Sunday
2:00 pm - 9:00 pm
Arrival and Check-in
6:00 pm - 7:00 pm
Dinner
7:30 pm - 7:40 pm
Introductory Comments by GRC Site Staff / Welcome from the GRC Chair
7:40 pm - 9:30 pm
Keynote Session: Drug Carriers Revolutionizing Therapeutic Approaches
Discussion Leaders: Dennis Lee (Bill & Melinda Gates Foundation, United States) and Vladimir Muzykantov (PENN, United States)
7:40 pm - 8:05 pm
Paula Hammond (Massachusetts Institute of Technology, United States)
"Tuning Sticky Nanoparticles: Manipulating Charge for Controlled Targeting and Trafficking"
8:05 pm - 8:20 pm
Discussion
8:20 pm - 8:45 pm
David Mooney (Harvard University, United States)
"Biomaterials to Enhance Adoptive T Cell Therapy"
8:45 pm - 8:55 pm
Discussion
8:55 pm - 9:20 pm
David Schaffer (University of California, Berkeley, United States)
"Directed Evolution of Novel AAV Vectors for Clinical Gene Therapy"
9:20 pm - 9:30 pm
Discussion
Monday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
New Materials for Drug Delivery
Discussion Leader: Ester Kwon (UCSD, United States)
9:00 am - 9:30 am
Theresa Reineke (University of Minnesota, United States)
"Tunable Multifunctional Macromolecules for Drug and Nucleic Acid Delivery via Parallel Synthesis, Characterization, and Machine Learning"
9:30 am - 9:45 am
Discussion
9:45 am - 10:15 am
Paul Wender (Stanford University, United States)
"Breaching Biological Barriers: Organ Targeting, Therapeutic Vaccinations and Enhanced Immunotherapy with the CART Delivery System"
10:15 am - 10:30 am
Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:30 am
Kristy Ainslie (University of North Carolina at Chapel Hill, United States)
"Effect of Polymer Degradation Rate on Immune Response and Universal Influenza Vaccine Efficacy"
11:30 am - 11:45 am
Discussion
11:45 am - 12:15 pm
Jean-Christophe Leroux (ETH Zurich, Switzerland)
"3D-Printed Drug Delivery Devices: From Prototyping to Personalized Medicine"
12:15 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
3:00 pm - 4:00 pm
The GRC Power Hourâ„¢
The GRC Power Hourâ„¢ is designed to address diversity and inclusion in the scientific workplace by providing a safe environment for informal and meaningful conversations amongst colleagues of all career stages. The program supports the professional growth of all members of our communities, including ethnicity, race and/or gender identity by providing an open forum for discussion and mentoring.
Organizer: Kristy Ainslie (University of North Carolina at Chapel Hill, United States)
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Immunology Applications and Carrier Interactions with the Immune System
Discussion Leader: Elizabeth Nance (University of Washington, United States)
7:30 pm - 7:55 pm
Jinming Gao (University of Texas Southwestern Medical Center, United States)
"Design and Development of Polyvalent STING Agonist to Augment Antitumor Immunity"
7:55 pm - 8:10 pm
Discussion
8:10 pm - 8:35 pm
Anna Schwendeman (University of Michigan, United States)
"Clinical Translation of Synthetic High-Density Lipoprotein Therapeutics and Drug Carriers"
8:35 pm - 8:50 pm
Discussion
8:50 pm - 9:15 pm
Evan Scott (Northwestern University, United States)
"Nanotherapy for Targeted Immunosuppression and Tolerance"
9:15 pm - 9:30 pm
Discussion
Tuesday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Group Photo
9:00 am - 12:30 pm
Drug Carriers in Oncology
Discussion Leader: Rizia Bardhan (Iowa State University, United States)
9:00 am - 9:30 am
Natalie Artzi (Brigham and Women's Hospital / Harvard Medical School / Massachusetts Institute of Technology, United States)
"Biomaterials for Immune Modulation"
9:30 am - 9:45 am
Discussion
9:45 am - 10:15 am
Anand Subramony (AstraZeneca, United States)
"Re-Emergence of Drug Targeting Using Nanocarriers-Immune Targeting and Nano Drug Conjugates"
10:15 am - 10:30 am
Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:30 am
Yoon Yeo (Purdue University, United States)
"Carrier Engineering for Systemic Gene Delivery - Beyond the Liver"
11:30 am - 11:45 am
Discussion
11:45 am - 12:15 pm
Tatiana Novobrantseva (Verseau Therapeutics, United States)
"Utilizing siRNA-LNP to Open up Novel Biology of Human Macrophage Repolarization"
12:15 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Cell-Mediated Drug Delivery
Discussion Leader: Juliane Nguyen (University of North Carolina at Chapel Hill, United States)
7:30 pm - 7:55 pm
Omid Veiseh (Rice University, United States)
"Developing Immunomodulatory Biomaterials for Cell-Based Therapeutics"
7:55 pm - 8:10 pm
Discussion
8:10 pm - 8:35 pm
Elena Batrakova (University of North Carolina at Chapel Hill, United States)
"Autologous Macrophages as Potent and Versatile Drug Carriers for Treatment of Neurodegenerative Disorders"
8:35 pm - 8:50 pm
Discussion
8:50 pm - 9:15 pm
Richard Klemke (University of California, San Diego, United States)
"Bioengineered Enucleated Cell-like Drones: a New Platform Technology for Targeted Therapeutic Delivery"
9:15 pm - 9:30 pm
Discussion
Wednesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Translational Advances in Drug Delivery
Discussion Leaders: Joerg Lahann (University of Michigan, United States)
9:00 am - 9:30 am
Muthiah (Mano) Manoharan (Alnylam Pharmaceuticals, United States)
"Living in the World of RNA Medicine: Have We Solved the Delivery?"
