Saturday
1:00 pm - 5:00 pm
Arrival and Check-in
3:30 pm - 3:45 pm
Introductory Comments by GRC Site Staff / Welcome from the GRS Chair
3:45 pm - 4:30 pm
Keynote Session: Base Excision Repair and Cancer
Discussion Leader: Lindsey Jackson (Penn State College of Medicine, United States)
3:45 pm - 4:20 pm
Joann Sweasy (University of Arizona Cancer Center, United States)
"Base Excision Repair and Cancer"
4:20 pm - 4:30 pm
Discussion
4:30 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
DNA Damage Response in Cancer
Discussion Leaders: Shrabasti Roychoudhury (Dana-Farber Cancer Institute, United States) and Connor McBrine (Yale University, United States)
7:30 pm - 7:45 pm
Emily Cybulla (St. Louis University School of Medicine, United States)
"Identifying a RAD18/UBC13-dependent Mechanism of Replication Fork Recovery to Modulate Chemoresponse in BRCA1-Deficient Cancers"
7:45 pm - 7:50 pm
Discussion
7:50 pm - 8:05 pm
Ke Cong (UMass Medical School, United States)
"Replication Gaps are a Key Determinant of PARP Inhibitor Synthetic Lethality with BRCA Deficiency"
8:05 pm - 8:10 pm
Discussion
8:10 pm - 8:25 pm
Victoria Brown (Blueprint Medicines, United States)
"CDK2 Coordinates Collapsed Replication Fork Repair in CCNE1 Amplified Ovarian Cancer Cells via Homologous Recombination"
8:25 pm - 8:30 pm
Discussion
8:30 pm - 8:45 pm
John Krais (Fox Chase Cancer Center, United States)
"Exploring Mutation-Specific BRCA1 Localization Defects"
8:45 pm - 8:50 pm
Discussion
8:50 pm - 9:05 pm
Gemma Moore (Yale University, United States)
"BRCA2 Reversion Alleles in BRC Repeats Confer PARPi Resistance via Homology-Directed Repair, not Fork Protection"
9:05 pm - 9:10 pm
Discussion
9:10 pm - 9:25 pm
Anna Palovcak (University of Miami, United States)
"Protein Interactions of Fanconi Anemia Protein FANCA in the DNA Double-Strand Break Repair Response"
9:25 pm - 9:30 pm
Discussion
Sunday
7:30 am - 8:30 am
Breakfast
9:00 am - 11:00 am
DNA Replication and Repair Pathway Choice
Discussion Leaders: Beth Osia (City of Hope, United States) and Catherine Miller (Harvard, United States)
9:00 am - 9:15 am
Carolyn Milano (New York University, United States)
"A Hop1-PHD/WHD Domain Affects Repair of Meiotic DSBs via Direct Interaction with Unmodified Histones"
9:15 am - 9:20 am
Discussion
9:20 am - 9:35 am
Ashna Dhoonmoon (Pennsylvania State University College of Medicine, United States)
"The KU-PARP14 Axis Differentially Regulates Nascent Strand Resection at Stalled Replication Forks by the MRE11 and EXO1 Nucleases"
9:35 am - 9:40 am
Discussion
9:40 am - 9:55 am
Rachana Tomar (Vanderbilt University, United States)
"Correlating the Mutagenic Spectrum of the Aflatoxin B1-Fapy-dG Adduct with Sequence-Specific Modulation of Adduct Conformation and Configuration in DNA"
9:55 am - 10:00 am
Discussion
10:00 am - 10:15 am
Hannah Trost (City of Hope Medical Center - Irell and Manella Graduate School, United States)
"Distinct Pathways Suppress Repeat-Mediated Deletions"
10:15 am - 10:20 am
Discussion
10:20 am - 10:35 am
Elena Martin Doncel (Københavns Universitet (KU), Denmark)
"POLA1 Prevents Post-Replicative ssDNA Gaps Caused by Strand Uncoupling"
10:35 am - 10:40 am
Discussion
10:40 am - 10:55 am
Shiba Dandpat (LUMICKS USA Inc., United States)
"Dynamic Single-Molecule Approach to Directly Visualize the Molecular Mechanisms of DNA Repair Processes"
10:55 am - 11:00 am
Discussion
11:00 am - 12:30 pm
Poster Session
Coffee will be served in the poster area from 11:00 am - 11:30 am
12:30 pm - 1:30 pm
Lunch
1:30 pm - 2:30 pm
Mentorship Component: Navigating Career Independence
Discussion Leader: Matthew Volpe (Harvard University, United States)
1:30 pm - 2:30 pm
Panel Discussion
Navigating Career Independence
Angela Eggleston (Nature, United States)
Asli Muvaffak (GlaxoSmithKline, United States)
Chris Richardson (UC Santa Barbara, United States)
Alessandro Vindigni (Washington University School of Medicine, United States)
Joann Sweasy (University of Arizona Cancer Center, United States)
2:30 pm - 3:00 pm
Evaluation Period
Fill in GRS Evaluation Forms
3:00 pm
Seminar Concludes