Sunday
2:00 pm - 9:00 pm
Arrival and Check-in
6:00 pm - 7:00 pm
Dinner
7:30 pm - 7:40 pm
Introductory Comments by GRC Staff / Welcome and Introduction from the Chairs
7:40 pm - 9:30 pm
Keynote Session: DNA Repair Mechanisms and Disease
Discussion Leader: Shan Zha (Columbia University, United States)
7:40 pm - 8:25 pm
Wei Yang (National Institutes of Health, United States)
"Mechanisms of DNA Repair in 3D"
8:25 pm - 8:35 pm
Discussion
8:35 pm - 9:20 pm
Richard Wood (University of Texas MD Anderson Cancer Center, United States)
"Two Faces of DNA Polymerases: Protecting Genomes and Causing Mutations"
9:20 pm - 9:30 pm
Discussion
Monday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
End Joining Mechanisms and Cancer Therapeutics
Discussion Leader: Yuan He (Northwestern University, United States)
9:00 am - 9:20 am
Mauro Modesti (Cancer Research Center of Marseille / CNRS UMR7258, Aix Marseille University, France)
"Role of Disorder in NHEJ Proteins"
9:20 am - 9:30 am
Discussion
9:30 am - 9:50 am
Bo-Ruei Chen (University of Alabama at Birmingham, United States)
"Senataxin and DNAPKcs Redundantly Promote NHEJ-Mediated RAG DSB Repair During V(D)J Recombination"
9:50 am - 10:00 am
Discussion
10:00 am - 10:15 am
Metztli Cisneros (City of Hope, United States)
"Defining the Role of Chromosomal Break End Synapsis Factors in Blunt DSB EJ"
10:15 am - 10:20 am
Discussion
10:20 am - 10:50 am
Coffee Break
10:50 am - 11:10 am
Helen Robinson (Artios Pharma Ltd, United Kingdom)
"Targeting the DDR in Cancer Therapy"
11:10 am - 11:20 am
Discussion
11:20 am - 11:40 am
Dale Ramsden (University of North Carolina Lineberger Comprehensive Cancer Center, United States)
"The Last Poorly Understood DNA Repair Pathway: Now Better Understood?"
11:40 am - 11:50 am
Discussion
11:50 am - 12:05 pm
Yimeng Zhu (Columbia University, United States)
"The Unexpected Tale of Ku80 Tail"
12:05 pm - 12:10 pm
Discussion
12:10 pm - 12:25 pm
Short Talk Selected from Poster Abstracts
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
3:00 pm - 4:00 pm
The GRC Power Hourâ„¢
The GRC Power Hourâ„¢ is designed to address diversity and inclusion in the scientific workplace by providing a safe environment for informal and meaningful conversations amongst colleagues of all career stages. The program supports the professional growth of all members of our communities, including ethnicity, race and/or gender identity by providing an open forum for discussion and mentoring.
Organizer: Karen Vasquez (The University of Texas at Austin, United States)
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Structural Insights into the DNA Damage Response
Discussion Leader: Wei Yang (National Institutes of Health, United States)
7:30 pm - 7:50 pm
Amanda Chaplin (The University of Leicester, United Kingdom)
"NHEJ Complexes Come in all Shapes and Sizes"
7:50 pm - 8:00 pm
Discussion
8:00 pm - 8:20 pm
Sylvie Doublie (University of Vermont, United States)
"Quo Vadis, NEIL DNA Glycosylases? Functional Roles, Lesion Search, and Cancer Variants"
8:20 pm - 8:30 pm
Discussion
8:30 pm - 8:50 pm
Melike Caglayan (University of Florida, United States)
"Last Stop on the Road to Base Excision Repair: Nick Sealing by DNA Ligase"
8:50 pm - 9:00 pm
Discussion
9:00 pm - 9:20 pm
Yuan He (Northwestern University, United States)
"Structural Basis of DNA Double-Strand Break Repair by NHEJ"
9:20 pm - 9:30 pm
Discussion
Tuesday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Group Photo
9:00 am - 12:30 pm
Mutations and Deregulation of the DNA Damage Response and Cancer
Discussion Leader: Maria Jasin (Memorial Sloan Kettering Cancer Center, United States)
9:00 am - 9:20 am
Agata Smogorzewska (The Rockefeller University, United States)
"Sources of Endogenous DNA Damage in Tumorigenesis"
9:20 am - 9:30 am
Discussion
9:30 am - 9:50 am
Dineo Khabele (Washington University School of Medicine, United States)
"Targeting DNA Damage Repair in Ovarian Cancer with Epigenetic Drugs."
