Sunday
4:00 pm - 8:00 pm
Arrival and Check-in
6:00 pm - 7:00 pm
Dinner
7:30 pm - 7:40 pm
Introductory Comments by GRC Site Staff / Welcome from the GRC Chair
7:40 pm - 9:30 pm
Keynote Session: DNA Damage Response and Cancer
Discussion Leader: Sharon Cantor (University of Massachusetts Medical School, USA)
7:40 pm - 7:55 pm
Opening Remarks
7:55 pm - 8:10 pm
Introduction by Discussion Leader
8:10 pm - 8:45 pm
Jiri Bartek (Danish Cancer Society, Denmark)
"Mechanistic Understanding and Targeting of Cancer Cell Addictions to Stress-Tolerance Pathways"
8:45 pm - 9:10 pm
Discussion
9:10 pm - 9:30 pm
General Discussion
Monday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Mutational and Repair Processes
Discussion Leader: Jeremy Stark (City of Hope, USA)
9:00 am - 9:20 am
Irene Chiolo (University of Southern California, USA)
"Nuclear and Chromatin Dynamics for Heterochromatin Repair"
9:20 am - 9:30 am
Discussion
9:30 am - 9:50 am
Anna Malkova (University of Iowa, USA)
"Rad51 and Rad59 Cooperate to Promote One Unified Pathway of Alternative Lengthening of Telomeres"
9:50 am - 10:00 am
Discussion
10:00 am - 10:20 am
Dale Ramsden (University of North Carolina Lineberger Comprehensive Cancer Center, USA)
"Promiscuous Synthesis During Repair of Chromosome Breaks: What Goes in, When, and Why?"
10:20 am - 10:30 am
Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:20 am
Shamil Sunyaev (Brigham and Women's Hospital / Harvard Medical School, USA)
"From Statistical Models to Biological Mechanisms of Human Mutation"
11:20 am - 11:30 am
Discussion
11:30 am - 11:50 am
Martin Taylor (MRC Human Genetics Unit, University of Edinburgh, United Kingdom)
"Pervasive Segregation of DNA Lesions Generates Genetic Diversity in Cancer"
11:50 am - 12:00 pm
Discussion
12:00 pm - 12:20 pm
Xiaohua Wu (The Scripps Research Institute, USA)
"Break-Induced Replication Mechanisms in Mammalian Cells"
12:20 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
3:00 pm - 4:00 pm
The GRC Power Hour™
The GRC Power Hour™ is designed to address challenges women face in science and issues of diversity and inclusion. The program supports the professional growth of all members of our communities by providing an open forum for discussion and mentoring.
Organizer: Sharon Cantor (University of Massachusetts Medical School, USA)
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
DNA Repair Meets CRISPR
Discussion Leader: Maria Spies (University of Iowa, USA)
7:30 pm - 7:50 pm
Jacob Corn (ETH Zurich, Switzerland)
"Mechanisms of Genome Editing in Human Cells"
7:50 pm - 8:00 pm
Discussion
8:00 pm - 8:20 pm
Ilya Finkelstein (University of Texas at Austin, USA)
"NucleaSeq: Massively-Parallel Biophysical Profiling of Natural and Engineered CRISPR Nucleases"
8:20 pm - 8:30 pm
Discussion
8:30 pm - 8:50 pm
Anthony Forget (Intellia Therapeutics, USA)
"Complex Genome Editing In Vivo via Lipid Nanoparticle Delivery of CRISPR-Cas9"
8:50 pm - 9:00 pm
Discussion
9:00 pm - 9:20 pm
Stephen West (Francis Crick Institute, United Kingdom)
"Sensitization of HR-Deficient Cancer Cells by Targeting Nucleotide Metabolism"
9:20 pm - 9:30 pm
Discussion
Tuesday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Group Photo
9:00 am - 12:30 pm
Transcription and Replication Collisions
Discussion Leader: Philippe Pasero (Institute of Human Genetics (IGH) / University of Montpellier / CNRS, France)
9:00 am - 9:20 am
Aura Carreira (Institut Curie / CNRS, France)
