Sunday
2:00 pm - 9:00 pm
Arrival and Check-in
6:00 pm - 7:00 pm
Dinner
7:30 pm - 7:40 pm
Introductory Comments by GRC Staff / Welcome and Introduction from the Chairs
7:40 pm - 9:30 pm
Keynote Session: The Drug Delivery Revolution
7:40 pm - 8:20 pm
"Realizing the Promise of CRISPR Therapeutics"
8:20 pm - 8:35 pm
Discussion
8:35 pm - 9:15 pm
"Drug and Genomic Medicines Made Using Digital Fabrication Techniques and Multiphase Synthetic Approaches"
9:15 pm - 9:30 pm
Discussion
Monday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Lipid Nanoparticles in Drug Delivery
9:00 am - 9:30 am
"Strategies for Non-Viral Vectors Targeting Organs Beyond the Liver"
9:30 am - 9:45 am
Discussion
9:45 am - 10:15 am
"Non-Viral DNA Delivery: Selectivity for Liver, T Cells and Beyond"
10:15 am - 10:30 am
Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:30 am
"Protein Corona Formation on Lipid Nanoparticles and Implications for Nanoparticle Cellular Entry Kinetics"
11:30 am - 11:45 am
Discussion
11:45 am - 12:15 pm
"Structural Complexity of Lipid Nanoparticles: Implications for Efficient and Organ-Specific Gene Delivery"
12:15 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
3:00 pm - 4:00 pm
The GRC Power Hour™
The GRC Power Hour™ is designed to address diversity and inclusion in the scientific workplace by providing a safe environment for informal and meaningful conversations amongst colleagues of all career stages. The program supports the professional growth of all members of our communities, including ethnicity, race and/or gender identity by providing an open forum for discussion and mentoring.
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Therapeutic Carriers for Reproductive Health
7:30 pm - 8:00 pm
"Nanomaterial Applications and Toxicities in Perinatal Therapeutics"
8:00 pm - 8:15 pm
Discussion
8:15 pm - 8:45 pm
"Harnessing Innovative Engineering Tools to Develop Next Generation Multipurpose Technologies for Prevention of HIV and Unplanned Pregnancy"
8:45 pm - 9:00 pm
Discussion
9:00 pm - 9:20 pm
"Modulation of Nanoparticles’ Interaction with Human Placenta"
9:20 pm - 9:30 pm
Discussion
Tuesday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Group Photo
9:00 am - 12:30 pm
The Biomaterials-Drug Carrier Interface
9:00 am - 9:30 am
"Stimuli-Responsive Antimicrobial Drug Delivery Systems"
9:30 am - 9:45 am
Discussion
9:45 am - 10:15 am
"Engineered Indoleamine 2,3-Dioxygenase for Immunometabolic Suppression of Inflammation"
10:15 am - 10:30 am
Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:30 am
"The ECM Barrier to Drug and Gene Delivery"
11:30 am - 11:45 am
Discussion
11:45 am - 12:15 pm
"Therapeutic Agents as Biomaterials Building Blocks: Blurring the Line Between Drugs and Carriers"
12:15 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Immunoengineering-Enabling Technology
7:30 pm - 7:55 pm
"Engineering Therapeutic Cell-Cell Interactions"
7:55 pm - 8:10 pm
Discussion
8:10 pm - 8:35 pm
"Bionic Macrophages for Regenerative Medicine"
8:35 pm - 8:50 pm
Discussion
8:50 pm - 9:15 pm
"Lymphatic Targeting Therapeutic Delivery Systems"
9:15 pm - 9:30 pm
Discussion
Wednesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Next-Generation Nanoformulations
9:00 am - 9:30 am
"Enzymatically Gated Gene Expression Using Nucleic Acid Nanocapsules"
9:30 am - 9:45 am
Discussion
9:45 am - 10:15 am
"From Proteins to Probiotics - Advances in Targeted Drug Delivery"
10:15 am - 10:30 am
Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:30 am
"Modified Self-Amplifying RNA is the Next RNA Therapeutics"
11:30 am - 11:45 am
Discussion
11:45 am - 12:15 pm
"Engineering to Maximize Transport: Nanotherapeutics for the Developing Brain"
12:15 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Selected Poster Presentations
7:30 pm - 7:40 pm
"Leveraging Enterohepatic Transport Pathways for Drug Delivery to the Intestinal Mucosa"
7:40 pm - 7:45 pm
Discussion
7:45 pm - 7:55 pm
"Spatiotemporal Delivery and Activation of Immunomodulatory"
7:55 pm - 8:00 pm
Discussion
8:00 pm - 8:10 pm
"Platinum Nanoparticles as a Therapy for Triple Negative Breast Cancer"
8:10 pm - 8:15 pm
Discussion
8:15 pm - 8:25 pm
"Engineered Protein Cages for RNA Delivery"
8:25 pm - 8:30 pm
Discussion
8:30 pm - 8:40 pm
"Plant Viruses as Anti-Cancer Agents"
8:40 pm - 8:45 pm
Discussion
8:45 pm - 8:55 pm
"Targeted STING Agonism Differentially Impacts Expression and Immunogenicity of Self-Amplifying RNA Formulated in Polymer vs. Lipid Nanoparticles"
8:55 pm - 9:00 pm
Discussion
9:00 pm - 9:10 pm
"A Novel Modular Strategy to Augment Functionality of Cell Membrane-Coated Nanoparticles"
9:10 pm - 9:15 pm
Discussion
9:15 pm - 9:25 pm
"Ingestible Devices to Enable GI Delivery of Living Drugs"
9:25 pm - 9:30 pm
Discussion
Thursday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Business Meeting
Nominations for the Next Vice Chair(s); Complete the GRC Evaluation Forms; Election of the Next Vice Chair(s)
9:00 am - 12:30 pm
Precision Delivery Systems: Targeting Cells and Tissues
9:00 am - 9:30 am
"Polymeric Prodrugs For Infectious Disease and Immune Therapy"
9:30 am - 9:45 am
Discussion
9:45 am - 10:15 am
"Engineered Extracellular Vesicles for Targeted Delivery of RNA and Gene Editors"
10:15 am - 10:30 am
Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:30 am
"Hitting the Targets While Avoiding the Bystanders: Mechanistic Studies to Enable a Safety-First Approach in Designing Targeted Nanoparticles"
11:30 am - 11:45 am
Discussion
11:45 am - 12:15 pm
"Targeted Delivery of Oligonucleotides and Other Payloads for the Treatment of Neuromuscular Diseases"
12:15 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Drug Carrier Design for Imaging and Theranostics
7:30 pm - 8:00 pm
"Ultrasound-Mediated Drug-free Theranostics for Treatment of Prostate Cancer"
8:00 pm - 8:15 pm
Discussion
8:15 pm - 8:45 pm
"Activity Based Nanosensors for Precision Medicine in Traumatic Brain Injury"
8:45 pm - 9:00 pm
Discussion
9:00 pm - 9:15 pm
General Discussion
9:15 pm - 9:30 pm
Closing Remarks
Friday
7:30 am - 8:30 am
Breakfast
9:00 am
Departure