9:50 am - 10:00 am
Discussion
10:00 am - 10:20 am
Elizabeth Christie (Peter MacCallum Cancer Centre, Australia)
"Acquired Treatment Resistance in Homologous Recombination Deficient Ovarian Cancer"
10:20 am - 10:30 am
Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:20 am
Melinda Telli (Stanford University School of Medicine, United States)
"Targeting DNA Repair Defects in Hereditary Breast Cancer: Clinical Updates"
11:20 am - 11:30 am
Discussion
11:30 am - 11:50 am
Svasti Haricharan (Sanford Burnham Prebys, United States)
"DNA Damage Repair and Cancer Through the Lens of the Host"
11:50 am - 12:00 pm
Discussion
12:00 pm - 12:10 pm
Short Talk Selected from Poster Abstracts
12:10 pm - 12:15 pm
Discussion
12:15 pm - 12:25 pm
Short Talk Selected from Poster Abstracts
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
DNA Replication and Cancer Therapy
Discussion Leader: Agata Smogorzewska (The Rockefeller University, United States)
7:30 pm - 7:50 pm
Sharon Cantor (University of Massachusetts Medical School, United States)
"Leveraging the Gap Vulnerability in BRCA Deficient Cells to Combat Chemoresistance"
7:50 pm - 8:00 pm
Discussion
8:00 pm - 8:20 pm
Maria Jasin (Memorial Sloan Kettering Cancer Center, United States)
"Mechanisms of Genomic Instability in Mammalian Cells"
8:20 pm - 8:30 pm
Discussion
8:30 pm - 8:50 pm
Yi Yin (UCLA, United States)
"High-Throughput Mapping of Sister Chromatid Exchange and Other Structural Variation Events With Single-Cell Sequencing"
8:50 pm - 9:00 pm
Discussion
9:00 pm - 9:10 pm
Short Talk Selected from Poster Abstracts
9:10 pm - 9:15 pm
Discussion
9:15 pm - 9:25 pm
Short Talk Selected from Poster Abstracts
9:25 pm - 9:30 pm
Discussion
Wednesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
The DNA Damage Response and Chromosomal Rearrangements
Discussion Leader: Jessica Tyler (Weill Cornell Medicine, United States)
9:00 am - 9:20 am
Christine Beck (The Jackson Laboratory of Genomic Medicine / University of Connecticut Health Center, United States)
"Repetitive Sequences: Drivers of Genomic Instability"
9:20 am - 9:30 am
Discussion
9:30 am - 9:50 am
Tanya Paull (University of Texas at Austin, United States)
"Mechanisms of DNA Double-Strand Break Repair"
9:50 am - 10:00 am
Discussion
10:00 am - 10:15 am
Short Talk Selected from Poster Abstracts
10:15 am - 10:20 am
Discussion
10:20 am - 10:50 am
Coffee Break
10:50 am - 11:10 am
Andre Nussenzweig (National Cancer Institute, National Institutes of Health , United States)
"Structure of DNA Ends and Repair at Collapsed Forks"
11:10 am - 11:20 am
Discussion
11:20 am - 11:40 am
Gaorav Gupta (The University of North Carolina at Chapel Hill, United States)
"Immune Sensing of DNA Damage During Tumorigenesis"
11:40 am - 11:50 am
Discussion
11:50 am - 12:05 pm
Short Talk Selected from Poster Abstracts
12:05 pm - 12:10 pm
Discussion
12:10 pm - 12:25 pm
Short Talk Selected from Poster Abstracts
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Mechanisms of Genome Maintenance
Discussion Leader: Richard Wood (University of Texas MD Anderson Cancer Center, United States)
7:30 pm - 7:50 pm
Karen Vasquez (The University of Texas at Austin, United States)
"DNA Structure-Induced Genetic Instability in Cancer"
