Sunday |
2:00 pm - 9:00 pm | Arrival and Check-in |
6:00 pm | Dinner |
7:30 pm - 7:40 pm | Welcome / Introductory Comments by GRC Site Staff |
7:40 pm - 9:30 pm | Big Perspectives of Drug Delivery: Cell Biology, Physiology and Engineering Perspectives |
| Discussion Leader: Paula Hammond (Massachusetts Institute of Technology, USA) |
7:40 pm - 8:20 pm | Harold Dvorak (Beth Israel Deaconess Medical Center, USA) "The Tumor Vasculature: Barrier and Potential Target" |
8:20 pm - 8:35 pm | Discussion |
8:35 pm - 9:15 pm | Justin Hanes (Johns Hopkins School of Medicine, USA) "Nanomedicine: From Basic Concept to Success in the Clinic" |
9:15 pm - 9:30 pm | Discussion |
Monday |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | Barriers and Carriers for Delivery Across Epithelial and Extracellular Barriers |
| Discussion Leaders: Rebecca Carrier (Northeastern University, USA) and David Grainger (University of Utah, USA) |
9:00 am - 9:30 am | Claus-Michael Lehr (Helmholtz- Zentrum für Infektionsforschung (HZI), Germany) "Nanocarriers for Overcoming Epithelial and Microbial Barriers" |
9:30 am - 9:45 am | Discussion |
9:45 am - 10:15 am | Samir Mitragotri (University of California, Santa Barbara, USA) "Ionic Liquids for
Delivering Drugs Across the Skin" |
10:15 am - 10:30 am | Discussion |
10:30 am - 11:00 am | Group Photo / Coffee Break |
11:00 am - 11:30 am | Theresa Reineke (University of Minnesota, USA) "From Discovery to Design:
Enabling Functional Drug and Nucleic Acid Transport Through Controlled Polymer
Synthesis" |
11:30 am - 11:45 am | Discussion |
11:45 am - 12:15 pm | Kanjiro Miyata (The University of Tokyo, Japan) "Ligand-Installed Polymeric Nanocarriers for Targeted Drug and Nucleic Acid Delivery" |
12:15 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | Targets and Carriers to Overcome Endothelial Barriers |
| Discussion Leader: Jan Schnitzer (Proteogenomics Research Institute for Systems Medicine (PRISM), USA) |
7:30 pm - 8:00 pm | Fitz-Roy Curry (University of California, Davis, USA) "Transport Mechanisms Determining Uptake and Retention of Therapeutic Agents in Tumors" |
8:00 pm - 8:10 pm | Discussion |
8:10 pm - 8:40 pm | Silvia Muro (University of Maryland, College Park, USA) "Mechanistic of Intra- and Trans-Endothelial Transport of Nanotherapeutics" |
8:40 pm - 8:50 pm | Discussion |
8:50 pm - 9:20 pm | Vladimir Muzykantov (University of Pennsylvania, USA) "Endothelial Drug Targeting
with Sub-Cellular Precision" |
9:20 pm - 9:30 pm | Discussion |
Tuesday |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | Barriers and Carriers in Cancer: Treating Solid Tumors |
| Discussion Leaders: Nicole Steinmetz (Case Western Reserve University, USA) and Mark Grinstaff (Boston University, USA) |
9:00 am - 9:30 am | Angela Belcher (Massachusetts Institute of Technology, USA) "Targeting, Imaging and Treating Tiny Ovarian Tumors" |
9:30 am - 9:45 am | Discussion |
9:45 am - 10:15 am | Pete Choyke (National Cancer Institute, NIH, USA) "Super Enhanced Permeability and Retention After Photoimmunotherapy: Overcoming a Barrier
to Nano-Sized Drugs" |
10:15 am - 10:30 am | Discussion |
10:30 am - 11:00 am | Coffee Break |
11:00 am - 11:30 am | Gregory Lanza (Washington University in St. Louis, USA) "Achieving Effective Extravascular Targeted Drug Delivery in Solid and Liquid Cancers" |
11:30 am - 11:45 am | Discussion |
11:45 am - 12:15 pm | Martina Stenzel (University of New South Wales, Australia) "Unravelling the Influence of the Polymer on the Drug Delivery of Platinum Drugs" |
12:15 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | Overcoming Delivery Barriers to the Brain/BBB |
| Discussion Leader: Harold Dvorak (Beth Israel Deaconess Medical Center, USA) |
7:30 pm - 8:00 pm | Jennifer Cochran (Stanford University, USA) "Peptide-Drug Conjugates as Targeted Delivery Vehicles" |
8:00 pm - 8:10 pm | Discussion |
8:10 pm - 8:40 pm | Per-Ola Freskgard (Roche Innovation Center Basel, Switzerland) "Antibodies for CNS
Disorders and the Gateway to the Brain" |
8:40 pm - 8:50 pm | Discussion |
8:50 pm - 9:20 pm | Danica Stanimirovic (National Research Council / University of Ottawa, Canada) "Targeting Transcytosis
Pathways Across the Blood-Brain Barrier: Receptors, Antibodies and Endocytic
Sorting Pathways" |
9:20 pm - 9:30 pm | Discussion |
Wednesday |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | Challenges and Frontiers for Nanomedicine and Nanodelivery |
| Discussion Leaders: Christopher Alabi (Cornell University, USA) and Alexander Kabanov (University of North Carolina at Chapel Hill, USA) |
