Sunday
2:00 pm - 9:00 pm
Arrival and Check-in
6:00 pm - 7:00 pm
Dinner
7:30 pm - 7:40 pm
Introductory Comments by GRC Site Staff / Welcome from the GRC Chair
7:40 pm - 9:30 pm
Keynote Session: Replication Gaps in Signaling, Repair and Disease
Discussion Leader: Jeremy Stark (City of Hope, United States)
7:40 pm - 7:50 pm
Opening Remarks
7:50 pm - 7:55 pm
Introduction by Discussion Leader
7:55 pm - 8:30 pm
Helle Ulrich (Institute of Molecular Biology (IMB) Mainz, Germany)
"Mind the Gap – Daughter-Strand Gaps as Sites of Damage Bypass and Damage Signaling"
8:30 pm - 8:40 pm
Discussion
8:40 pm - 9:15 pm
Keith Caldecott (University of Sussex, United Kingdom)
"The Impact of Single-Strand Break Repair on Transcription, Replication, and Disease"
9:15 pm - 9:25 pm
Discussion
9:25 pm - 9:30 pm
General Discussion
Monday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
DNA Damage and Checkpoint Responses
Discussion Leaders: Nima Mosammaparast (Washington University in St. Louis, United States)
9:00 am - 9:05 am
Introduction by Discussion Leader
9:05 am - 9:25 am
Angelos Constantinou (CNRS - UNiversity of Montpellier, France)
"Functions of Biomolecular Condensates Assembled in Response to DNA Damage"
9:25 am - 9:30 am
Discussion
9:30 am - 9:50 am
Luis Toledo (University of Copenhagen, Denmark)
"Checking the Completion of DNA Replication at the S/G2 Transition"
9:50 am - 9:55 am
Discussion
9:55 am - 10:15 am
Marcel van Vugt (University of Groningen, The Netherlands)
"Processing DNA Damage During Mitosis"
10:15 am - 10:20 am
Discussion
10:20 am - 10:50 am
Group Photo / Coffee Break
10:50 am - 11:10 am
Michela Di Virgilio (Max-Delbruck Center for Molecular Medicine (MDC), Germany)
"Molecular Switches in Antibody Gene Diversification"
11:10 am - 11:15 am
Discussion
11:15 am - 11:35 am
Christopher Bakkenist (University of Pittsburgh, United States)
"ATR Kinase Inhibitors Induce Thymineless Death in CD8+ T Cells"
11:35 am - 11:40 am
Discussion
11:40 am - 12:00 pm
Robert Sobol (Mitchell Cancer Institute, United States)
"Base Excision Repair Mediated Regulation of the Replication-Stress Induced Intra S-Phase Checkpoint"
12:00 pm - 12:05 pm
Discussion
12:05 pm - 12:20 pm
Abby Green (Washington University School of Medicine in St. Louis, United States)
"Aberrant Activity of the APOBEC3A Cytidine Deaminase Causes Genome-Wide Indels and Altered DNA Methylation"
12:20 pm - 12:25 pm
Discussion
12:25 pm - 12:30 pm
General Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
3:00 pm - 4:00 pm
The GRC Power Hour™
The GRC Power Hour™ is designed to address challenges women face in science and issues of diversity and inclusion. The program supports the professional growth of all members of our communities by providing an open forum for discussion and mentoring.