"BRCA2 Promotes RNA-DNA Hybrids Resolution at DNA Double-Strand Breaks to Facilitate Homologous Recombination"
9:20 am - 9:30 am
Discussion
9:30 am - 9:50 am
Peter McKinnon (St. Jude Children's Research Hospital, USA)
"R-Loops and Aberrant RNA Splicing Cause Cerebellar Transcriptional Collapse in Genome Instability-Induced Neurodegeneration"
9:50 am - 10:00 am
Discussion
10:00 am - 10:20 am
Houra Merrikh (Vanderbilt University, USA)
"Transcription-Induced Mutagenesis in Bacteria"
10:20 am - 10:30 am
Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:20 am
Duncan Smith (New York University, USA)
"A Model for How Replicative Polymerase Deficiency Affects Genome Integrity"
11:20 am - 11:30 am
Discussion
11:30 am - 11:50 am
Junjie Chen (The University of Texas MD Anderson Cancer Center, USA)
"Dissecting the Molecular Mechanisms of DNA Damage Response Pathways"
11:50 am - 12:00 pm
Discussion
12:00 pm - 12:20 pm
Gaorav Gupta (The University of North Carolina at Chapel Hill, USA)
"Mre11 Suppresses Genome Instability at Oncogene-Induced R Loops"
12:20 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Chromosome Rearrangements in Cancer
Discussion Leader: Eli Rothenberg (New York University School of Medicine, USA)
7:30 pm - 7:50 pm
Batsheva Kerem (The Hebrew University of Jerusalem, Israel)
"The Role of Replication Regulation in Damage and Mutation in Cancer Development"
7:50 pm - 8:00 pm
Discussion
8:00 pm - 8:20 pm
Jeremy Stark (City of Hope, USA)
"Etiology of Chromosomal Rearrangements"
8:20 pm - 8:30 pm
Discussion
8:30 pm - 8:50 pm
Zuzana Storchova (University of Kaiserslautern, Germany)
"Functional Link Between DNA Replication Stress and Mitotic Errors"
8:50 pm - 9:00 pm
Discussion
9:00 pm - 9:10 pm
Mitch McVey (Tufts University, USA)
"REV1 Promotes Two Distinct Mechanisms of Damage Tolerance in Drosophila "
9:10 pm - 9:15 pm
Discussion
9:15 pm - 9:25 pm
Natalie Saini (National Institute of Environmental Health Sciences, NIH, USA)
"The Burden and Signatures of Somatic Mutations in Healthy Individuals"
9:25 pm - 9:30 pm
Discussion
Wednesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Immune Response and DNA Damage
Discussion Leader: Karen Usdin (National Institutes of Health, USA)
9:00 am - 9:20 am
Melinda Day (Cyteir Therapeutics, USA)
"Targeting Homologous Recombination: A New Synthetic Lethal Therapeutic Paradigm"
9:20 am - 9:30 am
Discussion
9:30 am - 9:50 am
Philippe Pasero (Institute of Human Genetics (IGH) / University of Montpellier / CNRS, France)
"Cellular Responses to Endogenous Replication Stress"
9:50 am - 10:00 am
Discussion
10:00 am - 10:20 am
Joann Sweasy (University of Arizona, USA)
"DNA Repair Landscape and Induction of the Inflammatory Response"
10:20 am - 10:30 am
Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:15 am
Nicholas Pannunzio (University of California, Irvine, USA)
"When V(D)J Goes Astray: Etiology of the Chromosomal Translocations that Drive B-Cell Malignancies"
11:15 am - 11:20 am
Discussion
11:20 am - 11:35 am
Reuben Harris (Howard Hughes Medical Institute / University of Minnesota, USA)
"APOBEC3A Catalyzes Mutation and Drives Carcinogenesis In Vivo "
11:35 am - 11:40 am
Discussion
11:40 am - 11:55 am
Lorenza Penengo (University of Zurich, Switzerland)
"Interferon-Stimulated Gene 15 Accelerates DNA Replication Leading to Chromosomal Breakage"
11:55 am - 12:00 pm
Discussion
12:00 pm - 12:15 pm
Faye Rogers (Yale School of Medicine, USA)
"Targeting Gene Amplifications to Exploit DDR for Cancer Therapy"
12:15 pm - 12:20 pm
Discussion