9:00 am - 9:30 am | Doo Sung Lee (Sungkyunkwan University, South Korea) "Acidic-Local Targeting Polymeric Nanocarriers: Theranostic Applications" |
9:30 am - 9:45 am | Discussion |
9:45 am - 10:15 am | Bogdan Olenyuk (Proteogenomics Research Institute for Systems Medicine, USA) "Design and Tumor-Specific
Delivery of Small Molecules Targeting Hypoxia-Inducible Transcription" |
10:15 am - 10:30 am | Discussion |
10:30 am - 11:00 am | Coffee Break |
11:00 am - 11:30 am | Suzie Pun (University of Washington, USA) "Phage, Peptides and Polymers: Targeted Drug Delivery Using Peptide Ligands Identified by Phage Display" |
11:30 am - 11:45 am | Discussion |
11:45 am - 12:15 pm | Maria Vicent (Centro de Investigacion Principe Felipe, Spain) "Polyglutamates as Versatile Drug Delivery Carriers" |
12:15 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session |
6:00 pm | Dinner |
7:00 pm - 7:30 pm | Business Meeting |
| Nominations for the Next Vice Chair; Fill in Conference Evaluation Forms; Discuss Future Site and Scheduling Preferences; Election of the Next Vice Chair |
7:30 pm - 9:30 pm | Late-Breaking Topics / Young Investigator Presentations |
| Discussion Leader: Muthiah Manoharan (Alnylam Pharmaceuticals, USA) |
7:30 pm - 7:40 pm | Samantha Berry (Boston University, USA) "Leveraging Peritoneal Tumor Localization of pH-Responsive Expansile Nanoparticles as a Tool for Fluorescence Guided Surgery and Drug Delivery" |
7:40 pm - 7:45 pm | Discussion |
7:45 pm - 7:55 pm | Julie Champion (Georgia Institute of Technology, USA) "Protein Nanocarriers for Intracellular Antibody Delivery" |
7:55 pm - 8:00 pm | Discussion |
8:00 pm - 8:10 pm | Honggang Cui (Johns Hopkins University, USA) "One-Component Nanomedicine" |
8:10 pm - 8:15 pm | Discussion |
8:15 pm - 8:25 pm | Christopher Collins (Purdue University, USA) "ß-Cyclodextrin Polyrotaxanes as Potential Niemann-Pick Type C Therapeutics: Performance and Structure-Property Relationships" |
8:25 pm - 8:30 pm | Discussion |
8:30 pm - 8:40 pm | Maria Daniela Garcia-Castillo (Boston Children's Hospital / Harvard Medical School, USA) "Glycoceramides as a Platform for Drug Delivery of Therapeutic Peptides" |
8:40 pm - 8:45 pm | Discussion |
8:45 pm - 8:55 pm | Christopher Jewell (University of Maryland, College Park, USA) "Design of Polyelectrolyte Multilayers to Promote Immune Tolerance" |
8:55 pm - 9:00 pm | Discussion |
9:00 pm - 9:10 pm | Liangliang Hao (Massachusetts Institute of Technology, USA) "Tumor Penetrating RNA Delivery for Therapeutic Benefit of Pancreatic Cancer" |
9:10 pm - 9:15 pm | Discussion |
9:15 pm - 9:25 pm | Millicent Sullivan (University of Delaware, USA) "Collagen Turnover Stimulated Gene Delivery to Enhance Wound Repair" |
9:25 pm - 9:30 pm | Discussion |
Thursday |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | Barriers and Carriers for Infectious Disease and Vaccines: Targeting the Immune System |
| Discussion Leader: Darrell Irvine (Massachusetts Institute of Technology, USA) |
9:00 am - 9:30 am | Mark Prausnitz (Georgia Institute of Technology, USA) "Drug and Vaccine Delivery
Using Microneedle Patches" |
9:30 am - 9:45 am | Discussion |
9:45 am - 10:00 am | John Wilson (Vanderbilt University, USA) "pH-Responsive Polymer Vesicles for Immunotherapeutic Targeting of STING Pathway" |
10:00 am - 10:05 am | Discussion |
10:05 am - 10:25 am | Joe Akin (Novartis Institutes for Biomedical Research, USA) "Introduction to in-situ vaccination" |
10:25 am - 10:30 am | Discussion |
10:30 am - 11:00 am | Coffee Break |
11:00 am - 11:30 am | Matthias Stephan (Fred Hutchinson Cancer Research Center, USA) "Biopolymer Implants that Co-Deliver Programmed T Cells and STING Agonists Can Control Tumor Escape Variants" |
11:30 am - 11:45 am | Discussion |
11:45 am - 12:15 pm | Liangfang Zhang (University of California, San Diego, USA) "Nanotherapeutics and
Nanovaccines for Antibiotic-Resistant Bacteria" |
12:15 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 5:30 pm | Poster Session |
5:30 pm - 7:30 pm | Translational Approaches to RNA Delivery |
| Discussion Leader: Kathryn Whitehead (Carnegie Mellon University, USA) |
5:30 pm - 6:00 pm | Debra Auguste (City College of New York, USA) "Liposomal Gene Editing and Delivery" |
6:00 pm - 6:10 pm | Discussion |
6:10 pm - 6:40 pm | Judy Lieberman (Harvard Medical School, USA) "Breaking Out: siRNA Release from Endosomes and Target Gene Knockdown" |
6:40 pm - 6:50 pm | Discussion |
6:50 pm - 7:20 pm | Anil Sood (University of Texas MD Anderson Cancer Center, USA) "New Approaches for Targeting Tumor Angiogenesis" |
7:20 pm - 7:30 pm | Discussion |
8:00 pm | Dinner |
Friday |
7:30 am - 8:30 am | Breakfast |
9:00 am | Departure |