Organizers: Patricia Opresko (University of Pittsburgh, United States) and Kara Bernstein (University of Pennsylvania School of Medicine, United States)
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
DNA Damage and Structures Engaging Repair vs. Bypass Mechanisms
Discussion Leader: Helle Ulrich (Institute of Molecular Biology (IMB) Mainz, Germany)
7:30 pm - 7:35 pm
Introduction by Discussion Leader
7:35 pm - 7:55 pm
Orlando Schärer (IBS Center for Genomic Integrity, South Korea)
"Two Interaction Sites Between XPA and RPA Sculpt the Precision Complex in Human Nucleotide Excision Repair"
7:55 pm - 8:00 pm
Discussion
8:00 pm - 8:20 pm
Hannah Klein (New York Grossman University School of Medicine, United States)
"Genome Damage and Mutations Arising from Persistent Ribonucleotides in DNA"
8:20 pm - 8:25 pm
Discussion
8:25 pm - 8:45 pm
Richard Wood (University of Texas MD Anderson Cancer Center, United States)
"DNA End Manipulation by Pol Theta"
8:45 pm - 8:50 pm
Discussion
8:50 pm - 9:05 pm
Kara Bernstein (University of Pennsylvania School of Medicine, United States)
"RAD51 Paralog Function in DNA Damage Tolerance"
9:05 pm - 9:10 pm
Discussion
9:10 pm - 9:25 pm
Alice Pyne (The University of Sheffield, United Kingdom)
"Single-Molecule Insights into Stressed DNA: Supercoiling, Secondary Structures and Topological Problems"
9:25 pm - 9:30 pm
Discussion
Tuesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
DNA Repair, Replication and Cancer Therapy
Discussion Leader: Karlene Cimprich (Stanford University School of Medicine, United States)
9:00 am - 9:05 am
Introduction by Discussion Leader
9:05 am - 9:25 am
George-Lucian Moldovan (Penn State College of Medicine, United States)
"The Impact of Lagging Strand ssDNA Gaps on Replication Fork Protection and Genomic Stability"
9:25 am - 9:30 am
Discussion
9:30 am - 9:50 am
Shan Zha (Columbia University, United States)
"Catalytically Inactive PARP2 Blocks Nick Repair During Replication and Cause Lethal Anemia in Mice"
9:50 am - 9:55 am
Discussion
9:55 am - 10:10 am
Ke Cong (UMass Medical School, United States)
"Replication Gaps are a Key Determinant of PARP Inhibitor Synthetic Lethality with BRCA Deficiency"
10:10 am - 10:15 am
Discussion
10:15 am - 10:50 am
Coffee Break
10:50 am - 11:10 am
Alessandro Vindigni (Washington University School of Medicine, United States)
"Linking DNA Replication for Dynamics with Chemotherapy Response"
11:10 am - 11:15 am
Discussion
11:15 am - 11:35 am
Anja Bielinsky (University of Minnesota, United States)
"Pathways that Defy DNA Under-Replication"
11:35 am - 11:40 am
Discussion
11:40 am - 12:00 pm
Bevin Engelward (MIT, United States)
"Blocks versus Breaks: Cancer and Toxicity Pivot Depending on Aag Levels"
12:00 pm - 12:05 pm
Discussion
12:05 pm - 12:20 pm
Shrabasti Roychoudhury (Dana-Farber Cancer Institute, United States)
"High-Throughput Screening Strategy Identifies Novel Regulator of Replication Stress Response"
12:20 pm - 12:25 pm
Discussion
12:25 pm - 12:30 pm
General Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Chromosomal Dynamics, DNA Damage Signaling and Immune Responses
Discussion Leader: Marcel van Vugt (University of Groningen, The Netherlands)
7:30 pm - 7:35 pm
Introduction by Discussion Leader
7:35 pm - 7:55 pm
Helen Walden (University of Glasgow, United Kingdom)
"Mechanism of Site-Specific Ubiquitin Removal in the Fanconi Anemia Pathway"
7:55 pm - 8:00 pm
