| SUNDAY |
| 2:00 pm - 9:00 pm | Arrival and Check-in |
| 6:00 pm | Dinner |
| 7:30 pm - 9:30 pm | Opening Session |
| Discussion Leaders: Peter Senter, Jindrich (Henry) Kopecek |
| Rakesh Jain, Harvard University
"Imaging the Inner Workings of Solid Tumors: A 25 Year Odyssey" |
| Edward A. Sausville, National Cancer Institute
"Signal Transduction Inhibitors for Cancer Treatment: Progress and Issues" |
| MONDAY |
| 7:30 am - 8:30 am | Breakfast |
| 8:30 am | Photo |
| 9:00 am - 12:30 pm | Imaging Technologies |
| Discussion Leader: Peter Senter |
| Alexei Bogdanov, Jr., Massachusetts General Hospital
"Drug Carriers in Molecular Imaging" |
| Zheng-Rong Lu, University of Utah
"Design of Biodegradable Macromolecular MRI Contrast Agents" |
| Jonathon Lindner, University of Virginia
"Diagnostic and Therapeutic Potential of Targeted Microbubbles and Ultrasound" |
| Marcel Bruchez, Quantum Dot Corporation
"In Vivo Applications of Quantum Dot Nanocrystal Tagged Cells and Molecules" |
| 12:30 pm | Lunch |
| 6:00 pm | Dinner |
| 7:30 pm - 9:30 pm | Advances in Drug Carriers |
| Discussion Leader: Jindrich (Henry) Kopecek |
| Karen L. Wooley, Washington University
"The Development of Shell Crosslinked Polymer Micelles as Nanoscopically-Resolved Packaging and Delivery Vehicles" |
| Kazunori Kataoka, University of Tokyo
"Polyion Complex Micelles Encapsulating Light Harvesting Ionic Dendrimer Porphyrins for Photodynamic Therapy" |
| Alexander Kabanov, University of Nebraska
"Polymer Genomics" |
| TUESDAY |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am - 12:30 pm | Self-Assembling Materials |
| Discussion Leader: Kazunori Kataoka |
| Timothy J. Deming, University of California, Santa Barbara
"Self-Assembly and Properties of Block Copolypeptide Amphiphiles" |
| M. Reza Ghadiri, Scripps Institute
"Self-Assembling Antimicrobial Peptide Nanotubes" |
| Samuel Stupp, Northwestern University
"Self-Assembling Materials for Regeneration of Human Tissue" |
| David Tirrell, California Institute of Technology
"Genetically Engineered Biomaterials and Drug Delivery Systems" |
| 12:30 pm | Lunch |
| 6:00 pm | Dinner |
| 7:30 pm - 9:30 pm | Targets for Drug Delivery |
| Discussion Leader: Alexander (Sasha) Kabanov |
| Dieter Brömme, Mount Sinai School of Medicine
"Cathepsins as Drug Targets for Joint Diseases" |
| Peter B. Dervan, California Institute of Technology
"Toward Regulation of Endogenous Gene Expression in Mammalian Cells By Small Molecules" |
| Klaus Bosslet, Schering, Germany
"Inhibition of Tumor Angiogenesis with the VEGF-receptor Tyrosine Kinase
Inhibitor PTK/ZK: Preclinical and Clinical Results" |
| WEDNESDAY |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am - 12:30 pm | Antibody-Mediated Targeting |
| Discussion Leader: Vladimir Muzykantov |
| Hartmut Koeppen, Genentech
"Antibody-Drug Conjugates for HER2-Targeted Therapy" |
| Volker Schellenberger, Genencor International
"Optimization of Recombinant Fusion Proteins for Tumor-Selective Prodrug Activation" |
| Sherie Morrison, UCLA
"Role of Amino Acid Sequence and Glycosylation in Antibody Function" |
| Anna Wu, UCLA
"Tailoring Antibodies for Radionuclide Delivery" |
| 12:30 pm | Lunch |
| 6:00 pm | Dinner |
| 7:30 pm - 9:30 pm | Selected Short Presentations |
| TBA |
| THURSDAY |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am - 12:30 pm | Novel Ligands for Drug Delivery |
| Discussion Leader: Thomas Kissel |
| Michael Flannagan, Sunesis
"Fragment-Based Drug Discovery" |
| Marty Stanton, Archemix Corp.
"Aptamers - Tunable therapeutics to target protein-protein interactions" |
| Herbert I. Hurwitz, Duke University
"Targeting Colorectal Cancer with Avastin (Bevacizumab)" |
| Bernard Lebleu, CNRS-Université de Montpellier
"Peptide-Mediated Delivery of Macromolecules" |
| 12:30 pm | Lunch |
| 6:00 pm | Dinner |
| 7:30 pm - 9:30 pm | Clinical Trials with Drug Carriers and Macromolecules |
| Discussion Leader: Gregory Russell-Jones |
| Paul Herrmann, National Cancer Institute
"Clinical Applications of Proteomics" |
| Jack Singer, Cell Therapeutics
"Polyglutamate-Based Macromolecular Drug Conjugates in Cancer: Lessons in the Complexity of Simplicity" |
| David Scheinberg, Sloan Kettering
"Targeted Alpha Particles and Alpha Particle Generators" |
| FRIDAY |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am | Depart |