9:30 am - 9:45 am
Discussion
9:45 am - 10:15 am
Giovanni Traverso (MIT, United States)
"GI Devices for Drug Delivery and Sensing"
10:15 am - 10:30 am
Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:30 am
Kannan Rangaramanujam (Johns Hopkins University School of Medicine, United States)
"Taking Advantage of Disease Pathology: Development and Translation of Inflammation-Targeted Systemic Nanomedicines"
11:30 am - 11:45 am
Discussion
11:45 am - 12:15 pm
Sujatha Sonti (GSK, United States)
"Drug Delivery Approaches: From Concept to Commercialization"
12:15 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Selected Poster Presentations
Discussion Leader: Vadim Dudkin (NewCo, United States)
7:30 pm - 7:40 pm
Ester Kwon (UCSD, United States)
"Reprogramming clots in the injured brain for chemical ligation with multiscale materials"
7:40 pm - 7:45 pm
Discussion
7:45 pm - 7:55 pm
Anirudh Gairola (Texas A&M University, United States)
"Hetero-multivalent targeted drug delivery against P.aeruginosa"
7:55 pm - 8:00 pm
Discussion
8:00 pm - 8:10 pm
Jeonghwan Kim (Oregon State University, United States)
"Inhalable Lipid Nanoparticles for Messenger RNA Therapeutics"
8:10 pm - 8:15 pm
Discussion
8:15 pm - 8:25 pm
Natalie Jasiewicz (UNC Chapel Hill, United States)
"ZipperCells Exhibit Enhanced Accumulation and Retention at the site of Myocardial Infarction"
8:25 pm - 8:30 pm
Discussion
8:30 pm - 8:40 pm
Nicholas Lamson (Massachusetts Institute of Technology, United States)
"Comparing Uptake and Transport of Nanomaterials in Preclinical Blood Brain Barrier (BBB) Models using a Layer-by-Layer Electrostatically Assembled Nanoparticle Library"
8:40 pm - 8:45 pm
Discussion
8:45 pm - 8:55 pm
Wayne Ngo (University of Toronto, Canada)
"Identifying cell receptors for the nanoparticle protein corona using genome screens"
8:55 pm - 9:00 pm
Discussion
9:00 pm - 9:10 pm
Shraddha Sawant (University of Connecticut, United States)
"Targeted GATA-3 regulation in immune cells using Peptide Crosslinked Nucleic Acid Nanocapsules as a Treatment for Asthma"
9:10 pm - 9:15 pm
Discussion
9:15 pm - 9:25 pm
Fan Zhang (University of Florida College of Pharmacy, United States)
"Secretion of T-cell engagers from in situ programmed myeloid cells overcomes poor delivery kinetics, inefficient tumor penetration and autoimmune toxicity"
9:25 pm - 9:30 pm
Discussion
Thursday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Business Meeting
Nominations for the Next Vice Chair(s); Complete the GRC Evaluation Forms; Discuss Future Dates and Venue; Election of the Next Vice Chair(s)
9:00 am - 12:30 pm
Intracellular Drug Delivery
Discussion Leader: Michael Mitchell (University of Pennsylvania, United States)
9:00 am - 9:30 am
Julie Champion (Georgia Institute of Technology, United States)
"Self-Assembled Protein Nanocarriers for Intracellular Delivery"
9:30 am - 9:45 am
Discussion
9:45 am - 10:15 am
Paul Burke (Burke Bioventures, United States)
"Engineering Intracellular Pre-drug Therapeutics for Radical Cure of Malaria"
10:15 am - 10:30 am
Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:30 am
Craig Duvall (Vanderbilt University, United States)
"Engineering of siRNA with Albumin-Binding PK Modifiers"
11:30 am - 11:45 am
Discussion
11:45 am - 12:15 pm
Maria Jose Alonso (University of Santiago de Compostela, Spain)
"Intracellular Delivery of Biological Drugs"
12:15 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Biological Carriers
Discussion Leader: Olivia Merkel (Ludwig Maximilian University of Munich, Germany)
7:30 pm - 7:55 pm
Laura Ensign (Johns Hopkins University, United States)
"Bugs as Drugs: Women's Health Edition"
7:55 pm - 8:10 pm
Discussion
8:10 pm - 8:35 pm
Nicole Steinmetz (University of California, San Diego, United States)
"Plant Viruses Against Cancer"
8:35 pm - 8:50 pm
Discussion
8:50 pm - 9:15 pm
Donald Hilvert (ETH Zurich, Switzerland)
"Engineered Protein Cages as Versatile Delivery Vehicles"
9:15 pm - 9:30 pm
Discussion
Friday
7:30 am - 8:30 am
Breakfast
9:00 am
Departure