Discussion
8:00 pm - 8:20 pm
Sandra Demaria (Weill Cornell Medical College, United States)
"Message in a Small Extracellular Vesicle: An Unexpected Cargo Informs Innate Immune Cells About Cancer Cell DNA Damage"
8:20 pm - 8:25 pm
Discussion
8:25 pm - 8:40 pm
Mary Helen Barcellos-Hoff (University of California, San Francisco, United States)
"Signatures of TGFß Competency and DNA Repair Predict Response to Anti-PD1 and Anti-PDL1 Therapies"
8:40 pm - 8:45 pm
Discussion
8:45 pm - 9:00 pm
Gaorav Gupta (The University of North Carolina at Chapel Hill, United States)
"New Insights Into Innate Immune Sensing During Tumorigenesis"
9:00 pm - 9:05 pm
Discussion
9:05 pm - 9:20 pm
Remi Buisson (University of California, Irvine, United States)
"Regulation of APOBEC3A Mutagenesis and Inflammation by the DNA Damage Response"
9:20 pm - 9:25 pm
Discussion
9:25 pm - 9:30 pm
General Discussion
Wednesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Replication, Collisions and Recovery
Discussion Leader: Alessandro Vindigni (Washington University School of Medicine, United States)
9:00 am - 9:05 am
Introduction by Discussion Leader
9:05 am - 9:25 am
Karlene Cimprich (Stanford University School of Medicine, United States)
"The Causes and Consequences of Replication Stress"
9:25 am - 9:30 am
Discussion
9:30 am - 9:50 am
Frederic Chedin (University of California, Davis, United States)
"Splicing Inhibition Triggers Global Alterations in Transcriptional Dynamics and R-Loop Landscapes: Implications for Genome Instability Mechanisms"
9:50 am - 9:55 am
Discussion
9:55 am - 10:10 am
Robert Fuchs (INSERM U1251, France)
"When Repair Accidents Lead to DSB’s"
10:10 am - 10:15 am
Discussion
10:15 am - 10:25 am
Tovah Day (Northeastern University, United States)
"Epigenetic Control of G Quadruplex DNA"
10:25 am - 10:30 am
Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:20 am
Martijn Luijsterburg (Leiden University Medical Center (LUMC), The Netherlands)
"Molecular Mechanisms in Transcription-Coupled DNA Repair"
11:20 am - 11:25 am
Discussion
11:25 am - 11:45 am
Sergei Mirkin (Tufts University, United States)
"Mechanisms of DNA Repeat Expansions: From Yeast to Human Cells"
11:45 am - 11:50 am
Discussion
11:50 am - 12:05 pm
Shailja Pathania (University of Massachusetts Boston, United States)
"Uracil Excision and Abasic Site Accumulation Dictate Stalled Fork Stability in BRCA2-Deficient Cells"
12:05 pm - 12:10 pm
Discussion
12:10 pm - 12:20 pm
John Krais (Fox Chase Cancer Center, United States)
"BRCA1 Mutations and Polymerase Theta Addiction"
12:20 pm - 12:25 pm
Discussion
12:25 pm - 12:30 pm
General Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:00 pm - 7:30 pm
Business Meeting
Nominations for the Next Vice Chair; Fill in Conference Evaluation Forms; Discuss Future Site and Scheduling Preferences; Election of the Next Vice Chair
7:30 pm - 9:30 pm
CRISPR Screens to Gene Editing in Disease
Discussion Leader: Shan Zha (Columbia University, United States)
7:30 pm - 7:35 pm
Introduction by Discussion Leader
7:35 pm - 7:55 pm
Laura Sepp-Lorenzino (Intellia Therapeutics, United States)
"Transforming Medicine: In Vivo and Ex Vivo Therapeutic Gene Editing"
7:55 pm - 8:00 pm
Discussion
8:00 pm - 8:20 pm
Joanna Loizou (Center for Cancer Research, Austria)
"Identifying Genetic Interactions for FA Through Genetic Screens"
8:20 pm - 8:25 pm
Discussion
8:25 pm - 8:45 pm
