA)
"Crystal Structure Analysis of Cancer-Associated Mutations in DNA Repair Enzymes"
11:20 am - 11:30 am
Discussion
11:30 am - 11:50 am
Sheila David (University of California, Davis, USA)
"MUTYH Glycosylase Variants Associated with Colorectal Cancer"
11:50 am - 12:00 pm
Discussion
12:00 pm - 12:15 pm
Selected from Poster Abstracts: Dong Wang (University of California, San Diego, USA)
"Molecular Mechanism of Eukaryotic Transcription-Coupled Repair Initiation"
12:15 pm - 12:20 pm
Discussion
12:20 pm - 12:30 pm
General Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:00 pm - 7:30 pm
Business Meeting
Nominations for the Next Vice Chair; Fill in Conference Evaluation Forms; Discuss Future Site and Scheduling Preferences; Election of the Next Vice Chair
7:30 pm - 9:30 pm
DNA Damage Responses
Discussion Leader: Joann Sweasy (Yale University, USA)
7:30 pm - 7:50 pm
Christopher Bakkenist (University of Pittsburgh, USA)
"DNA Damage Signaling to Immune Checkpoints"
7:50 pm - 8:00 pm
Discussion
8:00 pm - 8:20 pm
Sharon Cantor (University of Massachusetts Medical School, USA)
"The BRCA-FA Pathway and the Replication Stress Response"
8:20 pm - 8:30 pm
Discussion
8:30 pm - 8:50 pm
Paul Mischel (San Diego Branch, Ludwig Cancer Research / University of California, San Diego, USA)
"Location Matters: The Role of Extrachromosomal Oncogene Amplification in Cancer Evolution"
8:50 pm - 9:00 pm
Discussion
9:00 pm - 9:15 pm
Selected from Poster Abstracts: Eli Rothenberg (New York University School of Medicine, USA)
"Visualizing Replication Fork Repair Dynamics in Cells"
9:15 pm - 9:20 pm
Discussion
9:20 pm - 9:30 pm
General Discussion
Thursday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Mutation and Cancer: New Insights from Model Systems
Discussion Leader: Sharon Cantor (University of Massachusetts Medical School, USA)
9:00 am - 9:20 am
Yolanda Sanchez (Geisel School of Medicine, Dartmouth College, USA)
"Promises and Challenges for Checkpoint Inhibitors as Anti-Cancer Drugs"
9:20 am - 9:30 am
Discussion
9:30 am - 9:50 am
Megan King (Yale University, USA)
"Insights into Mechanisms of PARP Inhibitor Resistance"
9:50 am - 10:00 am
Discussion
10:00 am - 10:20 am
Polina Shcherbakova (Eppley Institute for Research in Cancer and Allied Diseases, USA)
"DNA Polymerase Epsilon Mutations in Cancers"
10:20 am - 10:30 am
Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:20 am
Hannah Klein (New York University School of Medicine, USA)
"Mutation and Genome Instability Events from Ribonucleotides in DNA"
11:20 am - 11:30 am
Discussion
11:30 am - 11:50 am
Kara Bernstein (University of Pittsburgh School of Medicine, USA)
"Therapeutic Alkylating Agents and the Role of Rad51 Paralogs"
11:50 am - 12:00 pm
Discussion
12:00 pm - 12:15 pm
Selected from Poster Abstracts: Alain Nepveu (McGill University, Canada)
"Acute Dependence of Cancer Cells on Base Excision Repair Auxiliary Factors"
12:15 pm - 12:20 pm
Discussion
12:20 pm - 12:30 pm
General Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Mutations Facilitated by DNA Damage and Structure
Discussion Leader: Sylvie Doublie (University of Vermont, USA)
7:30 pm - 7:50 pm
Hilde Nilsen (University of Oslo, Norway)
"Uracil Accumulation and Mutagenesis Dominated by Cytosine Deamination in Mice Lacking UNG and SMUG1"
7:50 pm - 8:00 pm
Discussion
8:00 pm - 8:20 pm
Alba Guarne (McGill University, Canada)
"MUTL Structures and Variants"
8:20 pm - 8:30 pm
Discussion
8:30 pm - 8:50 pm
Karen Vasquez (The University of Texas at Austin, USA)
"DNA Structure, Mutation, and Cancer"
8:50 pm - 9:00 pm
Discussion
9:00 pm - 9:20 pm
Patricia Kannouche (UMR 8200, CNRS / Gustave Roussy, Université Paris-Sud, France)
"Specialized DNA Polymerases and Replication of Heterochromatin in the Genome"
9:20 pm - 9:30 pm
Discussion
Friday
7:30 am - 8:30 am
Breakfast
9:00 am
Departure