| SUNDAY |
| 4:00 pm - 9:00 pm | Arrival and Check-in |
| 6:00 pm | Dinner |
| 7:30 pm - 7:45 pm | Welcome / Introductory Comments by GRC Site Staff and Conference Chairs |
| 7:45 pm - 9:30 pm | Drugging the Undruggable |
| 7:45 pm - 7:55 pm | Discussion Leaders: Kyung-Dall Lee (Univ. of Michigan, Ann Arbor) & David Scheinberg (MSKCC) |
| 7:55 pm - 8:40 pm | Gregory Verdine (Harvard University)
"Enabling Cell Uptake of alpha-Helical Peptides Through Hydrocarbon Stapling" |
| 8:40 pm - 8:55 pm | Discussion |
| 8:55 pm - 9:15 pm | Theresa Allen (Univ. of Alberta)
"Stealth Liposomes" |
| 9:15 pm - 9:30 pm | Discussion |
| MONDAY |
| 7:30 am - 8:30 am | Breakfast |
| 8:30 am | Group Photo |
| 9:00 am - 12:30 pm | Self-Assembling Drug Carriers, Polymers, and Lipidic Particles |
| 9:00 am - 9:10 am | Discussion Leader: Frank Szoka (Univ. of California, San Francisco) |
| 9:10 am - 9:35 am | Jean Fréchet (Univ. of California, Berkeley)
"Novel Polymeric Constructs" |
| 9:35 am - 9:50 am | Discussion |
| 9:50 am - 10:15 am | Mark Grinstaff (Boston University)
"A Very Short Synopsis on PGLSA Dendrimers and a New Story on Functional Nanoparticles" |
| 10:15 am - 10:30 am | Discussion |
| 10:30 am | Coffee Break |
| 11:00 am - 11:25 am | Paula Hammond (Massachusetts Institute of Technology)
"Patchy Particles: Linear-Dendritic Micellar Assembly for Ligand Variable Targeted Delivery" |
| 11:25 am - 11:40 am | Discussion |
| 11:40 am - 12:05 pm | David Thompson (Purdue University)
"Design & Performance of Bioresponsive Carrier Systems for Drug & Gene Delivery" |
| 12:05 pm - 12:30 pm | Discussion |
| 12:30 pm | Lunch |
| 1:30 pm - 6:00 pm | Free Time |
| 6:00 pm | Dinner |
| 7:30 pm - 9:30 pm | Vasculature, Lymphatics, and Barriers |
| 7:30 pm - 7:40 pm | Discussion Leader: Philip Thorpe (Univ. of Texas Southwestern Medical Center) |
| 7:40 pm - 8:00 pm | Vladimir Muzykantov (U. Penn)
"Targeting anti-thrombotic and anti-inflammatory prodrugs to endothelium" |
| 8:00 pm - 8:15 pm | Discussion |
| 8:15 pm - 8:35 pm | Bronek Pytowski (ImClone, Inc.)
"Therapeutic targeting of lymphatic endothelium" |
| 8:35 pm - 8:50 pm | Discussion |
| 8:50 pm - 9:10 pm | David Lyden (Weill Cornell Medical College)
"Preparing the Soil: The Pre-Metastatic Microenvironment" |
| 9:10 pm - 9:30 pm | Discussion |
| TUESDAY |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am - 12:30 pm | Nanomaterial-Based Agents |
| 9:00 am - 9:10 am | Discussion Leader: Henry Kopecek (Univ. of Utah) |
| 9:10 am - 9:30 am | Shiladitya Sengupta (Massachusetts Institute of Technology)
"Pathophysiology-inspired engineering of hybrid nanoparticles" |
| 9:30 am - 9:45 am | Discussion |
| 9:45 am - 10:05 am | Joseph DeSimone (Univ. of North Carolina, Chapel Hill)
"Opportunities Associated with the Control of Size, Shape, Surface Chemistry and Modulus of Carriers for Use in Medicine" |
| 10:05 am - 10:20 am | Discussion |
| 10:20 am | Coffee Break |
| 10:50 am - 11:10 am | Kimberly Hamad-Schifferli (Massachusetts Institute of Technology)
"Interfacing Nanoparticles to Biology: Multifunctional Nanoparticles" |
| 11:10 am - 11:25 am | Discussion |
| 11:25 am - 11:35 am | Omolola E. Adefeso (U.Mich.)