12:20 pm - 12:30 pm
General Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:00 pm - 7:30 pm
Business Meeting
Nominations for the Next Vice Chair; Fill in Conference Evaluation Forms; Discuss Future Site and Scheduling Preferences; Election of the Next Vice Chair
7:30 pm - 9:30 pm
Cell Susceptibility from Repair Processes and Cancer Treatments
Discussion Leader: Mary Helen Barcellos-Hoff (University of California, San Francisco, USA)
7:30 pm - 7:50 pm
Dipanjan Chowdhury (Dana-Farber Cancer Institute, USA)
"Investigating Factors at the Interface of DNA Repair and Replication"
7:50 pm - 8:00 pm
Discussion
8:00 pm - 8:20 pm
Marcus Smolka (Cornell University, USA)
"Exploring Signaling Networks for Novel DNA Repair Regulatory Mechanisms"
8:20 pm - 8:30 pm
Discussion
8:30 pm - 8:50 pm
Richard Wood (University of Texas MD Anderson Cancer Center, USA)
"A DNA Polymerase for Stress Relief and Cancer Suppression"
8:50 pm - 9:00 pm
Discussion
9:00 pm - 9:10 pm
Jacqueline Barlow (University of California, Davis, USA)
"Mechanisms Underlying the Formation of Complex Chromosomal Rearrangements"
9:10 pm - 9:15 pm
Discussion
9:15 pm - 9:25 pm
Richard Frock (Stanford University, USA)
"Repair Fate Mapping of Broken Ends in Non-Dividing Cells"
9:25 pm - 9:30 pm
Discussion
Thursday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
DNA Structures and DNA Damage
Discussion Leader: Houra Merrikh (Vanderbilt University, USA)
9:00 am - 9:20 am
Sergei Mirkin (Tufts University, USA)
"Mechanisms of Genome Instability Mediated by Simple DNA Repeats"
9:20 am - 9:30 am
Discussion
9:30 am - 9:50 am
Eli Rothenberg (New York University School of Medicine, USA)
"Dynamics and Regulation of DNA Repair at Complex Chromosomal Breaks"
9:50 am - 10:00 am
Discussion
10:00 am - 10:20 am
Maria Spies (University of Iowa, USA)
"RAD52 Protein: A Protector of Stalled Replication Forks"
10:20 am - 10:30 am
Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:20 am
Karen Usdin (National Institutes of Health, USA)
"Breaking Bad: Aberrant DNA Repair and Repeat Expansion in the Fragile X-Related Disorders"
11:20 am - 11:30 am
Discussion
11:30 am - 11:45 am
Richard Pomerantz (Lewis Katz School of Medicine, Temple University, USA)
"DNA End-Joining Involving DNA and RNA Substrates"
11:45 am - 11:55 am
Discussion
11:55 am - 12:10 pm
Catherine Freudenreich (Tufts University, USA)
"SUMOylation of DNA Repair Proteins at Collapsed Forks Mediates Relocation to Nuclear Pore Complexes to Promote Repair"
12:10 pm - 12:20 pm
Discussion
12:20 pm - 12:30 pm
General Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
New Targets for Cancer Therapies
Discussion Leader: Dipanjan Chowdhury (Dana-Farber Cancer Institute, USA)
7:30 pm - 7:50 pm
Roman Chabanon (Institute of Cancer Research, United Kingdom)
"Linking DNA Repair and Anticancer Immune Response to Design Rational Therapeutic Approaches"
7:50 pm - 8:00 pm
Discussion
8:00 pm - 8:15 pm
Steven Roberts (Washington State University, USA)
"APOBEC3A Is a Prominent Cytidine Deaminase Active in Human Cancers"
8:15 pm - 8:25 pm
Discussion
8:25 pm - 8:40 pm
Remi Buisson (University of California, Irvine, USA)
"Monitoring APOBEC3A Activity in Patient Tumors for Targeted Therapy"
8:40 pm - 8:50 pm
Discussion
8:50 pm - 9:10 pm
Mary Helen Barcellos-Hoff (University of California, San Francisco, USA)
"TGFβ Regulation of Alternative End Joining"
9:10 pm - 9:20 pm
Discussion
9:20 pm - 9:30 pm
General Discussion
Friday
7:30 am - 8:30 am
Breakfast
9:00 am
Departure