Britt Adamson (Princeton University, United States)
"Mapping the DNA Repair Processes that Enable CRISPR-Based Genome Editing"
8:45 pm - 8:50 pm
Discussion
8:50 pm - 9:05 pm
Petr Cejka (Università Della Svizzera Italiana, Switzerland)
"Mechanism of DNA End Sensing by the MRE11 Complex: Implications for CRISPR-Based Genome Editing"
9:05 pm - 9:10 pm
Discussion
9:10 pm - 9:25 pm
Michael Yaffe (Massachusetts Institute of Technology, United States)
"Synthetic Lethality for Platinum-Induced DNA Damage Using CRISPRi Screens and Nanoparticle Delivery"
9:25 pm - 9:30 pm
Discussion
Thursday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Cancer, Aging and Neurodegeneration
Discussion Leader: Keith Caldecott (University of Sussex, United Kingdom)
9:00 am - 9:05 am
Introduction by Discussion Leader
9:05 am - 9:25 am
Bjoern Schmacher (University of Cologne, Germany)
"Genome Stability in Aging, Inheritance and Disease: An Organismal Perspective from C. elegans"
9:25 am - 9:30 am
Discussion
9:30 am - 9:50 am
Matthew Yousefzadeh (University of Minnesota, United States)
"Endogenous DNA Damage as a Driver of Aging"
9:50 am - 9:55 am
Discussion
9:55 am - 10:10 am
Laurie Sanders (Duke University, United States)
"Persistent Activation of the DNA Damage Response in LRRK2-Related Parkinson’s Disease"
10:10 am - 10:15 am
Discussion
10:15 am - 10:50 am
Coffee Break
10:50 am - 11:10 am
Peter Adams (Sanford Burnham Prebys Medical Discovery Institute, United States)
"The DNA Damage Response in Senescent Cells – Impacts on Genome Integrity, Aging and Cancer"
11:10 am - 11:15 am
Discussion
11:15 am - 11:35 am
Sihan Wu (University of Texas Southwestern Medical Center, United States)
"Extrachromosomal DNA: An Emerging Hallmark in Human Cancer"
11:35 am - 11:40 am
Discussion
11:40 am - 12:00 pm
Patricia Opresko (University of Pittsburgh, United States)
"The Processing of 8-Oxoguanine at Telomeres Promotes Cellular Senescence"
12:00 pm - 12:05 pm
Discussion
12:05 pm - 12:20 pm
Mohammad Moshahid Khan (University of Tennessee Health Science Center, United States)
"DNA Damage-Based Mechanisms and Therapeutics for Age-Relative Neurodegenerative Diseases"
12:20 pm - 12:25 pm
Discussion
12:25 pm - 12:30 pm
General Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Genomic Instability and Emerging Targets for Therapy
Discussion Leader: Nima Mosammaparast (Washington University in St. Louis, United States)
7:30 pm - 7:35 pm
Introduction by Discussion Leader
7:35 pm - 7:50 pm
Nima Mosammaparast (Washington University in St. Louis, United States)
"Linking RNA Processing Defects and Genome Integrity"
7:50 pm - 7:55 pm
Discussion
7:55 pm - 8:10 pm
Advaitha Madireddy (Rutgers Cancer Institute of New Jersey, United States)
"Replication Stress as a Potential Driver of Clonal Hematopoiesis in 9/11 Firefighters"
8:10 pm - 8:15 pm
Discussion
8:15 pm - 8:35 pm
Dipanjan Chowdhury (Dana-Farber Cancer Institute, United States)
"Expanding the Scope of DNA Repair Factors - Novel Roles and Applications"
8:35 pm - 8:40 pm
Discussion
8:40 pm - 9:00 pm
Jill Bargonetti (Hunter College, United States)
"Exploring the Interface Between the Mtp53-PARP Axis and DNA Replication Regulation"
9:00 pm - 9:05 pm
Discussion
9:05 pm - 9:25 pm
Ricky Sharma (Varian, United Kingdom)
"Translation to Clinical Trials: How Do We Accelerate Progress?"
9:25 pm - 9:30 pm
Discussion
Friday
7:30 am - 8:30 am
Breakfast
9:00 am
Departure