"Fabrication of nanoparticles for vasculature" |
| 11:35 am - 11:40 am | Discussion |
| 11:40 am - 11:50 am | Kristy Ainslie (UCSF)
"Microfabricated oral delivery vehicle" |
| 11:50 am - 11:55 am | Discussion |
| 11:55 am - 12:05 pm | Jinming Gao (UTSouthwestern)
"Non spherical nanomedicines platforms" |
| 12:05 pm - 12:10 pm | Discussion |
| 12:30 pm | Lunch |
| 1:30 pm - 4:00 pm | Free Time |
| 4:00 pm - 6:00 pm | Poster Session (Last Names A-K) |
| 6:00 pm | Dinner |
| 7:30 pm - 9:30 pm | Genetic and Cell-Based Therapies |
| 7:30 pm - 7:40 pm | Discussion Leader: Kyung-Dall Lee (Univ. of Michigan) |
| 7:40 pm - 8:00 pm | Martin Brown (Stanford University)
"Anaerobic bacteria as tumor specific drug targeting agents" |
| 8:00 pm - 8:15 pm | Discussion |
| 8:15 pm - 8:35 pm | Neil Forbes (Univ. of Massachusetts, Amherst)
"Spatial and temporal control of delivery to tumors using engineered S. typhimurium" |
| 8:35 pm - 8:50 pm | Discussion |
| 8:50 pm - 9:15 pm | Adrian Krainer (Cold Spring Harbor Laboratory)
"Splicing Correction as a Therapeutic Approach in Spinal Muscular Atrophy" |
| 9:15 pm - 9:30 pm | Discussion |
| WEDNESDAY |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am - 12:30 pm | Novel Agents, Pharmacogenomics |
| 9:00 am - 9:10 am | Discussion Leader: Peter Senter (Seattle Genetics, Inc.) |
| 9:10 am - 9:30 am | Michael Shuler (Cornell University)
"A Body-on-a Chip for Testing Pharmaceuticals" |
| 9:30 am - 9:45 am | Discussion |
| 9:45 am - 10:05 am | Yana Reshetnyak (Univ. of Rhode Island)
"pHLIP Nanotechnology platform for cancer imaging and therapy" |
| 10:05 am - 10:20 am | Discussion |
| 10:20 am | Coffee Break |
| 10:50 am - 11:10 am | Kathy Giacomini (Univ. of California, San Francisco)
"Pharmacogenetics of Transporters: From SNP Discovery to Drug Therapy" |
| 11:10 am - 11:25 am | Discussion |
| 11:25 am - 11:35 am | Young Investigator Presentation (TBA) |
| 11:35 am - 11:40 am | Discussion |
| 11:40 am - 11:50 am | Anu Puri (NCI-Frederick)
"Radiosensitive liposomes" |
| 11:50 am - 12:00 pm | Stavroula Sofou (Polytech U)
"pH sensitive liposomes" |
| 12:00 pm - 12:10 pm | Discussion |
| 12:30 pm | Lunch |
| 1:30 pm - 4:00 pm | Free Time |
| 4:00 pm - 6:00 pm | Poster Session (Last Names L-Z) |
| 6:00 pm | Dinner |
| 7:30 pm - 8:00 pm | Business Meeting |
| (Nominations for the next Vice Chair; Fill out Conference Evaluation Forms; Discuss future Site & Scheduling preferences; Election of the next Vice Chair) |
| 8:00 pm - 9:30 pm | Student, Post Doc, Young Investigator Presentations |
| Discussion Leaders: Philip Low (Purdue University) & Patrick Stayton (Univ. of Washington) |
| (Presentations selected from Poster Session: All poster presenters should be prepared to give a short talk (ppt file) if selected) |
| THURSDAY |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am - 12:30 pm | Antibodies and Conjugates |
| 9:00 am - 9:10 am | Discussion Leader: David Scheinberg (MSKCC) |
| 9:10 am - 9:35 am | Ira Pastan (NCI)
"Immunotoxins in 2008: Successes and Challenges" |
| 9:35 am - 9:50 am | Discussion |
| 9:50 am - 10:15 am | Oliver Press (Univ. of Washington)
"Pretargeted Radioimmunotherapy for Hematologic Malignancies" |
| 10:15 am - 10:30 am | Discussion |
| 10:30 am | Coffee Break |
| 11:00 am - 11:25 am | Ezio Bonvini (MacroGenics, Inc.)
"Exploiting Fc-Receptors for Therapeutic Purposes" |
| 11:25 am - 11:40 am | Discussion |
| 11:40 am - 12:05 pm | Allen Ebens (Genentech, Inc.)
"Antibody-Drug Conjugates: Principles of Safety and Efficacy, Promising Candidates for Treatment of Lymphoma" |
| 12:05 pm - 12:30 pm | Discussion |
| 12:30 pm | Lunch |
| 1:30 pm - 6:00 pm | Free Time |
| 6:00 pm | Dinner |
| 7:30 pm - 9:30 pm | Molecular Imaging |
| 7:30 pm - 7:40 pm | Discussion Leaders: David Scheinberg (MSKCC) & Oliver Press (Univ. of Washington) |
| 7:40 pm - 8:00 pm | Brian Ross (Univ. of Michigan, Ann Arbor)
"Imaging Biomarkers of Cancer Drug Response" |
| 8:00 pm - 8:15 pm | Discussion |
| 8:15 pm - 8:35 pm | Dwight Seferos (Northwestern University)
"Nano-Flares for Intracellular Imaging" |
| 8:35 pm - 8:50 pm | Discussion |
| 8:50 pm - 9:10 pm | David Piwnica-Worms (Washington University in St. Louis)
"Dynamic Imaging of Signal Transduction Pathways and Target-Specific Drug Pharmacodynamics In Vivo" |
| 9:10 pm - 9:30 pm | Discussion |
| FRIDAY |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am | Depart |