SUNDAY |
2:00 pm - 9:00 pm | Arrival and Check-in |
6:00 pm | Dinner |
7:30 pm - 7:40 pm | Welcome / Introductory Comments by GRC Site Staff |
7:40 pm - 9:30 pm | A Global Perspective on the Drug Resistance Problem |
| Discussion Leader: Manuel Navia (Oxford Bioscience Partners)
"Introduction" |
7:40 pm - 8:20 pm | Pradip Rathod (University of Washington)
"Initiation of Drug Resistance in Malaria Parasites"
|
8:20 pm - 8:35 pm | Discussion |
8:35 pm - 9:15 pm | Jean Patel (Centers for Disease Control)
"Antibiotic Resistant Threats in the United States"
|
9:15 pm - 9:30 pm | Discussion |
MONDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | Evolution of Drug Resistance |
9:00 am - 9:10 am | Discussion Leader: Peg Riley (University of Massachusetts)
"Introduction" |
9:10 am - 9:50 am | Gerard Wright (McMaster University)
"Resisting Resistance: Rescuing Antibiotics by Inhibiting Resistance Mechanisms"
|
9:50 am - 10:05 am | Discussion |
10:05 am | Coffee Break |
10:35 am - 11:15 am | Alan Perelson (Los Alamos National Laboratory)
"Modeling Resistance to Direct-Acting Antiviral Compounds for Hepatitis C"
|
11:15 am - 11:30 am | Discussion |
11:30 am - 12:10 pm | Edison Liu (Jackson Laboratories)
"Systems Explanations for Relative Sensitivity"
|
12:10 pm - 12:25 pm | Discussion |
12:25 pm - 12:30 pm | General Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | Understanding and Overcoming Chronic Resistance |
7:30 pm - 7:40 pm | Discussion Leader: TBA |
7:40 pm - 8:20 pm | Kim Lewis (Northeastern University)
"Combating Drug Resistance and Tolerance"
|
8:20 pm - 8:35 pm | Discussion |
8:35 pm - 9:15 pm | Sreenath Sharma (Novartis Institutes for Biomedical Research)
"Resisting Resistance to Anti-Cancer Therapeutics"
|
9:15 pm - 9:30 pm | Discussion |
TUESDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | Designing Drugs to Overcome Resistance |
9:00 am - 9:10 am | Discussion Leader: Lynn Silver (LL Silver Consulting)
"Introduction" |
9:10 am - 9:50 am | Erin Duffy (Melinta Therapeutics)
"Structure-Based Design of New Ribosome Inhibitors Robust to Multidrug-Resistant Pathogens"
|
9:50 am - 10:05 am | Discussion |
10:05 am | Coffee Break |
10:35 am - 11:15 am | Xiao Tong (InnovaTID Pharmaceuticals)
"Monitoring the Emergence of Resistance to HCV Antiviral Therapy in Clinical Trials"
|
11:15 am - 11:30 am | Discussion |
11:30 am - 12:10 pm | Paul Carey (Case Western Reserve University)
"Following Drug Penetration and Reactions Inside Bacterial Cells by Raman Microscopy"
|
12:10 pm - 12:25 pm | Discussion |
12:25 pm - 12:30 pm | General Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | Emerging Resistance |
7:30 pm - 7:40 pm | Discussion Leaders: Michael Nailor (Hartford Hospital) and Jeffrey Aeschlimann (University of Connecticut Health Center)
"Introduction" |
7:40 pm - 8:20 pm | Evan Snitkin (NIH)
"Application of Whole Genome Sequencing to Track the Spread of Infections in Hospitals"
|
8:20 pm - 8:35 pm | Discussion |
8:35 pm - 9:15 pm | Daniel Zurawski (Walter Reed Army Institute of Research)
"Colistin-Resistance in A. baumannii: Impacts on the Membrane and Virulence that are Compensated by Mutation in the Host"
|
9:15 pm - 9:30 pm | Discussion |
WEDNESDAY |
7:30 am - 8:30 am | Breakfast |
8:30 am | Group Photo |
9:00 am - 12:30 pm | The Evolution of New Drug-Resistant Populations |
9:00 am - 9:10 am | Discussion Leader: Sally Blower (University of California, Los Angeles)
"Introduction" |
9:10 am - 9:50 am | David Perlin (New Jersey Medical School)
"Echinocandin Antifungal Drug Resistance: Epidemiology and Mechanism"
|
9:50 am - 10:05 am | Discussion |
10:05 am | Coffee Break |
10:35 am - 11:15 am | Mercedes Becerra (Harvard Medical School)
"New Methods for Counting Children with Drug-Resistant Tuberculosis"
|
11:15 am - 11:30 am | Discussion |
11:30 am - 12:10 pm | Jeffrey Scott (Cornell University)
"Insecticide Resistance"
|
12:10 pm - 12:25 pm | Discussion |
12:25 pm - 12:30 pm | General Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session |
6:00 pm | Dinner |
7:00 pm - 7:30 pm | Business Meeting |
| Nominations for the Next Vice Chair; Fill in Conference Evaluation Forms; Discuss Future Site and Scheduling Preferences; Election of the Next Vice Chair |
7:30 pm - 9:30 pm | In Vitro/In Vivo Modeling of Resistance |
7:30 pm - 7:50 pm | Discussion Leader: Jared Silverman (Cubist Pharmaceuticals)
"Introduction" |
7:50 pm - 8:30 pm | David Hooper (Massachusetts General Hospital)
"Quinolone Resistance - Microbial Ingenuity in Action"
|
8:30 pm - 8:40 pm | Discussion |
8:40 pm - 9:20 pm | Jennifer Leeds (Novartis Pharmaceuticals)
"Critical Assessment of In Vitro and In Vivo Models of Antibacterial Resistance and Fitness Costs Using Peptide Deformylase Inhibitors as Validation Tools"
|
9:20 pm - 9:30 pm | Discussion |
THURSDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | Genomic Profiling in Drug Resistance |
9:00 am - 9:10 am | Discussion Leader: Celia Schiffer (University of Massachusetts, Medical School)
"Introduction" |
9:10 am - 9:50 am | David Rogers (University of Tennessee)
"The Genetic Basis of Azole Antifungal Resistance in Candida Species"
|
9:50 am - 10:05 am | Discussion |
10:05 am | Coffee Break |
10:35 am - 11:15 am | Celia Schiffer (University of Massachusetts Medical School)
"Combating Drug Resistance: Lessons from the Viral Proteases of HIV-1 and HCV"
|
11:15 am - 11:30 am | Discussion |
11:30 am - 11:50 am | TBA (Poster Presenters) |
11:50 am - 12:00 pm | Discussion |
12:00 pm - 12:20 pm | TBA (Poster Presenters) |
12:20 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 5:30 pm | Poster Session |
5:30 pm - 7:30 pm | Resistance at the Molecular Level |
5:30 pm - 5:40 pm | Discussion Leader: Norton Peet (Microbiotix, Inc.)
"Introduction" |
5:40 pm - 6:20 pm | Jennifer McKimm-Breschkin (Commonwealth Scientific and Industrial Research Organization)
"Influenza Neuraminidase Inhibitors - Lessons in Drug Design from Drug Resistance Studies"
|
6:20 pm - 6:35 pm | Discussion |
6:35 pm - 7:15 pm | John Manchester (AstraZeneca)
"The Hunt for New Drugs to Combat the Challenge of Antibacterial Resistance"
|
7:15 pm - 7:30 pm | Discussion |
8:00 pm | Dinner |
FRIDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am | Departure |