7:50 pm - 8:00 pm
Discussion
8:00 pm - 8:20 pm
Jessica Tyler (Weill Cornell Medicine, United States)
"Insights into Mechanisms to Promote Genome Stability from Studies in Budding Yeast"
8:20 pm - 8:30 pm
Discussion
8:30 pm - 8:50 pm
Richard Adeyemi (Fred Hutchinson Cancer Center, United States)
"Regulation of Homologous Recombination Following Replicative Damage"
8:50 pm - 9:00 pm
Discussion
9:00 pm - 9:10 pm
Carol Manhart (Temple University, United States)
"The Role of DNA Discontinuities and ATP in Promoting MutLalpha Endonuclease Activity in DNA Mismatch Repair"
9:10 pm - 9:15 pm
Discussion
9:15 pm - 9:25 pm
Xiaohua Wu (The Scripps Research Institute, United States)
"Investigating Break-Induced Replication in Mammalian Cells"
9:25 pm - 9:30 pm
Discussion
Thursday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Business Meeting
Nominations for the Next Vice Chair(s); Complete the GRC Evaluation Forms; Discuss Future Dates and Venue; Election of the Next Vice Chair(s)
9:00 am - 12:30 pm
Genome Stability in the Brain and Aging
Discussion Leader: Tanya Paull (University of Texas at Austin, United States)
9:00 am - 9:20 am
Peter McKinnon (St. Jude Children's Research Hospital, United States)
"Delineating Topoisomerase Induced DNA Breaks as a Disease Etiology in the Brain."
9:20 am - 9:30 am
Discussion
9:30 am - 9:50 am
E. Alice Lee (Boston Children's Hospital, United States)
"Somatic Mutation in Aging and Neurodegeneration Revealed by Single Cell DNA Sequencing"
9:50 am - 10:00 am
Discussion
10:00 am - 10:20 am
Vishnu Dileep (Massachusetts Institute of Technology, United States)
"Neuronal DNA Double-Strand Breaks Lead to Genome Structural Variations and 3D Genome Disruption in Neurodegeneration"
10:20 am - 10:30 am
Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:20 am
Late-Breaking Topic
11:20 am - 11:30 am
Discussion
11:30 am - 11:50 am
Late-Breaking Topic
11:50 am - 12:00 pm
Discussion
12:00 pm - 12:10 pm
Short Talk Selected from Poster Abstracts
12:10 pm - 12:15 pm
Discussion
12:15 pm - 12:25 pm
Short Talk Selected from Poster Abstracts
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
DNA Damage and Immune Signaling
Discussion Leader: Andre Nussenzweig (National Cancer Institute, National Institutes of Health , United States)
7:30 pm - 7:50 pm
Roger Greenberg (University of Pennsylvania, United States)
"BLM Helicase Unwinds Lagging Strand Substrates to Assemble the ALT Telomere Damage Response"
7:50 pm - 8:00 pm
Discussion
8:00 pm - 8:20 pm
Meredith Morgan (University of Michigan, United States)
"Translating DNA Damage Response Therapeutics with Radiotherapy to Improved Anti-Tumor Immune Responses in Patients"
8:20 pm - 8:30 pm
Discussion
8:30 pm - 8:50 pm
Samuel Bakhoum (Memorial Sloan Kettering Cancer Center, United States)
"Chromosomal Instability-Driven Inflammation as a Driver of Cancer Progression"
8:50 pm - 9:00 pm
Discussion
9:00 pm - 9:10 pm
Christopher Bakkenist (University of Pittsburgh, United States)
"Mechanisms Underlying Anti-Metabolite Induced Innate Immune Signaling"
9:10 pm - 9:15 pm
Discussion
9:15 pm - 9:25 pm
Short Talk Selected from Poster Abstracts
9:25 pm - 9:30 pm
Discussion
Friday
7:30 am - 8:30 am
Breakfast
9:00 am
Departure