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Drug Metabolism (GRS)

Gordon Research Seminar

Expanding Upon and Moving Beyond Paradigms

July 6 - 7, 2024
Chairs and
Holderness School
33 Chapel Lane
Holderness, New Hampshire, United States
 Venue and Travel Information

Conference Description

The Drug Metabolism GRS provides a unique forum for young doctoral and post-doctoral researchers to present their work, discuss new methods, cutting edge ideas, and pre-published data, as well as to build collaborative relationships with their peers. Experienced mentors and trainee moderators will facilitate active participation in scientific discussion to allow all attendees to be engaged participants rather than spectators.

This year’s GRS will take stock of paradigms within the field of drug metabolism, and additionally explore developments into new research territories. This will include sessions that highlight non-hepatic drug metabolism pathways, pharmacokinetic considerations for non-small molecule drug modalities, and clinical translation to special populations. Oral presentations by trainees and early-career scientists will be chosen from the submitted poster abstracts, and all attendees are encouraged to present at the poster sessions. The GRS meeting will conclude with a mentorship panel composed of early stage and established scientists from academia, nonprofit/government, and industry sectors.

Due to limited accommodations at this venue, guest housing is very limited. To request family/guest housing please reach out to your Conference Operations Associate.

Related Meeting

This GRS will be held in conjunction with the "Drug Metabolism" Gordon Research Conference (GRC). Those interested in attending both meetings must submit an application for the GRC in addition to an application for the GRS. Refer to the associated GRC program page for more information.

Conference Program

Saturday
1:00 pm - 5:00 pm
Arrival and Check-in
3:30 pm - 3:45 pm
Introductory Comments by GRC Staff / Welcome and Introduction from the Chairs
3:45 pm - 4:30 pm
Pharmacokinetic Considerations for Non-Small Molecule Drug Modalities
Discussion Leader:
3:45 pm - 4:05 pm
"Simulations Driven Decision-Making for the Lead Optimization of a Solid Tumor Targeting Bispecific Antibody"
4:05 pm - 4:10 pm
Discussion
4:10 pm - 4:25 pm
"Characterization of Antibody-Drug Conjugates Exposures in Bone Marrow-Hematopoietic Stem Cells Differentiated Neutrophil Precursors"
4:25 pm - 4:30 pm
Discussion
4:30 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Extra-Hepatic Drug Metabolism and IVIVE
Discussion Leader:
7:30 pm - 7:40 pm
"Mapping Host-Microbe Metabolism of Glucuronidated Chemicals via Mass Spectrometry"
7:40 pm - 7:45 pm
Discussion
7:45 pm - 7:55 pm
"Use of In Vitro and In Vivo Studies Together with PBPK Modeling to Understand Cortisol Kidney Disposition and Signaling"
7:55 pm - 8:00 pm
Discussion
8:00 pm - 8:10 pm
"THC and CBD Acyl Glucuronides are Formed by Different UGT Enzymes and Show Different Migration Rates"
8:10 pm - 8:15 pm
Discussion
8:15 pm - 8:25 pm
"Assessment of Cross-Platform Concordance of PBPK Model Performance Using Isoniazid as a Case Study"
8:25 pm - 8:30 pm
Discussion
8:30 pm - 8:40 pm
"Propranolol Glucuronide: A Potential Substrate for CYP2C8"
8:40 pm - 8:45 pm
Discussion
8:45 pm - 8:55 pm
"Predicting Impact of the Pgp Transporter on Drug Distribution and Disposition From Invitro Drug Transport Assays with Modeling and Simulation Approaches"
8:55 pm - 9:00 pm
Discussion
9:00 pm - 9:10 pm
"Impact of Allosteric Modulation by Progesterone on the Prediction of Time-Dependent Inhibition of CYP3A4 Using Static and Dynamic Models"
9:10 pm - 9:15 pm
Discussion
9:15 pm - 9:25 pm
"Evaluating Glycocalyx Partitioning of Basic Drugs and Developing a Novel Rat PBPK Model"
9:25 pm - 9:30 pm
Discussion
Sunday
7:30 am - 8:30 am
Breakfast
9:00 am - 11:00 am
Clinical Translation and Specific Populations
Discussion Leader:
9:00 am - 9:30 am
"Bedside to Bench and Back Again: A Clinical and Translational Approach to Precision Therapeutics"
9:30 am - 9:40 am
Discussion
9:40 am - 9:55 am
"Interindividual Variability in Sulfamethoxazole Metabolism in Primary Human Hepatocytes"
9:55 am - 10:05 am
Discussion
10:05 am - 10:20 am
"Quantification of Drug-Metabolising Enzymes and Transporters in Polycystic Kidney Disease"
10:20 am - 10:30 am
Discussion
10:30 am - 10:45 am
"Inter-Individual Variability of Aldo-Keto Reductases (AKRs) and Hydroxy-Steroid Dehydrogenases (HSDs) in Humans and Its Potential Impact on Metabolism of their Substrates"
10:45 am - 11:00 am
Discussion
11:00 am - 12:30 pm
Poster Session
Coffee will be served in the poster area from 11:00 am - 11:30 am
12:30 pm - 1:30 pm
Lunch
1:30 pm - 2:30 pm
Mentorship Component: Defining a Career Path in Drug Metabolism and Pharmacokinetics Research
Discussion Leader:
1:30 pm - 2:30 pm
Panel Discussion
Defining a Career Path in Drug Metabolism and Pharmacokinetics Research
2:30 pm - 3:00 pm
Evaluation Period
Complete the GRS Evaluation Forms; Election of Future Chair(s)
3:00 pm
Seminar Concludes

Contributors

Gordon Research Conferences
National Institutes of Health (NIH)

Funding for this conference was made possible (in part) by PA-21-151 from the National Center for Advancing Translational Sciences (NCATS). The views expressed in written conference materials or publications and by speakers and moderators do not necessarily reflect the official policies of the Department of Health and Human Services; nor does mention by trade names, commercial practices, or organizations imply endorsement by the U.S. Government.

Conference Links

Conference History Drug Metabolism
Additional Fee Info

Drug Metabolism
July 6 - 11, 2025


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